GREMLIN Database
MBHS - Hydrogenase-1 small chain
UniProt: P69739 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10468
Length: 372 (329)
Sequences: 757 (397)
Seq/√Len: 21.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_T296_G5.0511.00
247_V264_M4.5921.00
138_R146_R3.8951.00
273_N298_A3.6751.00
113_N150_G3.6021.00
103_E107_D3.3521.00
126_L177_T3.2321.00
58_H61_E3.0621.00
163_W221_G3.0431.00
118_L147_A2.8290.99
157_W201_M2.8230.99
116_Y150_G2.7580.99
94_M101_A2.6510.99
106_E146_R2.6200.99
60_L123_N2.5790.98
248_Q263_K2.5670.98
59_G140_F2.5610.98
155_I205_I2.4680.98
200_V274_A2.4350.98
115_K152_S2.3830.97
159_T163_W2.3450.97
128_E131_M2.3070.97
116_Y149_A2.2990.97
61_E167_Q2.2850.96
29_A42_I2.2710.96
64_C165_C2.2560.96
207_Y215_P2.1330.95
53_P86_S2.1190.95
163_W300_N2.0950.94
279_R289_Q2.0900.94
196_P250_W2.0870.94
183_I186_K2.0820.94
141_I145_K2.0430.93
308_F312_V2.0390.93
133_C140_F1.9740.92
127_G175_Q1.9570.92
163_W192_P1.9210.91
274_A278_T1.9150.91
105_F147_A1.8890.90
196_P201_M1.8790.90
138_R142_E1.8550.90
201_M205_I1.8430.89
66_T90_D1.8390.89
197_I200_V1.8310.89
334_V338_A1.8260.89
118_L148_A1.8170.89
126_L141_I1.7990.88
124_P144_L1.7980.88
68_S280_W1.7870.88
285_S289_Q1.7860.88
65_C196_P1.7530.87
328_G342_H1.7510.87
191_V196_P1.7300.86
207_Y213_R1.7280.86
182_V186_K1.7210.86
46_L206_T1.7170.85
161_A178_P1.7030.85
182_V185_D1.6810.84
27_L31_S1.6710.84
218_D222_R1.6650.84
58_H121_E1.6640.84
340_G343_A1.6470.83
119_A201_M1.6420.83
155_I201_M1.6140.82
127_G131_M1.6140.82
250_W264_M1.6100.82
152_S208_M1.6020.81
20_S23_K1.5960.81
58_H65_C1.5950.81
118_L144_L1.5810.80
337_A341_V1.5760.80
308_F311_R1.5630.80
53_P88_D1.5530.79
94_M105_F1.5370.78
240_H245_E1.5320.78
58_H63_T1.5130.77
334_V337_A1.5130.77
126_L130_G1.4690.75
107_D111_Q1.4560.74
54_V87_L1.4460.74
191_V227_Y1.4400.74
220_M300_N1.4270.73
127_G132_F1.4030.72
58_H167_Q1.3960.71
56_W218_D1.3940.71
69_F77_A1.3840.70
238_R242_D1.3800.70
55_V109_I1.3730.70
327_V335_V1.3450.68
110_T113_N1.3410.68
61_E65_C1.3280.67
63_T196_P1.3210.67
195_P268_G1.3120.66
124_P156_A1.3110.66
329_L337_A1.2880.65
197_I251_D1.2860.65
134_I139_P1.2700.64
109_I116_Y1.2700.64
148_A154_I1.2650.63
329_L333_G1.2640.63
88_D104_V1.2540.63
330_T333_G1.2410.62
197_I274_A1.2320.61
236_Y288_I1.2310.61
53_P112_Y1.2140.60
326_T330_T1.2110.60
189_I216_D1.2020.59
138_R143_K1.1910.59
24_Y28_A1.1910.59
39_A43_A1.1870.58
325_D342_H1.1870.58
87_L196_P1.1790.58
296_G299_E1.1740.57
59_G144_L1.1600.57
124_P141_I1.1450.56
107_D112_Y1.1420.55
226_F274_A1.1360.55
159_T301_G1.1270.54
59_G133_C1.1210.54
330_T341_V1.1170.54
116_Y147_A1.1170.54
