GREMLIN Database
PTFAH - Multiphosphoryl transfer protein
UniProt: P69811 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10005
Length: 376 (374)
Sequences: 211 (142)
Seq/√Len: 7.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
288_A361_L3.6660.94
323_D347_R3.5480.93
366_D370_A3.3620.91
320_T329_A2.9580.84
303_G330_N2.8840.83
131_T275_L2.7770.80
319_V350_F2.7630.80
45_A66_D2.7590.80
210_N238_A2.5940.75
21_A81_F2.5910.75
7_Q125_Q2.5680.74
201_I233_M2.4630.71
169_A173_A2.4450.70
362_K366_D2.3560.67
313_F363_A2.3230.66
303_G342_V2.2860.65
272_L275_L2.2830.65
86_T90_G2.2750.64
85_V238_A2.2700.64
292_V368_I2.2150.62
203_L324_G2.1650.60
36_A72_L2.1610.60
13_E96_A2.1590.60
182_D251_L2.1220.59
251_L263_L2.1210.59
93_A111_R2.1010.58
56_N126_L2.0990.58
214_A233_M2.0970.58
205_D210_N2.0230.55
181_V185_F2.0130.55
223_A232_A2.0130.55
96_A127_K1.9980.54
41_N45_A1.9860.54
180_A214_A1.9710.53
12_G309_T1.9480.52
98_G313_F1.9330.51
185_F206_S1.9210.51
67_T97_I1.8820.49
271_L275_L1.8750.49
95_V190_I1.8700.49
305_M342_V1.8690.49
219_R233_M1.8680.49
174_R332_R1.8220.47
22_I43_M1.8180.47
224_F237_V1.8080.47
291_V304_T1.7770.45
175_L181_V1.7760.45
109_L171_N1.7600.45
224_F342_V1.7560.45
82_P197_L1.7300.44
66_D315_S1.7230.43
310_I331_G1.7210.43
80_Q127_K1.7030.42
17_D359_Q1.6930.42
255_L260_A1.6830.42
50_T349_R1.6480.40
17_D20_E1.6470.40
37_E41_N1.6390.40
93_A349_R1.6080.39
22_I321_N1.6020.39
96_A119_D1.5970.38
205_D219_R1.5920.38
96_A176_K1.5920.38
237_V241_D1.5900.38
16_G20_E1.5830.38
95_V179_G1.5820.38
129_A367_A1.5750.38
309_T366_D1.5720.38
133_E245_I1.5610.37
188_K206_S1.5610.37
282_T353_Q1.5500.37
17_D89_D1.5470.37
45_A193_Q1.5440.37
120_D127_K1.5430.36
22_I335_M1.5340.36
182_D209_G1.5130.35
286_L361_L1.5080.35
220_A223_A1.5080.35
189_A236_S1.5040.35
89_D329_A1.4950.35
259_K262_R1.4780.34
9_I53_F1.4770.34
203_L244_P1.4660.34
309_T312_Q1.4650.34
289_E332_R1.4540.33
348_L372_L1.4460.33
38_G206_S1.4210.32
207_A238_A1.4210.32
96_A129_A1.4200.32
358_E362_K1.4090.32
8_D366_D1.4090.32
321_N346_H1.3980.31
180_A318_T1.3910.31
131_T230_T1.3870.31
318_T358_E1.3830.31
78_V324_G1.3790.31
88_G96_A1.3700.30
304_T332_R1.3690.30
151_D178_A1.3460.30
348_L371_G1.3400.29
187_T268_A1.3390.29
30_V148_L1.3380.29
292_V342_V1.3360.29
367_A371_G1.3340.29
215_I247_V1.3250.29
160_V337_V1.3220.29
18_K88_G1.3150.29
228_G342_V1.3140.29
4_L21_A1.3110.28
67_T88_G1.3100.28
249_K258_N1.3020.28
126_L300_A1.3010.28
171_N236_S1.3010.28
290_F335_M1.2830.28
45_A189_A1.2780.27
22_I346_H1.2700.27
82_P167_L1.2690.27
79_F93_A1.2630.27
92_V327_K1.2630.27
166_T171_N1.2590.27
109_L159_I1.2550.27
293_R303_G1.2530.27
333_S341_G1.2480.27
228_G262_R1.2450.26
69_D133_E1.2420.26
109_L313_F1.2410.26
51_S173_A1.2400.26
210_N218_S1.2240.26
65_T303_G1.2230.26
70_Q154_M1.2200.26
173_A190_I1.2190.26
50_T93_A1.2190.26
241_D250_R1.2140.25
115_H212_R1.2110.25
160_V170_L1.2090.25
25_V79_F1.2070.25
25_V143_K1.2050.25
