GREMLIN Database
PTXB - Phosphotransferase enzyme IIB component GlvB
UniProt: P69789 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11709
Length: 161 (130)
Sequences: 2160 (1644)
Seq/√Len: 144.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_R32_L4.3561.00
109_D122_R4.2101.00
87_S101_H3.2071.00
37_C43_D2.8511.00
13_I17_L2.4111.00
102_D105_Q2.1711.00
17_L21_L2.1241.00
30_L34_F2.0571.00
91_N135_V2.0471.00
89_I146_I2.0461.00
70_L141_Q2.0341.00
77_L142_L2.0221.00
79_A111_V1.9371.00
76_I131_I1.9241.00
80_L129_V1.9231.00
108_D111_V1.9131.00
139_R143_D1.9121.00
6_A9_M1.8461.00
72_Q134_H1.7841.00
22_L26_V1.7601.00
111_V114_K1.6991.00
24_F28_R1.6791.00
29_T33_Q1.6441.00
26_V30_L1.6391.00
77_L145_L1.6301.00
14_A18_C1.6141.00
11_T14_A1.6091.00
89_I142_L1.5951.00
109_D113_K1.5931.00
21_L25_V1.5841.00
10_L14_A1.5751.00
131_I135_V1.5021.00
87_S125_D1.4901.00
88_S99_A1.4311.00
38_T41_R1.3581.00
17_L20_T1.3431.00
103_M127_I1.3281.00
48_L51_K1.3041.00
100_L103_M1.2901.00
77_L146_I1.2681.00
121_F130_I1.2611.00
87_S99_A1.2591.00
80_L142_L1.2401.00
75_G111_V1.2341.00
98_I142_L1.2291.00
15_I19_F1.2161.00
31_I38_T1.2141.00
79_A115_L1.2131.00
75_G115_L1.2051.00
37_C42_E1.2041.00
80_L98_I1.1741.00
136_S140_E1.1721.00
47_K51_K1.1360.99
103_M125_D1.1310.99
25_V29_T1.1020.99
35_N41_R1.0960.99
86_I146_I1.0770.99
30_L36_M1.0770.99
68_K71_D1.0540.99
78_Q111_V1.0530.99
29_T34_F1.0390.99
9_M12_Q1.0370.99
117_A120_V1.0350.99
24_F32_L1.0230.99
16_G23_Y0.9950.99
99_A126_A0.9630.98
10_L126_A0.9600.98
115_L131_I0.9570.98
93_A133_L0.9370.98
90_N139_R0.9370.98
31_I41_R0.9140.97
76_I112_F0.9110.97
73_A141_Q0.9090.97
112_F129_V0.9080.97
10_L15_I0.9000.97
84_G105_Q0.8970.97
103_M122_R0.8940.97
75_G78_Q0.8810.97
29_T36_M0.8770.97
83_V146_I0.8700.97
93_A135_V0.8680.97
77_L89_I0.8660.96
91_N139_R0.8580.96
137_Q140_E0.8550.96
72_Q138_L0.8470.96
73_A145_L0.8440.96
8_M11_T0.8390.96
67_K141_Q0.8330.96
136_S143_D0.8240.95
46_V66_P0.8230.95
14_A17_L0.8210.95
103_M123_S0.8200.95
115_L135_V0.8150.95
96_L139_R0.8140.95
107_L127_I0.8050.95
110_E114_K0.8050.95
12_Q15_I0.7980.94
89_I143_D0.7950.94
142_L145_L0.7910.94
76_I138_L0.7900.94
35_N38_T0.7880.94
11_T15_I0.7880.94
91_N138_L0.7810.94
77_L86_I0.7780.94
45_E48_L0.7770.94
123_S126_A0.7740.93
118_H131_I0.7630.93
100_L107_L0.7610.93
47_K50_S0.7590.93
71_D74_A0.7540.93
91_N115_L0.7510.92
131_I138_L0.7500.92
12_Q19_F0.7470.92
35_N42_E0.7460.92
84_G101_H0.7390.92
131_I139_R0.7380.92
46_V49_Y0.7370.92
74_A145_L0.7350.92
80_L127_I0.7350.92
31_I40_G0.7320.91
98_I129_V0.7320.91
74_A78_Q0.7310.91
107_L112_F0.7080.90
22_L25_V0.7070.90
46_V51_K0.7010.90
76_I115_L0.7000.90
91_N133_L0.6970.89
75_G114_K0.6940.89
7_D15_I0.6930.89
94_T130_I0.6920.89
25_V28_R0.6880.89
19_F22_L0.6770.88
76_I140_E0.6770.88
129_V135_V0.6720.88
91_N137_Q0.6630.87
69_E137_Q0.6530.86
109_D120_V0.6480.86
29_T35_N0.6460.85
133_L140_E0.6450.85
18_C22_L0.6420.85
91_N136_S0.6280.84
135_V138_L0.6260.84
103_M124_G0.6240.83
93_A118_H0.6220.83
93_A134_H0.6210.83
112_F120_V0.6140.82
10_L13_I0.6090.82
118_H134_H0.6030.81
16_G73_A0.5960.81
9_M14_A0.5930.80
108_D112_F0.5870.80
9_M23_Y0.5840.79
6_A10_L0.5800.79
79_A112_F0.5800.79
65_E83_V0.5780.79
69_E134_H0.5760.78
135_V142_L0.5760.78
133_L136_S0.5750.78
98_I139_R0.5750.78
86_I89_I0.5720.78
73_A138_L0.5710.78
133_L137_Q0.5670.77
29_T32_L0.5650.77
95_R128_Q0.5640.77
112_F117_A0.5600.76
64_A84_G0.5580.76
19_F26_V0.5540.76
91_N131_I0.5540.76
99_A125_D0.5520.75
69_E141_Q0.5490.75
101_H105_Q0.5490.75
48_L114_K0.5490.75
84_G102_D0.5480.75
63_A71_D0.5470.75
18_C48_L0.5450.74
50_S66_P0.5440.74
73_A142_L0.5420.74
141_Q144_S0.5380.73
72_Q115_L0.5370.73
66_P70_L0.5360.73
24_F33_Q0.5360.73
89_I98_I0.5320.73
74_A104_S0.5320.73
89_I139_R0.5320.73
98_I123_S0.5280.72
7_D12_Q0.5260.72
137_Q141_Q0.5250.72
63_A66_P0.5230.71
86_I100_L0.5230.71
19_F136_S0.5210.71
67_K70_L0.5210.71
45_E51_K0.5200.71
142_L146_I0.5100.70
99_A103_M0.5090.69
13_I18_C0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ibaA 1 0.4845 99.9 0.561 Contact Map
3bp3A 1 0.5031 99.9 0.561 Contact Map
3ipjA 1 0.5776 99.9 0.592 Contact Map
3qnqA 2 0.3106 92.4 0.9 Contact Map
2kncA 1 0.3043 18.2 0.947 Contact Map
5a2fA 1 0 16.2 0.948 Contact Map
1ldfA 3 0.2174 11.7 0.951 Contact Map
3s8fC 1 0.1925 7.6 0.955 Contact Map
2dlaA 2 0.5652 6.3 0.957 Contact Map
4zw9A 1 0.2981 5 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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