197_I280_W1.1150.53
76_L79_D1.1120.53
332_L335_V1.1110.53
44_W48_N1.1060.53
236_Y274_A1.1020.53
88_D112_Y1.1010.53
324_A328_G1.0980.52
110_T150_G1.0920.52
273_N303_W1.0910.52
106_E110_T1.0870.52
323_T342_H1.0640.50
105_F206_T1.0610.50
333_G343_A1.0590.50
324_A342_H1.0540.49
199_D278_T1.0520.49
60_L176_A1.0500.49
120_V140_F1.0470.49
107_D221_G1.0470.49
154_I188_I1.0430.49
64_C157_W1.0330.48
24_Y46_L1.0330.48
189_I217_V1.0320.48
66_T121_E1.0290.48
82_L133_C1.0280.48
274_A280_W1.0260.47
253_D257_K1.0250.47
230_R272_Y1.0210.47
60_L140_F1.0150.47
148_A176_A1.0060.46
23_K27_L1.0050.46
190_K300_N1.0030.46
130_G141_I1.0020.46
125_P174_T0.9960.45
128_E132_F0.9940.45
147_A154_I0.9930.45
60_L125_P0.9910.45
55_V108_I0.9910.45
80_V154_I0.9890.45
157_W205_I0.9880.45
189_I214_L0.9810.44
58_H91_D0.9780.44
59_G124_P0.9750.44
123_N176_A0.9740.44
236_Y289_Q0.9730.44
54_V117_I0.9720.44
40_P45_A0.9660.43
156_A161_A0.9620.43
68_S132_F0.9570.43
29_A38_M0.9530.43
267_K299_E0.9530.43
285_S290_S0.9490.42
131_M139_P0.9470.42
327_V331_A0.9410.42
61_E196_P0.9370.42
113_N149_A0.9370.42
118_L154_I0.9350.41
167_Q174_T0.9340.41
144_L148_A0.9330.41
328_G338_A0.9320.41
55_V105_F0.9210.40
328_G334_V0.9150.40
127_G130_G0.9130.40
200_V280_W0.9130.40
200_V236_Y0.9120.40
142_E219_R0.9070.40
200_V226_F0.9060.39
149_A252_D0.9050.39
163_W190_K0.8940.39
65_C287_P0.8900.38
72_S202_S0.8880.38
192_P263_K0.8880.38
248_Q252_D0.8820.38
326_T335_V0.8790.38
101_A108_I0.8760.38
191_V205_I0.8760.38
76_L202_S0.8760.38
323_T333_G0.8670.37
339_V342_H0.8660.37
36_A39_A0.8650.37
85_I191_V0.8650.37
142_E146_R0.8640.37
48_N52_I0.8620.37
123_N167_Q0.8610.37
339_V343_A0.8610.37
69_F117_I0.8580.36
337_A343_A0.8550.36
276_S286_F0.8540.36
69_F80_V0.8500.36
66_T73_A0.8480.36
29_A34_L0.8460.36
126_L175_Q0.8460.36
25_C97_A0.8440.36
104_V107_D0.8440.36
116_Y152_S0.8430.35
323_T329_L0.8430.35
18_R21_F0.8400.35
328_G339_V0.8390.35
53_P247_V0.8380.35
191_V201_M0.8350.35
71_R303_W0.8350.35
60_L167_Q0.8290.35
180_D190_K0.8230.34
155_I179_I0.8190.34
183_I187_P0.8180.34
69_F286_F0.8160.34
159_T162_S0.8160.34
218_D302_F0.8150.34
142_E145_K0.8130.34
83_S220_M0.8130.34
226_F240_H0.8130.34
231_I273_N0.8130.34
290_S302_F0.8110.34
192_P214_L0.8110.34
135_S143_K0.8100.33
93_L307_S0.8100.33
63_T221_G0.8090.33
237_R291_G0.8090.33
80_V202_S0.8090.33
126_L182_V0.8080.33
196_P251_D0.8050.33
236_Y286_F0.8030.33
199_D280_W0.8010.33
274_A287_P0.7990.33
100_Q103_E0.7990.33
68_S156_A0.7980.33
325_D328_G0.7970.33
139_P163_W0.7970.33
35_G293_G0.7950.33
207_Y211_F0.7940.32
216_D224_L0.7880.32
109_I114_G0.7820.32
24_Y105_F0.7810.32
323_T331_A0.7800.32
