PTGCB - ECOLI - GREMLIN Contacts

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PTGCB - PTS system glucose-specific EIICB component

UniProt:	P69786	Sequences: MFKNAFANLQKVGKSLMLPVSVLPIAGILLGVGSANFSWLPAVVSHVMAEAGGSVFANMPLIFAIGVALGFTNNDGVSALAAVVAYGIMVKTMAVVAPLVLHLPAEEIASKHLADTGVLGGIISGAIAAYMFNRFYRIKLPEYLGFFAGKRFVPIISGLAAIFTGVVLSFIWPPIGSAIQTFSQWAAYQNPVVAFGIYGFIERCLVPFGLHHIWNVPFQMQIGEYTNAAGQVFHGDIPRYMAGDPTAGKLSGGFLFKMYGLPAAAIAIWHSAKPENRAKVGGIMISAALTSFLTGITEPIEFSFMFVAPILYIIHAILAGLAFPICILLGMRDGTSFSHGLIDFIVLSGNSSKLWLFPIVGIGYAIVYYTIFRVLIKALDLKTPGREDATEDAKATGTSEMAPALVAAFGGKENITNLDACITRLRVSVADVSKVDQAGLKKLGAAGVVVAGSGVQAIFGTKSDNLKTEMDEYIRNH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10787
Length:	477 (434)
Sequences:	2904 (1653)
Seq/√Len:	79.3

ECOLI - PTGCB PTW3C PTOCB PTXC PTIBC PTTBC PTV3B PTYBC
BACSU - PTG3C PTW3C PTOCB PTWCB PTSBC PTTBC SACX PTV3B PTXBC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
270_H	373_R	5.276	1.00
263_A	365_A	4.858	1.00
270_H	369_Y	4.622	1.00
373_R	377_K	4.586	1.00
65_I	83_V	3.818	1.00
416_T	430_A	3.793	1.00
27_G	336_S	3.602	1.00
53_G	57_A	3.572	1.00
382_K	388_D	3.520	1.00
265_A	300_I	3.356	1.00
276_N	279_K	3.355	1.00
271_S	377_K	3.340	1.00
276_N	389_A	3.291	1.00
358_P	362_I	3.235	1.00
85_A	157_S	3.208	1.00
362_I	366_I	3.190	1.00
313_I	317_I	3.041	1.00
318_L	371_I	3.006	1.00
431_D	434_K	2.880	1.00
268_I	284_M	2.737	1.00
273_K	388_D	2.712	1.00
436_D	439_G	2.642	1.00
271_S	373_R	2.562	1.00
314_I	318_L	2.555	1.00
138_I	152_F	2.551	1.00
375_L	379_L	2.515	1.00
200_F	320_G	2.468	1.00
330_G	353_K	2.432	1.00
439_G	442_K	2.427	1.00
329_L	360_V	2.414	1.00
259_Y	361_G	2.270	1.00
408_A	439_G	2.249	1.00
324_P	328_L	2.241	1.00
202_E	253_G	2.226	1.00
310_I	379_L	2.202	1.00
258_M	292_F	2.192	1.00
128_A	157_S	2.192	1.00
199_G	323_F	2.143	1.00
269_W	281_G	2.126	1.00
126_A	130_Y	2.108	1.00
367_V	371_I	2.095	1.00
237_I	240_Y	2.053	1.00
420_A	443_L	2.051	1.00
417_N	428_S	2.032	1.00
138_I	148_A	2.018	1.00
429_V	432_V	2.017	1.00
15_S	71_F	1.988	1.00
200_F	313_I	1.942	1.00
315_H	368_Y	1.936	1.00
127_I	164_T	1.919	1.00
326_C	360_V	1.917	1.00
314_I	371_I	1.914	1.00
325_I	364_Y	1.891	1.00
406_V	418_L	1.880	1.00
156_I	160_A	1.880	1.00
34_S	49_A	1.874	1.00
344_F	348_S	1.863	1.00
201_I	214_W	1.830	1.00
341_L	345_I	1.801	1.00
25_I	158_G	1.799	1.00
429_V	435_V	1.792	1.00