134_E137_A1.2030.25
80_Q123_A1.2020.25
313_F366_D1.2020.25
72_L331_G1.2000.25
76_V90_G1.1900.25
20_E212_R1.1780.24
2_F79_F1.1570.24
294_N374_E1.1560.24
182_D211_L1.1520.24
333_S348_L1.1490.24
169_A293_R1.1440.23
220_A224_F1.1370.23
109_L195_L1.1360.23
220_A288_A1.1300.23
7_Q259_K1.1220.23
22_I304_T1.1180.23
210_N310_I1.1160.23
121_S194_P1.1130.23
51_S190_I1.1120.23
210_N213_S1.1110.23
79_F111_R1.1070.22
319_V336_K1.1030.22
365_G368_I1.0830.22
109_L166_T1.0800.22
25_V96_A1.0770.22
171_N205_D1.0740.22
328_P358_E1.0700.21
271_L274_L1.0690.21
6_V10_H1.0660.21
124_E128_S1.0640.21
126_L179_G1.0610.21
88_G313_F1.0530.21
214_A275_L1.0460.21
121_S124_E1.0430.21
23_R323_D1.0420.21
111_R166_T1.0420.21
23_R243_Q1.0390.21
36_A217_V1.0370.21
304_T321_N1.0350.21
4_L287_S1.0340.20
336_K360_A1.0290.20
135_L332_R1.0290.20
196_N217_V1.0280.20
239_M337_V1.0250.20
131_T326_G1.0230.20
7_Q313_F1.0230.20
175_L185_F1.0230.20
251_L323_D1.0230.20
26_A76_V1.0180.20
40_V119_D1.0180.20
11_P163_D1.0150.20
263_L324_G1.0130.20
196_N230_T1.0130.20
144_Q327_K1.0110.20
20_E183_A1.0110.20
35_V169_A1.0080.20
205_D318_T1.0070.20
367_A372_L1.0040.20
24_Q227_D1.0020.20
86_T355_A1.0000.20
109_L205_D0.9980.20
65_T343_K0.9980.20
17_D152_N0.9940.19
330_N346_H0.9940.19
266_A326_G0.9930.19
292_V359_Q0.9930.19
272_L315_S0.9850.19
14_K363_A0.9820.19
188_K191_N0.9810.19
45_A153_E0.9800.19
155_L272_L0.9750.19
119_D146_E0.9720.19
122_V336_K0.9710.19
304_T344_K0.9700.19
175_L180_A0.9690.19
304_T335_M0.9660.19
251_L270_T0.9630.19
67_T290_F0.9630.19
22_I290_F0.9610.19
57_G141_G0.9570.19
34_N50_T0.9560.19
102_S155_L0.9560.19
171_N210_N0.9550.19
51_S126_L0.9540.19
38_G258_N0.9490.18
94_Y141_G0.9470.18
18_K335_M0.9470.18
286_L358_E0.9460.18
210_N219_R0.9430.18
112_Q350_F0.9400.18
85_V283_D0.9390.18
72_L332_R0.9380.18
77_Q129_A0.9360.18
33_G340_L0.9310.18
258_N329_A0.9300.18
27_A83_E0.9260.18
291_V316_D0.9260.18
30_V222_N0.9240.18
45_A53_F0.9230.18
67_T335_M0.9200.18
264_L315_S0.9170.18
68_R74_T0.9170.18
11_P56_N0.9130.18
40_V66_D0.9130.18
31_Q359_Q0.9120.18
74_T103_S0.9120.18
124_E194_P0.9110.18
17_D276_T0.9050.17
32_A78_V0.9040.17
185_F255_L0.9040.17
259_K369_A0.8980.17
199_Q309_T0.8980.17
67_T71_V0.8950.17
5_S89_D0.8930.17
321_N335_M0.8920.17
230_T329_A0.8910.17
369_A375_G0.8900.17
25_V154_M0.8890.17
123_A127_K0.8890.17
67_T141_G0.8850.17
29_L197_L0.8840.17
266_A274_L0.8830.17
326_G361_L0.8820.17
76_V112_Q0.8810.17
342_V368_I0.8770.17
249_K328_P0.8770.17
304_T346_H0.8760.17
148_L250_R0.8680.17
18_K141_G0.8680.17
22_I77_Q0.8660.17
96_A123_A0.8650.16
127_K163_D0.8650.16
186_V268_A0.8640.16
158_D326_G0.8630.16
18_K313_F0.8610.16
35_V164_L0.8590.16
350_F363_A0.8580.16
50_T108_G0.8520.16
205_D209_G0.8520.16
79_F115_H0.8510.16
203_L275_L0.8510.16
292_V317_I0.8450.16
18_K67_T0.8430.16
69_D366_D0.8410.16
308_N312_Q0.8360.16
167_L224_F0.8350.16
189_A293_R0.8350.16
259_K266_A0.8340.16
121_S195_L0.8340.16
69_D72_L0.8340.16