59_G287_P0.7790.32
161_A288_I0.7790.32
162_S259_Y0.7780.32
41_K44_W0.7760.31
76_L201_M0.7730.31
168_A301_G0.7710.31
67_E89_Y0.7680.31
54_V110_T0.7670.31
66_T281_N0.7650.31
197_I287_P0.7650.31
208_M212_D0.7650.31
112_Y115_K0.7650.31
329_L332_L0.7640.31
335_V338_A0.7640.31
108_I112_Y0.7640.31
35_G46_L0.7630.31
330_T334_V0.7630.31
250_W293_G0.7620.31
148_A183_I0.7610.31
71_R196_P0.7610.31
326_T331_A0.7600.30
65_C159_T0.7590.30
124_P179_I0.7560.30
195_P231_I0.7560.30
325_D335_V0.7540.30
274_A286_F0.7540.30
66_T155_I0.7490.30
41_K159_T0.7470.30
120_V144_L0.7450.30
327_V330_T0.7450.30
234_K276_S0.7350.29
67_E71_R0.7350.29
71_R287_P0.7290.29
35_G220_M0.7290.29
16_V343_A0.7290.29
198_P321_H0.7290.29
58_H66_T0.7270.29
44_W178_P0.7270.29
137_G154_I0.7260.29
208_M213_R0.7260.29
31_S72_S0.7250.29
331_A338_A0.7230.28
197_I236_Y0.7230.28
157_W165_C0.7220.28
92_T101_A0.7190.28
319_G342_H0.7180.28
68_S177_T0.7180.28
23_K191_V0.7170.28
71_R273_N0.7160.28
317_Q320_T0.7120.28
284_V298_A0.7090.28
58_H196_P0.7080.28
131_M134_I0.7070.28
59_G282_D0.7060.27
156_A190_K0.7060.27
145_K182_V0.7060.27
188_I221_G0.7030.27
130_G204_I0.7010.27
224_L228_G0.6980.27
162_S263_K0.6970.27
84_L202_S0.6950.27
65_C68_S0.6910.27
337_A342_H0.6870.26
72_S227_Y0.6860.26
61_E287_P0.6820.26
104_V108_I0.6800.26
185_D188_I0.6780.26
38_M41_K0.6760.26
188_I327_V0.6740.26
127_G141_I0.6730.26
18_R23_K0.6690.26
26_S30_T0.6680.25
327_V332_L0.6680.25
326_T329_L0.6650.25
42_I121_E0.6640.25
59_G83_S0.6640.25
39_A189_I0.6610.25
328_G335_V0.6600.25
257_K278_T0.6580.25
245_E255_A0.6570.25
96_A104_V0.6560.25
74_H227_Y0.6530.25
72_S283_G0.6520.25
338_A342_H0.6510.25
180_D221_G0.6510.25
226_F251_D0.6500.25
207_Y210_T0.6500.25
165_C300_N0.6490.25
200_V278_T0.6490.25
333_G337_A0.6480.24
16_V278_T0.6470.24
267_K296_G0.6440.24
130_G139_P0.6430.24
319_G324_A0.6430.24
53_P114_G0.6400.24
59_G267_K0.6390.24
95_A153_A0.6390.24
239_A244_G0.6380.24
197_I201_M0.6360.24
189_I246_F0.6360.24
156_A162_S0.6360.24
139_P310_S0.6330.24
16_V39_A0.6320.24
200_V273_N0.6300.24
271_T275_C0.6290.24
193_G258_G0.6290.24
171_P287_P0.6290.24
21_F45_A0.6270.23
205_I313_V0.6250.23
323_T328_G0.6230.23
228_G300_N0.6220.23
319_G327_V0.6200.23
191_V200_V0.6190.23
202_S280_W0.6170.23
52_I117_I0.6170.23
81_I267_K0.6150.23
49_K201_M0.6140.23
109_I150_G0.6140.23
66_T203_A0.6140.23
177_T181_K0.6130.23
226_F280_W0.6110.23
33_G65_C0.6110.23
25_C29_A0.6100.23
66_T92_T0.6060.22
269_P296_G0.6050.22
19_R22_L0.6030.22
173_P287_P0.6030.22
227_Y271_T0.6030.22
334_V341_V0.6020.22
181_K186_K0.6020.22
58_H197_I0.6020.22
148_A242_D0.6010.22
109_I147_A0.5980.22
