GREMLIN Database
PTQA - N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component
UniProt: P69791 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10142
Length: 116 (100)
Sequences: 1395 (1027)
Seq/√Len: 102.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_K112_E4.4961.00
41_Q46_D3.1791.00
46_D49_A3.0571.00
43_K109_E2.9781.00
43_K106_E2.9521.00
35_A57_S2.7151.00
74_G79_G2.6111.00
41_Q53_M2.2811.00
34_L56_Q2.2161.00
27_N60_A2.1991.00
39_L104_I2.1551.00
107_L110_L1.9541.00
58_R101_R1.8731.00
30_Q60_A1.8191.00
41_Q49_A1.8071.00
40_K106_E1.5681.00
110_L114_L1.5441.00
49_A53_M1.5371.00
26_I30_Q1.5081.00
49_A52_A1.5001.00
83_V88_V1.4981.00
54_M108_I1.4971.00
22_M26_I1.4911.00
68_Q91_Q1.4911.00
58_R105_T1.4721.00
34_L53_M1.3550.99
37_A53_M1.3500.99
55_D59_M1.3250.99
52_A56_Q1.3080.99
53_M56_Q1.3060.99
107_L111_H1.3050.99
75_D78_E1.2910.99
70_K74_G1.2230.99
52_A55_D1.1990.99
63_E66_L1.1970.99
55_D58_R1.1590.98
51_K55_D1.1410.98
69_T91_Q1.1290.98
39_L107_L1.1290.98
71_L87_L1.1220.98
45_G113_K1.1120.98
47_F112_E1.1030.98
101_R105_T1.0970.98
42_A108_I1.0910.97
41_Q44_Q1.0750.97
21_V87_L1.0680.97
59_M63_E1.0680.97
28_S64_A1.0340.97
73_E77_G1.0190.96
36_Y102_E1.0100.96
62_N66_L0.9950.96
87_L90_A0.9730.95
33_S37_A0.9720.95
68_Q98_M0.9570.95
36_Y100_A0.9500.94
74_G81_M0.9290.94
56_Q59_M0.9260.94
16_E19_E0.9120.93
25_I90_A0.9090.93
93_H98_M0.8910.92
32_R102_E0.8910.92
96_T100_A0.8820.92
35_A97_S0.8590.91
21_V85_L0.8590.91
60_A63_E0.8260.89
42_A47_F0.8250.89
95_M99_L0.8110.88
35_A54_M0.8070.88
74_G77_G0.8020.88
39_L103_L0.7980.87
42_A111_H0.7900.87
93_H102_E0.7850.87
35_A101_R0.7830.86
21_V86_V0.7790.86
91_Q96_T0.7510.84
91_Q98_M0.7450.84
23_G27_N0.7390.83
18_E86_V0.7390.83
67_V70_K0.7330.83
68_Q93_H0.7260.82
28_S97_S0.7180.81
43_K111_H0.7160.81
36_Y104_I0.7050.80
33_S36_Y0.7050.80
100_A104_I0.7050.80
19_E23_G0.7050.80
17_L87_L0.7010.80
43_K113_K0.6960.79
68_Q96_T0.6910.79
88_V91_Q0.6900.79
57_S101_R0.6880.78
48_A52_A0.6810.78
88_V93_H0.6790.77
30_Q34_L0.6770.77
35_A104_I0.6750.77
72_I85_L0.6730.77
75_D84_S0.6730.77
72_I76_A0.6720.77
71_L85_L0.6690.76
34_L60_A0.6640.76
27_N63_E0.6620.76
36_Y99_L0.6490.74
46_D52_A0.6430.74
21_V26_I0.6410.73
28_S93_H0.6390.73
32_R99_L0.6340.73
99_L102_E0.6270.72
59_M62_N0.6240.71
27_N30_Q0.6150.70
100_A103_L0.6120.70
52_A59_M0.6120.70
51_K105_T0.6080.69
54_M105_T0.5980.68
75_D86_V0.5970.68
72_I88_V0.5940.68
44_Q48_A0.5890.67
48_A55_D0.5830.66
28_S99_L0.5740.65
96_T99_L0.5720.65
39_L43_K0.5700.64
63_E67_V0.5700.64
50_A104_I0.5700.64
56_Q60_A0.5690.64
24_L28_S0.5690.64
45_G111_H0.5680.64
98_M101_R0.5670.64
32_R96_T0.5600.63
38_A42_A0.5600.63
84_S87_L0.5560.63
61_L98_M0.5480.61
99_L104_I0.5460.61
57_S102_E0.5450.61
43_K110_L0.5380.60
20_V70_K0.5330.59
66_L105_T0.5320.59
72_I90_A0.5310.59
73_E76_A0.5300.59
108_I111_H0.5240.58
42_A50_A0.5220.58
36_Y39_L0.5190.57
97_S100_A0.5150.57
35_A50_A0.5120.56
30_Q93_H0.5090.56
21_V90_A0.5060.55
55_D109_E0.5060.55
15_E18_E0.5040.55
47_F50_A0.5020.55
40_K43_K0.5010.55
39_L47_F0.5010.55
57_S61_L0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l8rA 3 0.8793 100 0.101 Contact Map
2e2aA 3 0.8966 100 0.106 Contact Map
1wcrA 3 0.8879 100 0.109 Contact Map
3k1sA 6 0.9138 100 0.119 Contact Map
2zanA 1 0 9.4 0.934 Contact Map
3bu8A 4 0.7759 6.3 0.939 Contact Map
4udxX 2 0.931 5.7 0.94 Contact Map
4pjrA 1 0.319 5.2 0.941 Contact Map
4i2zA 1 0.6121 5 0.942 Contact Map
3ro2A 1 0.4828 4 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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