359_I	363_G	1.789	1.00
239_R	244_D	1.785	1.00
14_K	419_D	1.778	1.00
369_Y	373_R	1.775	1.00
200_F	204_C	1.769	1.00
366_I	370_T	1.767	1.00
374_V	378_A	1.735	1.00
416_T	428_S	1.735	1.00
124_S	161_A	1.734	1.00
270_H	377_K	1.715	1.00
263_A	366_I	1.709	1.00
437_Q	441_K	1.703	1.00
166_V	170_F	1.700	1.00
192_V	328_L	1.680	1.00
159_L	163_F	1.676	1.00
371_I	375_L	1.674	1.00
261_L	264_A	1.663	1.00
200_F	316_A	1.661	1.00
326_C	331_M	1.658	1.00
227_N	231_Q	1.653	1.00
281_G	285_I	1.653	1.00
17_M	212_H	1.640	1.00
314_I	375_L	1.626	1.00
408_A	443_L	1.579	1.00
239_R	245_P	1.567	1.00
256_F	319_A	1.561	0.99
318_L	368_Y	1.530	0.99
407_A	439_G	1.528	0.99
9_L	12_V	1.503	0.99
266_I	270_H	1.500	0.99
409_F	427_V	1.499	0.99
362_I	365_A	1.498	0.99
204_C	316_A	1.483	0.99
231_Q	234_H	1.464	0.99
125_G	165_G	1.454	0.99
10_Q	70_G	1.436	0.99
404_A	439_G	1.434	0.99
372_F	376_I	1.431	0.99
322_A	364_Y	1.426	0.99
59_M	118_V	1.426	0.99
356_L	359_I	1.420	0.99
278_A	281_G	1.410	0.99
33_G	52_G	1.407	0.99
305_M	312_Y	1.406	0.99
321_L	364_Y	1.403	0.99
145_G	296_I	1.401	0.99
124_S	164_T	1.399	0.99
192_V	324_P	1.399	0.99
255_L	322_A	1.395	0.99
236_D	239_R	1.383	0.99
413_E	434_K	1.373	0.99
274_P	277_R	1.366	0.99
85_A	124_S	1.349	0.99
127_I	130_Y	1.345	0.98
131_M	156_I	1.338	0.98
283_I	287_A	1.334	0.98
193_V	197_I	1.320	0.98
369_Y	377_K	1.320	0.98
233_F	242_A	1.315	0.98
265_A	284_M	1.308	0.98
267_A	370_T	1.306	0.98
397_G	400_E	1.305	0.98
221_Q	234_H	1.304	0.98
74_N	132_F	1.296	0.98
272_A	280_V	1.286	0.98
226_T	232_V	1.281	0.98
185_W	189_Q	1.276	0.98
61_L	83_V	1.275	0.98
127_I	160_A	1.264	0.98
325_I	328_L	1.261	0.98
374_V	379_L	1.257	0.98
269_W	285_I	1.257	0.98
141_P	144_L	1.256	0.98
355_W	359_I	1.253	0.98
269_W	277_R	1.250	0.98
196_G	324_P	1.247	0.98
237_I	241_M	1.230	0.97
139_K	142_E	1.217	0.97
257_K	291_S	1.213	0.97
370_T	374_V	1.213	0.97
30_L	53_G	1.211	0.97
199_G	319_A	1.209	0.97
239_R	243_G	1.206	0.97
238_P	242_A	1.206	0.97
83_V	87_G	1.203	0.97
226_T	230_G	1.199	0.97
131_M	160_A	1.197	0.97
325_I	329_L	1.195	0.97
71_F	126_A	1.193	0.97
246_T	249_K	1.185	0.97
383_T	386_R	1.180	0.97
418_L	427_V	1.177	0.96
195_F	327_I	1.176	0.96
226_T	229_A	1.175	0.96
370_T	373_R	1.162	0.96
382_K	387_E	1.160	0.96
268_I	271_S	1.159	0.96
135_F	156_I	1.159	0.96
269_W	284_M	1.155	0.96
178_A	181_T	1.154	0.96
438_A	442_K	1.148	0.96
