GREMLIN Database
AMTB - Ammonia channel
UniProt: P69681 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11821
Length: 428 (393)
Sequences: 5418 (2876)
Seq/√Len: 145.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_V389_G4.6071.00
44_F229_I4.5581.00
397_K400_D4.0541.00
346_V350_M3.5741.00
293_G313_A3.3191.00
266_G311_V3.2881.00
200_G396_Y3.2281.00
84_Y159_T3.1951.00
301_I309_I3.1431.00
320_G342_V2.9011.00
408_P411_Q2.8881.00
174_L383_I2.8051.00
349_I378_L2.7191.00
227_T284_C2.7061.00
121_I250_A2.6651.00
353_I369_T2.6201.00
75_A264_I2.5841.00
345_I381_I2.5801.00
397_K401_L2.5331.00
375_L379_E2.5141.00
235_F257_V2.4481.00
272_W278_P2.4441.00
180_A380_S2.3251.00
316_A346_V2.3081.00
317_G343_C2.2791.00
105_L123_V2.2541.00
239_A253_F2.2471.00
393_F397_K2.2311.00
39_T124_A2.2151.00
312_V346_V2.1901.00
168_M174_L2.1871.00
294_V301_I2.0981.00
264_I287_A2.0861.00
203_L393_F2.0771.00
208_V409_E2.0591.00
181_L299_G2.0321.00
251_L255_N2.0301.00
152_I403_V2.0001.00
262_A307_L1.9731.00
78_C127_G1.9601.00
378_L382_A1.9551.00
165_I192_N1.9401.00
77_V158_L1.9281.00
407_V416_L1.9051.00
161_S391_V1.9041.00
38_C240_G1.8961.00
165_I384_T1.8911.00
187_T348_C1.8911.00
264_I283_A1.8741.00
88_L97_F1.8681.00
83_V104_M1.8641.00
141_L145_I1.8431.00
70_V138_V1.8081.00
134_V154_V1.7741.00
80_L155_V1.7581.00
224_F280_L1.7221.00
350_M353_I1.7071.00
82_V258_V1.6981.00
196_A388_S1.6971.00
31_D116_S1.6891.00
293_G309_I1.6871.00
372_H376_V1.6851.00
89_A166_A1.6781.00
178_H379_E1.6761.00
90_F122_H1.6681.00
57_L281_L1.6391.00
149_A399_A1.6361.00
72_V151_L1.6181.00
387_W391_V1.6161.00
270_G315_L1.5981.00
79_I307_L1.5791.00
78_C257_V1.5751.00
80_L163_I1.5561.00
223_V284_C1.5501.00
123_V254_V1.5391.00
102_W119_Q1.5311.00
194_A341_G1.5251.00
195_I389_G1.5171.00
411_Q419_N1.4921.00
349_I374_L1.4811.00
196_A392_A1.4771.00
86_Y119_Q1.4691.00
168_M383_I1.4661.00
178_H376_V1.4611.00
400_D404_G1.4491.00
191_I195_I1.4481.00
34_F37_I1.4471.00
30_A33_A1.4461.00
375_L378_L1.4441.00
258_V307_L1.4401.00
208_V413_R1.4351.00
146_R404_G1.4191.00
152_I399_A1.4161.00
68_T283_A1.4121.00
78_C261_A1.4121.00
399_A403_V1.3851.00
181_L300_Y1.3841.00
320_G338_G1.3821.00
379_E383_I1.3801.00
376_V379_E1.3641.00
220_L281_L1.3621.00
80_L159_T1.3571.00
43_L74_F1.3531.00
399_A402_T1.3351.00
43_L232_I1.3281.00
76_L155_V1.3271.00
80_L84_Y1.3251.00
195_I385_I1.3131.00
136_L336_V1.3101.00
367_G370_M1.3071.00
409_E413_R1.3061.00
346_V353_I1.2991.00
169_V188_V1.2781.00
156_V395_G1.2761.00
