GREMLIN Database
PTFB2 - Fructose-like phosphotransferase enzyme IIB component 2
UniProt: P69816 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11909
Length: 106 (97)
Sequences: 2050 (1132)
Seq/√Len: 115.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_K53_D3.4611.00
51_A55_A3.1421.00
90_R93_A2.9261.00
31_K96_S2.7511.00
52_E56_S2.4751.00
5_I60_V2.4311.00
45_L48_E2.4031.00
30_A92_D2.3041.00
3_K34_E2.2051.00
31_K92_D2.1811.00
6_A37_V2.0551.00
59_M98_I2.0201.00
3_K56_S1.9981.00
86_D90_R1.8831.00
69_K72_E1.8761.00
21_A25_E1.8601.00
28_A35_V1.7661.00
92_D96_S1.7371.00
25_E29_K1.7161.00
27_A30_A1.6821.00
24_L35_V1.6681.00
60_V77_K1.6081.00
27_A31_K1.5821.00
96_S100_A1.5731.00
38_E73_R1.4751.00
50_T53_D1.4341.00
5_I49_L1.4281.00
27_A91_A1.3551.00
22_E25_E1.3381.00
36_K47_N1.2870.99
65_D84_I1.2500.99
85_S89_K1.2470.99
49_L54_V1.1900.99
64_K68_I1.1660.99
84_I87_A1.1470.99
17_T39_T1.1320.99
93_A97_K1.1290.99
7_V40_Q1.1200.99
43_I46_E1.1170.99
9_A66_I1.1060.98
52_E55_A1.1000.98
48_E70_F1.0990.98
40_Q73_R1.0960.98
39_T47_N1.0940.98
34_E56_S1.0700.98
4_I59_M1.0630.98
27_A92_D1.0580.98
82_V94_I1.0270.97
80_V94_I1.0240.97
86_D97_K1.0240.97
6_A35_V0.9710.96
3_K58_D0.9630.96
64_K81_R0.9540.96
33_W95_M0.9460.96
22_E26_S0.9370.96
72_E75_A0.9110.95
18_Y46_E0.8890.94
33_W99_E0.8870.94
26_S29_K0.8860.94
54_V77_K0.8740.94
18_Y39_T0.8710.94
10_C13_G0.8700.93
9_A40_Q0.8620.93
4_I33_W0.8530.93
36_K50_T0.8360.92
19_M23_A0.8240.92
60_V76_G0.8180.91
82_V86_D0.8180.91
31_K99_E0.8180.91
87_A90_R0.8130.91
40_Q70_F0.7860.89
27_A95_M0.7830.89
21_A47_N0.7700.89
40_Q67_G0.7560.88
9_A64_K0.7560.88
7_V70_F0.7510.87
62_L79_I0.7500.87
24_L28_A0.7440.87
65_D83_N0.7300.86
59_M80_V0.7230.85
13_G17_T0.7170.85
62_L69_K0.7100.84
62_L70_F0.7000.83
4_I28_A0.6970.83
91_A95_M0.6920.83
61_I98_I0.6920.83
83_N86_D0.6890.82
5_I57_A0.6820.82
11_P66_I0.6760.81
63_T82_V0.6740.81
80_V86_D0.6720.81
12_S43_I0.6680.80
7_V74_F0.6660.80
62_L68_I0.6500.79
90_R97_K0.6470.78
20_A88_V0.6460.78
23_A27_A0.6450.78
93_A96_S0.6430.78
6_A16_H0.6430.78
38_E74_F0.6410.78
4_I99_E0.6350.77
29_K81_R0.6340.77
40_Q62_L0.6280.76
10_C17_T0.6220.75
40_Q69_K0.6100.74
87_A94_I0.6060.74
8_T13_G0.5980.73
60_V79_I0.5980.73
19_M43_I0.5940.72
31_K95_M0.5900.72
53_D56_S0.5870.71
42_S46_E0.5790.70
11_P83_N0.5790.70
23_A26_S0.5790.70
34_E58_D0.5780.70
54_V57_A0.5710.69
45_L70_F0.5710.69
11_P21_A0.5660.68
18_Y41_G0.5650.68
10_C14_V0.5580.67
80_V98_I0.5560.67
83_N89_K0.5530.67
70_F80_V0.5500.66
84_I91_A0.5480.66
8_T84_I0.5440.65
23_A88_V0.5440.65
40_Q49_L0.5430.65
59_M99_E0.5430.65
87_A91_A0.5420.65
6_A33_W0.5390.65
97_K100_A0.5340.64
55_A58_D0.5320.64
4_I95_M0.5220.62
58_D77_K0.5190.62
78_T97_K0.5140.61
7_V60_V0.5130.61
29_K32_G0.5130.61
18_Y22_E0.5130.61
25_E47_N0.5120.61
82_V98_I0.5110.61
27_A96_S0.5110.61
25_E35_V0.5060.60
39_T44_G0.5060.60
40_Q66_I0.5060.60
24_L61_I0.5020.59
49_L77_K0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r48A 1 0.9906 100 0.126 Contact Map
2kyrA 1 1 100 0.284 Contact Map
2r4qA 1 0.9623 100 0.303 Contact Map
2m1zA 1 0.9906 99.9 0.318 Contact Map
4tn5A 2 1 99.9 0.329 Contact Map
4mgeA 3 0.9057 99.6 0.58 Contact Map
1e2bA 1 0.9245 99.5 0.591 Contact Map
2l2qA 1 0.9057 99.3 0.631 Contact Map
3czcA 1 0.8679 98.5 0.736 Contact Map
1tvmA 1 0.8774 98.4 0.74 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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