GREMLIN Database
TATA - Sec-independent protein translocase protein TatA
UniProt: P69428 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11478
Length: 89 (74)
Sequences: 684 (570)
Seq/√Len: 66.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_Q11_I2.3051.00
4_I9_L2.2941.00
69_A72_N2.2551.00
14_V17_V2.1791.00
70_D74_E2.1461.00
49_K52_K2.0061.00
4_I8_Q1.9941.00
1_M13_A1.9071.00
71_T74_E1.8061.00
3_G9_L1.6430.99
70_D73_Q1.5260.99
9_L19_L1.5000.99
13_A35_S1.4830.99
2_G6_I1.4790.99
26_G34_A1.4670.98
50_Q53_T1.4650.98
36_I42_A1.4300.98
41_K44_S1.4040.98
46_D49_K1.4020.98
56_D59_F1.4000.98
67_K70_D1.3990.98
2_G7_W1.3870.98
23_K30_S1.3790.98
30_S35_S1.3500.97
1_M9_L1.3360.97
67_K71_T1.3200.97
65_A68_Q1.3140.97
41_K45_D1.2680.96
30_S38_G1.2600.96
15_I19_L1.2480.96
60_T63_T1.2410.96
13_A43_M1.2230.95
68_Q74_E1.2160.95
17_V24_K1.1850.94
12_I15_I1.1730.94
28_I35_S1.0970.92
19_L42_A1.0960.92
59_F62_K1.0700.91
18_L28_I1.0560.90
24_K36_I1.0380.89
7_W11_I1.0280.89
17_V22_T1.0220.88
1_M8_Q1.0060.88
59_F64_I1.0050.88
62_K66_D1.0040.88
28_I32_L1.0000.87
38_G43_M0.9850.87
41_K46_D0.9830.86
68_Q71_T0.9460.84
12_I19_L0.9240.83
45_D48_P0.9050.81
8_Q19_L0.8810.80
1_M34_A0.8790.80
69_A73_Q0.8650.78
28_I38_G0.8560.78
2_G12_I0.8450.77
15_I45_D0.8380.76
16_V24_K0.8170.74
9_L15_I0.8130.74
52_K56_D0.8070.73
24_K35_S0.8060.73
64_I67_K0.8040.73
23_K26_G0.7990.73
2_G9_L0.7930.72
26_G30_S0.7870.72
9_L42_A0.7830.71
51_D54_S0.7720.70
17_V34_A0.7650.69
29_G38_G0.7580.69
23_K36_I0.7480.68
50_Q54_S0.7210.65
23_K28_I0.7140.64
8_Q42_A0.7080.63
61_A64_I0.7050.63
4_I19_L0.7030.63
16_V36_I0.7020.63
4_I15_I0.7020.63
14_V18_L0.6980.62
37_K45_D0.6950.62
55_Q58_D0.6940.62
8_Q15_I0.6870.61
51_D55_Q0.6780.60
66_D72_N0.6710.59
34_A40_K0.6640.59
28_I34_A0.6460.56
27_S49_K0.6460.56
35_S43_M0.6420.56
3_G8_Q0.6320.55
32_L38_G0.6310.55
12_I40_K0.6170.53
13_A24_K0.6140.53
52_K55_Q0.5910.50
26_G45_D0.5880.50
65_A69_A0.5820.49
8_Q16_V0.5690.47
18_L22_T0.5690.47
23_K27_S0.5670.47
24_K34_A0.5570.46
65_A70_D0.5560.46
17_V44_S0.5550.46
5_S32_L0.5460.45
58_D62_K0.5440.44
18_L42_A0.5340.43
63_T66_D0.5290.43
14_V32_L0.5280.43
26_G29_G0.5270.42
8_Q12_I0.5090.40
55_Q60_T0.5090.40
66_D70_D0.5030.40
13_A23_K0.5030.40
5_S36_I0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mn6B 2 0.5169 99.7 0.464 Contact Map
2l16A 1 0.573 99.4 0.577 Contact Map
2lzrA 1 0.5506 99.3 0.607 Contact Map
2mi2A 1 1 99.3 0.607 Contact Map
4fu6A 1 0.5955 56.7 0.889 Contact Map
4cosA 1 0.9438 40.6 0.899 Contact Map
4rxjA 2 0.7416 40.3 0.899 Contact Map
1ri0A 1 0.6404 23.7 0.91 Contact Map
3qbyA 3 0.618 21.7 0.912 Contact Map
4n4gA 1 0.6966 20.8 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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