GREMLIN Database
PTNAB - PTS system mannose-specific EIIAB component
UniProt: P69797 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10567
Length: 323 (318)
Sequences: 313 (163)
Seq/√Len: 9.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
255_E293_K7.9251.00
93_V98_L5.6911.00
250_V263_V4.5430.99
36_F72_S4.5070.99
285_E289_E3.7980.98
22_E27_E3.7460.97
276_Q283_V3.3110.94
21_A102_L3.2890.94
227_I256_G3.2780.94
47_E51_A2.9740.90
30_N57_D2.9710.90
150_P156_M2.9060.89
49_Y77_A2.6020.83
224_A228_R2.5630.82
31_V102_L2.5190.81
45_L49_Y2.5100.81
32_G55_K2.4880.80
165_G186_T2.4870.80
156_M161_Y2.4710.80
183_T216_V2.4290.79
300_E311_K2.4020.78
252_R256_G2.3850.77
262_S300_E2.3840.77
154_K159_N2.3390.76
291_F314_M2.3360.76
58_T61_G2.3240.75
69_W74_F2.2660.73
3_I111_F2.2400.72
36_F45_L2.1740.70
283_V317_L2.1720.70
12_W15_E2.1400.69
254_V263_V2.1380.69
265_V280_A2.0940.67
225_K228_R2.0920.67
110_S113_E1.9770.62
124_E134_V1.9580.62
7_I98_L1.9440.61
169_I265_V1.9120.60
265_V291_F1.9110.60
255_E297_R1.9050.59
128_A134_V1.8990.59
254_V294_L1.8920.59
156_M237_G1.8790.58
155_P159_N1.8100.55
100_E117_L1.7640.53
150_P153_A1.7620.53
248_T286_K1.7600.53
46_I79_R1.7570.53
7_I36_F1.7290.52
7_I72_S1.7260.52
247_P268_M1.7210.51
260_I294_L1.7050.51
13_A20_T1.6940.50
277_V283_V1.6890.50
13_A35_D1.6750.49
111_F115_V1.6380.48
6_V293_K1.6160.47
100_E121_T1.6130.47
283_V292_K1.6120.47
265_V314_M1.5960.46
36_F87_Y1.5720.45
293_K296_A1.5680.45
280_A314_M1.5480.44
72_S87_Y1.5420.44
282_S318_I1.5340.43
12_W98_L1.5200.43
61_G86_H1.5180.43
18_L49_Y1.4840.41
154_K238_E1.4840.41
115_V211_V1.4760.41
183_T186_T1.4750.41
234_K276_Q1.4720.41
40_E48_K1.4650.40
103_M107_D1.4570.40
280_A291_F1.4520.40
189_S238_E1.4470.40
15_E33_W1.4250.39
7_I37_V1.4110.38
20_T24_L1.4080.38
45_L98_L1.3680.36
91_A227_I1.3610.36
12_W93_V1.3410.35
276_Q317_L1.3380.35
107_D114_L1.3350.35
283_V321_I1.3340.35
40_E77_A1.3270.35
45_L72_S1.3200.34
252_R255_E1.3130.34
282_S312_L1.2980.33
81_V122_G1.2870.33
270_F276_Q1.2550.32
162_M238_E1.2540.32
254_V299_I1.2410.31
82_V129_L1.2410.31
247_P291_F1.2340.31
77_A89_V1.2210.31
159_N238_E1.2110.30
276_Q292_K1.2010.30
233_P288_I1.1930.29
91_A121_T1.1890.29
252_R292_K1.1880.29
6_V77_A1.1670.29
152_P155_P1.1600.28
85_E112_D1.1560.28
278_N281_V1.1540.28
225_K229_V1.1530.28
148_A153_A1.1490.28
185_E241_M1.1470.28
233_P238_E1.1370.27
126_V281_V1.1320.27
174_I235_Y1.1290.27
7_I121_T1.1290.27
43_E47_E1.1280.27
91_A129_L1.1200.27
34_I123_R1.1190.27
169_I281_V1.1180.27
152_P163_V1.1070.26
