GREMLIN Database
PTND - Mannose permease IID component
UniProt: P69805 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10569
Length: 283 (264)
Sequences: 1340 (835)
Seq/√Len: 51.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_T116_A5.8991.00
50_I61_R4.3731.00
260_N263_W4.0771.00
17_D52_R3.7971.00
14_T17_D3.3811.00
58_N62_K3.2871.00
56_E60_A3.2361.00
266_V270_V3.2061.00
49_A87_L3.1531.00
250_A253_W3.0751.00
233_T236_D2.9371.00
246_L250_A2.9301.00
63_Q101_D2.8781.00
13_L87_L2.8301.00
275_G281_L2.8271.00
230_T233_T2.6731.00
232_Q236_D2.6471.00
271_I275_G2.6301.00
135_G146_G2.5481.00
13_L49_A2.5121.00
212_I231_V2.4491.00
42_F86_T2.4401.00
251_C268_F2.3951.00
51_R61_R2.3321.00
163_Y167_A2.2821.00
15_Q167_A2.2591.00
24_R44_F2.0611.00
82_I116_A2.0571.00
259_V267_G1.9531.00
18_I166_V1.8810.99
72_F82_I1.8690.99
43_C65_I1.8640.99
13_L17_D1.8430.99
19_R167_A1.8410.99
68_H90_E1.8330.99
91_E170_Y1.8170.99
239_M242_L1.7990.99
14_T52_R1.7640.99
247_L268_F1.7340.99
168_Y171_S1.7250.99
274_A278_C1.7240.99
132_A150_F1.7160.99
49_A53_L1.6910.99
93_R101_D1.6840.99
46_M50_I1.6630.98
72_F79_A1.6480.98
29_Q32_W1.6300.98
74_T82_I1.6290.98
210_V281_L1.6040.98
25_S79_A1.5890.98
55_P60_A1.5780.98
244_P248_T1.5060.97
212_I243_V1.4980.97
259_V263_W1.4910.97
89_L103_A1.4890.97
68_H108_K1.4860.97
31_S40_L1.4490.96
82_I115_L1.4430.96
270_V274_A1.4340.96
45_S83_L1.4210.96
274_A277_A1.3940.95
93_R104_I1.3700.95
56_E59_E1.3690.95
144_L147_P1.3630.95
70_E105_N1.3610.95
60_A63_Q1.3390.94
58_N61_R1.3370.94
215_V228_V1.3320.94
11_K95_N1.3130.93
214_L231_V1.3110.93
61_R65_I1.2920.93
131_F153_L1.2920.93
21_V49_A1.2830.93
105_N109_V1.2830.93
146_G149_L1.2820.93
13_L18_I1.2630.92
96_G99_I1.2590.92
38_Q116_A1.2490.92
251_C264_I1.2450.91
204_V248_T1.2320.91
66_R69_L1.2310.91
167_A171_S1.2280.91
213_P281_L1.2100.90
59_E63_Q1.2080.90
278_C281_L1.2060.90
18_I167_A1.2040.90
50_I64_A1.1910.89
210_V243_V1.1830.89
136_A140_M1.1770.89
80_A166_V1.1670.88
263_W267_G1.1520.88
72_F83_L1.1480.88
16_S20_G1.1380.87
254_L267_G1.1380.87
262_L266_V1.1330.87
149_L153_L1.1310.87
215_V225_K1.1230.86
217_S228_V1.1160.86
41_G170_Y1.1160.86
22_F163_Y1.1140.86
55_P58_N1.1120.86
172_K179_D1.1090.86
47_V65_I1.1060.86
33_N36_R1.0990.85
254_L259_V1.0970.85
32_W39_A1.0960.85
152_I156_L1.0830.84
62_K66_R1.0810.84
148_L152_I1.0750.84
245_L249_F1.0740.84
147_P150_F1.0730.84
264_I268_F1.0710.84
54_Y64_A1.0660.83
233_T237_Q1.0650.83
242_L246_L1.0380.82
275_G278_C1.0370.82
28_F38_Q1.0360.82
275_G280_L1.0350.82
43_C47_V1.0330.81
67_R108_K1.0310.81
51_R58_N1.0230.81
60_A64_A1.0230.81
21_V166_V1.0160.80
93_R96_G1.0150.80
12_K95_N1.0130.80
93_R99_I1.0120.80
172_K175_D1.0100.80
22_F162_R1.0070.80
78_V115_L0.9970.79
36_R39_A0.9940.79
15_Q19_R0.9870.78
76_P199_V0.9860.78
38_Q74_T0.9810.78
