GREMLIN Database
PTMCB - PTS system mannitol-specific cryptic EIICB component
UniProt: P69826 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11792
Length: 462 (454)
Sequences: 573 (362)
Seq/√Len: 17.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
280_S322_V5.9061.00
276_A330_I5.7661.00
228_L274_M5.0861.00
182_N218_V4.8681.00
285_F319_G4.5661.00
54_G58_T4.5441.00
182_N199_Y4.0391.00
393_K397_K3.9451.00
66_G86_T3.8761.00
179_S279_M3.8241.00
115_V119_L3.7051.00
114_Y117_K3.5861.00
217_M304_Y3.4270.99
179_S282_T3.4040.99
187_V264_V3.3540.99
426_E439_L3.3510.99
290_G316_T3.3490.99
273_A331_T3.2830.99
49_F145_L3.1640.99
81_M136_L3.1570.99
288_L315_A3.0870.99
305_L317_I3.0680.99
285_F290_G2.9690.99
372_R415_D2.9580.98
111_V139_A2.9260.98
37_L44_L2.9080.98
115_V139_A2.8630.98
269_L334_I2.7670.98
167_E171_H2.7360.97
199_Y218_V2.6490.97
249_I253_L2.6310.97
436_P455_Q2.5910.96
67_S71_H2.5210.96
108_G112_I2.4480.95
220_S304_Y2.4340.95
308_T313_F2.4330.95
39_I53_V2.4110.95
373_I395_L2.3960.94
284_M322_V2.3330.94
349_F357_K2.2180.92
329_A333_L2.2120.92
426_E437_L2.1980.91
325_L329_A2.1740.91
200_Y295_G2.1550.90
296_P304_Y2.1500.90
290_G315_A2.1450.90
220_S296_P2.1270.90
33_F141_M2.0910.89
180_V275_I2.0760.89
52_I91_V2.0520.88
267_K338_E2.0480.88
448_K451_T2.0460.88
187_V274_M1.9740.86
49_F149_E1.9700.86
28_F61_L1.9160.84
272_I276_A1.9020.84
71_H76_K1.8790.83
41_T297_S1.8570.82
67_S76_K1.8430.82
19_A72_L1.8350.81
109_G112_I1.8320.81
305_L313_F1.8170.81
290_G312_S1.8150.81
245_P248_M1.7770.79
271_I274_M1.7610.79
352_S356_V1.7600.79
354_N359_M1.7550.78
333_L337_M1.7480.78
75_G79_A1.7440.78
418_I452_L1.7240.77
270_T331_T1.7150.77
395_L400_L1.7050.76
138_I142_L1.7020.76
85_G104_M1.6940.76
34_I52_I1.6940.76
398_A453_F1.6570.74
61_L98_F1.6540.74
81_M112_I1.6520.74
125_A389_T1.6300.73
168_A172_A1.5940.71
312_S315_A1.5860.71
305_L308_T1.5710.70
413_P416_A1.5410.68
163_K198_V1.5390.68
288_L318_A1.5380.68
220_S295_G1.5320.68
349_F356_V1.5200.67
200_Y204_M1.5140.67
104_M147_G1.5120.67
391_F449_L1.4810.65
370_V418_I1.4780.65
251_H324_T1.4740.65
279_M282_T1.4690.65
7_R360_K1.4630.64
446_D449_L1.4540.64
406_H437_L1.4300.62
228_L270_T1.4250.62
394_R450_D1.4240.62
81_M108_G1.4220.62
390_T444_I1.4160.62
115_V135_S1.4150.62
311_G317_I1.3970.61
187_V271_I1.3960.61
204_M216_F1.3790.60
82_G108_G1.3750.59
301_I320_V1.3580.58