314_M317_L1.1050.26
17_L93_V1.0970.26
281_V295_N1.0840.26
36_F48_K1.0810.26
62_V256_G1.0800.26
114_L117_L1.0730.25
91_A98_L1.0590.25
310_P318_I1.0580.25
126_V223_V1.0520.25
239_R263_V1.0500.25
159_N233_P1.0490.25
138_A149_A1.0480.24
32_G49_Y1.0370.24
76_A208_L1.0280.24
91_A119_V1.0210.24
29_E79_R1.0210.24
199_A281_V1.0190.24
48_K72_S1.0120.23
13_A24_L1.0100.23
169_I308_T1.0080.23
283_V288_I1.0060.23
144_A149_A1.0050.23
260_I263_V1.0050.23
150_P154_K1.0050.23
91_A126_V1.0020.23
47_E50_N0.9840.22
254_V260_I0.9820.22
18_L33_W0.9810.22
183_T221_V0.9800.22
171_D280_A0.9790.22
174_I267_G0.9780.22
53_L169_I0.9750.22
153_A159_N0.9690.22
164_I250_V0.9690.22
159_N163_V0.9610.22
122_G126_V0.9560.22
79_R93_V0.9550.22
171_D241_M0.9550.22
233_P237_G0.9500.21
246_N253_L0.9400.21
100_E110_S0.9350.21
54_A316_D0.9330.21
7_I12_W0.9280.21
147_K150_P0.9260.21
7_I93_V0.9230.21
64_F100_E0.9160.20
59_T72_S0.9150.20
263_V285_E0.9130.20
124_E128_A0.9100.20
113_E116_A0.9070.20
147_K239_R0.9040.20
218_A291_F0.9020.20
61_G89_V0.9020.20
265_V268_M0.8980.20
30_N49_Y0.8960.20
169_I291_F0.8960.20
66_V129_L0.8950.20
295_N314_M0.8940.20
229_V233_P0.8840.20
255_E285_E0.8830.20
234_K238_E0.8820.20
66_V90_I0.8700.19
55_K59_T0.8690.19
3_I114_L0.8650.19
155_P233_P0.8650.19
223_V252_R0.8650.19
78_S129_L0.8620.19
41_N44_T0.8610.19
189_S217_T0.8590.19
104_A108_D0.8580.19
205_K209_T0.8550.19
9_T122_G0.8540.19
135_E144_A0.8530.19
293_K297_R0.8510.19
156_M159_N0.8470.19
36_F98_L0.8450.19
251_E293_K0.8400.18
155_P163_V0.8380.18
100_E114_L0.8360.18
82_V90_I0.8360.18
150_P163_V0.8320.18
198_V243_L0.8320.18
181_R219_H0.8300.18
21_A25_L0.8280.18
66_V110_S0.8280.18
73_P257_G0.8240.18
189_S237_G0.8210.18
13_A16_Q0.8180.18
21_A31_V0.8170.18
32_G72_S0.8140.18
207_L282_S0.8140.18
119_V128_A0.8140.18
48_K59_T0.8090.18
18_L250_V0.8080.18
279_N309_D0.8060.18
154_K233_P0.8060.18
250_V254_V0.8040.17
141_P145_A0.8020.17
169_I247_P0.8020.17
137_A140_A0.8010.17
207_L226_M0.8000.17
66_V263_V0.8000.17
79_R98_L0.7990.17
219_H262_S0.7990.17
18_L242_L0.7980.17
3_I106_D0.7980.17
171_D314_M0.7970.17
33_W56_L0.7960.17
5_I251_E0.7960.17
183_T215_G0.7930.17
152_P159_N0.7920.17
100_E187_N0.7910.17
171_D207_L0.7890.17
64_F167_A0.7850.17
81_V129_L0.7840.17
66_V70_G0.7810.17
295_N315_M0.7800.17
311_K318_I0.7780.17
162_M234_K0.7750.17
103_M117_L0.7740.17
83_D207_L0.7690.17
27_E308_T0.7680.17
21_A98_L0.7670.17
181_R185_E0.7660.17
29_E83_D0.7660.17
250_V279_N0.7640.16
186_T214_P0.7630.16
12_W39_G0.7630.16
159_N162_M0.7620.16