161_T165_G0.9780.78
128_R150_F0.9760.78
210_V247_L0.9690.77
160_A164_Y0.9500.76
19_R163_Y0.9490.76
50_I53_L0.9450.75
46_M53_L0.9450.75
64_A67_R0.9360.75
42_F68_H0.9360.75
37_M123_F0.9330.74
118_V159_L0.9310.74
211_N275_G0.9210.73
273_I277_A0.9190.73
42_F46_M0.9140.73
87_L166_V0.9120.73
53_L95_N0.9100.72
131_F152_I0.9100.72
138_I141_S0.9100.72
43_C46_M0.9080.72
247_L269_F0.9050.72
36_R69_L0.8990.72
68_H86_T0.8970.71
145_L148_L0.8920.71
59_E62_K0.8810.70
17_D20_G0.8730.69
28_F79_A0.8670.69
20_G52_R0.8610.68
209_H241_G0.8590.68
129_P157_V0.8590.68
210_V244_P0.8580.68
157_V203_L0.8580.68
129_P203_L0.8580.68
183_G192_A0.8570.68
17_D91_E0.8540.68
43_C51_R0.8490.67
138_I191_G0.8470.67
233_T278_C0.8450.67
10_E14_T0.8440.67
72_F112_M0.8430.67
146_G151_F0.8430.67
9_T12_K0.8410.66
53_L60_A0.8400.66
247_L251_C0.8380.66
247_L271_I0.8370.66
92_Q96_G0.8370.66
214_L243_V0.8280.65
267_G271_I0.8260.65
131_F157_V0.8250.65
33_N248_T0.8240.65
103_A106_G0.8240.65
268_F272_G0.8200.64
29_Q37_M0.8120.64
26_N80_A0.8080.63
21_V87_L0.8080.63
175_D178_K0.8070.63
256_R278_C0.8020.63
26_N159_L0.7960.62
60_A68_H0.7880.61
21_V44_F0.7830.61
130_V134_L0.7820.61
13_L91_E0.7800.61
25_S132_A0.7780.60
210_V213_P0.7780.60
20_G24_R0.7750.60
33_N76_P0.7750.60
81_P165_G0.7720.60
132_A136_A0.7690.59
19_R23_L0.7590.58
41_G48_P0.7570.58
212_I281_L0.7530.58
54_Y116_A0.7460.57
131_F148_L0.7390.56
81_P177_V0.7320.56
53_L91_E0.7320.56
149_L152_I0.7310.56
135_G153_L0.7310.56
151_F155_N0.7290.55
252_M256_R0.7270.55
127_V157_V0.7260.55
103_A107_I0.7220.55
215_V230_T0.7180.54
60_A242_L0.7170.54
115_L160_A0.7160.54
272_G276_Y0.7150.54
13_L53_L0.7140.54
157_V160_A0.7130.54
229_T234_I0.7110.54
69_L151_F0.7040.53
267_G275_G0.7030.53
40_L69_L0.7000.52
46_M105_N0.6980.52
224_G227_H0.6970.52
75_Q123_F0.6950.52
59_E225_K0.6940.52
25_S125_G0.6930.52
191_G195_L0.6920.52
110_G161_T0.6920.52
249_F252_M0.6890.51
59_E156_L0.6870.51
184_F187_K0.6830.51
203_L207_W0.6830.51
51_R65_I0.6800.50
70_E102_G0.6750.50
36_R58_N0.6680.49
12_K91_E0.6670.49
153_L235_L0.6660.49
93_R100_D0.6640.49
52_R170_Y0.6630.49
100_D189_T0.6630.49
42_F108_K0.6620.48
39_A69_L0.6570.48
188_L195_L0.6560.48
267_G270_V0.6540.48
11_K53_L0.6480.47
94_A125_G0.6470.47
102_G186_Q0.6460.47
11_K91_E0.6450.47
234_I237_Q0.6450.47
122_I175_D0.6430.46
31_S235_L0.6430.46
212_I235_L0.6380.46
53_L82_I0.6370.46
58_N71_F0.6370.46
53_L94_A0.6370.46
117_G125_G0.6360.46
90_E201_G0.6300.45
29_Q38_Q0.6300.45
244_P249_F0.6280.45
277_A280_L0.6280.45
253_W256_R0.6260.45
151_F157_V0.6260.45
130_V146_G0.6260.45
25_S162_R0.6250.45
12_K55_P0.6230.44
266_V280_L0.6210.44
31_S44_F0.6200.44
118_V121_P0.6190.44
80_A165_G0.6190.44
250_A267_G0.6180.44
77_F154_F0.6130.43
86_T90_E0.6130.43
66_R145_L0.6120.43
110_G116_A0.6100.43
32_W195_L0.6100.43
89_L241_G0.6090.43
