GREMLIN Database
TATC - Sec-independent protein translocase protein TatC
UniProt: P69423 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11479
Length: 258 (238)
Sequences: 3433 (2165)
Seq/√Len: 140.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_C233_S4.2941.00
193_R227_E4.0501.00
26_A86_V3.9741.00
18_K22_N3.7501.00
190_R234_R3.6711.00
22_N86_V3.3981.00
89_Y93_A3.1601.00
201_F219_A2.9551.00
186_P237_V2.7791.00
15_E19_R2.7371.00
31_F79_S2.5881.00
23_C87_I2.2191.00
196_V226_F2.1791.00
58_T146_Q2.1081.00
34_L78_V2.0891.00
32_L36_Y2.0691.00
175_I189_L1.9891.00
185_S188_D1.9891.00
41_I78_V1.9861.00
186_P233_S1.9731.00
178_L183_I1.9611.00
197_L223_Y1.9551.00
21_L25_I1.9371.00
123_A127_F1.9311.00
22_N90_Q1.9131.00
141_A147_V1.8621.00
62_T150_D1.8501.00
79_S83_S1.8501.00
99_L103_E1.8461.00
226_F230_V1.8361.00
30_I79_S1.8341.00
118_F166_G1.8201.00
195_Y199_G1.7651.00
60_I148_S1.7481.00
27_V76_F1.7461.00
66_S150_D1.7371.00
111_L115_S1.7351.00
37_F40_D1.7131.00
47_A51_K1.6851.00
63_D66_S1.6691.00
201_F215_Q1.6671.00
114_S170_E1.6661.00
8_P11_T1.6641.00
187_E191_K1.6561.00
190_R193_R1.6411.00
19_R90_Q1.6351.00
20_L24_I1.6351.00
83_S87_I1.6301.00
19_R93_A1.6091.00
30_I82_L1.6051.00
200_A222_M1.6051.00
192_K195_Y1.5761.00
212_V215_Q1.5721.00
188_D192_K1.5691.00
184_T189_L1.5661.00
119_Y123_A1.5221.00
179_C186_P1.5131.00
186_P190_R1.4881.00
186_P234_R1.4851.00
203_V207_L1.4691.00
64_V134_F1.4681.00
96_A104_R1.4561.00
7_Q11_T1.4381.00
190_R227_E1.4341.00
23_C83_S1.4161.00
22_N25_I1.4081.00
33_C36_Y1.4021.00
30_I83_S1.3821.00
210_P215_Q1.3571.00
236_Y240_G1.3481.00
44_L127_F1.3471.00
61_A67_P1.3361.00
130_F158_V1.3281.00
64_V67_P1.3151.00
48_P154_Y1.3131.00
26_A83_S1.2891.00
27_V83_S1.2821.00
198_V202_V1.2591.00
231_F235_F1.2571.00
176_V236_Y1.2531.00
138_A147_V1.2481.00
63_D153_S1.2481.00
205_M215_Q1.2401.00
150_D153_S1.2311.00
180_W236_Y1.2251.00
64_V157_F1.2151.00
29_V33_C1.2141.00
116_L120_I1.2061.00
84_A88_L1.2041.00
207_L218_L1.1971.00
27_V87_I1.1941.00
122_M162_F1.1921.00
71_P140_T1.1681.00
62_T148_S1.1640.99
175_I229_G1.1580.99
175_I233_S1.1430.99
65_A137_L1.1400.99
187_E190_R1.1400.99
14_I18_K1.1370.99
94_F97_P1.1350.99
33_C37_F1.1250.99
189_L226_F1.1210.99
227_E231_F1.1170.99
98_A103_E1.1080.99
61_A145_V1.1030.99
216_T220_I1.0830.99
25_I28_I1.0810.99
23_C26_A1.0770.99
171_V200_A1.0760.99
38_A71_P1.0740.99
80_L87_I1.0740.99
101_K105_R1.0470.99
133_A214_S1.0440.99
90_Q93_A1.0380.99
200_A223_Y1.0310.99
34_L82_L1.0230.99
22_N89_Y1.0180.99
122_M166_G1.0130.99
12_H103_E1.0030.98
