GREMLIN Database
BAER - Transcriptional regulatory protein BaeR
UniProt: P69228 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11618
Length: 240 (207)
Sequences: 72923 (51440)
Seq/√Len: 3575.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_G39_L3.6801.00
23_G41_S3.2011.00
27_I39_L3.1141.00
16_V46_V2.6971.00
47_L75_E2.5961.00
44_D66_G2.5641.00
38_T55_P2.4141.00
67_T75_E2.3801.00
43_G67_T2.3651.00
42_H66_G2.3361.00
51_R79_F2.3291.00
12_R38_T2.2071.00
12_R36_A2.1151.00
29_Y114_P2.0911.00
27_I31_R2.0681.00
33_A118_V2.0181.00
40_I49_Y1.9701.00
96_R116_E1.8911.00
63_M90_K1.8621.00
41_S45_Q1.8531.00
199_R202_D1.8371.00
164_A167_R1.8201.00
42_H45_Q1.7671.00
38_T49_Y1.7561.00
60_L72_L1.7301.00
86_M99_G1.7281.00
73_C84_I1.7111.00
93_E113_S1.7061.00
77_R105_D1.6991.00
14_L40_I1.6741.00
182_R202_D1.6371.00
75_E79_F1.6281.00
11_P125_L1.5881.00
170_K174_H1.5711.00
67_T71_T1.5691.00
171_T188_H1.5551.00
86_M104_A1.5491.00
49_Y53_T1.5431.00
30_L121_V1.5321.00
38_T53_T1.5211.00
43_G72_L1.5191.00
68_D71_T1.4901.00
106_D120_R1.4681.00
181_S184_Q1.4631.00
204_H207_N1.4571.00
49_Y52_Q1.4561.00
90_K95_D1.4491.00
75_E78_R1.4331.00
58_I82_I1.4221.00
74_R102_I1.4201.00
180_F188_H1.4111.00
44_D67_T1.4041.00
50_V76_I1.4021.00
71_T74_R1.3891.00
85_V124_I1.3871.00
57_L121_V1.3721.00
20_P41_S1.3611.00
73_C86_M1.3611.00
165_E211_K1.3571.00
47_L72_L1.3411.00
144_I153_S1.3261.00
175_E178_K1.3051.00
151_Q158_M1.2681.00
142_P155_R1.2531.00
17_E23_G1.2471.00
62_L70_L1.2441.00
35_Y122_K1.2301.00
16_V64_L1.2301.00
48_P52_Q1.2251.00
105_D127_R1.2201.00
49_Y55_P1.2201.00
60_L73_C1.2201.00
12_R53_T1.2191.00
47_L67_T1.2121.00
14_L55_P1.2071.00
62_L86_M1.2071.00
18_D61_D1.2061.00
45_Q48_P1.2001.00
139_A144_I1.1931.00
40_I46_V1.1761.00
44_D48_P1.1661.00
92_E95_D1.1651.00
184_Q188_H1.1641.00
101_E122_K1.1551.00
45_Q49_Y1.1421.00
70_L99_G1.1321.00
33_A122_K1.1321.00
70_L98_L1.1301.00
166_F170_K1.1271.00
34_S122_K1.1241.00
14_L46_V1.1151.00
171_T175_E1.1101.00
171_T180_F1.1081.00
118_V122_K1.0981.00
105_D124_I1.0951.00
183_E198_D1.0941.00
13_I35_Y1.0941.00
147_E170_K1.0881.00
146_D149_R1.0831.00
93_E97_L1.0771.00
57_L125_L1.0601.00
145_I173_S1.0581.00
203_S206_K1.0571.00
98_L102_I1.0511.00
199_R203_S1.0281.00
94_I98_L1.0251.00
119_A123_T1.0171.00
116_E119_A1.0161.00
40_I45_Q1.0151.00
14_L49_Y1.0141.00
74_R98_L1.0141.00
167_R170_K1.0131.00
163_P167_R1.0061.00
47_L51_R0.9981.00
96_R109_C0.9981.00
15_I26_L0.9831.00
200_T204_H0.9821.00
11_P35_Y0.9791.00
70_L102_I0.9741.00
216_D219_Q0.9721.00
46_V50_V0.9661.00
46_V72_L0.9651.00
171_T185_L0.9651.00
27_I37_P0.9641.00
60_L84_I0.9601.00
215_L219_Q0.9461.00
58_I76_I0.9441.00
145_I166_F0.9401.00
180_F184_Q0.9381.00
97_L101_E0.9371.00
24_Q39_L0.9371.00
26_L87_V0.9361.00
62_L68_D0.9341.00
20_P24_Q0.9301.00
153_S158_M0.9271.00
21_K25_L0.9261.00
12_R56_D0.9121.00
14_L50_V0.9111.00
16_V40_I0.9061.00
148_G178_K0.9051.00
124_I127_R0.9021.00
16_V58_I0.9021.00
35_Y118_V0.8911.00
73_C102_I0.8881.00
71_T75_E0.8861.00
178_K184_Q0.8821.00
15_I37_P0.8781.00
199_R206_K0.8761.00
48_P51_R0.8721.00
20_P23_G0.8651.00
60_L86_M0.8571.00
198_D202_D0.8471.00
64_L72_L0.8411.00
205_I209_R0.8391.00
73_C104_A0.8361.00
162_T211_K0.8361.00
93_E96_R0.8331.00
28_D32_A0.8301.00
150_F167_R0.8301.00
97_L115_R0.8281.00
72_L76_I0.8251.00
24_Q27_I0.8211.00
59_L117_V0.8151.00
