GREMLIN Database
IF1 - Translation initiation factor IF-1
UniProt: P69222 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10504
Length: 72 (70)
Sequences: 1008 (420)
Seq/√Len: 50.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_T71_S3.5471.00
25_E29_G2.9801.00
14_L25_E2.9681.00
12_T25_E2.9001.00
40_M69_F2.8111.00
16_T49_T2.5651.00
21_M33_T2.5641.00
27_E52_K2.4981.00
8_E54_T2.4311.00
25_E31_V2.2111.00
10_Q52_K1.9610.99
36_I47_I1.8880.99
10_Q71_S1.8800.99
23_R31_V1.7900.99
36_I44_Y1.5490.97
9_M57_L1.4220.95
17_L23_R1.3850.95
10_Q27_E1.3100.93
42_K69_F1.2820.92
32_V55_V1.2820.92
13_V47_I1.2800.92
10_Q54_T1.2440.91
12_T52_K1.2140.90
44_Y47_I1.1550.87
30_H62_L1.1050.85
32_V65_G1.0900.84
55_V65_G1.0690.83
40_M43_N1.0640.83
18_P22_F1.0490.82
57_L62_L1.0480.82
15_E23_R1.0290.80
8_E68_V1.0240.80
39_K58_T1.0150.79
11_G24_V0.9910.78
18_P58_T0.9780.77
59_P62_L0.9380.74
22_F41_R0.9250.73
32_V57_L0.9060.71
23_R33_T0.8770.69
15_E18_P0.8540.67
40_M71_S0.8470.66
22_F66_R0.8450.66
68_V71_S0.8360.65
39_K42_K0.8210.64
21_M35_H0.8140.63
14_L31_V0.8060.62
20_T41_R0.7980.61
21_M36_I0.7900.61
15_E46_R0.7730.59
18_P33_T0.7690.58
19_N35_H0.7660.58
37_S40_M0.7580.57
24_V60_Y0.7460.56
36_I58_T0.7290.54
36_I40_M0.7230.54
7_I62_L0.7060.52
4_E35_H0.6960.51
35_H45_I0.6870.50
16_T19_N0.6820.50
36_I42_K0.6760.49
52_K71_S0.6540.47
10_Q14_L0.6520.47
28_N37_S0.6440.46
50_G54_T0.6420.46
57_L64_K0.6360.45
30_H63_S0.6320.45
15_E48_L0.6260.44
14_L63_S0.6250.44
33_T52_K0.6230.44
35_H64_K0.6100.42
33_T64_K0.6090.42
9_M55_V0.6090.42
8_E56_E0.6060.42
19_N41_R0.6050.42
37_S47_I0.6050.42
27_E45_I0.6040.42
16_T44_Y0.5970.41
24_V34_A0.5950.41
19_N33_T0.5900.40
26_L45_I0.5890.40
39_K69_F0.5750.39
7_I59_P0.5740.39
42_K49_T0.5720.39
13_V24_V0.5690.38
22_F33_T0.5680.38
61_D64_K0.5590.37
30_H40_M0.5480.36
48_L68_V0.5460.36
18_P46_R0.5450.36
34_A58_T0.5420.36
47_I57_L0.5420.36
11_G61_D0.5320.35
27_E67_I0.5200.34
2_A64_K0.5200.34
28_N63_S0.5190.34
50_G71_S0.5140.33
6_N56_E0.5120.33
3_K48_L0.5120.33
12_T39_K0.5100.33
31_V55_V0.5070.32
24_V66_R0.5060.32
56_E66_R0.5050.32
16_T36_I0.5050.32
36_I41_R0.5020.32
28_N62_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bpe0 1 0.9722 99.9 0.319 Contact Map
3wbkC 1 0 99.9 0.335 Contact Map
2oqkA 1 0.9722 99.9 0.335 Contact Map
3j80i 1 0.9861 99.9 0.34 Contact Map
4kzyn 1 0.9028 99.9 0.347 Contact Map
4mnoA 1 0.9583 99.9 0.349 Contact Map
1jt8A 1 0.9722 99.9 0.354 Contact Map
4ql5A 4 0.9444 99.9 0.378 Contact Map
1hr0W 1 0.9861 99.9 0.39 Contact Map
3i4oA 1 0.9306 99.9 0.395 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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