238_G241_R0.9930.98
186_P230_V0.9920.98
239_K242_N0.9660.98
192_K196_V0.9650.98
171_V229_G0.9630.98
35_V71_P0.9500.98
15_E90_Q0.9440.98
94_F98_A0.9390.98
12_H94_F0.9300.97
28_I32_L0.9270.97
145_V151_I0.9240.97
24_I28_I0.9240.97
130_F134_F0.9230.97
61_A151_I0.9230.97
35_V72_I0.9190.97
133_A137_L0.9170.97
185_S241_R0.9160.97
25_I29_V0.9140.97
80_L84_A0.9090.97
134_F157_F0.9060.97
184_T188_D0.9050.97
61_A66_S0.9040.97
164_A207_L0.8990.97
204_G207_L0.8900.97
12_H15_E0.8900.97
193_R197_L0.8820.97
208_T218_L0.8800.96
94_F103_E0.8730.96
64_V149_T0.8710.96
215_Q219_A0.8620.96
19_R98_A0.8560.96
197_L227_E0.8560.96
190_R230_V0.8480.96
108_V112_V0.8450.96
27_V80_L0.8440.96
204_G208_T0.8400.95
194_P215_Q0.8350.95
121_G166_G0.8340.95
30_I34_L0.8320.95
137_L171_V0.8310.95
12_H16_L0.8300.95
197_L219_A0.8280.95
233_S237_V0.8270.95
73_K156_S0.8240.95
132_L135_G0.8220.95
46_S50_I0.8200.95
193_R231_F0.8150.95
114_S173_V0.8140.95
61_A147_V0.8140.95
171_V222_M0.8100.94
84_A87_I0.8100.94
129_V165_F0.8060.94
20_L23_C0.8030.94
107_V111_L0.8000.94
63_D152_A0.7990.94
81_I122_M0.7990.94
208_T215_Q0.7990.94
15_E94_F0.7960.94
189_L230_V0.7950.94
12_H97_P0.7940.94
31_F76_F0.7940.94
68_F140_T0.7890.94
92_W107_V0.7800.93
231_F234_R0.7710.93
205_M208_T0.7700.93
42_Y46_S0.7690.93
132_L217_L0.7680.93
200_A204_G0.7650.93
199_G202_V0.7590.92
208_T211_D0.7560.92
12_H98_A0.7550.92
26_A87_I0.7550.92
194_P197_L0.7540.92
168_S222_M0.7490.92
107_V115_S0.7460.92
175_I184_T0.7430.91
61_A141_A0.7340.91
181_M184_T0.7340.91
17_R21_L0.7310.91
35_V39_N0.7290.91
86_V90_Q0.7290.91
43_H46_S0.7280.91
34_L79_S0.7240.90
94_F99_L0.7230.90
100_Y103_E0.7210.90
9_L18_K0.7200.90
40_D43_H0.7150.90
39_N71_P0.7110.90
67_P140_T0.7070.89
51_K54_P0.7040.89
106_L177_L0.7030.89
151_I173_V0.7000.89
205_M212_V0.6980.89
84_A115_S0.6970.89
106_L109_P0.6970.89
201_F223_Y0.6950.89
138_A149_T0.6920.88
124_F229_G0.6900.88
239_K243_R0.6900.88
161_L165_F0.6870.88
45_V158_V0.6840.88
36_Y75_T0.6840.88
238_G242_N0.6830.88
30_I33_C0.6780.87
165_F210_P0.6760.87
39_N43_H0.6750.87
92_W129_V0.6730.87
58_T148_S0.6720.87
210_P214_S0.6690.87
50_I57_S0.6660.86
220_I224_C0.6650.86
135_G139_N0.6640.86
80_L114_S0.6620.86
187_E234_R0.6620.86
204_G219_A0.6610.86
35_V75_T0.6600.86
46_S59_M0.6570.86
42_Y74_L0.6550.85
141_A145_V0.6520.85
115_S119_Y0.6520.85
67_P147_V0.6510.85
34_L37_F0.6490.85
120_I123_A0.6450.85
160_A163_M0.6430.84
156_S160_A0.6420.84
22_N26_A0.6390.84
76_F80_L0.6390.84
75_T78_V0.6380.84
69_F73_K0.6380.84
39_N61_A0.6350.84
49_L149_T0.6350.84
211_D215_Q0.6310.83
