GREMLIN Database
ULAC - Ascorbate-specific phosphotransferase enzyme IIA component
UniProt: P69820 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12495
Length: 154 (139)
Sequences: 7037 (5431)
Seq/√Len: 460.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_D135_R3.3631.00
10_N141_Q2.6071.00
139_T142_E2.3261.00
27_K44_Y2.3021.00
31_D35_A2.1741.00
30_V44_Y2.1271.00
40_E76_K2.0681.00
42_R74_G2.0201.00
85_L102_L1.9921.00
14_R32_L1.9611.00
29_G104_T1.9541.00
19_A28_I1.9501.00
47_I104_T1.9111.00
132_D136_A1.9091.00
21_T24_E1.8801.00
18_E86_K1.8361.00
88_P100_D1.8211.00
12_S36_A1.8111.00
38_V77_K1.8031.00
16_Q86_K1.7481.00
34_V39_V1.7331.00
19_A25_A1.7331.00
17_A83_V1.6591.00
11_K36_A1.6471.00
38_V79_G1.6371.00
45_Q49_D1.6261.00
16_Q84_T1.6111.00
79_G106_A1.5911.00
29_G83_V1.5301.00
78_T108_V1.5251.00
75_V106_A1.5161.00
23_Q52_E1.4591.00
138_R142_E1.4531.00
10_N144_L1.4411.00
27_K48_L1.4251.00
43_Y106_A1.4151.00
20_E24_E1.4121.00
49_D52_E1.4011.00
25_A102_L1.3961.00
63_G100_D1.3731.00
85_L88_P1.3611.00
137_C143_V1.3531.00
14_R28_I1.3441.00
46_A69_G1.3311.00
26_V47_I1.3081.00
46_A49_D1.3021.00
141_Q145_D1.2971.00
90_E98_P1.2921.00
15_L84_T1.2861.00
32_L35_A1.2631.00
23_Q48_L1.2551.00
32_L36_A1.2351.00
62_P131_F1.2211.00
30_V47_I1.2131.00
99_V102_L1.2031.00
137_C142_E1.1911.00
73_E109_D1.1891.00
49_D53_Q1.1821.00
82_L143_V1.1651.00
91_F102_L1.1621.00
131_F135_R1.1601.00
133_R149_R1.1371.00
40_E74_G1.1051.00
90_E93_H1.1001.00
9_E12_S1.0961.00
19_A85_L1.0931.00
144_L148_D1.0801.00
10_N140_E1.0731.00
23_Q27_K1.0661.00
44_Y48_L1.0571.00
71_P74_G1.0361.00
39_V43_Y1.0261.00
17_A28_I1.0251.00
51_V56_P1.0241.00
22_W92_N1.0091.00
133_R146_L1.0091.00
13_I143_V1.0001.00
28_I32_L0.9951.00
88_P98_P0.9951.00
14_R17_A0.9871.00
137_C146_L0.9801.00
124_L130_N0.9721.00
24_E27_K0.9691.00
15_L143_V0.9661.00
101_I135_R0.9651.00
78_T107_A0.9641.00
142_E145_D0.9591.00
34_V41_P0.9581.00
30_V104_T0.9511.00
13_I140_E0.9491.00
18_E87_K0.9331.00
84_T143_V0.9251.00
37_D76_K0.9201.00
119_M123_N0.9191.00
82_L101_I0.9171.00
26_V44_Y0.9161.00
33_L81_S0.9141.00
32_L81_S0.9131.00
85_L100_D0.9111.00
31_D34_V0.9061.00
127_D130_N0.9041.00
24_E28_I0.8941.00
33_L106_A0.8851.00
140_E144_L0.8841.00
34_V44_Y0.8821.00
25_A85_L0.8661.00
48_L52_E0.8491.00
20_E87_K0.8421.00
133_R136_A0.8321.00
41_P45_Q0.8291.00
84_T101_I0.8241.00
122_V126_E0.8221.00
43_Y47_I0.8051.00
22_W51_V0.7991.00
28_I31_D0.7921.00
42_R46_A0.7911.00
109_D112_T0.7841.00
93_H96_N0.7821.00
25_A89_L0.7811.00
130_N146_L0.7791.00
83_V104_T0.7741.00
78_T112_T0.7681.00
145_D149_R0.7661.00
27_K45_Q0.7651.00
119_M122_V0.7591.00
15_L140_E0.7561.00
113_H118_I0.7541.00
28_I83_V0.7541.00
29_G81_S0.7531.00
46_A74_G0.7221.00
85_L89_L0.7211.00
82_L103_I0.7201.00
57_Y93_H0.7191.00
12_S38_V0.7151.00
31_D44_Y0.7121.00
26_V48_L0.7111.00
61_A64_L0.7101.00
81_S104_T0.7051.00
46_A71_P0.7041.00
121_I125_F0.7031.00
145_D148_D0.6941.00
133_R142_E0.6891.00
66_M118_I0.6871.00
33_L79_G0.6821.00
27_K31_D0.6771.00
19_A83_V0.6711.00
50_G67_P0.6711.00
124_L147_I0.6701.00
128_E132_D0.6691.00
63_G135_R0.6681.00
13_I144_L0.6591.00
87_K100_D0.6521.00
9_E36_A0.6491.00
9_E77_K0.6451.00
64_L125_F0.6360.99
17_A86_K0.6340.99
80_F103_I0.6250.99
65_A99_V0.6210.99
30_V34_V0.6200.99
64_L131_F0.6120.99
9_E38_V0.6070.99
33_L39_V0.6020.99
22_W26_V0.5960.99
16_Q138_R0.5950.99
18_E28_I0.5890.99
14_R140_E0.5890.99
14_R83_V0.5880.99
50_G54_F0.5870.99
140_E143_V0.5840.99
81_S106_A0.5840.99
33_L43_Y0.5840.99
129_E133_R0.5830.99
103_I121_I0.5830.99
62_P97_D0.5830.99
122_V125_F0.5830.99
92_N97_D0.5830.99
43_Y104_T0.5800.99
133_R137_C0.5580.99
114_Q119_M0.5570.99
50_G56_P0.5570.99
107_A113_H0.5510.99
107_A116_V0.5500.99
80_F121_I0.5480.99
8_A82_L0.5450.98
123_N127_D0.5440.98
84_T134_L0.5430.98
84_T138_R0.5410.98
130_N133_R0.5380.98
29_G102_L0.5370.98
60_I122_V0.5330.98
134_L143_V0.5330.98
129_E132_D0.5300.98
71_P75_V0.5290.98
61_A99_V0.5290.98
51_V67_P0.5230.98
42_R45_Q0.5230.98
60_I107_A0.5210.98
55_G92_N0.5200.98
9_E144_L0.5160.98
132_D135_R0.5100.98
57_Y91_F0.5090.98
22_W91_F0.5080.98
57_Y95_D0.5070.98
27_K41_P0.5050.97
93_H98_P0.5030.97
42_R73_E0.5020.97
7_L116_V0.5020.97
22_W52_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oq3A 1 0.9481 100 0.16 Contact Map
1a6jA 4 0.9545 100 0.16 Contact Map
3oxpA 2 0.9545 100 0.163 Contact Map
3bjvA 2 0.9805 100 0.164 Contact Map
2oqtA 2 0.9805 100 0.167 Contact Map
1a3aA 2 0.9351 100 0.169 Contact Map
3urrA 2 0.961 100 0.17 Contact Map
2a0jA 1 0.9286 100 0.17 Contact Map
4m62S 1 0.961 100 0.184 Contact Map
3t43A 2 0.8636 100 0.241 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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