GREMLIN Database
PTNC - Mannose permease IIC component
UniProt: P69801 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10568
Length: 266 (247)
Sequences: 1421 (899)
Seq/√Len: 57.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_N135_A5.2551.00
212_L233_V4.9951.00
45_D48_T4.9621.00
222_F226_A4.0071.00
14_V38_L3.6301.00
41_I46_M3.4701.00
123_A126_K3.4671.00
16_C148_A3.4201.00
31_R57_E3.4131.00
215_V230_I3.0641.00
176_E180_N3.0061.00
14_V42_V2.9091.00
126_K130_N2.8661.00
215_V229_V2.8081.00
127_A135_A2.6801.00
211_Y229_V2.6581.00
168_Q172_N2.5211.00
122_H125_D2.5101.00
8_I12_F2.4711.00
36_C49_G2.4711.00
38_L42_V2.2731.00
134_T138_W2.2681.00
209_F241_L2.2431.00
16_C152_A2.2131.00
123_A127_A2.1571.00
5_T9_V2.1441.00
11_V39_V2.0961.00
127_A132_N2.0881.00
43_L87_A2.0411.00
180_N184_I1.9631.00
37_T46_M1.9021.00
127_A139_I1.8821.00
126_K129_D1.8801.00
217_A227_L1.8761.00
207_M211_Y1.8541.00
135_A138_W1.8501.00
219_F223_N1.8070.99
76_L106_G1.7960.99
48_T52_I1.7920.99
127_A130_N1.7910.99
10_L42_V1.7890.99
47_K51_I1.7860.99
209_F238_Y1.7560.99
132_N138_W1.6900.99
12_F152_A1.6680.99
15_A155_A1.6680.99
17_I29_F1.6440.99
123_A139_I1.6390.99
85_V95_G1.6300.99
209_F237_L1.6280.99
223_N226_A1.5970.99
55_T59_I1.5910.98
12_F157_I1.5790.98
184_I187_G1.5660.98
165_S168_Q1.5480.98
180_N183_N1.5160.98
33_L37_T1.5010.98
170_M173_A1.4850.98
5_T161_S1.4800.98
238_Y241_L1.4660.97
48_T86_I1.4500.97
128_A131_G1.4410.97
148_A152_A1.4070.97
94_A97_A1.3650.96
25_D31_R1.3460.96
219_F225_V1.3240.95
77_A83_I1.2910.95
128_A136_I1.2860.94
124_A140_H1.2810.94
124_A128_A1.2260.93
9_V157_I1.2210.93
105_A171_L1.2130.93
6_L10_L1.2080.92
228_G231_G1.1970.92
177_V181_G1.1870.92
128_A135_A1.1860.92
109_L154_P1.1840.92
69_A114_R1.1740.91
113_V146_L1.1670.91
31_R34_I1.1650.91
34_I37_T1.1640.91
216_T220_T1.1550.91
169_N172_N1.1440.90
73_D76_L1.1400.90
77_A103_A1.1360.90
174_I178_V1.1350.90
7_Q42_V1.1330.90
49_G53_G1.1260.89
61_L104_A1.1130.89
248_V251_A1.1090.89
247_R250_G1.1080.89
14_V35_A1.1000.88
68_A186_G1.0860.88
219_F222_F1.0700.87
110_T114_R1.0700.87
90_Q94_A1.0670.87
166_E169_N1.0660.87
103_A144_L1.0650.87
72_P103_A1.0650.87
222_F227_L1.0640.87
98_L102_L1.0580.86
215_V222_F1.0510.86
6_L9_V1.0450.86
152_A157_I1.0150.84
249_A252_P1.0120.84
202_R210_F1.0100.84
138_W142_S1.0020.83
61_L78_S0.9990.83
48_T51_I0.9990.83
43_L86_I0.9990.83
224_L228_G0.9910.82
181_G185_A0.9900.82
158_V166_E0.9860.82
61_L75_A0.9750.81
128_A132_N0.9640.81
85_V189_I0.9600.80
176_E179_T0.9530.80
242_S245_Y0.9450.79
237_L241_L0.9390.79
11_V79_I0.9370.79
124_A139_I0.9330.78
47_K50_I0.9300.78
11_V42_V0.9280.78
248_V252_P0.9240.78
