GREMLIN Database
PTGA - Glucose-specific phosphotransferase enzyme IIA component
UniProt: P69783 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10165
Length: 169 (150)
Sequences: 3838 (3194)
Seq/√Len: 260.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_K49_D3.1131.00
69_G81_E2.7511.00
64_V82_S2.6381.00
59_K119_T2.4541.00
107_I122_E2.3811.00
65_D115_K2.2891.00
109_E112_Q2.2741.00
28_S57_G2.2541.00
107_I119_T2.2541.00
105_K122_E2.2511.00
92_F121_I2.1521.00
67_T113_R2.1261.00
83_D113_R2.0851.00
103_G127_L2.0301.00
98_E133_K2.0211.00
127_L131_K2.0101.00
75_N106_R1.9251.00
38_P134_S1.8921.00
30_E54_K1.8811.00
102_E131_K1.8741.00
37_V52_A1.8501.00
24_I116_V1.8181.00
58_N125_L1.7511.00
59_K122_E1.7021.00
35_E45_K1.6911.00
54_K134_S1.6381.00
65_D116_V1.6301.00
115_K118_D1.6281.00
60_M90_V1.6021.00
27_L60_M1.5991.00
67_T81_E1.5341.00
40_V44_E1.5181.00
32_V136_L1.4851.00
61_V159_V1.4471.00
92_F123_F1.4441.00
102_E127_L1.4361.00
112_Q118_D1.4351.00
38_P136_L1.3971.00
22_E163_P1.3931.00
21_I84_S1.3911.00
158_T161_E1.3861.00
125_L135_T1.3791.00
78_F121_I1.3761.00
61_V119_T1.3741.00
28_S158_T1.3721.00
125_L129_E1.3501.00
28_S159_V1.3181.00
52_A136_L1.2921.00
126_P130_E1.2821.00
99_L127_L1.2821.00
66_G80_I1.2751.00
68_I78_F1.2681.00
126_P129_E1.2631.00
27_L137_T1.2541.00
68_I108_A1.2481.00
28_S56_T1.2281.00
56_T156_S1.2201.00
62_A80_I1.2151.00
30_E156_S1.2131.00
54_K135_T1.2061.00
65_D83_D1.1931.00
123_F128_L1.1851.00
127_L130_E1.1721.00
135_T138_P1.1581.00
41_V46_I1.1331.00
33_N36_D1.1291.00
95_D98_E1.1221.00
119_T122_E1.1151.00
31_I51_I1.0861.00
86_V147_I1.0861.00
106_R121_I1.0791.00
21_I82_S1.0711.00
51_I164_V1.0701.00
94_I138_P1.0621.00
51_I139_V1.0611.00
32_V52_A1.0611.00
87_E143_N1.0571.00
71_I106_R1.0561.00
144_M147_I1.0541.00
54_K129_E1.0531.00
64_V80_I1.0471.00
124_D127_L1.0071.00
81_E87_E1.0061.00
23_I64_V1.0061.00
32_V54_K0.9951.00
71_I110_E0.9871.00
99_L103_G0.9821.00
79_S142_S0.9791.00
103_G131_K0.9721.00
31_I157_V0.9641.00
60_M123_F0.9631.00
143_N147_I0.9561.00
68_I80_I0.9511.00
78_F120_V0.9411.00
37_V136_L0.9181.00
70_K110_E0.9121.00
64_V88_L0.9081.00
92_F137_T0.9071.00
49_D144_M0.9031.00
75_N105_K0.8981.00
34_I50_G0.8861.00
99_L102_E0.8791.00
24_I163_P0.8761.00
99_L128_L0.8701.00
53_I139_V0.8691.00
32_V37_V0.8661.00
21_I86_V0.8651.00
25_A157_V0.8641.00
129_E135_T0.8611.00
25_A53_I0.8500.99
54_K136_L0.8430.99
34_I37_V0.8420.99
103_G133_K0.8390.99
47_V142_S0.8340.99
141_I144_M0.8300.99
71_I75_N0.8150.99
108_A112_Q0.8090.99
99_L133_K0.8080.99
52_A138_P0.8080.99