32_A115_H0.8320.16
12_G178_A0.8320.16
31_Q251_L0.8300.16
333_S372_L0.8290.16
138_L182_D0.8270.16
41_N261_D0.8260.16
92_V144_Q0.8260.16
324_G351_T0.8200.16
22_I344_K0.8150.15
322_L325_T0.8150.15
202_W334_L0.8150.15
322_L346_H0.8100.15
1_M4_L0.8100.15
215_I233_M0.8090.15
30_V40_V0.8090.15
201_I217_V0.8080.15
78_V95_V0.8070.15
2_F14_K0.8060.15
118_S196_N0.8030.15
204_S358_E0.8030.15
64_T114_T0.8030.15
32_A91_Q0.8010.15
18_K311_K0.8000.15
15_A214_A0.8000.15
28_A242_D0.7980.15
261_D284_D0.7980.15
148_L241_D0.7970.15
339_A346_H0.7940.15
239_M338_V0.7930.15
157_L185_F0.7920.15
152_N375_G0.7910.15
186_V369_A0.7870.15
151_D187_T0.7870.15
39_Y55_G0.7860.15
18_K98_G0.7840.15
245_I268_A0.7840.15
163_D238_A0.7840.15
144_Q163_D0.7800.15
152_N257_D0.7800.15
23_R135_L0.7790.15
315_S356_D0.7790.15
112_Q186_V0.7750.15
118_S351_T0.7750.15
4_L340_L0.7740.15
88_G335_M0.7740.15
173_A186_V0.7690.15
292_V305_M0.7680.14
256_L265_K0.7680.14
17_D207_A0.7680.14
88_G141_G0.7670.14
343_K365_G0.7640.14
263_L273_A0.7620.14
19_E358_E0.7610.14
276_T337_V0.7590.14
135_L244_P0.7550.14
69_D328_P0.7540.14
5_S8_D0.7540.14
57_G364_I0.7530.14
91_Q220_A0.7520.14
128_S326_G0.7510.14
174_R177_E0.7510.14
317_I360_A0.7490.14
151_D268_A0.7470.14
12_G223_A0.7450.14
77_Q166_T0.7440.14
186_V328_P0.7400.14
85_V115_H0.7400.14
247_V251_L0.7390.14
271_L280_A0.7390.14
303_G335_M0.7380.14
93_A289_E0.7380.14
40_V343_K0.7370.14
170_L188_K0.7360.14
18_K96_A0.7350.14
20_E193_Q0.7350.14
240_N244_P0.7340.14
66_D375_G0.7320.14
276_T280_A0.7310.14
274_L326_G0.7290.14
125_Q363_A0.7270.14
83_E148_L0.7270.14
291_V344_K0.7260.14
213_S310_I0.7260.14
292_V311_K0.7260.14
129_A248_L0.7260.14
337_V355_A0.7250.14
138_L288_A0.7250.14
67_T118_S0.7240.14
96_A361_L0.7230.14
142_E346_H0.7230.14
122_V271_L0.7200.14
27_A279_D0.7180.14
330_N353_Q0.7180.14
17_D158_D0.7160.14
130_T242_D0.7140.13
7_Q56_N0.7130.13
227_D369_A0.7110.13
191_N216_A0.7100.13
67_T313_F0.7080.13
2_F140_M0.7070.13
172_A191_N0.7040.13
98_G141_G0.7030.13
334_L345_G0.7020.13
136_R140_M0.7020.13
138_L257_D0.7020.13
304_T331_G0.7010.13
164_L308_N0.7000.13
79_F166_T0.7000.13
130_T134_E0.6980.13
135_L213_S0.6980.13
91_Q185_F0.6970.13
292_V370_A0.6960.13
333_S371_G0.6960.13
303_G346_H0.6940.13
292_V365_G0.6940.13
329_A339_A0.6920.13
50_T300_A0.6910.13
185_F198_G0.6910.13
199_Q214_A0.6890.13
288_A362_K0.6850.13
342_V346_H0.6820.13
9_I35_V0.6820.13
25_V361_L0.6820.13
9_I219_R0.6770.13
86_T177_E0.6720.13
259_K264_L0.6710.13
43_M321_N0.6700.13
163_D254_L0.6700.13
36_A252_A0.6650.13
270_T274_L0.6640.13
39_Y87_W0.6610.13
93_A310_I0.6610.13
2_F291_V0.6550.12
310_I330_N0.6510.12
186_V288_A0.6510.12
48_Q90_G0.6500.12
186_V190_I0.6490.12
183_A369_A0.6460.12
124_E237_V0.6430.12
84_G103_S0.6430.12
228_G253_D0.6430.12
303_G375_G0.6400.12
233_M271_L0.6390.12
73_K83_E0.6390.12
21_A334_L0.6370.12
314_N322_L0.6340.12
51_S201_I0.6330.12
48_Q183_A0.6330.12
130_T258_N0.6300.12
85_V136_R0.6260.12
