GREMLIN Database
CITD - Citrate lyase acyl carrier protein
UniProt: P69330 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13543
Length: 98 (90)
Sequences: 385 (298)
Seq/√Len: 31.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_V65_V5.1311.00
49_I65_V3.4331.00
46_R50_L3.1021.00
17_V75_L2.9861.00
38_E46_R2.7391.00
53_L63_L2.6271.00
31_L50_L2.5951.00
44_A48_T2.2380.99
48_T52_V2.1530.98
17_V49_I2.1330.98
5_Q88_G2.0780.98
33_I61_V1.9850.97
56_Y83_L1.9030.97
47_T51_D1.7130.94
30_D62_Q1.6850.93
53_L83_L1.6030.91
28_D60_G1.5420.90
49_I79_L1.5350.89
20_R66_D1.5020.88
29_I61_V1.4960.88
21_I61_V1.4440.86
26_T60_G1.4290.86
44_A47_T1.3740.83
80_E84_A1.3740.83
18_M66_D1.3090.80
12_L18_M1.3020.80
4_N76_R1.2540.77
51_D76_R1.2160.75
54_A59_R1.2150.75
34_N66_D1.1760.72
48_T68_K1.1080.68
65_V75_L1.0830.66
21_I63_L1.0540.64
43_D74_I0.9880.59
39_K86_A0.9880.59
14_S85_R0.9840.58
33_I75_L0.9780.58
31_L38_E0.9760.58
26_T49_I0.9690.57
81_A86_A0.9590.56
2_K60_G0.9480.56
46_R54_A0.9460.55
33_I65_V0.9430.55
41_F80_E0.9180.53
5_Q41_F0.9040.52
32_Q64_N0.8830.50
29_I33_I0.8790.50
21_I53_L0.8760.50
25_D51_D0.8750.50
51_D55_R0.8730.50
14_S71_L0.8720.49
9_A13_E0.8640.49
11_T37_V0.8610.49
73_C77_A0.8610.49
19_I81_A0.8600.48
71_L77_A0.8590.48
19_I79_L0.8420.47
50_L54_A0.8360.47
41_F74_I0.8260.46
11_T58_V0.8220.45
4_N86_A0.8210.45
81_A89_I0.8020.44
34_N64_N0.7990.44
48_T76_R0.7980.43
52_V56_Y0.7950.43
8_V15_G0.7910.43
58_V83_L0.7880.43
53_L58_V0.7810.42
4_N47_T0.7720.41
23_P40_Q0.7610.41
22_A62_Q0.7530.40
79_L83_L0.7480.40
21_I87_S0.7460.39
56_Y80_E0.7350.39
54_A58_V0.7310.38
56_Y79_L0.7230.38
36_S68_K0.7060.36
39_K77_A0.7040.36
72_D75_L0.7020.36
12_L37_V0.6990.36
6_P20_R0.6940.35
8_V68_K0.6920.35
15_G74_I0.6880.35
24_L60_G0.6850.35
51_D91_A0.6840.35
11_T14_S0.6810.34
4_N88_G0.6810.34
21_I56_Y0.6750.34
46_R90_P0.6750.34
6_P22_A0.6720.34
40_Q58_V0.6670.33
11_T35_S0.6640.33
58_V61_V0.6600.33
26_T57_N0.6470.32
43_D84_A0.6470.32
71_L74_I0.6400.32
22_A40_Q0.6360.31
19_I60_G0.6360.31
46_R59_R0.6340.31
36_S74_I0.6300.31
36_S66_D0.6220.30
15_G73_C0.6130.30
24_L34_N0.6120.30
13_E73_C0.6070.29
5_Q64_N0.6070.29
14_S36_S0.6020.29
32_Q47_T0.6010.29
52_V68_K0.6010.29
43_D47_T0.5960.29
48_T51_D0.5890.28
32_Q55_R0.5820.28
15_G79_L0.5790.27
42_G74_I0.5790.27
23_P26_T0.5770.27
36_S84_A0.5690.27
17_V44_A0.5650.27
3_I71_L0.5550.26
43_D50_L0.5540.26
2_K33_I0.5510.26
55_R90_P0.5510.26
25_D91_A0.5490.26
22_A59_R0.5460.25
5_Q90_P0.5450.25
47_T89_I0.5390.25
81_A87_S0.5380.25
8_V24_L0.5370.25
29_I60_G0.5330.25
24_L66_D0.5310.24
44_A52_V0.5300.24
33_I38_E0.5290.24
6_P29_I0.5220.24
57_N60_G0.5220.24
13_E68_K0.5120.23
88_G91_A0.5020.23
14_S68_K0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ffvA 1 0.5714 16.3 0.931 Contact Map
3tixA 1 0.8265 11.3 0.936 Contact Map
3hs8A 1 0.5306 9.6 0.937 Contact Map
2k6lA 2 0.449 8.9 0.938 Contact Map
2jvfA 1 0.6531 8.1 0.94 Contact Map
3j25A 1 1 7.8 0.94 Contact Map
3h0gC 1 0.8367 7.6 0.941 Contact Map
3netA 2 0.9388 6.3 0.942 Contact Map
3hwuA 3 0.6327 6 0.943 Contact Map
1twfC 1 0.8571 5.8 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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