GREMLIN Database
PTGCB - PTS system glucose-specific EIICB component
UniProt: P69786 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10787
Length: 477 (434)
Sequences: 2904 (1653)
Seq/√Len: 79.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_H373_R5.2761.00
263_A365_A4.8581.00
270_H369_Y4.6221.00
373_R377_K4.5861.00
65_I83_V3.8181.00
416_T430_A3.7931.00
27_G336_S3.6021.00
53_G57_A3.5721.00
382_K388_D3.5201.00
265_A300_I3.3561.00
276_N279_K3.3551.00
271_S377_K3.3401.00
276_N389_A3.2911.00
358_P362_I3.2351.00
85_A157_S3.2081.00
362_I366_I3.1901.00
313_I317_I3.0411.00
318_L371_I3.0061.00
431_D434_K2.8801.00
268_I284_M2.7371.00
273_K388_D2.7121.00
436_D439_G2.6421.00
271_S373_R2.5621.00
314_I318_L2.5551.00
138_I152_F2.5511.00
375_L379_L2.5151.00
200_F320_G2.4681.00
330_G353_K2.4321.00
439_G442_K2.4271.00
329_L360_V2.4141.00
259_Y361_G2.2701.00
408_A439_G2.2491.00
324_P328_L2.2411.00
202_E253_G2.2261.00
310_I379_L2.2021.00
258_M292_F2.1921.00
128_A157_S2.1921.00
199_G323_F2.1431.00
269_W281_G2.1261.00
126_A130_Y2.1081.00
367_V371_I2.0951.00
237_I240_Y2.0531.00
420_A443_L2.0511.00
417_N428_S2.0321.00
138_I148_A2.0181.00
429_V432_V2.0171.00
15_S71_F1.9881.00
200_F313_I1.9421.00
315_H368_Y1.9361.00
127_I164_T1.9191.00
326_C360_V1.9171.00
314_I371_I1.9141.00
325_I364_Y1.8911.00
406_V418_L1.8801.00
156_I160_A1.8801.00
34_S49_A1.8741.00
344_F348_S1.8631.00
201_I214_W1.8301.00
341_L345_I1.8011.00
25_I158_G1.7991.00
429_V435_V1.7921.00
359_I363_G1.7891.00
239_R244_D1.7851.00
14_K419_D1.7781.00
369_Y373_R1.7751.00
200_F204_C1.7691.00
366_I370_T1.7671.00
374_V378_A1.7351.00
416_T428_S1.7351.00
124_S161_A1.7341.00
270_H377_K1.7151.00
263_A366_I1.7091.00
437_Q441_K1.7031.00
166_V170_F1.7001.00
192_V328_L1.6801.00
159_L163_F1.6761.00
371_I375_L1.6741.00
261_L264_A1.6631.00
200_F316_A1.6611.00
326_C331_M1.6581.00
227_N231_Q1.6531.00
281_G285_I1.6531.00
17_M212_H1.6401.00
314_I375_L1.6261.00
408_A443_L1.5791.00
239_R245_P1.5671.00
256_F319_A1.5610.99
318_L368_Y1.5300.99
407_A439_G1.5280.99
9_L12_V1.5030.99
266_I270_H1.5000.99
409_F427_V1.4990.99
362_I365_A1.4980.99
204_C316_A1.4830.99
231_Q234_H1.4640.99
125_G165_G1.4540.99
10_Q70_G1.4360.99
404_A439_G1.4340.99
372_F376_I1.4310.99
322_A364_Y1.4260.99
59_M118_V1.4260.99
356_L359_I1.4200.99
278_A281_G1.4100.99
33_G52_G1.4070.99
305_M312_Y1.4060.99
321_L364_Y1.4030.99
145_G296_I1.4010.99
124_S164_T1.3990.99
192_V324_P1.3990.99
255_L322_A1.3950.99
236_D239_R1.3830.99
413_E434_K1.3730.99
274_P277_R1.3660.99
85_A124_S1.3490.99
127_I130_Y1.3450.98
131_M156_I1.3380.98
283_I287_A1.3340.98
193_V197_I1.3200.98
369_Y377_K1.3200.98
233_F242_A1.3150.98
265_A284_M1.3080.98
267_A370_T1.3060.98
397_G400_E1.3050.98
221_Q234_H1.3040.98
