GREMLIN Database
APT - Adenine phosphoribosyltransferase
UniProt: P69503 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10051
Length: 183 (167)
Sequences: 4547 (2611)
Seq/√Len: 202.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_K148_E3.2881.00
94_E113_V2.6891.00
159_F179_P2.6731.00
59_K120_D2.6501.00
98_E140_K2.5641.00
17_S27_L2.5391.00
162_G165_Q2.4691.00
98_E144_R2.3961.00
157_N164_E2.3441.00
99_T108_Q2.3311.00
164_E168_E2.2821.00
58_T120_D2.2061.00
46_D77_G2.1971.00
16_K93_R2.1431.00
101_D106_T2.1041.00
142_I147_G2.0781.00
135_I154_F2.0031.00
51_R175_Y1.9551.00
14_S40_A1.9451.00
136_E140_K1.9051.00
97_S108_Q1.8851.00
42_A77_G1.8811.00
17_S29_R1.8311.00
136_E166_R1.8141.00
49_V77_G1.7991.00
117_K120_D1.7851.00
61_V85_V1.7851.00
50_E53_K1.7441.00
85_V138_T1.7201.00
96_I145_L1.7171.00
57_I80_V1.7161.00
56_G121_K1.6911.00
97_S110_E1.6841.00
63_T138_T1.6751.00
143_R170_Q1.6631.00
20_D24_P1.6471.00
99_T106_T1.5721.00
14_S37_D1.5471.00
139_V152_A1.5231.00
47_L50_E1.5161.00
75_A82_F1.5141.00
41_Y72_A1.4871.00
61_V142_I1.4691.00
118_P146_G1.4631.00
121_K150_A1.4571.00
42_A76_L1.4541.00
55_A173_T1.4411.00
96_I113_V1.4021.00
135_I152_A1.3741.00
48_L153_A1.3691.00
59_K83_V1.3531.00
32_T112_H1.3501.00
52_Y153_A1.3351.00
19_Q27_L1.3201.00
39_K79_G1.3011.00
125_V153_A1.2891.00
165_Q168_E1.2861.00
93_R112_H1.2591.00
48_L74_V1.2371.00
52_Y151_D1.2351.00
52_Y123_L1.2331.00
116_I147_G1.2311.00
62_G82_F1.2201.00
128_L156_I1.2161.00
71_G82_F1.2131.00
165_Q169_K1.1731.00
29_R160_D1.1581.00
46_D76_L1.1451.00
15_I178_V1.1441.00
88_P108_Q1.1381.00
124_V138_T1.1381.00
88_P107_D1.1361.00
42_A46_D1.1231.00
49_V74_V1.1221.00
42_A79_G1.1141.00
43_L46_D1.1131.00
49_V78_L1.1101.00
60_V80_V1.1031.00
57_I123_L1.0891.00
116_I142_I1.0731.00
102_L105_G1.0711.00
140_K143_R1.0711.00
142_I149_V1.0691.00
56_G80_V1.0681.00
44_S155_I1.0631.00
59_K81_G1.0471.00
139_V143_R1.0431.00
57_I78_L1.0321.00
123_L151_D1.0281.00
51_R151_D1.0271.00
52_Y57_I1.0191.00
143_R148_E1.0141.00
164_E174_S0.9881.00
123_L150_A0.9680.99
49_V53_K0.9670.99
32_T84_P0.9630.99
41_Y73_P0.9530.99
45_I74_V0.9360.99
72_A82_F0.9300.99
124_V135_I0.9300.99
47_L51_R0.9240.99
119_G148_E0.9180.99
70_F155_I0.9160.99
58_T119_G0.9130.99
11_L43_L0.9130.99
11_L47_L0.9090.99
139_V149_V0.9000.99
96_I144_R0.8970.99
61_V138_T0.8730.99
59_K116_I0.8640.99
176_S179_P0.8630.99
73_P76_L0.8550.99
69_L84_P0.8530.99
157_N179_P0.8440.99
74_V125_V0.8410.99
61_V111_I0.8320.98
63_T109_L0.8310.98
157_N163_G0.8190.98
41_Y45_I0.8100.98
45_I73_P0.8070.98
44_S48_L0.8050.98
124_V139_V0.7960.98
48_L125_V0.7940.98
47_L177_L0.7940.98
140_K144_R0.7900.98
23_K26_I0.7770.98
95_T110_E0.7730.98
45_I76_L0.7690.97
61_V124_V0.7650.97
43_L47_L0.7610.97
48_L51_R0.7600.97
16_K33_S0.7580.97
