GREMLIN Database
TATB - Sec-independent protein translocase protein TatB
UniProt: P69425 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14322
Length: 171 (146)
Sequences: 859 (707)
Seq/√Len: 58.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_L28_A4.7261.00
55_K59_F3.3031.00
44_T47_Q3.0481.00
37_R41_S2.6321.00
34_G38_A2.3891.00
77_E80_A2.2711.00
59_F62_S2.2611.00
57_Q60_Q2.1711.00
24_R46_V2.1371.00
33_A37_R2.0911.00
24_R29_V2.0441.00
2_F8_E1.8871.00
31_T34_G1.7730.99
34_G42_L1.7150.99
29_V43_A1.7100.99
139_E145_T1.6930.99
24_R54_L1.6890.99
55_K63_L1.6680.99
6_F24_R1.6560.99
4_I9_L1.6490.99
143_E146_P1.6380.99
40_R46_V1.6190.99
60_Q64_K1.6030.99
23_Q29_V1.5960.99
12_V39_L1.5920.99
110_T121_A1.5830.99
137_S146_P1.5550.98
83_D86_R1.5250.98
133_T137_S1.5100.98
137_S142_P1.4800.98
142_P146_P1.4640.98
23_Q46_V1.4630.98
50_L53_E1.4330.97
33_A38_A1.3700.96
120_E143_E1.3580.96
137_S143_E1.3480.96
40_R69_A1.3400.96
124_E132_Q1.3350.96
13_F60_Q1.3080.95
123_H126_V1.3040.95
13_F17_L1.2920.95
29_V33_A1.2570.94
42_L46_V1.2550.94
57_Q61_D1.2430.94
17_L28_A1.2390.94
51_T54_L1.2380.94
35_W40_R1.2350.94
29_V32_V1.2210.93
111_I115_V1.2040.93
52_Q57_Q1.2020.93
115_V124_E1.1920.92
6_F54_L1.1820.92
46_V54_L1.1550.91
119_N123_H1.1410.91
119_N126_V1.1410.91
112_H118_D1.1350.90
144_T147_E1.1180.90
76_P80_A1.1160.90
18_V29_V1.1150.89
38_A42_L1.1030.89
142_P145_T1.0980.89
28_A54_L1.0930.89
20_L24_R1.0920.88
51_T55_K1.0900.88
4_I10_L1.0830.88
68_K72_T1.0770.88
61_D65_K1.0770.88
41_S44_T1.0700.87
52_Q56_L1.0600.87
16_G24_R1.0590.87
108_A112_H1.0470.86
23_Q54_L1.0470.86
138_P143_E1.0420.86
105_S113_N1.0250.85
122_A137_S1.0150.85
16_G20_L1.0130.84
55_K61_D1.0130.84
17_L32_V1.0040.84
43_A46_V1.0030.84
138_P145_T0.9960.83
126_V129_A0.9920.83
28_A36_I0.9900.83
50_L55_K0.9760.82
5_G14_I0.9710.82
108_A118_D0.9650.81
6_F46_V0.9630.81
124_E130_A0.9570.81
32_V36_I0.9420.80
82_M85_L0.9390.80
89_A92_M0.9390.80
28_A31_T0.9220.78
129_A134_Q0.9140.78
40_R47_Q0.9130.78
131_A147_E0.9130.78
24_R27_V0.9120.78
87_Q90_E0.9110.78
62_S66_V0.9040.77
140_Q143_E0.9000.77
35_W42_L0.8980.76
24_R50_L0.8970.76
128_P134_Q0.8930.76
66_V70_S0.8890.76
16_G33_A0.8880.76
7_S48_N0.8880.76
52_Q55_K0.8820.75
113_N118_D0.8780.75
9_L38_A0.8760.75
87_Q92_M0.8750.75
141_K146_P0.8730.74
139_E142_P0.8710.74
27_V31_T0.8630.74
70_S73_N0.8620.74
34_G46_V0.8610.73
117_K135_A0.8600.73
28_A58_E0.8540.73
51_T60_Q0.8520.73