103_A194_Y0.9170.77
51_I54_G0.9080.76
158_V195_A0.9070.76
221_N224_L0.9060.76
234_M237_L0.9030.76
7_Q87_A0.8960.75
220_T223_N0.8960.75
73_D110_T0.8950.75
115_T118_V0.8920.75
80_I159_A0.8910.75
11_V43_L0.8870.75
104_A108_V0.8860.75
6_L240_Q0.8860.75
133_L137_S0.8810.74
51_I84_L0.8770.74
40_G53_G0.8770.74
157_I161_S0.8700.73
50_I53_G0.8640.73
135_A139_I0.8590.72
149_M153_I0.8570.72
157_I162_V0.8540.72
211_Y233_V0.8540.72
175_P181_G0.8520.72
134_T137_S0.8490.71
159_A167_V0.8480.71
232_T236_V0.8470.71
116_I146_L0.8410.71
51_I58_M0.8410.71
125_D129_D0.8300.70
169_N173_A0.8300.70
247_R251_A0.8260.69
101_P104_A0.8160.68
35_A79_I0.8110.68
80_I84_L0.8100.68
21_G72_P0.8090.68
246_N251_A0.8060.67
205_Y244_K0.8060.67
166_E170_M0.8010.67
56_L78_S0.7990.67
33_L54_G0.7930.66
60_A77_A0.7920.66
130_N135_A0.7920.66
206_L211_Y0.7900.66
35_A78_S0.7890.66
18_A35_A0.7890.66
134_T246_N0.7880.66
36_C68_A0.7850.65
11_V155_A0.7820.65
219_F226_A0.7790.65
28_Q78_S0.7750.64
39_V83_I0.7720.64
185_A189_I0.7700.64
243_P246_N0.7660.64
58_M141_V0.7620.63
10_L13_I0.7590.63
58_M198_I0.7570.63
161_S165_S0.7570.63
123_A138_W0.7540.62
80_I102_L0.7510.62
57_E200_M0.7510.62
93_G221_N0.7480.62
7_Q43_L0.7460.61
7_Q11_V0.7440.61
85_V91_S0.7410.61
128_A133_L0.7400.61
11_V14_V0.7380.61
196_M201_M0.7330.60
216_T230_I0.7290.60
165_S169_N0.7240.59
73_D151_V0.7220.59
77_A84_L0.7210.59
106_G154_P0.7200.59
141_V145_F0.7180.59
208_P211_Y0.7180.59
78_S82_T0.7170.58
9_V12_F0.7130.58
15_A197_V0.7130.58
170_M211_Y0.7120.58
57_E107_Q0.7120.58
175_P213_G0.7110.58
208_P236_V0.7110.58
14_V79_I0.7060.57
17_I20_M0.7050.57
72_P107_Q0.7030.57
245_Y249_A0.6910.56
104_A107_Q0.6900.56
19_G151_V0.6900.56
247_R252_P0.6880.55
81_S85_V0.6870.55
108_V111_I0.6860.55
15_A79_I0.6820.55
18_A30_H0.6770.54
118_V121_Q0.6760.54
123_A135_A0.6740.54
21_G197_V0.6740.54
152_A171_L0.6740.54
172_N176_E0.6740.54
33_L36_C0.6720.54
216_T234_M0.6710.53
77_A81_S0.6680.53
66_I70_V0.6620.52
167_V189_I0.6590.52
14_V18_A0.6580.52
246_N249_A0.6520.51
124_A242_S0.6520.51
117_T154_P0.6510.51
36_C82_T0.6510.51
61_L73_D0.6500.51
144_L147_Q0.6500.51
234_M238_Y0.6490.51
15_A19_G0.6430.50
82_T86_I0.6410.50
126_K244_K0.6380.50
202_R207_M0.6370.50
107_Q111_I0.6360.50
80_I83_I0.6350.49
240_Q244_K0.6340.49
56_L76_L0.6310.49
220_T227_L0.6270.49
236_V244_K0.6260.49
5_T8_I0.6250.48
58_M102_L0.6220.48
37_T41_I0.6220.48
245_Y251_A0.6210.48
61_L110_T0.6210.48
25_D95_G0.6200.48
122_H153_I0.6170.48
21_G210_F0.6140.47
7_Q10_L0.6140.47
233_V236_V0.6120.47
39_V86_I0.6120.47
88_G99_A0.6090.47
62_G127_A0.6070.46
192_V239_I0.6070.46
108_V182_L0.6060.46
32_P210_F0.6040.46
