GREMLIN Database
MDTJ - Spermidine export protein MdtJ
UniProt: P69212 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13927
Length: 121 (104)
Sequences: 4750 (3293)
Seq/√Len: 322.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_G101_L2.8331.00
14_T43_L2.6461.00
50_F53_K2.4971.00
77_V84_L2.3511.00
21_S36_L2.3221.00
4_Y54_K2.2871.00
7_L50_F2.2841.00
17_T40_M2.0601.00
75_F79_L2.0031.00
73_T92_L1.8991.00
12_I67_I1.8661.00
94_T98_G1.7441.00
55_I60_A1.7201.00
52_V60_A1.7081.00
46_I50_F1.6291.00
18_G40_M1.5781.00
93_T97_A1.5321.00
32_G36_L1.5231.00
86_L90_A1.5111.00
41_I45_Y1.5031.00
25_A34_F1.4991.00
20_L75_F1.4971.00
38_L42_S1.4741.00
52_V57_L1.4601.00
20_L24_W1.4371.00
25_A28_S1.4261.00
17_T36_L1.4231.00
94_T97_A1.4001.00
22_M37_M1.3831.00
30_G33_G1.3741.00
28_S34_F1.3691.00
91_G105_G1.3461.00
18_G41_I1.3361.00
16_I71_F1.3291.00
7_L47_F1.3241.00
14_T40_M1.2681.00
91_G98_G1.2681.00
85_S88_K1.2671.00
100_V104_S1.2661.00
51_A60_A1.2601.00
24_W80_F1.2511.00
87_M105_G1.2461.00
89_I93_T1.2061.00
31_N34_F1.2011.00
95_L98_G1.1821.00
17_T21_S1.1391.00
95_L99_I1.1301.00
88_K102_I1.1271.00
83_S88_K1.1021.00
42_S46_I1.0901.00
69_I73_T1.0901.00
48_L60_A1.0731.00
92_L102_I1.0691.00
84_L89_I1.0601.00
76_S82_E1.0511.00
26_S30_G1.0461.00
87_M90_A1.0311.00
91_G95_L1.0181.00
32_G35_I1.0101.00
82_E88_K0.9981.00
69_I96_V0.9701.00
9_G67_I0.9441.00
23_K27_V0.9241.00
6_I10_L0.9151.00
86_L89_I0.9081.00
21_S24_W0.9061.00
74_L78_L0.8991.00
5_W63_L0.8891.00
84_L88_K0.8761.00
26_S29_E0.8731.00
12_I44_S0.8701.00
29_E34_F0.8661.00
9_G12_I0.8641.00
58_G62_A0.8641.00
4_Y55_I0.8591.00
70_L92_L0.8591.00
57_L72_I0.8571.00
31_N35_I0.8511.00
35_I39_V0.8361.00
62_A65_E0.8321.00
10_L47_F0.8311.00
91_G94_T0.8281.00
56_A59_V0.8251.00
11_A47_F0.8161.00
21_S40_M0.8101.00
75_F80_F0.8091.00
59_V88_K0.8071.00
97_A101_L0.8051.00
63_L67_I0.7981.00
66_G99_I0.7651.00
29_E53_K0.7641.00
87_M91_G0.7630.99
34_F37_M0.7580.99
16_I75_F0.7560.99
76_S80_F0.7380.99
21_S37_M0.7370.99
19_T72_I0.7190.99
83_S86_L0.7190.99
13_A71_F0.7160.99
39_V43_L0.7050.99
21_S25_A0.7020.99
101_L105_G0.6960.99
41_I65_E0.6860.99
8_L51_A0.6820.99
78_L81_D0.6800.99
7_L51_A0.6780.99
25_A30_G0.6760.99
50_F54_K0.6750.99
70_L96_V0.6740.99
51_A54_K0.6740.99
28_S33_G0.6730.99
20_L76_S0.6700.99
96_V100_V0.6650.99
20_L80_F0.6630.99
19_T41_I0.6630.99
15_E44_S0.6600.99
22_M64_W0.6510.98
77_V89_I0.6470.98
94_T101_L0.6470.98
29_E33_G0.6450.98
82_E85_S0.6430.98
25_A29_E0.6430.98
90_A94_T0.6430.98
4_Y7_L0.6430.98
67_I71_F0.6430.98
57_L80_F0.6250.98
66_G69_I0.6230.98
36_L40_M0.6190.98
65_E72_I0.6160.98
13_A17_T0.6100.98
59_V62_A0.6000.97
25_A37_M0.5950.97
56_A106_T0.5920.97
41_I57_L0.5850.97
20_L23_K0.5800.97
18_G37_M0.5720.96
11_A48_L0.5670.96
76_S88_K0.5640.96
103_K106_T0.5580.96
35_I38_L0.5550.96
62_A92_L0.5500.96
65_E76_S0.5450.95
71_F75_F0.5450.95
22_M45_Y0.5430.95
62_A102_I0.5330.95
39_V42_S0.5290.95
21_S38_L0.5260.94
25_A33_G0.5250.94
8_L60_A0.5230.94
73_T102_I0.5210.94
77_V83_S0.5110.93
23_K26_S0.5060.93
9_G13_A0.5050.93
29_E83_S0.5040.93
77_V88_K0.5010.93
28_S31_N0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5dA 2 0.843 99.9 0.402 Contact Map
2i68A 2 0.6446 99.9 0.408 Contact Map
4ikvA 1 0.9091 13 0.931 Contact Map
1pw4A 1 0.9917 7.6 0.938 Contact Map
4qtnA 3 0.9008 7.6 0.938 Contact Map
4xnjA 1 0.8926 6.5 0.94 Contact Map
2cfqA 1 0.9752 6 0.941 Contact Map
2r9rB 3 0.686 5.2 0.942 Contact Map
3j8eG 3 0.9669 4.9 0.943 Contact Map
4gx0A 3 0.7686 4.8 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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