76_L151_L1.2761.00
32_N121_I1.2731.00
141_L200_G1.2711.00
145_I405_L1.2681.00
203_L397_K1.2651.00
79_I262_A1.2591.00
315_L319_W1.2531.00
32_N118_Y1.2521.00
28_D31_D1.2491.00
187_T384_T1.2421.00
270_G319_W1.2351.00
79_I265_L1.2351.00
65_S69_Q1.2321.00
82_V307_L1.2321.00
73_T150_V1.2221.00
218_H426_Y1.2181.00
242_A249_A1.2171.00
34_F38_C1.2031.00
35_M117_I1.2021.00
74_F131_C1.2001.00
242_A246_N1.1921.00
175_L380_S1.1841.00
219_N222_M1.1831.00
288_I339_V1.1721.00
195_I199_V1.1701.00
192_N388_S1.1681.00
210_F325_K1.1631.00
124_A253_F1.1621.00
414_E419_N1.1621.00
62_N416_L1.1621.00
352_G374_L1.1561.00
31_D246_N1.1511.00
374_L378_L1.1430.99
379_E382_A1.1420.99
140_A197_G1.1350.99
251_L303_V1.1350.99
201_A330_V1.1330.99
231_Y287_A1.1310.99
302_G356_A1.1270.99
55_G63_V1.1260.99
394_I398_L1.1220.99
40_A232_I1.1140.99
43_L128_S1.1110.99
169_V384_T1.1100.99
345_I385_I1.1070.99
304_G308_I1.1030.99
349_I381_I1.0880.99
39_T121_I1.0880.99
411_Q420_S1.0870.99
191_I385_I1.0850.99
146_R149_A1.0830.99
191_I381_I1.0820.99
35_M121_I1.0780.99
341_G385_I1.0720.99
158_L163_I1.0700.99
69_Q138_V1.0660.99
151_L155_V1.0650.99
198_L330_V1.0620.99
190_H193_A1.0580.99
80_L158_L1.0580.99
302_G305_G1.0560.99
46_T131_C1.0550.99
90_F126_Q1.0540.99
348_C381_I1.0530.99
57_L223_V1.0480.99
385_I389_G1.0480.99
410_E414_E1.0470.99
309_I350_M1.0450.99
399_A404_G1.0430.99
266_G314_G1.0400.99
65_S421_H1.0360.99
109_E113_V1.0300.99
258_V303_V1.0260.99
257_V260_T1.0200.99
202_Y330_V1.0200.99
171_G176_A1.0180.99
409_E412_E1.0150.99
398_L401_L1.0150.99
48_P225_T1.0140.99
159_T163_I1.0130.99
320_G324_L1.0090.99
33_A37_I1.0050.99
187_T191_I1.0030.99
308_I312_V1.0020.99
311_V315_L1.0020.99
179_G376_V0.9960.99
191_I345_I0.9940.99
386_V390_V0.9880.98
330_V338_G0.9870.98
262_A311_V0.9870.98
165_I387_W0.9860.98
40_A253_F0.9840.98
63_V218_H0.9840.98
391_V395_G0.9830.98
260_T263_A0.9810.98
102_W105_L0.9740.98
242_A248_I0.9740.98
111_T115_G0.9710.98
395_G399_A0.9700.98
199_V393_F0.9640.98
199_V203_L0.9640.98
396_Y405_L0.9630.98
66_M142_A0.9610.98
180_A348_C0.9610.98
312_V316_A0.9610.98
104_M304_G0.9570.98
209_G215_F0.9550.98
117_I243_G0.9530.98
35_M243_G0.9500.98
145_I204_I0.9480.98
59_R143_E0.9460.98
263_A286_G0.9450.98
285_S339_V0.9430.98
352_G377_Q0.9420.98
266_G315_L0.9360.98
353_I374_L0.9350.98
357_S370_M0.9350.98
203_L400_D0.9350.98
231_Y257_V0.9340.98
122_H243_G0.9340.98
120_Y251_L0.9340.98
160_L391_V0.9320.98
127_G257_V0.9310.98
389_G393_F0.9310.98
72_V268_I0.9270.98