217_M316_T1.3520.58
444_I452_L1.3460.58
418_I438_I1.3440.58
40_P47_E1.3420.57
313_F317_I1.3340.57
233_T248_M1.3300.57
264_V274_M1.3300.57
74_G109_G1.3030.55
204_M208_S1.2940.55
353_A356_V1.2910.54
350_A353_A1.2910.54
293_V310_K1.2890.54
202_L264_V1.2870.54
216_F294_A1.2790.54
76_K79_A1.2750.53
74_G118_A1.2750.53
354_N358_A1.2730.53
334_I337_M1.2670.53
233_T245_P1.2540.52
395_L406_H1.2450.52
15_G215_F1.2340.51
281_G323_G1.2310.51
350_A354_N1.2310.51
449_L453_F1.2290.51
13_F16_F1.2280.51
228_L264_V1.2240.50
311_G319_G1.2170.50
181_I198_V1.2090.50
9_K12_A1.2000.49
406_H439_L1.1990.49
142_L146_L1.1970.49
170_V206_Q1.1820.48
84_I140_G1.1780.48
248_M253_L1.1780.48
47_E51_K1.1750.48
38_F42_G1.1730.47
33_F138_I1.1720.47
308_T315_A1.1540.46
48_H149_E1.1480.46
203_G216_F1.1460.46
217_M220_S1.1320.45
130_V195_D1.1230.44
48_H148_F1.1180.44
147_G181_I1.1160.44
352_S357_K1.1140.44
195_D200_Y1.1130.44
15_G440_I1.1120.44
67_S79_A1.1110.44
196_Q200_Y1.1000.43
8_A427_G1.0970.43
391_F394_R1.0970.43
22_I196_Q1.0900.42
395_L404_V1.0870.42
349_F352_S1.0820.42
412_V416_A1.0810.42
302_F306_A1.0790.42
95_I159_N1.0760.42
394_R446_D1.0730.42
25_I263_Y1.0600.41
406_H426_E1.0560.41
183_E225_G1.0460.40
413_P434_D1.0460.40
236_G240_S1.0450.40
95_I155_V1.0440.40
127_F249_I1.0280.39
108_G142_L1.0250.39
26_G133_N1.0220.39
159_N205_Q1.0170.38
173_G412_V1.0170.38
350_A360_K1.0120.38
349_F353_A1.0110.38
220_S285_F1.0080.38
272_I279_M1.0050.38
60_L83_G1.0050.38
63_V87_I1.0010.37
81_M440_I0.9990.37
390_T453_F0.9980.37
12_A396_E0.9950.37
209_V220_S0.9950.37
393_K445_G0.9940.37
68_T76_K0.9880.37
232_F441_N0.9860.37
350_A359_M0.9850.37
267_K335_L0.9850.37
218_V282_T0.9840.36
112_I136_L0.9840.36
406_H409_I0.9820.36
228_L331_T0.9820.36
226_L248_M0.9810.36
7_R400_L0.9770.36
183_E222_P0.9750.36
440_I448_K0.9720.36
394_R449_L0.9700.36
274_M278_G0.9700.36
42_G45_P0.9700.36
22_I195_D0.9680.36
264_V418_I0.9630.35
312_S316_T0.9620.35
230_L324_T0.9620.35
169_L172_A0.9610.35
319_G375_F0.9610.35
232_F267_K0.9570.35
178_L182_N0.9550.35
309_P312_S0.9510.35
18_T387_G0.9490.35
408_A411_N0.9480.34
283_W287_L0.9470.34
182_N219_A0.9470.34
225_G257_H0.9460.34
252_F320_V0.9440.34
38_F45_P0.9400.34
120_E413_P0.9380.34
72_L402_I0.9360.34
294_A307_L0.9340.34
205_Q215_F0.9340.34
178_L279_M0.9290.33
395_L456_L0.9270.33
222_P225_G0.9260.33
35_T50_A0.9230.33
398_A449_L0.9220.33