268_I	280_V	1.144	0.96
376_I	386_R	1.129	0.96
200_F	317_I	1.123	0.95
69_L	79_A	1.115	0.95
235_G	239_R	1.108	0.95
280_V	284_M	1.107	0.95
344_F	355_W	1.103	0.95
177_S	181_T	1.103	0.95
301_E	315_H	1.102	0.95
18_L	69_L	1.094	0.95
351_S	354_L	1.093	0.95
152_F	156_I	1.085	0.94
310_I	313_I	1.084	0.94
429_V	437_Q	1.081	0.94
196_G	320_G	1.079	0.94
261_L	300_I	1.077	0.94
369_Y	372_F	1.073	0.94
131_M	152_F	1.070	0.94
408_A	420_A	1.066	0.94
401_M	443_L	1.062	0.94
413_E	430_A	1.061	0.94
301_E	312_Y	1.060	0.94
348_S	354_L	1.059	0.94
85_A	161_A	1.052	0.93
163_F	167_V	1.048	0.93
27_G	290_T	1.045	0.93
264_A	268_I	1.044	0.93
366_I	369_Y	1.042	0.93
261_L	305_M	1.039	0.93
58_N	87_G	1.034	0.93
376_I	383_T	1.029	0.93
30_L	56_F	1.027	0.93
225_Y	239_R	1.024	0.93
408_A	440_L	1.012	0.92
375_L	381_L	1.010	0.92
430_A	434_K	1.004	0.92
285_I	288_A	1.001	0.92
198_Y	251_S	0.999	0.92
118_V	121_G	0.997	0.91
64_A	77_V	0.995	0.91
40_L	44_V	0.994	0.91
29_L	52_G	0.994	0.91
229_A	232_V	0.994	0.91
221_Q	225_Y	0.993	0.91
276_N	390_T	0.991	0.91
239_R	247_A	0.990	0.91
196_G	200_F	0.985	0.91
138_I	156_I	0.984	0.91
174_P	178_A	0.984	0.91
230_G	233_F	0.974	0.91
270_H	277_R	0.971	0.90
358_P	363_G	0.967	0.90
240_Y	243_G	0.966	0.90
131_M	135_F	0.965	0.90
237_I	243_G	0.963	0.90
332_R	352_S	0.963	0.90
272_A	383_T	0.963	0.90
92_T	165_G	0.959	0.90
221_Q	248_G	0.958	0.90
403_P	407_A	0.958	0.90
374_V	381_L	0.957	0.90
31_G	35_A	0.953	0.90
182_F	185_W	0.949	0.89
400_E	403_P	0.948	0.89
344_F	359_I	0.946	0.89
68_A	82_A	0.945	0.89
65_I	75_D	0.941	0.89
255_L	326_C	0.940	0.89
314_I	376_I	0.936	0.89
242_A	245_P	0.930	0.88
236_D	240_Y	0.930	0.88
256_F	260_G	0.928	0.88
348_S	355_W	0.927	0.88
50_E	53_G	0.926	0.88
236_D	241_M	0.926	0.88
5_A	8_N	0.920	0.88
172_W	176_G	0.919	0.88
387_E	390_T	0.916	0.88
270_H	370_T	0.915	0.88
219_Q	338_S	0.914	0.87
184_Q	188_Y	0.912	0.87
404_A	443_L	0.911	0.87
124_S	128_A	0.910	0.87
136_Y	156_I	0.901	0.87
353_K	356_L	0.900	0.87
333_D	357_F	0.898	0.87
405_L	443_L	0.897	0.86
140_L	152_F	0.896	0.86
8_N	12_V	0.896	0.86
405_L	440_L	0.896	0.86
16_L	150_K	0.893	0.86
325_I	360_V	0.892	0.86
270_H	274_P	0.891	0.86
26_A	59_M	0.890	0.86
175_I	178_A	0.889	0.86
275_E	389_A	0.881	0.85
220_M	237_I	0.880	0.85
296_I	422_I	0.877	0.85
276_N	387_E	0.867	0.85
61_L	82_A	0.864	0.84
359_I	362_I	0.862	0.84
115_D	118_V	0.860	0.84
398_T	401_M	0.858	0.84
