GREMLIN Database
PTFB1 - Fructose-like phosphotransferase enzyme IIB component 1
UniProt: P69808 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14155
Length: 108 (97)
Sequences: 2066 (1145)
Seq/√Len: 116.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_K54_D3.4141.00
52_A56_A3.0751.00
91_N94_G2.8611.00
32_A97_K2.7731.00
53_Q57_E2.5131.00
6_I61_I2.4561.00
46_I49_R2.3551.00
31_E93_A2.2901.00
4_K35_E2.2171.00
32_A93_A2.2001.00
7_A38_I2.1371.00
4_K57_E2.1261.00
60_I99_I1.9961.00
72_N82_E1.9551.00
87_D91_N1.8601.00
22_A26_E1.8411.00
29_A36_V1.7761.00
26_E30_V1.7411.00
25_L36_V1.7131.00
28_A31_E1.7121.00
93_A97_K1.7101.00
97_K101_E1.5841.00
28_A32_A1.5531.00
61_I78_R1.5341.00
51_T54_D1.4531.00
6_I50_L1.4521.00
39_E74_R1.4421.00
23_Q26_E1.3451.00
28_A92_A1.3331.00
49_R71_D1.3191.00
37_K48_N1.2480.99
66_A85_L1.2390.99
50_L55_I1.2300.99
86_Q90_K1.1950.99
85_L88_A1.1640.99
18_T40_T1.1460.99
8_L41_Q1.1390.99
10_A67_V1.1320.99
94_G98_E1.1260.99
41_Q74_R1.0830.98
4_K59_T1.0800.98
53_Q56_A1.0770.98
40_T48_N1.0740.98
28_A93_A1.0670.98
35_E57_E1.0650.98
83_I95_I1.0600.98
44_D47_Q1.0530.98
87_D98_E1.0360.98
81_Y95_I1.0320.98
7_A36_V1.0230.97
65_V82_E1.0170.97
41_Q69_P1.0150.97
5_L60_I1.0120.97
34_Y100_E0.9310.96
27_E30_V0.9190.95
34_Y96_I0.9150.95
23_Q27_E0.8940.95
55_I78_R0.8930.94
19_F40_T0.8910.94
19_F47_Q0.8670.94
10_A41_Q0.8580.93
73_E76_E0.8550.93
5_L34_Y0.8470.93
83_I87_D0.8360.92
20_M24_A0.8310.92
37_K51_T0.8240.92
11_C14_G0.8190.91
32_A100_E0.8050.91
28_A96_I0.7910.90
63_H72_N0.7870.90
10_A65_V0.7730.89
22_A48_N0.7700.89
88_A91_N0.7660.89
61_I77_S0.7650.88
25_L29_A0.7640.88
63_H80_V0.7540.88
66_A84_T0.7480.87
60_I81_Y0.7480.87
92_A96_I0.7440.87
84_T87_D0.7180.85
91_N98_E0.7120.85
5_L29_A0.7100.84
6_I58_A0.7030.84
14_G18_T0.7030.84
64_S83_I0.6970.83
13_M44_D0.6870.82
7_A17_H0.6850.82
8_L75_F0.6680.81
62_I99_I0.6610.80
12_P67_V0.6610.80
24_A28_A0.6440.78
81_Y87_D0.6420.78
63_H69_P0.6420.78
65_V70_E0.6400.78
94_G97_K0.6390.78
39_E75_F0.6360.77
41_Q71_D0.6360.77
63_H70_E0.6280.77
5_L100_E0.6270.76
60_I100_E0.6090.74
11_C18_T0.6090.74
41_Q63_H0.6080.74
20_M44_D0.6080.74
30_V82_E0.6030.74
55_I58_A0.6030.74
21_A89_I0.6030.74
88_A95_I0.5950.73
9_C85_L0.5900.72
88_A92_A0.5880.72
41_Q72_N0.5880.72
19_F42_G0.5770.70
24_A89_I0.5750.70
25_L62_I0.5730.70
24_A27_E0.5690.69
5_L96_I0.5690.69
11_C15_L0.5680.69
9_C14_G0.5630.68
12_P22_A0.5630.68
26_E36_V0.5620.68
41_Q50_L0.5590.68
81_Y99_I0.5580.68
32_A96_I0.5570.68
12_P84_T0.5570.68
43_A47_Q0.5570.68
27_E31_E0.5560.68
35_E59_T0.5530.67
84_T90_K0.5520.67
56_A59_T0.5480.66
67_V70_E0.5450.66
85_L92_A0.5410.65
30_V33_G0.5410.65
61_I80_V0.5400.65
54_D57_E0.5400.65
65_V69_P0.5380.65
98_E101_E0.5380.65
19_F23_Q0.5300.64
83_I99_I0.5300.64
40_T45_G0.5290.64
59_T78_R0.5240.63
25_L38_I0.5230.63
72_N76_E0.5230.63
7_A34_Y0.5210.63
41_Q67_V0.5140.62
10_A69_P0.5110.61
26_E48_N0.5080.61
5_L36_V0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r48A 1 0.9722 100 0.126 Contact Map
2kyrA 1 1 100 0.262 Contact Map
2r4qA 1 0.9444 99.9 0.296 Contact Map
2m1zA 1 0.9815 99.9 0.305 Contact Map
4tn5A 2 0.9907 99.9 0.338 Contact Map
4mgeA 3 0.8981 99.5 0.58 Contact Map
1e2bA 1 0.9259 99.4 0.601 Contact Map
2l2qA 1 0.9167 99.3 0.63 Contact Map
3czcA 1 0.8519 98.3 0.74 Contact Map
1tvmA 1 0.8704 98.3 0.742 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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