423_A441_N0.9180.33
280_S325_L0.9160.33
228_L324_T0.9130.33
28_F96_P0.9120.33
85_G108_G0.9110.33
270_T273_A0.9100.32
349_F359_M0.9100.32
112_I115_V0.9060.32
334_I338_E0.9050.32
202_L205_Q0.9040.32
390_T449_L0.9030.32
275_I279_M0.9030.32
280_S326_V0.9020.32
420_V426_E0.8970.32
195_D443_Y0.8960.32
27_A80_V0.8920.32
318_A322_V0.8920.32
183_E257_H0.8920.32
288_L312_S0.8910.31
248_M264_V0.8900.31
81_M109_G0.8900.31
103_I122_R0.8890.31
406_H443_Y0.8890.31
145_L149_E0.8870.31
154_A370_V0.8870.31
34_I96_P0.8850.31
122_R394_R0.8840.31
393_K433_T0.8830.31
182_N282_T0.8810.31
335_L339_K0.8810.31
112_I139_A0.8790.31
75_G104_M0.8750.31
267_K448_K0.8740.31
391_F453_F0.8720.30
417_D451_T0.8710.30
19_A440_I0.8710.30
119_L122_R0.8670.30
166_I178_L0.8630.30
69_G72_L0.8610.30
374_A403_E0.8600.30
52_I148_F0.8590.30
304_Y308_T0.8550.30
280_S284_M0.8550.30
38_F43_W0.8540.30
123_I132_N0.8530.30
142_L145_L0.8530.30
26_G251_H0.8490.29
372_R403_E0.8460.29
334_I440_I0.8450.29
312_S319_G0.8450.29
21_V84_I0.8440.29
35_T92_G0.8440.29
110_L287_L0.8430.29
222_P257_H0.8400.29
183_E186_K0.8350.29
186_K222_P0.8340.29
117_K120_E0.8310.28
109_G143_L0.8270.28
30_A84_I0.8260.28
66_G90_I0.8200.28
97_M428_R0.8190.28
205_Q209_V0.8190.28
16_F72_L0.8190.28
164_E198_V0.8180.28
322_V325_L0.8180.28
350_A358_A0.8180.28
177_L279_M0.8160.28
414_A418_I0.8150.28
43_W253_L0.8130.28
288_L316_T0.8110.27
308_T314_L0.8100.27
308_T316_T0.8090.27
8_A15_G0.8080.27
98_F127_F0.8070.27
427_G430_K0.8050.27
7_R237_K0.8050.27
334_I396_E0.8040.27
204_M302_F0.8040.27
180_V279_M0.8030.27
43_W305_L0.8030.27
353_A357_K0.8020.27
278_G281_G0.8020.27
157_I161_F0.7990.27
236_G335_L0.7980.27
215_F267_K0.7970.27
204_M294_A0.7950.27
50_A96_P0.7930.27
444_I448_K0.7930.27
186_K225_G0.7920.27
228_L327_S0.7900.27
285_F316_T0.7860.26
43_W293_V0.7860.26
127_F253_L0.7840.26
103_I330_I0.7820.26
25_I29_I0.7810.26
285_F318_A0.7810.26
181_I371_K0.7770.26
253_L302_F0.7760.26
181_I264_V0.7750.26
74_G139_A0.7720.26
353_A359_M0.7660.25
419_V435_K0.7660.25
414_A434_D0.7650.25
420_V456_L0.7640.25
214_I319_G0.7640.25
173_G302_F0.7640.25
309_P317_I0.7630.25
21_V440_I0.7600.25
7_R204_M0.7570.25
203_G214_I0.7570.25
66_G83_G0.7560.25
20_M23_P0.7550.25
119_L131_I0.7530.25
352_S355_A0.7520.25
454_N457_T0.7510.25
43_W310_K0.7510.25
53_V273_A0.7490.25
273_A330_I0.7490.25
15_G18_T0.7490.25
391_F410_E0.7480.25