227_N	230_G	0.855	0.84
368_Y	372_F	0.855	0.84
229_A	233_F	0.854	0.84
236_D	243_G	0.852	0.84
158_G	161_A	0.852	0.84
416_T	429_V	0.851	0.83
151_R	154_P	0.848	0.83
28_I	32_V	0.847	0.83
195_F	249_K	0.846	0.83
421_C	426_R	0.842	0.83
233_F	237_I	0.840	0.83
428_S	432_V	0.836	0.82
203_R	301_E	0.834	0.82
406_V	415_I	0.832	0.82
229_A	234_H	0.832	0.82
130_Y	134_R	0.832	0.82
404_A	442_K	0.830	0.82
202_E	319_A	0.829	0.82
190_N	194_A	0.827	0.82
259_Y	362_I	0.824	0.81
233_F	239_R	0.824	0.81
421_C	424_R	0.822	0.81
231_Q	238_P	0.818	0.81
404_A	412_K	0.816	0.81
396_T	399_S	0.816	0.81
115_D	121_G	0.815	0.81
433_S	442_K	0.815	0.81
260_G	315_H	0.815	0.81
114_A	120_G	0.813	0.81
178_A	182_F	0.809	0.80
404_A	407_A	0.807	0.80
55_V	62_I	0.807	0.80
401_M	404_A	0.806	0.80
422_I	443_L	0.798	0.79
273_K	387_E	0.795	0.79
127_I	131_M	0.795	0.79
106_E	110_S	0.793	0.79
321_L	368_Y	0.792	0.79
253_G	335_T	0.789	0.79
257_K	339_H	0.789	0.79
56_F	237_I	0.788	0.78
135_F	152_F	0.788	0.78
147_F	267_A	0.785	0.78
376_I	385_G	0.785	0.78
181_T	185_W	0.784	0.78
331_M	357_F	0.783	0.78
415_I	418_L	0.779	0.78
119_L	123_I	0.778	0.78
171_I	174_P	0.777	0.78
233_F	241_M	0.775	0.77
141_P	147_F	0.775	0.77
380_D	383_T	0.773	0.77
204_C	313_I	0.772	0.77
260_G	318_L	0.772	0.77
65_I	78_S	0.771	0.77
310_I	314_I	0.769	0.77
36_N	39_W	0.769	0.77
266_I	365_A	0.767	0.77
376_I	384_P	0.766	0.76
202_E	335_T	0.766	0.76
272_A	277_R	0.763	0.76
291_S	297_T	0.760	0.76
50_E	95_V	0.760	0.76
127_I	161_A	0.758	0.76
367_V	370_T	0.758	0.76
217_P	222_I	0.756	0.76
263_A	267_A	0.755	0.75
196_G	321_L	0.755	0.75
238_P	241_M	0.755	0.75
224_E	234_H	0.754	0.75
156_I	159_L	0.754	0.75
255_L	343_D	0.752	0.75
294_T	340_G	0.751	0.75
399_S	403_P	0.747	0.75
73_N	133_N	0.745	0.74
86_Y	90_V	0.743	0.74
221_Q	224_E	0.742	0.74
273_K	375_L	0.741	0.74
266_I	271_S	0.736	0.74
72_T	77_V	0.736	0.74
161_A	165_G	0.733	0.73
407_A	416_T	0.733	0.73
253_G	319_A	0.731	0.73
37_F	42_A	0.731	0.73
254_F	257_K	0.730	0.73
247_A	250_L	0.729	0.73
195_F	324_P	0.728	0.73
21_S	24_P	0.727	0.73
38_S	41_P	0.726	0.73
333_D	347_L	0.726	0.73
415_I	429_V	0.725	0.72
321_L	353_K	0.725	0.72
51_A	162_I	0.724	0.72
7_A	401_M	0.723	0.72
374_V	377_K	0.723	0.72
112_H	115_D	0.722	0.72
64_A	121_G	0.719	0.72
261_L	315_H	0.718	0.72
8_N	130_Y	0.718	0.72
134_R	153_V	0.715	0.71
25_I	159_L	0.714	0.71
68_A	78_S	0.713	0.71