74_N132_F1.2960.98
272_A280_V1.2860.98
226_T232_V1.2810.98
185_W189_Q1.2760.98
61_L83_V1.2750.98
127_I160_A1.2640.98
325_I328_L1.2610.98
374_V379_L1.2570.98
269_W285_I1.2570.98
141_P144_L1.2560.98
355_W359_I1.2530.98
269_W277_R1.2500.98
196_G324_P1.2470.98
237_I241_M1.2300.97
139_K142_E1.2170.97
257_K291_S1.2130.97
370_T374_V1.2130.97
30_L53_G1.2110.97
199_G319_A1.2090.97
239_R243_G1.2060.97
238_P242_A1.2060.97
83_V87_G1.2030.97
226_T230_G1.1990.97
131_M160_A1.1970.97
325_I329_L1.1950.97
71_F126_A1.1930.97
246_T249_K1.1850.97
383_T386_R1.1800.97
418_L427_V1.1770.96
195_F327_I1.1760.96
226_T229_A1.1750.96
370_T373_R1.1620.96
382_K387_E1.1600.96
268_I271_S1.1590.96
135_F156_I1.1590.96
269_W284_M1.1550.96
178_A181_T1.1540.96
438_A442_K1.1480.96
268_I280_V1.1440.96
376_I386_R1.1290.96
200_F317_I1.1230.95
69_L79_A1.1150.95
235_G239_R1.1080.95
280_V284_M1.1070.95
344_F355_W1.1030.95
177_S181_T1.1030.95
301_E315_H1.1020.95
18_L69_L1.0940.95
351_S354_L1.0930.95
152_F156_I1.0850.94
310_I313_I1.0840.94
429_V437_Q1.0810.94
196_G320_G1.0790.94
261_L300_I1.0770.94
369_Y372_F1.0730.94
131_M152_F1.0700.94
408_A420_A1.0660.94
401_M443_L1.0620.94
413_E430_A1.0610.94
301_E312_Y1.0600.94
348_S354_L1.0590.94
85_A161_A1.0520.93
163_F167_V1.0480.93
27_G290_T1.0450.93
264_A268_I1.0440.93
366_I369_Y1.0420.93
261_L305_M1.0390.93
58_N87_G1.0340.93
376_I383_T1.0290.93
30_L56_F1.0270.93
225_Y239_R1.0240.93
408_A440_L1.0120.92
375_L381_L1.0100.92
430_A434_K1.0040.92
285_I288_A1.0010.92
198_Y251_S0.9990.92
118_V121_G0.9970.91
64_A77_V0.9950.91
40_L44_V0.9940.91
29_L52_G0.9940.91
229_A232_V0.9940.91
221_Q225_Y0.9930.91
276_N390_T0.9910.91
239_R247_A0.9900.91
196_G200_F0.9850.91
138_I156_I0.9840.91
174_P178_A0.9840.91
230_G233_F0.9740.91
270_H277_R0.9710.90
358_P363_G0.9670.90
240_Y243_G0.9660.90
131_M135_F0.9650.90
237_I243_G0.9630.90
332_R352_S0.9630.90
272_A383_T0.9630.90
92_T165_G0.9590.90
221_Q248_G0.9580.90
403_P407_A0.9580.90
374_V381_L0.9570.90
31_G35_A0.9530.90
182_F185_W0.9490.89
400_E403_P0.9480.89
344_F359_I0.9460.89
68_A82_A0.9450.89
65_I75_D0.9410.89
255_L326_C0.9400.89
314_I376_I0.9360.89
242_A245_P0.9300.88
236_D240_Y0.9300.88
256_F260_G0.9280.88
348_S355_W0.9270.88
50_E53_G0.9260.88
236_D241_M0.9260.88
5_A8_N0.9200.88
172_W176_G0.9190.88
387_E390_T0.9160.88
270_H370_T0.9150.88
219_Q338_S0.9140.87
184_Q188_Y0.9120.87
404_A443_L0.9110.87
124_S128_A0.9100.87
136_Y156_I0.9010.87
353_K356_L0.9000.87
333_D357_F0.8980.87
405_L443_L0.8970.86
140_L152_F0.8960.86
8_N12_V0.8960.86
405_L440_L0.8960.86
16_L150_K0.8930.86
325_I360_V0.8920.86
270_H274_P0.8910.86
26_A59_M0.8900.86
175_I178_A0.8890.86
275_E389_A0.8810.85
220_M237_I0.8800.85
296_I422_I0.8770.85
276_N387_E0.8670.85
61_L82_A0.8640.84