163_G197_V0.6030.46
125_D136_I0.6000.46
23_I70_V0.5980.45
124_A143_S0.5940.45
93_G183_N0.5940.45
115_T122_H0.5930.45
62_G181_G0.5930.45
9_V245_Y0.5900.45
7_Q158_V0.5870.44
59_I81_S0.5840.44
62_G101_P0.5830.44
87_A157_I0.5800.44
246_N250_G0.5790.43
212_L230_I0.5790.43
53_G213_G0.5750.43
106_G150_R0.5730.43
57_E219_F0.5730.43
8_I157_I0.5710.43
76_L151_V0.5710.43
19_G23_I0.5710.43
84_L87_A0.5700.42
6_L250_G0.5700.42
176_E221_N0.5690.42
73_D107_Q0.5690.42
55_T221_N0.5680.42
12_F161_S0.5670.42
229_V232_T0.5620.42
56_L77_A0.5620.42
14_V57_E0.5600.41
93_G187_G0.5590.41
89_H93_G0.5570.41
68_A199_N0.5570.41
54_G74_A0.5560.41
120_F123_A0.5560.41
106_G224_L0.5560.41
17_I172_N0.5560.41
54_G185_A0.5550.41
179_T182_L0.5540.41
202_R208_P0.5500.40
153_I170_M0.5500.40
105_A180_N0.5500.40
54_G228_G0.5500.40
11_V96_I0.5480.40
5_T205_Y0.5460.40
38_L49_G0.5450.40
97_A100_I0.5420.39
73_D100_I0.5410.39
79_I146_L0.5410.39
37_T50_I0.5400.39
107_Q110_T0.5400.39
20_M145_F0.5400.39
137_S141_V0.5400.39
18_A29_F0.5390.39
176_E249_A0.5390.39
243_P247_R0.5380.39
49_G66_I0.5380.39
62_G100_I0.5380.39
65_N151_V0.5370.39
88_G158_V0.5360.39
74_A81_S0.5350.39
204_G250_G0.5350.39
32_P96_I0.5350.39
107_Q223_N0.5320.38
19_G96_I0.5310.38
70_V74_A0.5310.38
241_L244_K0.5310.38
37_T57_E0.5300.38
107_Q201_M0.5280.38
124_A136_I0.5270.38
210_F226_A0.5270.38
79_I83_I0.5270.38
9_V176_E0.5270.38
94_A160_L0.5260.38
138_W143_S0.5260.38
89_H244_K0.5260.38
39_V82_T0.5250.38
120_F230_I0.5250.38
55_T96_I0.5250.38
245_Y248_V0.5250.38
60_A72_P0.5240.38
25_D152_A0.5240.38
58_M231_G0.5220.37
153_I161_S0.5220.37
168_Q176_E0.5220.37
47_K172_N0.5210.37
84_L167_V0.5180.37
18_A75_A0.5180.37
183_N223_N0.5170.37
236_V243_P0.5160.37
230_I245_Y0.5140.37
207_M236_V0.5140.37
99_A104_A0.5120.36
129_D249_A0.5110.36
97_A188_M0.5110.36
5_T38_L0.5100.36
216_T222_F0.5100.36
244_K249_A0.5100.36
122_H128_A0.5080.36
23_I114_R0.5070.36
38_L142_S0.5070.36
89_H116_I0.5070.36
131_G134_T0.5070.36
174_I179_T0.5060.36
168_Q221_N0.5060.36
19_G150_R0.5060.36
104_A221_N0.5050.36
132_N246_N0.5040.36
49_G83_I0.5040.36
58_M72_P0.5030.35
52_I82_T0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k1cA 4 0.6278 63.8 0.951 Contact Map
4kjrA 3 0.4887 38.1 0.958 Contact Map
4ltoA 3 0.4023 28.4 0.961 Contact Map
3qnqA 2 0.8609 26.6 0.962 Contact Map
3vopA 3 0.0188 23.7 0.963 Contact Map
3giaA 1 0.906 22.3 0.963 Contact Map
4cbcA 3 0.3195 21.7 0.963 Contact Map
3cx5I 1 0.1842 21.4 0.963 Contact Map
3qe7A 2 0.7932 20.2 0.964 Contact Map
3l1lA 2 0.9098 15.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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