77_V	81_A	0.712	0.71
50_E	57_A	0.711	0.71
199_G	320_G	0.711	0.71
407_A	434_K	0.710	0.71
30_L	342_I	0.708	0.71
310_I	375_L	0.707	0.71
180_Q	184_Q	0.707	0.71
256_F	364_Y	0.707	0.71
249_K	327_I	0.705	0.70
329_L	357_F	0.703	0.70
31_G	34_S	0.702	0.70
123_I	168_L	0.702	0.70
80_L	122_I	0.700	0.70
116_T	120_G	0.699	0.70
167_V	171_I	0.699	0.70
48_M	162_I	0.698	0.70
115_D	120_G	0.697	0.69
10_Q	13_G	0.696	0.69
235_G	244_D	0.696	0.69
179_I	205_L	0.693	0.69
387_E	391_E	0.691	0.69
403_P	433_S	0.690	0.69
192_V	327_I	0.689	0.69
10_Q	14_K	0.689	0.69
227_N	232_V	0.687	0.68
360_V	364_Y	0.686	0.68
234_H	237_I	0.686	0.68
119_L	217_P	0.685	0.68
164_T	168_L	0.685	0.68
265_A	269_W	0.684	0.68
236_D	247_A	0.682	0.68
420_A	427_V	0.679	0.67
185_W	188_Y	0.679	0.67
258_M	315_H	0.677	0.67
7_A	428_S	0.676	0.67
292_F	341_L	0.676	0.67
397_G	401_M	0.675	0.67
264_A	315_H	0.675	0.67
197_I	393_A	0.674	0.67
68_A	73_N	0.674	0.67
398_T	420_A	0.670	0.66
287_A	291_S	0.670	0.66
254_F	347_L	0.667	0.66
37_F	41_P	0.666	0.66
46_H	49_A	0.665	0.66
8_N	11_K	0.665	0.66
392_D	397_G	0.664	0.66
333_D	348_S	0.664	0.66
243_G	247_A	0.664	0.66
260_G	368_Y	0.664	0.66
135_F	138_I	0.663	0.66
219_Q	254_F	0.663	0.66
401_M	405_L	0.663	0.66
242_A	247_A	0.661	0.65
202_E	323_F	0.661	0.65
331_M	356_L	0.660	0.65
79_A	82_A	0.659	0.65
340_G	343_D	0.658	0.65
318_L	321_L	0.658	0.65
56_F	241_M	0.657	0.65
156_I	164_T	0.657	0.65
144_L	337_F	0.656	0.65
405_L	408_A	0.655	0.65
350_N	354_L	0.653	0.64
331_M	359_I	0.653	0.64
117_G	221_Q	0.652	0.64
398_T	406_V	0.650	0.64
314_I	372_F	0.649	0.64
263_A	369_Y	0.649	0.64
39_W	42_A	0.648	0.64
239_R	354_L	0.647	0.64
391_E	442_K	0.646	0.64
265_A	288_A	0.645	0.64
274_P	369_Y	0.644	0.63
143_Y	289_L	0.644	0.63
110_S	113_L	0.644	0.63
27_G	297_T	0.643	0.63
203_R	258_M	0.642	0.63
33_G	45_S	0.640	0.63
439_G	443_L	0.640	0.63
272_A	385_G	0.638	0.63
239_R	246_T	0.636	0.62
335_T	339_H	0.636	0.62
189_Q	197_I	0.634	0.62
142_E	145_G	0.632	0.62
253_G	323_F	0.632	0.62
380_D	386_R	0.631	0.62
260_G	264_A	0.631	0.62
396_T	400_E	0.631	0.62
167_V	170_F	0.630	0.62
288_A	291_S	0.630	0.62
261_L	287_A	0.630	0.62
318_L	322_A	0.629	0.62
61_L	78_S	0.629	0.62
254_F	338_S	0.628	0.61
229_A	243_G	0.627	0.61
26_A	29_L	0.626	0.61
216_V	237_I	0.626	0.61
233_F	240_Y	0.623	0.61
173_P	212_H	0.623	0.61
219_Q	337_F	0.622	0.61
416_T	434_K	0.622	0.61