265_L269_F0.9220.98
400_D403_V0.9210.98
289_A343_C0.9190.98
52_L225_T0.9190.98
406_R412_E0.9170.98
337_F341_G0.9140.97
301_I354_F0.9120.97
44_F232_I0.9110.97
372_H375_L0.9080.97
399_A405_L0.9060.97
63_V425_A0.9050.97
73_T154_V0.9030.97
79_I83_V0.9030.97
224_F284_C0.9020.97
234_W295_T0.9010.97
297_A301_I0.8960.97
138_V150_V0.8930.97
373_Q376_V0.8930.97
120_Y254_V0.8850.97
321_V338_G0.8820.97
312_V350_M0.8790.97
109_E112_A0.8760.97
41_L236_G0.8690.97
91_G99_N0.8660.97
319_W323_M0.8650.96
252_A298_C0.8650.96
172_G176_A0.8640.96
174_L379_E0.8610.96
272_W276_G0.8610.96
324_L338_G0.8610.96
120_Y250_A0.8600.96
58_I334_C0.8600.96
29_K244_T0.8550.96
202_Y389_G0.8540.96
174_L178_H0.8520.96
262_A266_G0.8470.96
390_V394_I0.8460.96
309_I354_F0.8450.96
378_L381_I0.8440.96
270_G314_G0.8390.96
149_A403_V0.8370.96
368_V371_G0.8350.96
269_F273_A0.8330.96
33_A245_A0.8320.96
382_A386_V0.8310.96
186_G296_P0.8280.96
259_A294_V0.8230.95
195_I341_G0.8220.95
126_Q241_S0.8210.95
255_N298_C0.8200.95
289_A339_V0.8180.95
268_I278_P0.8170.95
350_M354_F0.8120.95
111_T114_M0.8120.95
52_L221_P0.8100.95
63_V67_L0.8090.95
59_R215_F0.8090.95
30_A245_A0.8080.95
62_N143_E0.8040.95
46_T70_V0.8030.95
172_G177_S0.8030.95
323_M328_L0.8000.95
222_M225_T0.8000.95
300_Y355_A0.7970.94
305_G308_I0.7960.94
238_N295_T0.7920.94
165_I168_M0.7920.94
395_G398_L0.7910.94
393_F400_D0.7890.94
320_G323_M0.7880.94
66_M70_V0.7880.94
345_I349_I0.7870.94
110_L113_V0.7850.94
155_V159_T0.7840.94
374_L381_I0.7820.94
29_K32_N0.7780.94
394_I397_K0.7780.94
165_I388_S0.7720.93
263_A266_G0.7720.93
92_E101_N0.7720.93
84_Y163_I0.7710.93
220_L280_L0.7700.93
81_W166_A0.7670.93
35_M39_T0.7660.93
208_V212_K0.7650.93
112_A115_G0.7620.93
33_A38_C0.7600.93
192_N196_A0.7590.93
411_Q414_E0.7590.93
88_L163_I0.7580.93
156_V160_L0.7580.93
187_T292_V0.7570.93
73_T138_V0.7550.93
148_S152_I0.7540.93
52_L222_M0.7530.93
279_S423_E0.7520.93
161_S392_A0.7500.92
293_G346_V0.7470.92
293_G350_M0.7450.92
325_K335_D0.7440.92
266_G270_G0.7420.92
199_V202_Y0.7420.92
297_A309_I0.7420.92
167_H171_G0.7360.92
68_T147_F0.7340.92
294_V309_I0.7330.92
43_L131_C0.7320.92
392_A396_Y0.7320.92
117_I121_I0.7310.92
145_I396_Y0.7290.91
27_A32_N0.7280.91
118_Y121_I0.7250.91
195_I345_I0.7230.91
270_G318_L0.7230.91
102_W107_N0.7230.91
76_L265_L0.7220.91
64_L280_L0.7210.91
110_L114_M0.7200.91
198_L202_Y0.7200.91
407_V412_E0.7190.91
82_V123_V0.7180.91
157_W196_A0.7180.91
137_I196_A0.7170.91
321_V335_D0.7170.91
285_S314_G0.7150.91
187_T381_I0.7130.90