117_L225_L0.6290.83
62_T66_S0.6290.83
96_A100_Y0.6240.83
176_V232_F0.6230.82
134_F140_T0.6220.82
168_S218_L0.6180.82
59_M75_T0.6160.82
80_L163_M0.6150.82
23_C79_S0.6130.81
17_R211_D0.6110.81
206_L212_V0.6110.81
36_Y40_D0.6100.81
66_S70_T0.6070.81
44_L123_A0.6070.81
77_M81_I0.6060.81
10_I13_L0.6060.81
97_P103_E0.6040.81
88_L92_W0.6040.81
214_S218_L0.6040.81
70_T74_L0.6020.80
79_S106_L0.6000.80
37_F41_I0.5980.80
169_F225_L0.5970.80
197_L201_F0.5960.80
97_P154_Y0.5940.79
160_A214_S0.5920.79
67_P145_V0.5920.79
65_A69_F0.5900.79
130_F221_P0.5870.79
45_V125_A0.5870.79
113_S173_V0.5870.79
15_E98_A0.5820.78
45_V175_I0.5820.78
95_I107_V0.5820.78
88_L114_S0.5810.78
34_L75_T0.5810.78
206_L228_I0.5800.78
227_E230_V0.5790.78
132_L215_Q0.5790.78
44_L48_P0.5790.78
211_D214_S0.5770.77
197_L200_A0.5770.77
125_A161_L0.5750.77
104_R108_V0.5710.77
19_R97_P0.5710.77
77_M159_M0.5700.77
12_H19_R0.5680.76
71_P145_V0.5670.76
83_S86_V0.5650.76
118_F170_E0.5650.76
118_F121_G0.5640.76
9_L77_M0.5640.76
66_S149_T0.5630.76
9_L14_I0.5620.76
33_C82_L0.5620.76
223_Y227_E0.5580.75
133_A194_P0.5550.75
224_C235_F0.5550.75
125_A165_F0.5430.73
9_L94_F0.5430.73
154_Y158_V0.5410.73
186_P193_R0.5390.73
201_F216_T0.5390.73
204_G222_M0.5390.73
114_S165_F0.5390.73
109_P112_V0.5370.72
70_T151_I0.5360.72
79_S84_A0.5360.72
15_E93_A0.5350.72
193_R230_V0.5340.72
121_G169_F0.5340.72
237_V241_R0.5320.72
207_L215_Q0.5310.71
43_H47_A0.5300.71
66_S152_A0.5300.71
34_L41_I0.5290.71
10_I14_I0.5280.71
114_S162_F0.5240.70
7_Q10_I0.5220.70
191_K198_V0.5210.70
230_V233_S0.5200.70
106_L181_M0.5190.70
71_P151_I0.5190.70
83_S168_S0.5190.70
217_L222_M0.5160.69
177_L181_M0.5160.69
210_P216_T0.5140.69
165_F218_L0.5130.69
42_Y145_V0.5120.69
155_L231_F0.5120.69
27_V30_I0.5110.69
192_K199_G0.5110.69
216_T219_A0.5090.68
11_T14_I0.5090.68
12_H99_L0.5080.68
111_L155_L0.5070.68
59_M125_A0.5070.68
63_D76_F0.5060.68
24_I173_V0.5060.68
178_L184_T0.5050.68
73_K77_M0.5050.68
42_Y71_P0.5040.68
205_M209_P0.5030.67
7_Q74_L0.5020.67
49_L124_F0.5010.67
68_F137_L0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4httA 1 0.8643 100 0.114 Contact Map
4b4aA 1 0.8643 100 0.132 Contact Map
1pw4A 1 0.7713 45.1 0.95 Contact Map
4ikvA 1 0.8217 39.4 0.952 Contact Map
4m64A 1 0.7907 34.3 0.953 Contact Map
3o7qA 1 0.7364 27.1 0.956 Contact Map
4xnjA 1 0.7868 25.2 0.956 Contact Map
3wdoA 1 0.8023 14.9 0.961 Contact Map
1un0C 1 0.0039 13 0.962 Contact Map
2cfqA 1 0.7946 11.4 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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