158_A162_V0.7440.24
429_V443_Y0.7440.24
220_S311_G0.7430.24
446_D453_F0.7420.24
111_V145_L0.7410.24
195_D220_S0.7400.24
146_L151_I0.7390.24
409_I437_L0.7370.24
125_A253_L0.7330.24
77_R134_F0.7310.24
267_K339_K0.7280.24
438_I452_L0.7250.24
146_L150_V0.7230.24
186_K257_H0.7230.24
315_A424_S0.7220.23
12_A402_I0.7220.23
308_T332_S0.7210.23
392_R427_G0.7200.23
200_Y215_F0.7190.23
204_M305_L0.7180.23
195_D219_A0.7180.23
294_A319_G0.7170.23
406_H420_V0.7170.23
122_R373_I0.7170.23
63_V187_V0.7150.23
426_E430_K0.7150.23
334_I442_N0.7140.23
394_R398_A0.7130.23
370_V435_K0.7120.23
74_G112_I0.7120.23
297_S444_I0.7120.23
391_F446_D0.7110.23
73_V79_A0.7110.23
28_F58_T0.7100.23
343_T354_N0.7090.23
274_M327_S0.7090.23
51_K149_E0.7080.23
22_I443_Y0.7060.23
54_G303_A0.7030.23
232_F266_M0.7030.23
117_K241_K0.7030.23
240_S295_G0.7020.23
95_I202_L0.7010.23
392_R406_H0.7010.23
107_L110_L0.6990.22
296_P302_F0.6980.22
41_T303_A0.6980.22
202_L215_F0.6970.22
20_M31_W0.6950.22
142_L371_K0.6920.22
418_I436_P0.6890.22
283_W286_N0.6890.22
51_K56_M0.6880.22
272_I333_L0.6880.22
402_I418_I0.6880.22
74_G119_L0.6870.22
15_G393_K0.6850.22
75_G107_L0.6850.22
217_M390_T0.6850.22
335_L338_E0.6830.22
35_T96_P0.6820.22
10_V375_F0.6790.22
170_V282_T0.6780.22
349_F418_I0.6760.22
394_R453_F0.6760.22
285_F304_Y0.6750.22
154_A158_A0.6750.22
280_S317_I0.6750.22
402_I444_I0.6740.21
196_Q295_G0.6740.21
237_K373_I0.6730.21
309_P318_A0.6730.21
8_A441_N0.6730.21
438_I447_P0.6720.21
23_P31_W0.6700.21
79_A121_K0.6700.21
115_V206_Q0.6690.21
219_A259_L0.6690.21
413_P452_L0.6690.21
147_G159_N0.6680.21
29_I263_Y0.6680.21
138_I265_L0.6670.21
99_L301_I0.6670.21
156_L159_N0.6670.21
406_H412_V0.6650.21
287_L371_K0.6640.21
178_L199_Y0.6630.21
412_V440_I0.6630.21
441_N446_D0.6630.21
135_S246_G0.6630.21
217_M412_V0.6620.21
160_T302_F0.6610.21
121_K124_P0.6610.21
8_A109_G0.6600.21
410_E446_D0.6600.21
420_V437_L0.6600.21
169_L178_L0.6590.21
28_F49_F0.6580.21
109_G169_L0.6570.21
212_K312_S0.6570.21
207_A210_N0.6570.21
48_H51_K0.6550.21
82_G392_R0.6550.21
185_A228_L0.6540.21
34_I141_M0.6540.21
281_G439_L0.6540.21
99_L284_M0.6530.21
304_Y309_P0.6530.21
343_T346_E0.6510.21
162_V194_I0.6500.21
104_M107_L0.6490.20
374_A405_K0.6480.20
93_A150_V0.6470.20
180_V318_A0.6460.20
169_L203_G0.6460.20
421_T439_L0.6450.20
154_A418_I0.6450.20
409_I432_V0.6440.20
24_N88_G0.6430.20
67_S218_V0.6430.20