114_P118_V0.8141.00
12_R55_P0.8121.00
58_I84_I0.8091.00
214_S224_A0.8061.00
91_I109_C0.8061.00
98_L101_E0.8051.00
62_L95_D0.8021.00
207_N210_R0.7981.00
183_E187_N0.7971.00
59_L87_V0.7941.00
116_E120_R0.7921.00
123_T128_C0.7911.00
214_S220_S0.7901.00
76_I80_S0.7871.00
50_V82_I0.7821.00
182_R198_D0.7811.00
62_L90_K0.7801.00
85_V120_R0.7771.00
26_L117_V0.7771.00
94_I115_R0.7761.00
74_R78_R0.7741.00
206_K210_R0.7711.00
123_T126_R0.7701.00
83_P105_D0.7681.00
22_L112_Y0.7661.00
67_T72_L0.7651.00
63_M89_A0.7641.00
11_P129_K0.7591.00
50_V55_P0.7501.00
100_L120_R0.7481.00
87_V112_Y0.7451.00
95_D98_L0.7431.00
24_Q28_D0.7371.00
43_G47_L0.7341.00
213_E216_D0.7281.00
16_V72_L0.7211.00
171_T174_H0.7201.00
150_F166_F0.7171.00
209_R214_S0.7161.00
113_S116_E0.7151.00
93_E115_R0.7151.00
59_L121_V0.7091.00
184_Q187_N0.7081.00
47_L50_V0.7071.00
168_L172_L0.7061.00
13_I57_L0.7051.00
85_V106_D0.7001.00
167_R171_T0.6981.00
101_E119_A0.6951.00
43_G66_G0.6921.00
203_S207_N0.6911.00
153_S156_G0.6891.00
202_D205_I0.6851.00
125_L128_C0.6821.00
30_L35_Y0.6821.00
13_I30_L0.6801.00
112_Y117_V0.6771.00
15_I39_L0.6691.00
50_V58_I0.6691.00
174_H188_H0.6651.00
17_E64_L0.6651.00
25_L29_Y0.6641.00
213_E220_S0.6631.00
196_V201_I0.6621.00
31_R37_P0.6621.00
137_Q144_I0.6601.00
23_G27_I0.6601.00
96_R113_S0.6551.00
15_I27_I0.6551.00
29_Y118_V0.6521.00
83_P125_L0.6491.00
99_G104_A0.6481.00
164_A204_H0.6471.00
147_E174_H0.6451.00
47_L79_F0.6421.00
174_H180_F0.6381.00
43_G64_L0.6351.00
143_L154_W0.6341.00
51_R75_E0.6331.00
138_D141_S0.6331.00
197_T200_T0.6331.00
61_D110_K0.6321.00
172_L205_I0.6311.00
115_R119_A0.6251.00
19_E89_A0.6161.00
11_P56_D0.6141.00
213_E219_Q0.6141.00
135_Q138_D0.6131.00
128_C132_R0.6081.00
18_D88_T0.6051.00
76_I84_I0.6041.00
77_R82_I0.6011.00
70_L95_D0.6011.00
154_W213_E0.5991.00
31_R36_A0.5971.00
81_D130_P0.5941.00
112_Y116_E0.5921.00
154_W215_L0.5911.00
154_W157_K0.5871.00
145_I170_K0.5851.00
59_L85_V0.5811.00
142_P154_W0.5801.00
19_E22_L0.5791.00
29_Y33_A0.5791.00
88_T110_K0.5771.00
62_L99_G0.5751.00
81_D131_Q0.5741.00
45_Q66_G0.5731.00
88_T96_R0.5711.00
50_V79_F0.5691.00
171_T189_L0.5681.00
73_C77_R0.5631.00
120_R124_I0.5631.00
13_I121_V0.5551.00
145_I152_A0.5521.00
54_P80_S0.5511.00
83_P128_C0.5511.00
119_A122_K0.5501.00
60_L64_L0.5461.00
154_W214_S0.5441.00
91_I111_P0.5441.00
215_L220_S0.5401.00
146_D151_Q0.5391.00
77_R83_P0.5361.00
88_T107_Y0.5321.00
122_K126_R0.5311.00
106_D123_T0.5291.00
15_I23_G0.5261.00
50_V80_S0.5231.00
97_L100_L0.5221.00
94_I97_L0.5221.00
169_L220_S0.5211.00
46_V58_I0.5201.00
50_V72_L0.5201.00
162_T165_E0.5201.00
57_L124_I0.5161.00
18_D64_L0.5161.00
144_I156_G0.5151.00
47_L76_I0.5121.00
76_I82_I0.5121.00
99_G107_Y0.5121.00
22_L25_L0.5091.00
42_H64_L0.5071.00
121_V125_L0.5031.00
214_S219_Q0.5001.00
143_L152_A0.5001.00
115_R118_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4b09A 2 0.9 100 0.187 Contact Map
3r0jA 2 0.925 100 0.237 Contact Map
2gwrA 1 0.9375 100 0.243 Contact Map
4kfcA 2 0.9375 100 0.243 Contact Map
2oqrA 2 0.9333 100 0.246 Contact Map
1ys7A 2 0.9333 100 0.248 Contact Map
1kgsA 1 0.9083 100 0.271 Contact Map
3q9sA 1 0.875 100 0.286 Contact Map
1p2fA 1 0.9 100 0.29 Contact Map
2hqrA 2 0.9167 100 0.293 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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