138_V141_L0.7120.90
323_M327_L0.7120.90
223_V281_L0.7120.90
102_W108_I0.7100.90
305_G370_M0.7080.90
145_I200_G0.7070.90
67_L224_F0.7060.90
341_G345_I0.7050.90
78_C287_A0.7040.90
141_L396_Y0.7040.90
50_I228_A0.7010.90
144_R331_D0.6990.90
129_F237_F0.6980.90
293_G343_C0.6970.89
277_K422_G0.6950.89
161_S395_G0.6940.89
28_D32_N0.6930.89
65_S138_V0.6910.89
32_N117_I0.6900.89
181_L355_A0.6890.89
206_K329_R0.6850.89
86_Y122_H0.6830.89
147_F421_H0.6810.88
59_R209_G0.6800.88
153_F392_A0.6790.88
87_S100_I0.6780.88
87_S91_G0.6770.88
139_G332_D0.6770.88
183_F252_A0.6760.88
148_S272_W0.6750.88
132_I135_G0.6740.88
86_Y90_F0.6730.88
169_V176_A0.6720.88
72_V147_F0.6710.88
204_I405_L0.6690.88
195_I337_F0.6680.87
314_G317_G0.6680.87
130_A158_L0.6670.87
197_G201_A0.6660.87
274_L318_L0.6630.87
153_F196_A0.6610.87
50_I132_I0.6600.87
245_A249_A0.6570.87
316_A342_V0.6560.86
386_V393_F0.6560.86
356_A370_M0.6550.86
324_L337_F0.6550.86
100_I103_L0.6550.86
92_E95_N0.6540.86
242_A252_A0.6520.86
66_M69_Q0.6520.86
27_A113_V0.6500.86
78_C131_C0.6500.86
170_W188_V0.6490.86
280_L284_C0.6480.86
313_A346_V0.6470.86
271_E282_G0.6450.86
205_G406_R0.6450.86
153_F157_W0.6420.85
192_N384_T0.6390.85
180_A187_T0.6380.85
319_W324_L0.6360.85
113_V116_S0.6360.85
259_A313_A0.6360.85
88_L164_P0.6340.85
282_G317_G0.6320.84
314_G346_V0.6310.84
64_L423_E0.6310.84
390_V393_F0.6290.84
254_V303_V0.6290.84
268_I283_A0.6270.84
200_G392_A0.6260.84
36_M40_A0.6250.84
48_P229_I0.6220.83
153_F396_Y0.6210.83
69_Q142_A0.6200.83
74_F257_V0.6170.83
78_C258_V0.6160.83
351_T374_L0.6160.83
62_N407_V0.6160.83
195_I388_S0.6160.83
382_A385_I0.6150.83
238_N241_S0.6150.83
169_V180_A0.6150.83
45_M238_N0.6120.82
305_G356_A0.6110.82
39_T128_S0.6100.82
141_L150_V0.6090.82
348_C351_T0.6080.82
270_G316_A0.6070.82
36_M253_F0.6070.82
191_I341_G0.6060.82
86_Y102_W0.6050.82
146_R411_Q0.6050.82
74_F127_G0.6050.82
263_A293_G0.6050.82
418_V424_N0.6040.82
190_H340_H0.6030.82
289_A317_G0.5980.81
34_F242_A0.5980.81
234_W291_L0.5980.81
147_F278_P0.5970.81
308_I354_F0.5960.81
356_A359_L0.5960.81
81_W89_A0.5960.81
124_A127_G0.5930.80
137_I157_W0.5920.80
338_G341_G0.5920.80
274_L322_T0.5910.80
190_H348_C0.5910.80
128_S189_V0.5910.80
45_M230_L0.5890.80
88_L100_I0.5890.80
370_M374_L0.5890.80
101_N104_M0.5880.80
33_A40_A0.5870.80
302_G370_M0.5870.80
168_M387_W0.5850.80
175_L180_A0.5830.79
75_A265_L0.5830.79
237_F295_T0.5820.79
36_M250_A0.5820.79
69_Q150_V0.5810.79
143_E215_F0.5800.79
93_G167_H0.5790.79