359_I362_I0.8620.84
115_D118_V0.8600.84
398_T401_M0.8580.84
227_N230_G0.8550.84
368_Y372_F0.8550.84
229_A233_F0.8540.84
236_D243_G0.8520.84
158_G161_A0.8520.84
416_T429_V0.8510.83
151_R154_P0.8480.83
28_I32_V0.8470.83
195_F249_K0.8460.83
421_C426_R0.8420.83
233_F237_I0.8400.83
428_S432_V0.8360.82
203_R301_E0.8340.82
406_V415_I0.8320.82
229_A234_H0.8320.82
130_Y134_R0.8320.82
404_A442_K0.8300.82
202_E319_A0.8290.82
190_N194_A0.8270.82
259_Y362_I0.8240.81
233_F239_R0.8240.81
421_C424_R0.8220.81
231_Q238_P0.8180.81
404_A412_K0.8160.81
396_T399_S0.8160.81
115_D121_G0.8150.81
433_S442_K0.8150.81
260_G315_H0.8150.81
114_A120_G0.8130.81
178_A182_F0.8090.80
404_A407_A0.8070.80
55_V62_I0.8070.80
401_M404_A0.8060.80
422_I443_L0.7980.79
273_K387_E0.7950.79
127_I131_M0.7950.79
106_E110_S0.7930.79
321_L368_Y0.7920.79
253_G335_T0.7890.79
257_K339_H0.7890.79
56_F237_I0.7880.78
135_F152_F0.7880.78
147_F267_A0.7850.78
376_I385_G0.7850.78
181_T185_W0.7840.78
331_M357_F0.7830.78
415_I418_L0.7790.78
119_L123_I0.7780.78
171_I174_P0.7770.78
233_F241_M0.7750.77
141_P147_F0.7750.77
380_D383_T0.7730.77
204_C313_I0.7720.77
260_G318_L0.7720.77
65_I78_S0.7710.77
310_I314_I0.7690.77
36_N39_W0.7690.77
266_I365_A0.7670.77
376_I384_P0.7660.76
202_E335_T0.7660.76
272_A277_R0.7630.76
291_S297_T0.7600.76
50_E95_V0.7600.76
127_I161_A0.7580.76
367_V370_T0.7580.76
217_P222_I0.7560.76
263_A267_A0.7550.75
196_G321_L0.7550.75
238_P241_M0.7550.75
224_E234_H0.7540.75
156_I159_L0.7540.75
255_L343_D0.7520.75
294_T340_G0.7510.75
399_S403_P0.7470.75
73_N133_N0.7450.74
86_Y90_V0.7430.74
221_Q224_E0.7420.74
273_K375_L0.7410.74
266_I271_S0.7360.74
72_T77_V0.7360.74
161_A165_G0.7330.73
407_A416_T0.7330.73
253_G319_A0.7310.73
37_F42_A0.7310.73
254_F257_K0.7300.73
247_A250_L0.7290.73
195_F324_P0.7280.73
21_S24_P0.7270.73
38_S41_P0.7260.73
333_D347_L0.7260.73
415_I429_V0.7250.72
321_L353_K0.7250.72
51_A162_I0.7240.72
7_A401_M0.7230.72
374_V377_K0.7230.72
112_H115_D0.7220.72
64_A121_G0.7190.72
261_L315_H0.7180.72
8_N130_Y0.7180.72
134_R153_V0.7150.71
25_I159_L0.7140.71
68_A78_S0.7130.71
77_V81_A0.7120.71
50_E57_A0.7110.71
199_G320_G0.7110.71
407_A434_K0.7100.71
30_L342_I0.7080.71
310_I375_L0.7070.71
180_Q184_Q0.7070.71
256_F364_Y0.7070.71
249_K327_I0.7050.70
329_L357_F0.7030.70
31_G34_S0.7020.70
123_I168_L0.7020.70
80_L122_I0.7000.70
116_T120_G0.6990.70
167_V171_I0.6990.70
48_M162_I0.6980.70
115_D120_G0.6970.69
10_Q13_G0.6960.69
235_G244_D0.6960.69
179_I205_L0.6930.69
387_E391_E0.6910.69
403_P433_S0.6900.69
192_V327_I0.6890.69
10_Q14_K0.6890.69
227_N232_V0.6870.68
360_V364_Y0.6860.68
234_H237_I0.6860.68
119_L217_P0.6850.68
164_T168_L0.6850.68
265_A269_W0.6840.68
236_D247_A0.6820.68
420_A427_V0.6790.67
185_W188_Y0.6790.67