7_I193_V0.7600.16
246_N290_A0.7590.16
45_L207_L0.7590.16
151_T221_V0.7590.16
252_R299_I0.7550.16
86_H116_A0.7540.16
286_K308_T0.7540.16
308_T316_D0.7480.16
61_G142_A0.7430.16
157_G161_Y0.7420.16
68_T95_I0.7400.16
245_T267_G0.7370.16
77_A229_V0.7340.16
86_H104_A0.7320.16
224_A252_R0.7310.16
7_I80_I0.7300.16
140_A144_A0.7290.16
10_H26_G0.7280.16
136_K319_S0.7280.16
22_E102_L0.7270.16
24_L205_K0.7260.16
281_V314_M0.7260.16
206_T209_T0.7230.16
167_A303_V0.7230.16
192_I251_E0.7220.15
281_V289_E0.7220.15
190_R269_A0.7210.15
185_E200_A0.7160.15
311_K314_M0.7150.15
54_A140_A0.7080.15
140_A296_A0.7080.15
265_V278_N0.7080.15
50_N246_N0.7070.15
248_T290_A0.7050.15
103_M108_D0.7030.15
189_S219_H0.7010.15
184_K191_I0.7010.15
223_V256_G0.7010.15
250_V297_R0.7010.15
97_M204_R0.7000.15
316_D320_K0.7000.15
189_S239_R0.6980.15
232_N267_G0.6960.15
70_G100_E0.6950.15
104_A126_V0.6920.15
207_L278_N0.6920.15
276_Q296_A0.6900.15
227_I252_R0.6880.15
45_L93_V0.6870.15
150_P155_P0.6870.15
180_T198_V0.6860.15
36_F93_V0.6860.15
207_L241_M0.6800.15
83_D217_T0.6750.14
51_A85_E0.6730.14
108_D117_L0.6710.14
229_V250_V0.6670.14
263_V271_R0.6650.14
36_F49_Y0.6650.14
184_K214_P0.6590.14
258_V282_S0.6590.14
25_L95_I0.6590.14
227_I230_Y0.6560.14
247_P305_K0.6550.14
187_N239_R0.6550.14
244_F303_V0.6540.14
57_D138_A0.6520.14
183_T241_M0.6520.14
36_F59_T0.6510.14
72_S207_L0.6510.14
29_E139_P0.6500.14
199_A227_I0.6490.14
49_Y72_S0.6480.14
50_N83_D0.6470.14
83_D141_P0.6440.14
25_L102_L0.6420.14
235_Y267_G0.6410.14
47_E139_P0.6410.14
22_E202_T0.6380.14
278_N317_L0.6380.14
62_V122_G0.6350.14
80_I145_A0.6350.14
174_I208_L0.6330.14
116_A308_T0.6310.14
46_I50_N0.6300.13
122_G132_K0.6290.13
204_R267_G0.6290.13
30_N311_K0.6290.13
20_T95_I0.6280.13
159_N277_V0.6270.13
43_E137_A0.6260.13
148_A185_E0.6260.13
233_P277_V0.6250.13
195_S212_A0.6240.13
288_I292_K0.6220.13
58_T109_P0.6200.13
199_A300_E0.6200.13
155_P237_G0.6190.13
190_R244_F0.6180.13
232_N235_Y0.6180.13
141_P239_R0.6180.13
85_E100_E0.6170.13
23_M38_P0.6150.13
70_G85_E0.6150.13
32_G296_A0.6140.13
247_P290_A0.6140.13
186_T318_I0.6130.13
123_R296_A0.6120.13
56_L219_H0.6110.13
36_F80_I0.6100.13
290_A315_M0.6100.13
160_D251_E0.6080.13
83_D310_P0.6070.13
142_A199_A0.6070.13
56_L253_L0.6040.13
225_K233_P0.6040.13
201_D273_G0.6040.13
31_V104_A0.6020.13
169_I187_N0.6020.13
33_W119_V0.6000.13
292_K321_I0.6000.13
140_A313_K0.5990.13
207_L210_Q0.5970.13
149_A152_P0.5970.13
234_K288_I0.5970.13
99_V107_D0.5960.13
42_A179_A0.5940.13
16_Q24_L0.5920.13
