GREMLIN Database
KAD - Adenylate kinase
UniProt: P69441 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10032
Length: 214 (206)
Sequences: 4130 (2463)
Seq/√Len: 171.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_D172_H3.5851.00
50_K54_D3.0711.00
118_D136_K2.8361.00
35_L64_V2.7461.00
71_R76_D2.7101.00
52_I60_T2.6361.00
23_K210_E2.6241.00
200_K208_D2.5551.00
124_R135_V2.5041.00
48_Q51_D2.4751.00
110_D195_K2.4631.00
200_K204_E2.4321.00
37_A41_S2.3151.00
108_E195_K2.3111.00
97_K185_E2.2991.00
19_F206_R2.2831.00
65_I86_F2.2721.00
157_K160_Q2.2591.00
122_G134_H2.2581.00
38_A70_E2.2371.00
109_F198_G2.2141.00
126_H129_S2.1931.00
169_V173_Q2.1791.00
183_S195_K2.0951.00
127_A154_T2.0871.00
127_A151_E1.8621.00
44_E48_Q1.8421.00
24_Y210_E1.8401.00
65_I95_A1.7401.00
166_K169_V1.7191.00
42_G47_K1.6841.00
105_Y194_A1.6351.00
48_Q66_A1.6321.00
161_E165_R1.6001.00
44_E47_K1.5921.00
146_D149_T1.5741.00
75_E78_R1.5731.00
126_H149_T1.5721.00
145_K152_E1.5701.00
23_K206_R1.5501.00
120_I164_V1.5371.00
129_S149_T1.5251.00
127_A152_E1.5021.00
71_R74_Q1.5001.00
170_E174_M1.4951.00
115_L199_T1.4841.00
39_V53_M1.4811.00
194_A212_I1.4761.00
176_A180_G1.4711.00
51_D55_A1.4471.00
115_L118_D1.4411.00
19_F203_A1.4311.00
16_Q209_L1.4181.00
128_P149_T1.4111.00
126_H146_D1.4081.00
112_P199_T1.3971.00
201_P204_E1.3831.00
97_K181_Y1.3721.00
129_S146_D1.3591.00
117_V165_R1.3441.00
10_G120_I1.3291.00
11_A111_V1.3281.00
27_P71_R1.2821.00
122_G135_V1.2821.00
206_R210_E1.2721.00
207_A211_K1.2691.00
38_A43_S1.2611.00
142_V145_K1.2561.00
204_E208_D1.2531.00
111_V198_G1.2461.00
113_D165_R1.2361.00
60_T63_L1.2291.00
160_Q163_T1.2061.00
38_A41_S1.1951.00
125_V132_V1.1921.00
81_F103_V1.1631.00
69_K99_A1.1571.00
200_K205_V1.1491.00
2_R101_I1.1441.00
180_G184_K1.1401.00
38_A67_L1.1361.00
124_R155_T1.1311.00
172_H176_A1.1271.00
63_L66_A1.1231.00
121_V161_E1.1221.00
186_A193_Y1.1181.00
32_G36_R1.1151.00
18_Q22_E1.1061.00
52_I57_K1.1021.00
25_G79_N1.0991.00
117_V121_V1.0971.00
4_I103_V1.0961.00
113_D169_V1.0701.00
91_P94_D1.0691.00
197_D205_V1.0651.00
48_Q62_E1.0510.99
134_H137_F1.0490.99
166_K170_E1.0440.99
71_R77_C1.0370.99
107_L209_L1.0370.99
34_M38_A1.0270.99
108_E179_I1.0160.99
197_D200_K1.0100.99
168_L172_H1.0070.99
131_R148_V1.0020.99
8_A171_Y1.0020.99
35_L39_V0.9940.99
5_L109_F0.9930.99
6_L179_I0.9810.99
5_L20_I0.9800.99
26_I81_F0.9780.99
204_E207_A0.9750.99
156_R159_D0.9720.99
141_K147_D0.9690.99
165_R169_V0.9680.99
37_A71_R0.9650.99
69_K73_A0.9620.99
140_P147_D0.9600.99
196_V205_V0.9590.99
146_D151_E0.9550.99
43_S46_G0.9400.99
113_D168_L0.9390.99
202_V206_R0.9380.99
21_M28_Q0.9350.99
185_E192_K0.9330.99
49_A52_I0.9270.99
49_A66_A0.9230.99
5_L17_A0.9120.99
14_G84_D0.9040.98
19_F22_E0.9020.98
181_Y185_E0.8990.98
207_A210_E0.8970.98
186_A192_K0.8860.98
57_K166_K0.8850.98
102_N192_K0.8830.98
142_V147_D0.8810.98
106_V193_Y0.8810.98
131_R138_N0.8770.98
94_D97_K0.8750.98
49_A53_M0.8740.98
171_Y175_T0.8700.98
26_I80_G0.8700.98
20_I209_L0.8700.98
66_A69_K0.8690.98
16_Q206_R0.8670.98
5_L82_L0.8660.98
73_A99_A0.8650.98
208_D211_K0.8640.98
196_V212_I0.8630.98
126_H131_R0.8610.98
149_T152_E0.8610.98
27_P77_C0.8570.98
103_V192_K0.8550.98
90_I94_D0.8490.98
20_I82_L0.8390.97
94_D98_E0.8350.97
180_G183_S0.8320.97
163_T166_K0.8280.97
2_R103_V0.8120.97
97_K182_Y0.8100.97