6_F29_V0.8440.72
48_N60_Q0.8290.71
125_G130_A0.8260.70
132_Q146_P0.8240.70
55_K65_K0.8220.70
130_A134_Q0.8200.70
139_E146_P0.8110.69
105_S126_V0.7990.68
9_L60_Q0.7980.68
55_K60_Q0.7950.67
58_E61_D0.7940.67
113_N117_K0.7900.67
102_E114_P0.7900.67
88_A95_S0.7900.67
16_G32_V0.7890.67
138_P146_P0.7790.66
112_H141_K0.7750.65
112_H115_V0.7730.65
117_K122_A0.7710.65
59_F68_K0.7670.65
32_V39_L0.7490.63
6_F50_L0.7490.63
24_R51_T0.7480.63
28_A49_E0.7480.63
100_D117_K0.7460.62
100_D103_K0.7450.62
93_K97_V0.7370.61
140_Q144_T0.7330.61
115_V118_D0.7300.61
134_Q140_Q0.7280.60
4_I90_E0.7160.59
104_A114_P0.7150.59
48_N62_S0.7090.58
32_V35_W0.7070.58
82_M86_R0.7060.58
127_T130_A0.7040.58
40_R61_D0.7020.58
126_V130_A0.7010.58
48_N51_T0.6870.56
137_S144_T0.6820.56
124_E131_A0.6790.55
27_V55_K0.6730.55
34_G61_D0.6680.54
135_A138_P0.6670.54
109_H113_N0.6660.54
122_A126_V0.6620.53
6_F23_Q0.6620.53
39_L42_L0.6580.53
20_L51_T0.6560.53
133_T140_Q0.6520.52
136_S141_K0.6420.51
13_F47_Q0.6410.51
31_T47_Q0.6410.51
57_Q65_K0.6410.51
43_A48_N0.6400.51
38_A52_Q0.6360.50
124_E128_P0.6350.50
119_N122_A0.6350.50
53_E58_E0.6340.50
114_P119_N0.6330.50
138_P147_E0.6310.50
119_N141_K0.6300.50
5_G20_L0.6160.48
5_G8_E0.6160.48
8_E22_P0.6130.48
28_A32_V0.6130.48
111_I118_D0.6110.48
118_D126_V0.6010.47
29_V46_V0.5990.46
43_A50_L0.5940.46
11_L28_A0.5870.45
24_R45_T0.5820.44
8_E50_L0.5810.44
75_T78_L0.5810.44
122_A129_A0.5760.44
138_P141_K0.5750.44
7_S40_R0.5720.43
105_S124_E0.5690.43
131_A141_K0.5640.43
107_E135_A0.5640.43
104_A107_E0.5630.42
74_L85_L0.5600.42
72_T84_E0.5590.42
117_K124_E0.5550.42
117_K120_E0.5530.41
113_N127_T0.5530.41
28_A42_L0.5490.41
35_W39_L0.5480.41
104_A116_V0.5430.40
108_A111_I0.5420.40
108_A135_A0.5360.40
125_G128_P0.5340.39
122_A125_G0.5330.39
113_N119_N0.5230.38
34_G50_L0.5230.38
81_S84_E0.5200.38
109_H130_A0.5170.38
135_A140_Q0.5170.38
132_Q147_E0.5160.37
50_L54_L0.5080.37
113_N130_A0.5080.37
118_D121_A0.5060.36
121_A126_V0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mi2A 1 0.6082 99.9 0.436 Contact Map
2l16A 1 0.2982 99.8 0.561 Contact Map
2mn6B 2 0.269 99.7 0.58 Contact Map
2lzrA 1 0.2865 99.6 0.624 Contact Map
4d10G 1 0.4269 32.8 0.924 Contact Map
4lwsA 1 0.5848 28.4 0.927 Contact Map
4cq4A 4 0.5146 14.3 0.936 Contact Map
3rvyA 3 0.1988 14 0.936 Contact Map
4bgnA 3 0.269 13.6 0.937 Contact Map
3j8bF 1 0 12.5 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0066 seconds.