258_M315_H0.6770.67
7_A428_S0.6760.67
292_F341_L0.6760.67
397_G401_M0.6750.67
264_A315_H0.6750.67
197_I393_A0.6740.67
68_A73_N0.6740.67
398_T420_A0.6700.66
287_A291_S0.6700.66
254_F347_L0.6670.66
37_F41_P0.6660.66
46_H49_A0.6650.66
8_N11_K0.6650.66
392_D397_G0.6640.66
333_D348_S0.6640.66
243_G247_A0.6640.66
260_G368_Y0.6640.66
135_F138_I0.6630.66
219_Q254_F0.6630.66
401_M405_L0.6630.66
242_A247_A0.6610.65
202_E323_F0.6610.65
331_M356_L0.6600.65
79_A82_A0.6590.65
340_G343_D0.6580.65
318_L321_L0.6580.65
56_F241_M0.6570.65
156_I164_T0.6570.65
144_L337_F0.6560.65
405_L408_A0.6550.65
350_N354_L0.6530.64
331_M359_I0.6530.64
117_G221_Q0.6520.64
398_T406_V0.6500.64
314_I372_F0.6490.64
263_A369_Y0.6490.64
39_W42_A0.6480.64
239_R354_L0.6470.64
391_E442_K0.6460.64
265_A288_A0.6450.64
274_P369_Y0.6440.63
143_Y289_L0.6440.63
110_S113_L0.6440.63
27_G297_T0.6430.63
203_R258_M0.6420.63
33_G45_S0.6400.63
439_G443_L0.6400.63
272_A385_G0.6380.63
239_R246_T0.6360.62
335_T339_H0.6360.62
189_Q197_I0.6340.62
142_E145_G0.6320.62
253_G323_F0.6320.62
380_D386_R0.6310.62
260_G264_A0.6310.62
396_T400_E0.6310.62
167_V170_F0.6300.62
288_A291_S0.6300.62
261_L287_A0.6300.62
318_L322_A0.6290.62
61_L78_S0.6290.62
254_F338_S0.6280.61
229_A243_G0.6270.61
26_A29_L0.6260.61
216_V237_I0.6260.61
233_F240_Y0.6230.61
173_P212_H0.6230.61
219_Q337_F0.6220.61
416_T434_K0.6220.61
74_N133_N0.6210.61
237_I244_D0.6200.60
19_P66_G0.6200.60
417_N432_V0.6190.60
74_N137_R0.6180.60
236_D246_T0.6180.60
68_A129_A0.6170.60
223_G235_G0.6160.60
232_V236_D0.6150.60
408_A436_D0.6130.60
195_F200_F0.6130.60
287_A303_S0.6070.59
89_M120_G0.6050.59
236_D245_P0.6040.58
102_H105_A0.6020.58
408_A427_V0.6020.58
216_V221_Q0.6010.58
114_A118_V0.6010.58
84_V222_I0.6010.58
90_V93_M0.6000.58
225_Y247_A0.5980.58
89_M168_L0.5960.57
323_F327_I0.5960.57
144_L152_F0.5960.57
51_A92_T0.5950.57
91_K94_A0.5940.57
361_G368_Y0.5940.57
413_E417_N0.5940.57
207_P301_E0.5920.57
417_N427_V0.5890.57
115_D119_L0.5890.57
13_G16_L0.5890.57
65_I79_A0.5890.57
325_I357_F0.5880.56
129_A133_N0.5880.56
395_A399_S0.5880.56
267_A374_V0.5880.56
159_L433_S0.5880.56
430_A439_G0.5870.56
321_L325_I0.5870.56
407_A412_K0.5870.56
72_T75_D0.5870.56
186_A217_P0.5860.56
420_A428_S0.5860.56
272_A386_R0.5860.56
119_L170_F0.5820.56
176_G210_L0.5810.56
339_H343_D0.5810.56
226_T243_G0.5810.56
308_A378_A0.5810.56
120_G172_W0.5810.56
400_E404_A0.5780.55
205_L214_W0.5780.55
46_H50_E0.5760.55
21_S305_M0.5760.55
363_G442_K0.5750.55
308_A311_L0.5740.55
92_T113_L0.5730.55
219_Q339_H0.5730.55
416_T432_V0.5720.54
418_L432_V0.5720.54
146_F338_S0.5710.54
96_V169_S0.5690.54
403_P412_K0.5690.54
157_S161_A0.5690.54
66_G80_L0.5690.54
334_G343_D0.5680.54
105_A112_H0.5680.54
237_I242_A0.5680.54
108_I111_K0.5670.54