237_K338_E0.6430.20
279_M283_W0.6430.20
119_L139_A0.6420.20
420_V452_L0.6420.20
280_S288_L0.6420.20
74_G440_I0.6410.20
235_F332_S0.6400.20
79_A358_A0.6400.20
217_M445_G0.6390.20
151_I322_V0.6350.20
40_P51_K0.6340.20
166_I219_A0.6320.20
170_V178_L0.6310.20
39_I303_A0.6310.20
276_A333_L0.6310.20
241_K402_I0.6300.20
143_L456_L0.6300.20
215_F389_T0.6300.20
292_L296_P0.6290.20
302_F307_L0.6280.20
279_M326_V0.6280.20
162_V416_A0.6270.20
75_G407_Y0.6270.20
285_F295_G0.6260.20
6_A13_F0.6250.20
66_G147_G0.6240.20
118_A164_E0.6230.19
52_I284_M0.6230.19
304_Y319_G0.6210.19
162_V427_G0.6200.19
121_K242_R0.6190.19
89_V104_M0.6190.19
119_L316_T0.6190.19
178_L283_W0.6180.19
218_V294_A0.6170.19
354_N360_K0.6170.19
392_R412_V0.6160.19
304_Y320_V0.6160.19
454_N458_A0.6140.19
217_M296_P0.6140.19
53_V303_A0.6140.19
114_Y396_E0.6140.19
46_N50_A0.6120.19
165_C241_K0.6110.19
429_V435_K0.6110.19
304_Y324_T0.6110.19
203_G264_V0.6100.19
74_G390_T0.6100.19
124_P253_L0.6060.19
33_F420_V0.6060.19
66_G149_E0.6050.19
96_P188_L0.6030.19
65_I193_A0.6030.19
421_T426_E0.6020.19
302_F422_H0.6020.19
155_V281_G0.6020.19
389_T440_I0.6010.19
348_E356_V0.6010.19
296_P311_G0.6000.19
149_E187_V0.5990.19
15_G441_N0.5980.19
19_A141_M0.5960.18
136_L144_C0.5960.18
139_A144_C0.5950.18
10_V187_V0.5930.18
248_M335_L0.5910.18
72_L295_G0.5900.18
367_L436_P0.5890.18
316_T451_T0.5890.18
26_G115_V0.5880.18
143_L288_L0.5880.18
46_N310_K0.5870.18
7_R395_L0.5870.18
91_V96_P0.5870.18
56_M84_I0.5840.18
405_K441_N0.5830.18
390_T446_D0.5830.18
119_L123_I0.5830.18
160_T164_E0.5830.18
160_T163_K0.5830.18
372_R420_V0.5830.18
73_V118_A0.5830.18
57_I96_P0.5790.18
24_N68_T0.5780.18
166_I349_F0.5780.18
84_I109_G0.5770.18
186_K281_G0.5760.18
309_P313_F0.5750.18
61_L296_P0.5740.18
15_G235_F0.5730.18
151_I188_L0.5720.18
271_I417_D0.5720.18
218_V375_F0.5720.18
51_K318_A0.5720.18
180_V185_A0.5710.18
233_T240_S0.5710.18
8_A410_E0.5700.18
282_T323_G0.5700.18
368_S434_D0.5690.18
99_L141_M0.5690.18
33_F207_A0.5680.17
75_G89_V0.5680.17
181_I244_A0.5670.17
75_G335_L0.5660.17
273_A332_S0.5660.17
319_G444_I0.5640.17
15_G448_K0.5640.17
114_Y146_L0.5640.17
306_A309_P0.5630.17
358_A362_E0.5630.17
319_G372_R0.5620.17
377_C383_S0.5620.17
41_T302_F0.5610.17
166_I215_F0.5610.17
75_G358_A0.5600.17
98_F399_G0.5600.17
226_L251_H0.5590.17
295_G323_G0.5590.17
52_I412_V0.5590.17
154_A296_P0.5590.17
