GREMLIN Database
PTMA - Mannitol-specific cryptic phosphotransferase enzyme IIA component
UniProt: P69824 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11791
Length: 147 (138)
Sequences: 6873 (5266)
Seq/√Len: 448.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_K132_L3.3771.00
9_E138_K2.6481.00
136_S139_Q2.3121.00
26_D43_I2.2681.00
30_V34_D2.1761.00
39_S75_L2.1311.00
29_M43_I2.1301.00
41_N73_G2.0161.00
28_S102_G1.9991.00
129_E133_T1.9791.00
18_A27_F1.9571.00
13_S31_S1.9331.00
84_L100_L1.9221.00
46_I102_G1.9041.00
20_D23_E1.8961.00
11_S35_K1.8521.00
17_S85_E1.8521.00
37_Y76_K1.8101.00
87_G98_K1.8031.00
33_L38_I1.7751.00
15_I85_E1.7281.00
18_A24_A1.6921.00
10_S35_K1.6761.00
37_Y78_G1.6691.00
15_I83_L1.6401.00
16_H82_T1.6261.00
44_Q48_D1.6021.00
78_G104_S1.5921.00
22_Q51_I1.5771.00
74_A104_S1.5741.00
28_S82_T1.5631.00
77_T106_A1.5001.00
135_S139_Q1.4911.00
19_K23_E1.4771.00
42_Y104_S1.4511.00
26_D47_K1.4421.00
9_E141_A1.4301.00
48_D51_I1.4011.00
134_A140_L1.4001.00
62_G98_K1.3981.00
24_A100_L1.3741.00
45_A68_A1.3531.00
45_A48_D1.3481.00
138_K142_D1.3321.00
71_E107_D1.3141.00
84_L87_G1.3051.00
14_V83_L1.3041.00
89_Y96_P1.2981.00
25_I46_I1.2811.00
31_S35_K1.2801.00
13_S27_F1.2661.00
31_S34_D1.2621.00
22_Q47_K1.2431.00
61_P128_L1.2231.00
128_L132_L1.2021.00
48_D52_N1.2001.00
81_L140_L1.1811.00
29_M46_I1.1801.00
134_A139_Q1.1791.00
39_S73_G1.1751.00
97_I100_L1.1591.00
90_F100_L1.1301.00
8_P11_S1.1181.00
9_E137_E1.1031.00
43_I47_K1.0681.00
16_H27_F1.0631.00
18_A84_L1.0591.00
13_S16_H1.0501.00
89_Y92_G1.0411.00
99_L132_L1.0381.00
130_Q143_I1.0241.00
22_Q26_D1.0201.00
21_W91_P1.0181.00
23_E26_D0.9961.00
27_F31_S0.9941.00
50_T55_P0.9921.00
87_G96_P0.9861.00
134_A143_I0.9851.00
70_P73_G0.9751.00
17_S86_Q0.9671.00
33_L40_E0.9511.00
38_I42_Y0.9441.00
31_S80_S0.9431.00
83_L140_L0.9371.00
29_M102_G0.9311.00
14_V140_L0.9281.00
12_I140_L0.9271.00
139_Q142_D0.9251.00
116_Q120_E0.9251.00
79_M114_A0.9251.00
12_I137_E0.9221.00
36_N75_L0.9221.00
124_E127_I0.9201.00
121_L127_I0.9181.00
30_V33_L0.9161.00
137_E141_A0.9121.00
32_L104_S0.9051.00
119_S123_C0.9031.00
77_T105_A0.8971.00
32_L80_S0.8931.00
47_K51_I0.8811.00
24_A84_L0.8711.00
130_Q133_T0.8661.00
141_A145_S0.8621.00
84_L98_K0.8601.00
81_L99_L0.8591.00
23_E27_F0.8591.00
33_L43_I0.8461.00
27_F30_V0.8451.00
25_I43_I0.8421.00
40_E44_Q0.8351.00
127_I143_I0.8301.00
19_K86_Q0.8231.00
83_L99_L0.8141.00
77_T110_S0.8071.00
21_W50_T0.8071.00
82_T102_G0.8031.00
42_Y46_I0.7991.00
26_D44_Q0.7971.00
27_F82_T0.7691.00
41_N45_A0.7681.00
56_Y92_G0.7621.00
14_V137_E0.7551.00
105_A114_A0.7531.00
116_Q119_S0.7511.00
45_A73_G0.7491.00
65_M115_I0.7481.00
45_A70_P0.7361.00
84_L88_V0.7301.00
118_L122_L0.7241.00
107_D110_S0.7221.00
111_H115_I0.7211.00
30_V43_I0.7141.00
8_P35_K0.6941.00
28_S80_S0.6941.00
86_Q98_K0.6921.00
81_L101_I0.6851.00
24_A88_V0.6811.00
121_L144_I0.6771.00
26_D30_V0.6771.00
8_P76_K0.6771.00
130_Q139_Q0.6731.00
16_H85_E0.6721.00
11_S37_Y0.6691.00
125_E129_E0.6681.00
62_G132_L0.6661.00
80_S102_G0.6661.00
18_A82_T0.6621.00
25_I47_K0.6581.00
63_V122_L0.6571.00
64_A97_I0.6551.00
49_S66_P0.6531.00
142_D145_S0.6440.99
91_P95_E0.6420.99
32_L78_G0.6360.99
92_G95_E0.6270.99
17_S27_F0.6270.99
13_S137_E0.6240.99
60_A63_V0.6110.99
12_I141_A0.6050.99
36_N39_S0.6020.99
42_Y102_G0.6000.99
126_E130_Q0.5970.99
6_Y114_A0.5950.99
32_L38_I0.5950.99
29_M33_L0.5890.99
79_M101_I0.5880.99
15_I135_S0.5860.99
137_E140_L0.5800.99
8_P37_Y0.5800.99
59_L105_A0.5710.99
119_S122_L0.5650.99
49_S53_N0.5630.99
83_L131_L0.5630.99
80_S104_S0.5630.99
101_I118_L0.5620.99
130_Q134_A0.5570.99
127_I130_Q0.5560.99
26_D40_E0.5490.98
21_W25_I0.5450.98
63_V128_L0.5440.98
105_A111_H0.5430.98
59_L119_S0.5410.98
120_E124_E0.5410.98
61_P125_E0.5400.98
60_A97_I0.5390.98
129_E132_L0.5370.98
117_A121_L0.5360.98
56_Y93_N0.5360.98
41_N44_Q0.5360.98
49_S55_P0.5340.98
79_M118_L0.5330.98
56_Y90_F0.5320.98
32_L42_Y0.5300.98
112_I116_Q0.5300.98
8_P141_A0.5290.98
42_Y78_G0.5270.98
70_P74_A0.5160.98
131_L140_L0.5160.98
54_G91_P0.5110.97
28_S100_L0.5110.97
83_L135_S0.5110.97
113_G120_E0.5080.97
92_G96_P0.5060.97
61_P95_E0.5050.97
90_F97_I0.5000.97
50_T66_P0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oq3A 1 1 100 0.13 Contact Map
3bjvA 2 0.9932 100 0.147 Contact Map
2oqtA 2 0.9932 100 0.15 Contact Map
1a3aA 2 0.966 100 0.158 Contact Map
1a6jA 4 0.9796 100 0.162 Contact Map
3oxpA 2 0.9932 100 0.18 Contact Map
2a0jA 1 0.966 100 0.182 Contact Map
3urrA 2 0.9796 100 0.19 Contact Map
4m62S 1 0.9796 100 0.198 Contact Map
3t43A 2 0.8707 100 0.255 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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