114_E165_R0.8090.97
124_R153_L0.8080.97
94_D181_Y0.8070.97
126_H151_E0.8070.97
61_D92_Q0.8010.97
178_L193_Y0.7990.97
38_A49_A0.7910.96
117_V164_V0.7860.96
65_I68_V0.7830.96
196_V209_L0.7820.96
2_R104_D0.7810.96
144_G147_D0.7690.96
41_S74_Q0.7650.96
27_P76_D0.7620.96
122_G137_F0.7480.95
95_A98_E0.7460.95
42_G50_K0.7320.95
151_E154_T0.7240.94
108_E193_Y0.7210.94
197_D208_D0.7200.94
61_D89_T0.7200.94
37_A74_Q0.7160.94
45_L66_A0.7140.94
131_R146_D0.7120.94
71_R80_G0.7090.94
70_E74_Q0.7090.94
32_G88_R0.7070.93
39_V46_G0.7070.93
128_P151_E0.7060.93
35_L68_V0.7040.93
35_L53_M0.7000.93
110_D179_I0.6970.93
28_Q33_D0.6930.93
131_R149_T0.6920.93
6_L178_L0.6920.93
178_L182_Y0.6850.92
34_M67_L0.6830.92
47_K50_K0.6810.92
38_A46_G0.6790.92
199_T205_V0.6730.92
38_A66_A0.6670.91
30_S33_D0.6660.91
18_Q28_Q0.6660.91
87_P92_Q0.6650.91
112_P115_L0.6640.91
47_K51_D0.6620.91
139_P143_E0.6620.91
175_T178_L0.6600.91
159_D163_T0.6590.91
125_V154_T0.6560.91
6_L171_Y0.6470.90
208_D212_I0.6470.90
12_G15_T0.6470.90
123_R159_D0.6400.90
51_D54_D0.6350.89
111_V116_I0.6330.89
116_I164_V0.6300.89
134_H140_P0.6290.89
179_I193_Y0.6290.89
36_R88_R0.6260.89
3_I105_Y0.6260.89
149_T153_L0.6260.89
16_Q196_V0.6250.88
175_T179_I0.6240.88
122_G136_K0.6190.88
22_E148_V0.6190.88
14_G36_R0.6170.88
48_Q52_I0.6170.88
85_G88_R0.6150.88
129_S148_V0.6120.87
7_G10_G0.6080.87
117_V161_E0.6060.87
58_L88_R0.6060.87
58_L158_D0.6060.87
129_S151_E0.6040.87
24_Y206_R0.6030.87
62_E66_A0.6030.87
6_L106_V0.6030.87
41_S49_A0.6010.86
162_E166_K0.5970.86
2_R6_L0.5960.86
45_L67_L0.5960.86
135_V155_T0.5950.86
16_Q205_V0.5940.86
49_A55_A0.5910.86
10_G164_V0.5890.85
32_G58_L0.5880.85
27_P80_G0.5870.85
145_K150_G0.5860.85
77_C80_G0.5860.85
155_T161_E0.5850.85
29_I81_F0.5810.85
156_R167_R0.5800.84
71_R75_E0.5790.84
176_A179_I0.5780.84
93_A182_Y0.5770.84
64_V68_V0.5760.84
52_I63_L0.5760.84
106_V192_K0.5730.84
121_V160_Q0.5720.84
20_I206_R0.5720.84
146_D150_G0.5720.84
153_L159_D0.5710.84
66_A70_E0.5700.83
18_Q21_M0.5680.83
114_E118_D0.5650.83
52_I55_A0.5590.82
70_E73_A0.5590.82
48_Q63_L0.5580.82
72_I77_C0.5530.82
105_Y192_K0.5530.82
8_A11_A0.5440.81
56_G84_D0.5330.79
126_H152_E0.5330.79
90_I181_Y0.5320.79
99_A102_N0.5320.79
209_L212_I0.5320.79
69_K98_E0.5300.79
9_P116_I0.5300.79
22_E25_G0.5300.79
135_V153_L0.5290.79
34_M68_V0.5280.79
7_G12_G0.5260.78
35_L49_A0.5260.78
51_D63_L0.5250.78
54_D157_K0.5240.78
45_L48_Q0.5230.78
19_F202_V0.5230.78
43_S49_A0.5230.78
49_A60_T0.5220.78
116_I168_L0.5220.78
46_G49_A0.5210.78
15_T119_R0.5210.78
128_P131_R0.5200.78
113_D117_V0.5200.78
111_V119_R0.5180.77
140_P144_G0.5140.77
76_D80_G0.5140.77
49_A67_L0.5120.76
3_I103_V0.5120.76
155_T160_Q0.5110.76
140_P143_E0.5100.76
13_K32_G0.5090.76
5_L107_L0.5080.76
85_G92_Q0.5060.76
29_I34_M0.5030.75
21_M25_G0.5010.75
7_G11_A0.5010.75
14_G167_R0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qbgB 1 0.9766 100 0.322 Contact Map
4jzkA 1 1 100 0.322 Contact Map
3gmtA 1 0.9206 100 0.334 Contact Map
3be4A 1 0.9626 100 0.341 Contact Map
4pzlA 2 1 100 0.344 Contact Map
3tlxA 1 0.9766 100 0.353 Contact Map
2xb4A 4 0.9907 100 0.362 Contact Map
1ak2A 1 0.9766 100 0.366 Contact Map
1akyA 1 0.9766 100 0.368 Contact Map
1zd8A 1 0.9626 100 0.375 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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