74_N	133_N	0.621	0.61
237_I	244_D	0.620	0.60
19_P	66_G	0.620	0.60
417_N	432_V	0.619	0.60
74_N	137_R	0.618	0.60
236_D	246_T	0.618	0.60
68_A	129_A	0.617	0.60
223_G	235_G	0.616	0.60
232_V	236_D	0.615	0.60
408_A	436_D	0.613	0.60
195_F	200_F	0.613	0.60
287_A	303_S	0.607	0.59
89_M	120_G	0.605	0.59
236_D	245_P	0.604	0.58
102_H	105_A	0.602	0.58
408_A	427_V	0.602	0.58
216_V	221_Q	0.601	0.58
114_A	118_V	0.601	0.58
84_V	222_I	0.601	0.58
90_V	93_M	0.600	0.58
225_Y	247_A	0.598	0.58
89_M	168_L	0.596	0.57
323_F	327_I	0.596	0.57
144_L	152_F	0.596	0.57
51_A	92_T	0.595	0.57
91_K	94_A	0.594	0.57
361_G	368_Y	0.594	0.57
413_E	417_N	0.594	0.57
207_P	301_E	0.592	0.57
417_N	427_V	0.589	0.57
115_D	119_L	0.589	0.57
13_G	16_L	0.589	0.57
65_I	79_A	0.589	0.57
325_I	357_F	0.588	0.56
129_A	133_N	0.588	0.56
395_A	399_S	0.588	0.56
267_A	374_V	0.588	0.56
159_L	433_S	0.588	0.56
430_A	439_G	0.587	0.56
321_L	325_I	0.587	0.56
407_A	412_K	0.587	0.56
72_T	75_D	0.587	0.56
186_A	217_P	0.586	0.56
420_A	428_S	0.586	0.56
272_A	386_R	0.586	0.56
119_L	170_F	0.582	0.56
176_G	210_L	0.581	0.56
339_H	343_D	0.581	0.56
226_T	243_G	0.581	0.56
308_A	378_A	0.581	0.56
120_G	172_W	0.581	0.56
400_E	404_A	0.578	0.55
205_L	214_W	0.578	0.55
46_H	50_E	0.576	0.55
21_S	305_M	0.576	0.55
363_G	442_K	0.575	0.55
308_A	311_L	0.574	0.55
92_T	113_L	0.573	0.55
219_Q	339_H	0.573	0.55
416_T	432_V	0.572	0.54
418_L	432_V	0.572	0.54
146_F	338_S	0.571	0.54
96_V	169_S	0.569	0.54
403_P	412_K	0.569	0.54
157_S	161_A	0.569	0.54
66_G	80_L	0.569	0.54
334_G	343_D	0.568	0.54
105_A	112_H	0.568	0.54
237_I	242_A	0.568	0.54
108_I	111_K	0.567	0.54
350_N	353_K	0.567	0.54
259_Y	262_P	0.567	0.54
258_M	291_S	0.564	0.53
403_P	416_T	0.564	0.53
203_R	316_A	0.564	0.53
293_L	342_I	0.564	0.53
246_T	332_R	0.563	0.53
135_F	139_K	0.563	0.53
428_S	433_S	0.559	0.53
54_S	82_A	0.558	0.53
258_M	361_G	0.558	0.53
402_A	405_L	0.556	0.52
64_A	81_A	0.556	0.52
279_K	378_A	0.555	0.52
390_T	438_A	0.555	0.52
201_I	320_G	0.554	0.52
406_V	413_E	0.554	0.52
41_P	45_S	0.554	0.52
432_V	442_K	0.553	0.52
20_V	406_V	0.552	0.52
233_F	236_D	0.552	0.52
261_L	291_S	0.552	0.52
293_L	341_L	0.551	0.52
192_V	196_G	0.551	0.52
124_S	131_M	0.548	0.51
78_S	289_L	0.547	0.51
200_F	371_I	0.546	0.51
103_L	106_E	0.546	0.51
344_F	354_L	0.545	0.51
271_S	277_R	0.545	0.51
319_A	335_T	0.545	0.51
221_Q	263_A	0.544	0.51