91_G102_W0.5790.79
410_E413_R0.5770.79
161_S388_S0.5770.79
110_L115_G0.5770.79
357_S360_G0.5770.79
324_L328_L0.5740.78
207_R331_D0.5730.78
227_T287_A0.5710.78
65_S141_L0.5710.78
338_G342_V0.5700.78
123_V127_G0.5700.78
414_E418_V0.5690.78
251_L359_L0.5690.78
238_N256_T0.5680.78
237_F256_T0.5670.77
128_S253_F0.5630.77
248_I251_L0.5630.77
74_F78_C0.5610.77
375_L382_A0.5570.76
87_S101_N0.5560.76
71_T287_A0.5560.76
203_L396_Y0.5540.76
73_T135_G0.5540.76
312_V354_F0.5540.76
67_L280_L0.5530.76
376_V380_S0.5510.75
67_L221_P0.5490.75
300_Y360_G0.5470.75
155_V265_L0.5470.75
323_M330_V0.5460.75
73_T134_V0.5450.75
352_G369_T0.5450.75
109_E114_M0.5440.75
351_T373_Q0.5440.75
137_I141_L0.5440.75
84_Y158_L0.5430.74
384_T388_S0.5420.74
249_A252_A0.5420.74
59_R62_N0.5410.74
39_T253_F0.5400.74
248_I252_A0.5400.74
111_T116_S0.5390.74
387_W390_V0.5380.74
77_V134_V0.5380.74
89_A163_I0.5360.73
152_I395_G0.5360.73
66_M138_V0.5360.73
269_F272_W0.5350.73
367_G371_G0.5350.73
307_L311_V0.5350.73
184_A241_S0.5340.73
301_I306_A0.5340.73
302_G306_A0.5340.73
151_L272_W0.5290.72
263_A288_I0.5290.72
279_S282_G0.5280.72
82_V304_G0.5280.72
141_L154_V0.5280.72
61_K215_F0.5270.72
373_Q377_Q0.5270.72
199_V385_I0.5270.72
312_V353_I0.5260.72
50_I69_Q0.5260.72
134_V141_L0.5240.72
187_T380_S0.5240.72
153_F399_A0.5220.71
69_Q141_L0.5210.71
305_G354_F0.5200.71
31_D244_T0.5200.71
51_A67_L0.5200.71
117_I122_H0.5190.71
388_S392_A0.5180.71
103_L106_K0.5160.71
194_A344_G0.5160.71
367_G373_Q0.5160.71
248_I360_G0.5160.71
134_V158_L0.5160.71
324_L342_V0.5150.70
190_H260_T0.5150.70
91_G167_H0.5140.70
155_V158_L0.5140.70
29_K245_A0.5130.70
275_R322_T0.5120.70
46_T135_G0.5120.70
257_V261_A0.5120.70
27_A31_D0.5110.70
267_W282_G0.5110.70
44_F48_P0.5100.70
392_A395_G0.5100.70
188_V384_T0.5100.70
38_C128_S0.5090.70
122_H126_Q0.5080.69
386_V389_G0.5080.69
110_L176_A0.5070.69
95_N177_S0.5050.69
94_N97_F0.5040.69
146_R402_T0.5040.69
42_V236_G0.5040.69
301_I305_G0.5010.68
120_Y303_V0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b2hA 3 0.9065 100 0.067 Contact Map
1u7gA 3 0.8949 100 0.121 Contact Map
3hd6A 3 0.8785 100 0.287 Contact Map
3b9wA 3 0.8224 100 0.313 Contact Map
4tphA 2 0.4673 37.6 0.971 Contact Map
1pw4A 1 0.4556 36.8 0.971 Contact Map
4xnjA 1 0.4673 35.3 0.972 Contact Map
4j05A 3 0.8037 31.6 0.972 Contact Map
2qi9A 2 0.493 30.5 0.973 Contact Map
4pypA 1 0.4486 19.8 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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