82_S86_V0.8040.99
73_E110_E0.8040.99
78_F90_V0.8040.99
71_I121_I0.7950.99
139_V164_V0.7940.99
70_K79_S0.7920.99
59_K107_I0.7880.99
80_I120_V0.7870.99
108_A118_D0.7850.99
38_P94_I0.7720.99
49_D149_E0.7690.99
141_I165_I0.7630.99
68_I71_I0.7620.99
62_A65_D0.7500.99
34_I45_K0.7440.99
73_E100_K0.7440.99
26_P139_V0.7430.99
71_I78_F0.7360.99
32_V36_D0.7200.98
128_L133_K0.7150.98
116_V119_T0.7130.98
106_R110_E0.7100.98
20_T166_R0.7060.98
70_K73_E0.7060.98
36_D154_S0.7030.98
30_E56_T0.7020.98
58_N122_E0.7000.98
67_T111_G0.6990.98
22_E164_V0.6990.98
47_V140_V0.6920.98
87_E142_S0.6720.97
68_I114_V0.6630.97
51_I141_I0.6610.97
60_M137_T0.6590.97
90_V139_V0.6470.97
51_I165_I0.6440.97
144_M150_L0.6420.97
41_V47_V0.6360.96
46_I73_E0.6360.96
96_T128_L0.6350.96
31_I155_G0.6350.96
30_E155_G0.6290.96
58_N126_P0.6260.96
24_I160_G0.6230.96
37_V138_P0.6220.96
66_G82_S0.6210.96
27_L53_I0.6160.96
71_I108_A0.6150.96
141_I147_I0.6110.95
57_G125_L0.6080.95
88_L141_I0.6050.95
55_P123_F0.6040.95
75_N107_I0.6040.95
127_L132_A0.6040.95
31_I154_S0.5960.95
28_S160_G0.5950.95
34_I140_V0.5940.95
31_I164_V0.5930.95
21_I24_I0.5920.95
163_P166_R0.5910.95
23_I165_I0.5910.95
86_V141_I0.5890.94
27_L123_F0.5860.94
27_L55_P0.5800.94
107_I121_I0.5740.94
128_L135_T0.5670.93
151_I166_R0.5660.93
22_E166_R0.5640.93
94_I140_V0.5620.93
80_I90_V0.5610.93
23_I141_I0.5570.93
33_N45_K0.5570.93
152_K166_R0.5560.93
92_F106_R0.5560.93
70_K78_F0.5530.92
23_I163_P0.5490.92
94_I134_S0.5480.92
143_N146_E0.5480.92
37_V50_G0.5470.92
76_H91_H0.5460.92
69_G79_S0.5440.92
41_V44_E0.5370.91
99_L135_T0.5370.91
17_D148_K0.5360.91
79_S87_E0.5360.91
45_K50_G0.5350.91
64_V116_V0.5310.91
58_N123_F0.5300.91
95_D133_K0.5280.91
20_T148_K0.5270.91
58_N124_D0.5250.90
90_V120_V0.5210.90
78_F106_R0.5200.90
25_A28_S0.5170.90
147_I150_L0.5160.90
40_V95_D0.5140.89
153_L161_E0.5130.89
94_I136_L0.5110.89
81_E85_G0.5060.89
96_T101_G0.5060.89
91_H97_V0.5030.88
59_K159_V0.5030.88
18_T21_I0.5020.88
67_T110_E0.5010.88
45_K140_V0.5010.88
47_V70_K0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ourB 1 0.8876 100 0.05 Contact Map
1f3zA 2 0.8876 100 0.09 Contact Map
2gprA 1 0.9112 100 0.098 Contact Map
1ax3A 1 0.9527 100 0.125 Contact Map
1dczA 1 0.4556 98.2 0.831 Contact Map
2d5dA 1 0.4083 98.2 0.834 Contact Map
1z6hA 1 0.4024 96.9 0.871 Contact Map
2kccA 1 0.4379 96.7 0.873 Contact Map
1bdoA 2 0.4142 96.6 0.875 Contact Map
2dn8A 1 0.497 96.5 0.877 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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