62_K106_G0.6090.43
54_Y111_L0.6090.43
191_G202_A0.6080.43
270_V279_G0.6080.43
175_D271_I0.6070.43
211_N276_Y0.6060.43
121_P237_Q0.6050.43
193_S197_L0.6050.43
18_I45_S0.6040.42
29_Q76_P0.6040.42
229_T232_Q0.6040.42
139_A143_S0.5990.42
148_L277_A0.5990.42
107_I195_L0.5980.42
121_P207_W0.5970.42
16_S23_L0.5960.42
67_R94_A0.5950.42
71_F185_L0.5940.41
217_S242_L0.5920.41
87_L91_E0.5920.41
11_K55_P0.5920.41
165_G248_T0.5910.41
156_L280_L0.5910.41
227_H230_T0.5910.41
143_S146_G0.5910.41
29_Q34_F0.5900.41
41_G132_A0.5900.41
118_V156_L0.5890.41
206_K241_G0.5880.41
75_Q79_A0.5870.41
117_G169_G0.5860.41
89_L168_Y0.5850.41
106_G109_V0.5840.40
185_L205_N0.5840.40
159_L198_F0.5820.40
232_Q235_L0.5820.40
85_V237_Q0.5790.40
125_G128_R0.5780.40
130_V201_G0.5770.40
79_A83_L0.5740.39
261_P265_I0.5730.39
48_P278_C0.5720.39
140_M215_V0.5720.39
84_G201_G0.5720.39
96_G101_D0.5710.39
29_Q132_A0.5700.39
212_I271_I0.5680.39
199_V241_G0.5630.38
255_L258_K0.5620.38
121_P158_R0.5620.38
71_F117_G0.5610.38
148_L168_Y0.5600.38
17_D21_V0.5590.38
58_N80_A0.5570.38
208_T244_P0.5570.38
192_A261_P0.5560.38
75_Q129_P0.5550.38
34_F39_A0.5540.38
105_N260_N0.5540.38
107_I177_V0.5540.38
11_K258_K0.5540.38
164_Y168_Y0.5490.37
217_S230_T0.5490.37
122_I149_L0.5490.37
139_A203_L0.5490.37
153_L269_F0.5480.37
163_Y166_V0.5480.37
14_T91_E0.5470.37
213_P230_T0.5470.37
23_L26_N0.5470.37
47_V61_R0.5460.37
230_T280_L0.5450.37
17_D49_A0.5440.37
62_K65_I0.5440.37
210_V271_I0.5410.36
29_Q204_V0.5400.36
82_I86_T0.5400.36
254_L258_K0.5390.36
37_M75_Q0.5380.36
214_L280_L0.5370.36
89_L224_G0.5360.36
56_E62_K0.5350.36
73_N196_G0.5340.36
28_F123_F0.5330.35
31_S116_A0.5300.35
238_L258_K0.5300.35
50_I56_E0.5290.35
56_E61_R0.5280.35
68_H110_G0.5270.35
102_G256_R0.5270.35
145_L149_L0.5270.35
15_Q188_L0.5250.35
71_F104_I0.5230.35
94_A126_T0.5220.34
208_T248_T0.5210.34
117_G133_A0.5210.34
63_Q214_L0.5210.34
137_G150_F0.5190.34
133_A158_R0.5170.34
148_L246_L0.5140.34
88_A176_I0.5130.34
130_V242_L0.5120.34
138_I237_Q0.5100.33
199_V240_P0.5100.33
134_L198_F0.5090.33
32_W261_P0.5080.33
229_T233_T0.5080.33
72_F115_L0.5070.33
50_I55_P0.5060.33
46_M52_R0.5060.33
75_Q116_A0.5060.33
187_K272_G0.5050.33
84_G90_E0.5050.33
22_F26_N0.5050.33
9_T236_D0.5040.33
143_S205_N0.5030.33
55_P61_R0.5010.32
32_W77_F0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rp9A 2 0.1943 24.9 0.971 Contact Map
4afiA 2 0.265 19.1 0.972 Contact Map
1ashA 1 0.4099 11.7 0.975 Contact Map
2jttC 1 0.1095 7.3 0.977 Contact Map
3pf6A 2 0.1908 6.6 0.977 Contact Map
5by8A 1 0.2297 5.4 0.978 Contact Map
4b19A 1 0.1025 5.1 0.979 Contact Map
1t0fC 1 0.1731 4.4 0.979 Contact Map
3k9fC 1 0.2403 3.8 0.98 Contact Map
3g5sA 1 0.2827 3.8 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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