115_V140_G0.5560.17
112_I395_L0.5560.17
91_V95_I0.5550.17
343_T359_M0.5540.17
365_F373_I0.5530.17
399_G444_I0.5520.17
181_I333_L0.5500.17
93_A156_L0.5500.17
236_G342_E0.5500.17
270_T443_Y0.5490.17
217_M238_G0.5490.17
48_H145_L0.5490.17
215_F391_F0.5480.17
170_V173_G0.5480.17
438_I455_Q0.5470.17
66_G82_G0.5470.17
110_L322_V0.5460.17
162_V181_I0.5430.17
228_L259_L0.5420.17
8_A215_F0.5400.17
278_G282_T0.5400.17
76_K159_N0.5400.17
391_F420_V0.5390.17
421_T437_L0.5390.17
295_G319_G0.5390.17
307_L410_E0.5390.17
187_V445_G0.5390.17
288_L314_L0.5360.16
228_L272_I0.5360.16
84_I358_A0.5350.16
380_G383_S0.5350.16
89_V100_G0.5350.16
9_K441_N0.5350.16
52_I416_A0.5350.16
33_F265_L0.5350.16
98_F419_V0.5350.16
81_M140_G0.5330.16
241_K372_R0.5330.16
198_V340_T0.5330.16
111_V121_K0.5330.16
388_A406_H0.5320.16
403_E417_D0.5310.16
94_E149_E0.5300.16
56_M63_V0.5290.16
350_A357_K0.5290.16
391_F429_V0.5280.16
394_R439_L0.5280.16
110_L282_T0.5280.16
285_F293_V0.5280.16
17_L69_G0.5270.16
12_A440_I0.5270.16
290_G319_G0.5270.16
123_I234_L0.5260.16
417_D424_S0.5250.16
316_T319_G0.5240.16
46_N49_F0.5240.16
272_I362_E0.5240.16
15_G410_E0.5220.16
362_E427_G0.5200.16
396_E401_A0.5190.16
235_F411_N0.5190.16
352_S444_I0.5180.16
393_K396_E0.5170.16
141_M145_L0.5170.16
146_L371_K0.5170.16
199_Y215_F0.5170.16
395_L412_V0.5160.16
303_A326_V0.5150.16
446_D452_L0.5140.16
207_A251_H0.5140.16
12_A202_L0.5130.16
252_F284_M0.5120.16
39_I45_P0.5110.16
389_T457_T0.5110.16
326_V333_L0.5110.16
124_P139_A0.5110.16
34_I50_A0.5090.16
440_I449_L0.5090.16
416_A434_D0.5090.16
28_F133_N0.5080.16
352_S358_A0.5080.16
26_G152_G0.5070.15
56_M96_P0.5070.15
346_E352_S0.5060.15
218_V285_F0.5060.15
84_I112_I0.5060.15
264_V271_I0.5050.15
426_E429_V0.5040.15
119_L407_Y0.5030.15
392_R403_E0.5020.15
234_L287_L0.5020.15
424_S440_I0.5010.15
215_F446_D0.5010.15
214_I239_M0.5000.15
8_A390_T0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.7576 99.9 0.874 Contact Map
1vkrA 1 0.2056 99.8 0.91 Contact Map
3czcA 1 0.1926 99.4 0.93 Contact Map
1tvmA 1 0.2381 99.3 0.933 Contact Map
1e2bA 1 0.2035 99.2 0.936 Contact Map
2l2qA 1 0.2056 99 0.941 Contact Map
4mgeA 3 0.197 99 0.941 Contact Map
3nbmA 1 0.1905 98.6 0.95 Contact Map
4tn5A 2 0.1991 98 0.958 Contact Map
2kyrA 1 0.2013 97.9 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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