318_T328_P0.6260.12
129_A220_A0.6250.12
28_A79_F0.6240.12
50_T141_G0.6230.12
267_D270_T0.6220.12
7_Q271_L0.6200.12
307_V354_G0.6200.12
263_L271_L0.6190.12
267_D271_L0.6190.12
67_T303_G0.6190.12
20_E83_E0.6190.12
315_S325_T0.6180.12
80_Q325_T0.6180.12
34_N89_D0.6180.12
95_V272_L0.6170.12
122_V216_A0.6120.12
91_Q331_G0.6100.12
2_F10_H0.6090.12
183_A253_D0.6070.12
65_T330_N0.6020.12
158_D261_D0.6020.12
83_E293_R0.6010.12
43_M335_M0.6010.12
56_N165_L0.6000.12
53_F253_D0.6000.12
85_V338_V0.5990.12
311_K368_I0.5990.12
252_A256_L0.5980.11
257_D273_A0.5980.11
112_Q319_V0.5940.11
95_V116_V0.5920.11
10_H28_A0.5920.11
216_A317_I0.5910.11
257_D269_A0.5910.11
183_A222_N0.5890.11
126_L195_L0.5880.11
88_G311_K0.5860.11
334_L368_I0.5840.11
22_I65_T0.5830.11
11_P34_N0.5820.11
246_A358_E0.5800.11
96_A102_S0.5790.11
88_G349_R0.5780.11
194_P251_L0.5740.11
89_D358_E0.5720.11
303_G347_R0.5710.11
315_S365_G0.5710.11
37_E253_D0.5690.11
338_V347_R0.5690.11
215_I220_A0.5670.11
336_K348_L0.5670.11
189_A206_S0.5670.11
207_A260_A0.5660.11
309_T337_V0.5660.11
54_L84_G0.5640.11
135_L339_A0.5630.11
290_F311_K0.5630.11
97_I169_A0.5610.11
188_K208_E0.5600.11
214_A314_N0.5600.11
80_Q218_S0.5600.11
350_F368_I0.5590.11
163_D178_A0.5580.11
127_K161_A0.5570.11
32_A111_R0.5540.11
109_L160_V0.5540.11
26_A44_L0.5530.11
67_T96_A0.5530.11
159_I338_V0.5520.11
45_A172_A0.5510.11
50_T88_G0.5510.11
95_V369_A0.5510.11
179_G183_A0.5490.11
186_V342_V0.5490.11
173_A342_V0.5490.11
220_A358_E0.5490.11
255_L258_N0.5480.11
5_S253_D0.5480.11
18_K118_S0.5430.11
305_M338_V0.5400.11
95_V317_I0.5390.11
295_E339_A0.5380.11
24_Q195_L0.5370.11
137_A295_E0.5370.11
8_D11_P0.5370.11
320_T351_T0.5360.11
127_K176_K0.5360.11
56_N338_V0.5320.10
86_T362_K0.5310.10
97_I141_G0.5300.10
56_N116_V0.5290.10
168_Q320_T0.5280.10
269_A279_D0.5270.10
183_A194_P0.5260.10
247_V364_I0.5260.10
68_R103_S0.5260.10
133_E358_E0.5250.10
71_V78_V0.5250.10
339_A375_G0.5240.10
85_V142_E0.5240.10
18_K97_I0.5240.10
155_L194_P0.5220.10
217_V349_R0.5200.10
17_D130_T0.5200.10
70_Q313_F0.5200.10
166_T311_K0.5190.10
123_A140_M0.5170.10
191_N220_A0.5150.10
308_N323_D0.5140.10
228_G259_K0.5120.10
18_K22_I0.5120.10
78_V174_R0.5120.10
224_F308_N0.5120.10
187_T190_I0.5110.10
11_P331_G0.5070.10
319_V348_L0.5060.10
165_L168_Q0.5060.10
164_L180_A0.5060.10
37_E230_T0.5050.10
199_Q366_D0.5050.10
24_Q73_K0.5030.10
247_V320_T0.5020.10
73_K109_L0.5020.10
102_S109_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a3aA 2 0.3803 100 0.802 Contact Map
3bjvA 2 0.3936 100 0.813 Contact Map
2oqtA 2 0.391 100 0.814 Contact Map
1a6jA 4 0.3723 100 0.817 Contact Map
2oq3A 1 0.3723 100 0.818 Contact Map
3oxpA 2 0.3723 100 0.82 Contact Map
4m62S 1 0.375 100 0.821 Contact Map
2a0jA 1 0.3617 100 0.821 Contact Map
3urrA 2 0.375 100 0.822 Contact Map
3t43A 2 0.3856 99.9 0.838 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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