GREMLIN Database
CUTA - Divalent-cation tolerance protein CutA
UniProt: P69488 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12177
Length: 112 (102)
Sequences: 1692 (1312)
Seq/√Len: 129.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_E79_C2.5171.00
23_T85_P2.4311.00
99_G104_L2.4021.00
32_L49_L2.3071.00
73_Q77_L2.2861.00
11_S107_L2.0631.00
16_C80_L2.0221.00
25_Q58_Q1.9991.00
29_A58_Q1.8871.00
79_C83_H1.8091.00
40_A66_L1.7721.00
30_K79_C1.7501.00
81_K102_D1.7121.00
31_V66_L1.6811.00
72_H75_A1.6611.00
19_P85_P1.6181.00
37_A66_L1.6131.00
69_T72_H1.5611.00
20_D23_T1.5541.00
21_E25_Q1.5351.00
14_V76_L1.5331.00
19_P23_T1.4511.00
31_V76_L1.4071.00
63_Q90_E1.3971.00
25_Q47_T1.3841.00
53_E87_Q1.3691.00
12_V93_V1.3521.00
43_I63_Q1.3161.00
37_A40_A1.2781.00
47_T58_Q1.2721.00
42_L49_L1.2691.00
73_Q93_V1.2641.00
77_L81_K1.2551.00
30_K83_H1.2421.00
88_T102_D1.2221.00
42_L62_V1.2221.00
12_V73_Q1.2171.00
27_L83_H1.2030.99
16_C66_L1.2000.99
105_S109_A1.1940.99
35_K51_Y1.1910.99
18_A64_M1.1870.99
50_Y59_E1.1480.99
41_T46_A1.1320.99
41_T63_Q1.1300.99
40_A64_M1.1280.99
43_I65_I1.1140.99
15_L90_E1.1130.99
29_A33_A1.1080.99
51_Y56_L1.0860.99
11_S108_N1.0800.99
31_V37_A1.0770.99
30_K34_E1.0670.99
15_L94_L1.0580.99
90_E103_Y1.0460.98
88_T100_D1.0430.98
53_E57_E1.0420.98
79_C82_S1.0410.98
92_L96_V1.0320.98
12_V70_V1.0260.98
35_K110_S1.0210.98
46_A63_Q1.0200.98
11_S99_G1.0150.98
51_Y110_S0.9960.98
15_L65_I0.9890.98
32_L37_A0.9770.98
21_E47_T0.9760.98
23_T26_D0.9540.97
15_L63_Q0.9460.97
78_E82_S0.9400.97
81_K100_D0.9370.97
69_T111_L0.9320.97
96_V99_G0.9240.97
18_A62_V0.9180.97
28_A40_A0.9090.96
31_V79_C0.8890.96
74_Q78_E0.8790.96
18_A27_L0.8720.95
39_C67_K0.8700.95
101_T105_S0.8650.95
15_L41_T0.8600.95
11_S96_V0.8450.95
50_Y57_E0.8450.95
73_Q91_L0.8390.94
72_H111_L0.8200.94
69_T108_N0.8090.93
80_L91_L0.8010.93
68_T76_L0.7960.93
28_A42_L0.7950.93
33_A56_L0.7890.92
21_E60_Y0.7880.92
25_Q49_L0.7860.92
13_V65_I0.7780.92
38_A107_L0.7770.92
17_T63_Q0.7770.92
77_L91_L0.7730.91
32_L51_Y0.7700.91
17_T41_T0.7640.91
18_A85_P0.7610.91
41_T90_E0.7510.90
77_L100_D0.7420.90
13_V94_L0.7370.89
28_A49_L0.7350.89
105_S108_N0.7340.89
14_V91_L0.7300.89
33_A51_Y0.7300.89
27_L79_C0.7290.89
103_Y107_L0.7130.88
81_K91_L0.7080.87
21_E44_P0.7030.87
20_D62_V0.6750.85
16_C90_E0.6710.85
67_K90_E0.6700.84
93_V97_T0.6670.84
14_V73_Q0.6580.83
25_Q42_L0.6450.82
13_V90_E0.6360.81
74_Q77_L0.6340.81
11_S104_L0.6330.81
88_T107_L0.6290.81
77_L98_H0.6280.80
72_H76_L0.6240.80
34_E82_S0.6240.80
93_V98_H0.6130.79
36_L79_C0.6100.79
41_T65_I0.5960.77
43_I46_A0.5950.77
77_L93_V0.5940.77
99_G107_L0.5850.76
26_D30_K0.5830.75
74_Q98_H0.5800.75
96_V104_L0.5800.75
108_N111_L0.5710.74
49_L56_L0.5590.72
30_K33_A0.5540.72
39_C86_Y0.5530.71
49_L58_Q0.5510.71
44_P62_V0.5490.71
99_G108_N0.5470.71
45_G62_V0.5450.70
66_L90_E0.5420.70
73_Q100_D0.5390.70
75_A78_E0.5360.69
66_L80_L0.5340.69
25_Q29_A0.5300.68
34_E83_H0.5210.67
10_A70_V0.5170.66
18_A24_A0.5130.66
92_L103_Y0.5120.66
45_G60_Y0.5040.64
68_T111_L0.5030.64
14_V93_V0.5020.64
18_A23_T0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zfhA 3 0.9643 100 0.069 Contact Map
4e98A 3 0.9821 100 0.07 Contact Map
4iyqA 3 0.9464 100 0.082 Contact Map
3gsdA 6 0.9375 100 0.082 Contact Map
1oscA 5 0.9643 100 0.087 Contact Map
1naqA 5 0.9464 100 0.094 Contact Map
1kr4A 3 0.9643 100 0.104 Contact Map
2zomA 3 0.9554 100 0.105 Contact Map
2nuhA 3 0.9286 100 0.105 Contact Map
3ahpA 3 0.9464 100 0.122 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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