GREMLIN Database
ULAB - Ascorbate-specific phosphotransferase enzyme IIB component
UniProt: P69822 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12494
Length: 101 (88)
Sequences: 140 (87)
Seq/√Len: 9.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_I27_L4.0980.99
29_Q85_G3.6550.97
43_E54_I2.1360.69
26_F85_G2.0600.66
15_S21_M2.0510.66
11_N18_I1.8930.60
38_S64_I1.8230.57
24_D28_T1.8140.56
7_A23_V1.7060.51
53_I71_Y1.6910.51
10_G19_M1.6180.48
29_Q81_P1.6010.47
39_C88_L1.5530.45
60_I78_M1.5400.44
15_S23_V1.5370.44
19_M84_F1.5360.44
53_I88_L1.5210.43
87_K90_E1.4790.42
85_G89_L1.4660.41
13_Q42_G1.4650.41
67_T70_K1.4570.41
46_S70_K1.4350.40
40_A74_G1.4350.40
28_T34_H1.3880.38
19_M39_C1.3660.37
15_S75_V1.3620.37
53_I56_A1.3400.36
10_G13_Q1.2610.33
10_G20_K1.2440.32
10_G17_M1.2280.31
53_I86_P1.2270.31
7_A57_S1.1430.28
62_G89_L1.1410.28
56_A64_I1.1310.28
50_G89_L1.1180.27
73_V81_P1.1110.27
7_A69_N1.0950.26
62_G66_V1.0950.26
27_L88_L1.0780.26
41_V82_A1.0640.25
50_G62_G1.0580.25
17_M38_S1.0510.25
11_N17_M1.0460.25
49_S67_T1.0230.24
38_S80_S1.0190.24
26_F75_V1.0140.24
76_R80_S1.0020.23
15_S60_I0.9900.23
20_K74_G0.9750.23
35_T89_L0.9710.22
8_V19_M0.9650.22
32_I61_A0.9580.22
51_A54_I0.9490.22
73_V87_K0.9490.22
4_R81_P0.9470.22
35_T41_V0.9370.21
28_T68_G0.9300.21
32_I88_L0.9290.21
17_M55_I0.9280.21
75_V87_K0.9210.21
67_T76_R0.9180.21
10_G60_I0.9160.21
11_N29_Q0.9110.21
64_I80_S0.8990.20
3_V24_D0.8910.20
17_M22_K0.8840.20
20_K56_A0.8840.20
37_N43_E0.8820.20
39_C69_N0.8790.20
21_M87_K0.8430.19
82_A86_P0.8280.18
49_S70_K0.8270.18
21_M75_V0.8160.18
4_R57_S0.8020.18
5_I53_I0.7860.17
31_N90_E0.7730.17
7_A74_G0.7600.17
7_A36_V0.7550.16
41_V44_Y0.7520.16
20_K36_V0.7500.16
40_A72_V0.7490.16
47_E54_I0.7490.16
28_T71_Y0.7480.16
55_I75_V0.7330.16
51_A67_T0.7310.16
35_T84_F0.7300.16
9_C12_G0.7230.16
7_A59_H0.7150.16
8_V13_Q0.7080.15
6_L61_A0.7020.15
18_I42_G0.7010.15
39_C61_A0.6960.15
21_M56_A0.6920.15
4_R35_T0.6850.15
36_V79_L0.6780.15
39_C43_E0.6760.15
39_C86_P0.6670.14
8_V20_K0.6650.14
59_H78_M0.6650.14
26_F29_Q0.6640.14
29_Q53_I0.6560.14
13_Q19_M0.6510.14
51_A83_D0.6490.14
31_N72_V0.6480.14
6_L88_L0.6480.14
4_R44_Y0.6460.14
19_M53_I0.6460.14
6_L27_L0.6360.14
27_L45_K0.6290.14
13_Q78_M0.6250.14
37_N54_I0.6190.13
22_K81_P0.6170.13
37_N40_A0.6060.13
8_V44_Y0.6040.13
56_A68_G0.5840.13
17_M57_S0.5820.13
59_H63_E0.5810.13
11_N16_S0.5800.13
33_D65_T0.5730.12
25_Q45_K0.5590.12
15_S41_V0.5540.12
22_K63_E0.5530.12
4_R85_G0.5460.12
46_S59_H0.5460.12
31_N38_S0.5430.12
35_T50_G0.5240.12
19_M41_V0.5160.11
73_V86_P0.5110.11
27_L33_D0.5050.11
48_L63_E0.5040.11
3_V34_H0.5030.11
22_K87_K0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3czcA 1 0.9109 99.6 0.605 Contact Map
1tvmA 1 0.901 99.6 0.624 Contact Map
1vkrA 1 0.901 99.6 0.626 Contact Map
1e2bA 1 0.9604 99.5 0.631 Contact Map
4mgeA 3 0.9703 99.5 0.631 Contact Map
2l2qA 1 0.9604 99.5 0.645 Contact Map
2m1zA 1 0.9307 99.3 0.685 Contact Map
3nbmA 1 0.901 99.2 0.69 Contact Map
4tn5A 2 0.9604 99.2 0.693 Contact Map
2kyrA 1 0.9505 98.9 0.729 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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