GREMLIN Database
PTKA - Galactitol-specific phosphotransferase enzyme IIA component
UniProt: P69828 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12414
Length: 150 (135)
Sequences: 6670 (5098)
Seq/√Len: 438.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_S130_I3.3401.00
3_N135_T2.4761.00
20_T37_P2.2411.00
23_G37_P2.1741.00
24_N28_A2.1281.00
127_E131_T2.0161.00
78_P98_V2.0071.00
22_I100_A2.0061.00
35_T67_H1.9911.00
33_H69_K1.9811.00
12_F21_H1.9341.00
14_D17_E1.8971.00
40_L100_A1.8761.00
11_S79_T1.8461.00
31_V70_S1.7991.00
7_R25_E1.7791.00
9_G79_T1.7331.00
27_L32_V1.7201.00
12_F18_V1.7011.00
81_K96_S1.6821.00
5_F29_K1.6791.00
38_Q42_A1.6721.00
31_V72_A1.6271.00
9_G77_R1.6081.00
72_A102_I1.5831.00
22_I76_L1.5491.00
16_S45_A1.5461.00
4_L29_K1.5391.00
10_I76_L1.5341.00
68_A102_I1.5201.00
71_S104_E1.4821.00
13_V17_E1.4781.00
133_P136_Q1.4751.00
42_A45_A1.4751.00
36_W102_I1.4571.00
20_T41_I1.4291.00
132_L137_L1.4031.00
57_A96_S1.4001.00
18_V98_V1.3681.00
3_N138_K1.3651.00
39_A63_C1.3601.00
44_E51_I1.3571.00
66_I105_N1.3531.00
39_A42_A1.3331.00
135_T139_E1.3181.00
78_P81_K1.2741.00
132_L136_Q1.2731.00
25_E28_A1.2651.00
83_H94_A1.2561.00
7_R21_H1.2471.00
25_E29_K1.2421.00
19_L40_L1.2411.00
8_S77_R1.2331.00
16_S41_I1.2251.00
138_K142_T1.2041.00
95_V98_V1.1841.00
42_A46_E1.1841.00
33_H67_H1.1721.00
128_T143_K1.1531.00
126_V130_I1.1481.00
84_F98_V1.1411.00
23_G40_L1.1341.00
75_L137_L1.1301.00
128_T140_Y1.0991.00
53_L126_V1.0861.00
10_I21_H1.0851.00
7_R10_I1.0751.00
44_E49_T1.0461.00
97_L130_I1.0451.00
16_S20_T1.0421.00
32_V36_W1.0311.00
15_R85_Q1.0191.00
8_S137_L1.0191.00
37_P41_I1.0181.00
12_F78_P1.0101.00
132_L140_Y1.0081.00
119_K125_I1.0021.00
71_S103_V0.9981.00
50_G87_A0.9841.00
11_S80_N0.9771.00
114_R118_G0.9751.00
21_H25_E0.9651.00
90_D94_A0.9591.00
83_H86_Q0.9581.00
136_Q139_E0.9541.00
27_L34_D0.9471.00
73_I112_L0.9431.00
17_E20_T0.9301.00
81_K94_A0.9291.00
25_E74_Y0.9271.00
19_L37_P0.9231.00
6_V137_L0.9191.00
26_M74_Y0.9131.00
17_E21_H0.9091.00
78_P96_S0.9081.00
23_G100_A0.9031.00
26_M102_I0.8921.00
24_N27_L0.8871.00
128_T131_T0.8831.00
75_L97_L0.8821.00
117_F121_Q0.8781.00
122_Q125_I0.8671.00
13_V80_N0.8621.00
114_R117_F0.8561.00
41_I45_A0.8501.00
77_R137_L0.8471.00
18_V78_P0.8461.00
34_D38_Q0.8451.00
125_I140_Y0.8301.00
27_L37_P0.8291.00
60_I113_L0.8281.00
20_T38_Q0.8241.00
77_R97_L0.8231.00
103_V112_L0.8141.00
30_G69_K0.8141.00
21_H24_N0.8131.00
21_H76_L0.8061.00
36_W40_L0.8051.00
39_A65_A0.7981.00
76_L100_A0.7981.00
139_E142_T0.7921.00
52_M95_V0.7881.00
109_Q113_L0.7821.00
71_S108_Q0.7761.00
139_E143_K0.7561.00
35_T39_A0.7541.00
24_N37_P0.7541.00
15_R44_E0.7441.00
116_L120_L0.7431.00
119_K141_F0.7421.00
39_A67_H0.7271.00
105_N108_Q0.7181.00
5_F31_V0.7131.00
22_I74_Y0.7071.00
18_V82_V0.7061.00
128_T136_Q0.7051.00
75_L99_I0.7001.00
78_P82_V0.7001.00
43_R61_P0.6921.00
12_F76_L0.6871.00
80_N96_S0.6791.00
20_T24_N0.6701.00
110_L114_R0.6561.00
50_G86_Q0.6561.00
74_Y100_A0.6541.00
58_I120_L0.6510.99
26_M72_A0.6500.99
6_V138_K0.6470.99
36_W100_A0.6460.99
15_R19_L0.6430.99
19_L41_I0.6420.99
57_A130_I0.6390.99
65_A68_A0.6390.99
123_P127_E0.6360.99
53_L90_D0.6320.99
26_M36_W0.6250.99
74_Y102_I0.6230.99
43_R47_F0.6180.99
35_T38_Q0.6170.99
58_I126_V0.6150.99
11_S21_H0.6120.99
9_G133_P0.6110.99
73_I99_I0.6070.99
118_G122_Q0.5970.99
48_P52_M0.5890.99
103_V109_Q0.5820.99
43_R49_T0.5790.99
117_F120_L0.5750.99
99_I116_L0.5740.99
115_C119_K0.5690.99
26_M32_V0.5640.99
77_R133_P0.5610.98
23_G27_L0.5580.98
128_T132_L0.5570.98
125_I128_T0.5540.98
113_L117_F0.5520.98
124_D128_T0.5500.98
85_Q90_D0.5470.98
7_R76_L0.5470.98
36_W72_A0.5450.98
68_A72_A0.5450.98
73_I116_L0.5450.98
129_L137_L0.5410.98
20_T34_D0.5410.98
48_P85_Q0.5340.98
15_R41_I0.5310.98
44_E61_P0.5250.98
109_Q117_F0.5250.98
19_L84_F0.5240.98
22_I98_V0.5210.98
77_R129_L0.5170.97
118_G121_Q0.5160.97
124_D127_E0.5140.97
50_G84_F0.5100.97
32_V40_L0.5050.97
122_Q127_E0.5050.97
103_V106_P0.5040.97
32_V100_A0.5040.97
86_Q94_A0.5040.97
127_E130_I0.5040.97
10_I79_T0.5010.97
83_H87_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a6jA 4 0.9267 100 0.183 Contact Map
4m62S 1 0.96 100 0.19 Contact Map
1a3aA 2 0.92 100 0.204 Contact Map
2oq3A 1 0.9133 100 0.206 Contact Map
3oxpA 2 0.92 100 0.211 Contact Map
3urrA 2 0.9333 100 0.22 Contact Map
2a0jA 1 0.9067 100 0.222 Contact Map
3bjvA 2 0.9333 100 0.224 Contact Map
2oqtA 2 0.9467 100 0.226 Contact Map
3t43A 2 0.9 100 0.239 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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