350_N353_K0.5670.54
259_Y262_P0.5670.54
258_M291_S0.5640.53
403_P416_T0.5640.53
203_R316_A0.5640.53
293_L342_I0.5640.53
246_T332_R0.5630.53
135_F139_K0.5630.53
428_S433_S0.5590.53
54_S82_A0.5580.53
258_M361_G0.5580.53
402_A405_L0.5560.52
64_A81_A0.5560.52
279_K378_A0.5550.52
390_T438_A0.5550.52
201_I320_G0.5540.52
406_V413_E0.5540.52
41_P45_S0.5540.52
432_V442_K0.5530.52
20_V406_V0.5520.52
233_F236_D0.5520.52
261_L291_S0.5520.52
293_L341_L0.5510.52
192_V196_G0.5510.52
124_S131_M0.5480.51
78_S289_L0.5470.51
200_F371_I0.5460.51
103_L106_E0.5460.51
344_F354_L0.5450.51
271_S277_R0.5450.51
319_A335_T0.5450.51
221_Q263_A0.5440.51
405_L409_F0.5420.51
418_L438_A0.5420.51
63_F122_I0.5410.50
284_M303_S0.5400.50
407_A442_K0.5400.50
403_P417_N0.5390.50
195_F333_D0.5390.50
183_S224_E0.5390.50
308_A381_L0.5380.50
301_E304_F0.5380.50
20_V34_S0.5370.50
412_K439_G0.5370.50
326_C361_G0.5360.50
208_F302_F0.5350.50
427_V432_V0.5340.50
399_S402_A0.5340.50
349_G355_W0.5330.49
436_D440_L0.5330.49
172_W309_P0.5320.49
80_L158_G0.5320.49
239_R242_A0.5310.49
415_I435_V0.5310.49
203_R343_D0.5300.49
408_A442_K0.5300.49
395_A398_T0.5300.49
393_A442_K0.5290.49
236_D248_G0.5270.49
214_W218_F0.5270.49
396_T438_A0.5260.49
258_M288_A0.5260.49
244_D351_S0.5260.49
92_T96_V0.5250.48
233_F238_P0.5240.48
67_V71_F0.5240.48
264_A382_K0.5230.48
188_Y391_E0.5230.48
208_F305_M0.5220.48
394_K398_T0.5220.48
87_G109_A0.5220.48
174_P177_S0.5210.48
430_A442_K0.5210.48
179_I201_I0.5210.48
288_A292_F0.5200.48
266_I269_W0.5190.48
90_V94_A0.5180.47
104_P107_E0.5180.47
208_F322_A0.5170.47
274_P278_A0.5170.47
403_P438_A0.5160.47
296_I339_H0.5160.47
117_G290_T0.5150.47
8_N119_L0.5120.47
273_K389_A0.5120.47
140_L144_L0.5100.46
117_G161_A0.5100.46
84_V187_A0.5080.46
64_A172_W0.5080.46
198_Y214_W0.5070.46
266_I288_A0.5070.46
412_K432_V0.5060.46
25_I284_M0.5060.46
236_D354_L0.5060.46
49_A53_G0.5060.46
399_S442_K0.5050.46
271_S381_L0.5050.46
172_W207_P0.5050.46
211_H298_E0.5040.46
433_S438_A0.5040.46
397_G404_A0.5040.46
224_E227_N0.5030.46
234_H428_S0.5030.46
282_G286_S0.5030.46
196_G199_G0.5020.45
64_A68_A0.5020.45
222_I225_Y0.5020.45
376_I380_D0.5010.45
91_K159_L0.5010.45
289_L293_L0.5000.45
71_F129_A0.5000.45
114_A117_G0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.7966 100 0.666 Contact Map
3bp3A 1 0.1698 99.9 0.826 Contact Map
1ibaA 1 0.1614 99.9 0.826 Contact Map
3ipjA 1 0.174 99.8 0.843 Contact Map
4ea3A 2 0.174 45.8 0.973 Contact Map
1neeA 1 0.2055 37.4 0.974 Contact Map
4pypA 1 0.7065 35.4 0.975 Contact Map
3cw2K 1 0.2075 34.9 0.975 Contact Map
4ltoA 3 0.2558 33.6 0.975 Contact Map
3wdoA 1 0.8281 29.8 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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