244_F269_A0.5920.13
105_R125_G0.5910.13
104_A227_I0.5900.13
78_S82_V0.5890.13
75_N257_G0.5880.13
69_W193_V0.5870.13
233_P259_K0.5860.13
181_R276_Q0.5850.13
197_E250_V0.5840.13
49_Y81_V0.5830.13
22_E206_T0.5810.13
140_A145_A0.5800.12
20_T35_D0.5800.12
171_D219_H0.5770.12
214_P220_V0.5760.12
155_P238_E0.5760.12
155_P234_K0.5750.12
181_R187_N0.5730.12
197_E206_T0.5720.12
90_I118_A0.5720.12
189_S262_S0.5710.12
148_A159_N0.5700.12
18_L263_V0.5700.12
86_H127_K0.5700.12
91_A316_D0.5690.12
160_D236_A0.5690.12
39_G49_Y0.5690.12
72_S98_L0.5670.12
137_A151_T0.5660.12
256_G278_N0.5660.12
181_R220_V0.5650.12
159_N234_K0.5640.12
162_M276_Q0.5630.12
11_G26_G0.5630.12
42_A188_V0.5620.12
192_I210_Q0.5580.12
8_G13_A0.5580.12
88_E100_E0.5580.12
117_L120_E0.5570.12
59_T86_H0.5570.12
181_R270_F0.5550.12
230_Y283_V0.5540.12
113_E202_T0.5520.12
15_E169_I0.5520.12
95_I222_D0.5470.12
194_V226_M0.5460.12
164_I223_V0.5430.12
265_V311_K0.5420.12
45_L318_I0.5410.12
101_T123_R0.5400.12
276_Q284_D0.5390.12
85_E141_P0.5390.12
265_V281_V0.5380.12
220_V270_F0.5380.12
30_N80_I0.5360.12
209_T292_K0.5350.12
24_L93_V0.5330.12
122_G137_A0.5330.12
242_L250_V0.5330.12
42_A203_V0.5330.12
108_D113_E0.5320.12
3_I254_V0.5320.12
79_R112_D0.5310.12
102_L117_L0.5290.12
39_G214_P0.5290.12
18_L45_L0.5290.12
18_L32_G0.5290.12
153_A234_K0.5260.11
239_R259_K0.5260.11
22_E61_G0.5230.11
121_T124_E0.5220.11
153_A157_G0.5210.11
103_M109_P0.5190.11
6_V62_V0.5190.11
263_V279_N0.5180.11
154_K234_K0.5160.11
51_A140_A0.5150.11
166_L216_V0.5150.11
43_E54_A0.5140.11
47_E231_N0.5140.11
218_A278_N0.5120.11
85_E110_S0.5100.11
6_V35_D0.5100.11
84_K112_D0.5100.11
192_I244_F0.5090.11
13_A17_L0.5090.11
91_A214_P0.5070.11
104_A121_T0.5070.11
160_D321_I0.5060.11
80_I112_D0.5050.11
115_V222_D0.5050.11
188_V203_V0.5040.11
207_L270_F0.5040.11
171_D245_T0.5040.11
285_E297_R0.5030.11
113_E120_E0.5030.11
154_K162_M0.5030.11
232_N245_T0.5030.11
174_I232_N0.5020.11
260_I297_R0.5020.11
88_E130_K0.5020.11
76_A118_A0.5010.11
50_N56_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vsqC 1 0.5108 100 0.578 Contact Map
3lfjA 1 0.5077 100 0.584 Contact Map
1nrzA 2 0.5015 100 0.588 Contact Map
1bleA 3 0.4985 100 0.589 Contact Map
3p3vA 1 0.5015 100 0.61 Contact Map
3eyeA 1 0.4706 100 0.615 Contact Map
1pdoA 2 0.3994 100 0.748 Contact Map
3bedA 4 0.4025 100 0.755 Contact Map
3lfhA 2 0.4396 100 0.755 Contact Map
3iprA 2 0.418 100 0.755 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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