280_W286_F0.5980.22
105_F139_P0.5980.22
237_R261_L0.5930.22
71_R200_V0.5930.22
234_K239_A0.5930.22
236_Y280_W0.5920.22
183_I188_I0.5900.22
326_T342_H0.5870.22
261_L291_G0.5860.21
30_T33_G0.5840.21
318_M321_H0.5840.21
128_E178_P0.5830.21
331_A335_V0.5820.21
69_F201_M0.5810.21
312_V315_I0.5810.21
15_G176_A0.5800.21
325_D339_V0.5780.21
144_L184_T0.5780.21
202_S245_E0.5770.21
144_L179_I0.5760.21
106_E138_R0.5760.21
97_A141_I0.5750.21
29_A32_L0.5740.21
200_V286_F0.5740.21
210_T213_R0.5740.21
127_G177_T0.5740.21
27_L213_R0.5730.21
325_D331_A0.5700.21
323_T339_V0.5690.21
54_V85_I0.5680.21
77_A321_H0.5680.21
321_H325_D0.5680.21
238_R244_G0.5670.21
113_N175_Q0.5670.21
70_I124_P0.5670.21
159_T192_P0.5650.21
129_Q132_F0.5650.21
251_D255_A0.5640.20
41_K48_N0.5620.20
318_M328_G0.5610.20
124_P154_I0.5600.20
332_L339_V0.5590.20
119_A123_N0.5560.20
77_A311_R0.5550.20
67_E259_Y0.5540.20
68_S197_I0.5530.20
207_Y214_L0.5530.20
58_H94_M0.5510.20
322_S326_T0.5510.20
105_F208_M0.5510.20
246_F261_L0.5500.20
326_T333_G0.5490.20
161_A179_I0.5490.20
262_Y287_P0.5490.20
18_R22_L0.5480.20
31_S66_T0.5480.20
302_F324_A0.5460.20
131_M191_V0.5460.20
69_F149_A0.5450.20
319_G322_S0.5450.20
319_G328_G0.5450.20
250_W291_G0.5420.20
230_R245_E0.5410.19
192_P270_T0.5400.19
90_D165_C0.5390.19
61_E91_D0.5390.19
197_I286_F0.5350.19
33_G148_A0.5340.19
101_A267_K0.5320.19
281_N299_E0.5310.19
36_A217_V0.5310.19
179_I198_P0.5270.19
159_T165_C0.5270.19
33_G49_K0.5270.19
147_A150_G0.5270.19
120_V179_I0.5260.19
125_P176_A0.5260.19
53_P108_I0.5250.19
117_I150_G0.5250.19
26_S138_R0.5230.19
69_F84_L0.5220.19
31_S301_G0.5210.19
139_P189_I0.5200.19
110_T142_E0.5190.19
167_Q231_I0.5180.19
227_Y292_H0.5160.18
101_A167_Q0.5150.18
205_I213_R0.5150.18
330_T335_V0.5140.18
240_H259_Y0.5140.18
67_E291_G0.5130.18
91_D247_V0.5130.18
275_C293_G0.5120.18
56_W231_I0.5120.18
234_K241_F0.5110.18
75_P340_G0.5050.18
112_Y145_K0.5040.18
260_C336_A0.5040.18
145_K184_T0.5030.18
118_L188_I0.5030.18
72_S75_P0.5030.18
335_V342_H0.5030.18
176_A241_F0.5020.18
60_L174_T0.5020.18
139_P147_A0.5020.18
52_I70_I0.5000.18
247_V342_H0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h2aS 1 0.7124 100 0.28 Contact Map
4ue3S 2 0.7124 100 0.29 Contact Map
4iucS 1 0.7124 100 0.308 Contact Map
2wpnA 1 0.6882 100 0.314 Contact Map
3ayxB 2 0.7258 100 0.342 Contact Map
3myrA 3 0.7177 100 0.366 Contact Map
4u9hS 1 0.707 100 0.368 Contact Map
4kn9S 1 0.6935 100 0.377 Contact Map
1yq9A 2 0.6962 100 0.379 Contact Map
4uqlA 1 0.7016 100 0.379 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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