GREMLIN Database
PTQB - N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB component
UniProt: P69795 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10140
Length: 106 (98)
Sequences: 1209 (879)
Seq/√Len: 88.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_Y94_K3.4911.00
64_L68_Q3.4441.00
5_H35_I2.4051.00
80_D95_A2.2971.00
21_S24_R2.0671.00
83_L88_D1.9971.00
90_L94_K1.9801.00
53_V99_A1.9621.00
44_A67_I1.9181.00
45_G70_L1.9031.00
19_L92_V1.8801.00
77_E99_A1.8581.00
80_D83_L1.8351.00
20_V36_I1.7461.00
21_S25_A1.7081.00
32_V97_V1.6261.00
83_L91_G1.6111.00
7_Y39_F1.6061.00
7_Y51_A1.5971.00
68_Q72_P1.5801.00
23_M36_I1.5171.00
25_A29_K1.5131.00
30_Y90_L1.4801.00
26_Q30_Y1.4620.99
3_K33_P1.4410.99
95_A98_A1.3890.99
25_A28_E1.3660.99
65_P68_Q1.3420.99
26_Q29_K1.3230.99
55_L77_E1.3130.99
94_K98_A1.3110.99
63_M66_E1.2960.99
14_M17_S1.2610.98
34_V97_V1.2570.98
4_K100_I1.2390.98
18_L21_S1.2190.98
88_D91_G1.2150.98
26_Q89_G1.1960.98
9_F44_A1.1950.98
27_A36_I1.1660.97
83_L95_A1.1600.97
26_Q90_L1.1520.97
48_G71_L1.1420.97
83_L92_V1.1390.97
24_R28_E1.1110.96
77_E95_A1.1030.96
41_E63_M1.0910.96
30_Y97_V1.0800.96
91_G94_K1.0730.96
69_R72_P1.0620.95
37_E51_A1.0530.95
66_E69_R1.0500.95
18_L87_V1.0490.95
6_I34_V1.0330.95
8_L16_T1.0220.94
93_L97_V1.0060.94
67_I76_V1.0030.94
49_Q74_K0.9960.94
96_A99_A0.9840.93
7_Y37_E0.9770.93
6_I96_A0.9710.93
64_L77_E0.9400.91
23_M96_A0.9360.91
9_F39_F0.9340.91
64_L76_V0.9330.91
19_L79_I0.9280.91
32_V93_L0.9260.91
24_R35_I0.9260.91
64_L78_V0.9210.91
12_A40_P0.9210.91
29_K90_L0.9120.90
67_I71_L0.9110.90
56_L60_I0.9110.90
54_V71_L0.8950.89
44_A51_A0.8910.89
27_A34_V0.8890.89
47_K50_N0.8840.89
26_Q93_L0.8750.88
53_V96_A0.8480.87
9_F54_V0.8130.84
39_F51_A0.8110.84
54_V67_I0.8080.84
56_L64_L0.8060.84
48_G72_P0.7730.81
22_K25_A0.7520.79
27_A93_L0.7440.79
43_L46_E0.7370.78
37_E47_K0.7280.77
5_H37_E0.7200.76
89_G92_V0.7200.76
5_H50_N0.7040.75
87_V92_V0.6910.73
53_V100_I0.6860.73
16_T57_G0.6770.72
15_S84_Y0.6770.72
14_M18_L0.6640.70
18_L22_K0.6640.70
95_A99_A0.6590.70
86_K91_G0.6520.69
72_P75_P0.6400.67
7_Y71_L0.6360.67
56_L78_V0.6320.67
44_A54_V0.6310.66
5_H51_A0.6260.66
41_E67_I0.6230.65
11_S40_P0.6210.65
55_L95_A0.6170.65
42_T63_M0.6170.65
57_G76_V0.6140.64
71_L74_K0.6130.64
21_S28_E0.5980.62
15_S85_G0.5910.61
79_I92_V0.5880.61
70_L73_N0.5870.61
82_L88_D0.5860.61
10_C13_G0.5790.60
39_F43_L0.5710.59
11_S41_E0.5700.59
7_Y54_V0.5690.58
27_A32_V0.5640.58
20_V23_M0.5640.58
9_F60_I0.5630.58
39_F47_K0.5620.58
60_I63_M0.5540.56
43_L61_A0.5540.56
9_F43_L0.5520.56
23_M93_L0.5450.55
41_E54_V0.5410.55
4_K34_V0.5390.54
53_V95_A0.5370.54
56_L93_L0.5250.53
65_P69_R0.5240.52
28_E33_P0.5240.52
10_C38_A0.5170.51
46_E50_N0.5160.51
20_V84_Y0.5130.51
11_S59_Q0.5120.51
61_A64_L0.5120.51
23_M92_V0.5120.51
69_R73_N0.5100.50
41_E60_I0.5080.50
15_S57_G0.5070.50
52_D100_I0.5030.50
82_L86_K0.5030.50
48_G70_L0.5000.49
11_S63_M0.5000.49
61_A65_P0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e2bA 1 1 100 0.318 Contact Map
3nbmA 1 0.9245 100 0.322 Contact Map
4mgeA 3 0.9717 99.9 0.358 Contact Map
2l2qA 1 1 99.9 0.402 Contact Map
2kyrA 1 0.934 99.9 0.407 Contact Map
4tn5A 2 0.934 99.9 0.421 Contact Map
2m1zA 1 0.9151 99.9 0.425 Contact Map
2r4qA 1 0.9057 99.9 0.447 Contact Map
1tvmA 1 0.8774 99.7 0.56 Contact Map
3czcA 1 0.8585 99.4 0.628 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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