136_E170_Q0.7550.97
34_L44_S0.7540.97
124_V152_A0.7480.97
57_I60_V0.7440.97
159_F162_G0.7420.97
18_I93_R0.7380.97
129_L154_F0.7380.97
47_L175_Y0.7370.97
69_L82_F0.7360.97
96_I111_I0.7350.97
53_K77_G0.7320.97
17_S160_D0.7170.96
93_R113_V0.7140.96
31_V35_L0.7140.96
103_E106_T0.7090.96
151_D173_T0.7050.96
157_N176_S0.7040.96
114_D145_L0.7040.96
170_Q173_T0.6910.95
33_S36_E0.6870.95
11_L178_V0.6870.95
32_T155_I0.6830.95
40_A43_L0.6830.95
52_Y55_A0.6790.95
28_F156_I0.6780.95
41_Y69_L0.6780.95
22_P25_G0.6730.95
58_T80_V0.6720.94
23_K107_D0.6670.94
122_V142_I0.6660.94
14_S18_I0.6610.94
88_P110_E0.6610.94
88_P97_S0.6610.94
54_N57_I0.6590.94
18_I112_H0.6560.94
159_F164_E0.6530.94
128_L158_L0.6500.93
139_V170_Q0.6490.93
59_K117_K0.6470.93
153_A175_Y0.6450.93
39_K43_L0.6450.93
27_L160_D0.6450.93
55_A121_K0.6410.93
33_S128_L0.6400.93
41_Y70_F0.6400.93
113_V144_R0.6350.93
151_D175_Y0.6350.93
51_R153_A0.6330.93
61_V116_I0.6300.92
38_P76_L0.6290.92
45_I77_G0.6270.92
52_Y175_Y0.6260.92
69_L72_A0.6240.92
129_L163_G0.6240.92
12_K17_S0.6230.92
133_G166_R0.6220.92
94_E114_D0.6210.92
57_I151_D0.6140.91
140_K170_Q0.6140.91
11_L14_S0.6130.91
44_S70_F0.6090.91
16_K114_D0.6040.91
154_F174_S0.6020.91
124_V142_I0.6010.91
143_R152_A0.5960.90
112_H115_A0.5890.90
96_I99_T0.5840.89
13_N17_S0.5810.89
28_F90_K0.5780.89
60_V75_A0.5780.89
86_R107_D0.5780.89
48_L155_I0.5770.89
59_K122_V0.5770.89
60_V78_L0.5720.88
81_G84_P0.5690.88
37_D40_A0.5670.88
17_S128_L0.5610.87
154_F176_S0.5560.87
12_K178_V0.5550.87
94_E112_H0.5500.86
36_E117_K0.5470.86
38_P72_A0.5470.86
135_I167_L0.5450.86
70_F125_V0.5420.85
51_R173_T0.5390.85
49_V73_P0.5370.85
11_L44_S0.5370.85
15_I29_R0.5370.85
29_R158_L0.5320.84
152_A167_L0.5270.84
21_Y26_I0.5270.84
52_Y60_V0.5270.84
95_T112_H0.5260.84
120_D147_G0.5260.84
71_G78_L0.5250.84
60_V74_V0.5240.83
89_G110_E0.5240.83
31_V70_F0.5230.83
35_L69_L0.5230.83
55_A150_A0.5220.83
102_L107_D0.5170.83
31_V155_I0.5160.83
71_G75_A0.5160.83
35_L70_F0.5140.82
15_I18_I0.5130.82
136_E169_K0.5130.82
143_R149_V0.5090.82
86_R90_K0.5080.82
49_V123_L0.5070.81
44_S47_L0.5060.81
116_I120_D0.5030.81
129_L167_L0.5030.81
60_V123_L0.5030.81
62_G81_G0.5020.81
133_G162_G0.5020.81
41_Y125_V0.5010.81
93_R114_D0.5010.81
57_I121_K0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m0kA 2 0.9617 100 0.329 Contact Map
4lzaA 2 0.9399 100 0.336 Contact Map
2dy0A 2 0.9945 100 0.434 Contact Map
1qb7A 2 1 100 0.435 Contact Map
1zn8A 2 0.9617 100 0.477 Contact Map
1g2qA 2 0.9508 100 0.478 Contact Map
1l1qA 2 0.9727 100 0.478 Contact Map
1o57A 2 0.9399 100 0.544 Contact Map
1y0bA 2 0.9781 100 0.552 Contact Map
3qw4B 4 0.8907 100 0.555 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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