405_L	409_F	0.542	0.51
418_L	438_A	0.542	0.51
63_F	122_I	0.541	0.50
284_M	303_S	0.540	0.50
407_A	442_K	0.540	0.50
403_P	417_N	0.539	0.50
195_F	333_D	0.539	0.50
183_S	224_E	0.539	0.50
308_A	381_L	0.538	0.50
301_E	304_F	0.538	0.50
20_V	34_S	0.537	0.50
412_K	439_G	0.537	0.50
326_C	361_G	0.536	0.50
208_F	302_F	0.535	0.50
427_V	432_V	0.534	0.50
399_S	402_A	0.534	0.50
349_G	355_W	0.533	0.49
436_D	440_L	0.533	0.49
172_W	309_P	0.532	0.49
80_L	158_G	0.532	0.49
239_R	242_A	0.531	0.49
415_I	435_V	0.531	0.49
203_R	343_D	0.530	0.49
408_A	442_K	0.530	0.49
395_A	398_T	0.530	0.49
393_A	442_K	0.529	0.49
236_D	248_G	0.527	0.49
214_W	218_F	0.527	0.49
396_T	438_A	0.526	0.49
258_M	288_A	0.526	0.49
244_D	351_S	0.526	0.49
92_T	96_V	0.525	0.48
233_F	238_P	0.524	0.48
67_V	71_F	0.524	0.48
264_A	382_K	0.523	0.48
188_Y	391_E	0.523	0.48
208_F	305_M	0.522	0.48
394_K	398_T	0.522	0.48
87_G	109_A	0.522	0.48
174_P	177_S	0.521	0.48
430_A	442_K	0.521	0.48
179_I	201_I	0.521	0.48
288_A	292_F	0.520	0.48
266_I	269_W	0.519	0.48
90_V	94_A	0.518	0.47
104_P	107_E	0.518	0.47
208_F	322_A	0.517	0.47
274_P	278_A	0.517	0.47
403_P	438_A	0.516	0.47
296_I	339_H	0.516	0.47
117_G	290_T	0.515	0.47
8_N	119_L	0.512	0.47
273_K	389_A	0.512	0.47
140_L	144_L	0.510	0.46
117_G	161_A	0.510	0.46
84_V	187_A	0.508	0.46
64_A	172_W	0.508	0.46
198_Y	214_W	0.507	0.46
266_I	288_A	0.507	0.46
412_K	432_V	0.506	0.46
25_I	284_M	0.506	0.46
236_D	354_L	0.506	0.46
49_A	53_G	0.506	0.46
399_S	442_K	0.505	0.46
271_S	381_L	0.505	0.46
172_W	207_P	0.505	0.46
211_H	298_E	0.504	0.46
433_S	438_A	0.504	0.46
397_G	404_A	0.504	0.46
224_E	227_N	0.503	0.46
234_H	428_S	0.503	0.46
282_G	286_S	0.503	0.46
196_G	199_G	0.502	0.45
64_A	68_A	0.502	0.45
222_I	225_Y	0.502	0.45
376_I	380_D	0.501	0.45
91_K	159_L	0.501	0.45
289_L	293_L	0.500	0.45
71_F	129_A	0.500	0.45
114_A	117_G	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qnqA	2	0.7966	100	0.666	Contact Map
3bp3A	1	0.1698	99.9	0.826	Contact Map
1ibaA	1	0.1614	99.9	0.826	Contact Map
3ipjA	1	0.174	99.8	0.843	Contact Map
4ea3A	2	0.174	45.8	0.973	Contact Map
1neeA	1	0.2055	37.4	0.974	Contact Map
4pypA	1	0.7065	35.4	0.975	Contact Map
3cw2K	1	0.2075	34.9	0.975	Contact Map
4ltoA	3	0.2558	33.6	0.975	Contact Map
3wdoA	1	0.8281	29.8	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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