GREMLIN Database
MDTI - Spermidine export protein MdtI
UniProt: P69210 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13926
Length: 109 (102)
Sequences: 4388 (3012)
Seq/√Len: 298.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_G105_M3.0251.00
18_L47_A2.6861.00
54_Q57_K2.6191.00
8_H58_G2.5971.00
81_W88_L2.4071.00
11_W54_Q2.3161.00
25_F40_L2.3021.00
21_V44_A2.0751.00
77_L96_L2.0191.00
79_A83_L1.9881.00
16_I71_F1.8711.00
98_L102_G1.8331.00
56_V64_A1.8121.00
36_I40_L1.7781.00
59_I64_A1.7051.00
97_V101_A1.5301.00
42_L46_L1.5121.00
50_S54_Q1.5091.00
90_R94_I1.5081.00
22_A44_A1.5061.00
21_V40_L1.4871.00
29_S38_G1.4831.00
32_F38_G1.4611.00
24_V28_F1.4591.00
24_V79_A1.4391.00
45_V49_F1.4301.00
98_L101_A1.4121.00
56_V61_L1.3901.00
89_N92_G1.3871.00
22_A45_V1.3641.00
11_W51_A1.3321.00
18_L44_A1.3241.00
20_I75_A1.3191.00
104_I108_L1.3041.00
29_S32_F1.2981.00
28_F84_F1.2971.00
26_L41_S1.2911.00
35_K38_G1.2871.00
95_G102_G1.2831.00
99_L102_G1.2721.00
55_A64_A1.2291.00
95_G99_L1.2101.00
34_R37_F1.1961.00
87_R92_G1.1771.00
93_W97_V1.1621.00
96_L106_V1.1611.00
73_I77_L1.1511.00
52_L64_A1.1371.00
92_G106_V1.1231.00
21_V25_F1.1071.00
36_I39_L1.0871.00
99_L103_M1.0851.00
30_D34_R1.0441.00
86_Q92_G1.0371.00
91_K94_I1.0341.00
88_L93_W1.0341.00
46_L50_S1.0201.00
9_A67_L0.9841.00
13_A71_F0.9811.00
88_L92_G0.9691.00
10_A14_L0.9381.00
78_A82_I0.9321.00
8_H59_I0.9281.00
35_K39_L0.9231.00
27_K31_G0.9171.00
74_A96_L0.9121.00
67_L71_F0.8951.00
14_L51_A0.8841.00
95_G98_L0.8821.00
101_A105_M0.8781.00
25_F28_F0.8671.00
87_R90_R0.8661.00
8_H11_W0.8581.00
13_A16_I0.8291.00
61_L76_T0.8271.00
63_V92_G0.8171.00
90_R93_W0.8151.00
33_R38_G0.8121.00
79_A84_F0.7981.00
62_S66_A0.7940.99
73_I100_L0.7830.99
80_G84_F0.7800.99
23_N76_T0.7730.99
33_R37_F0.7710.99
30_D33_R0.7700.99
16_I48_A0.7690.99
66_A69_G0.7620.99
80_G86_Q0.7500.99
39_L43_A0.7470.99
24_V84_F0.7400.99
74_A100_L0.7360.99
33_R57_K0.7340.99
98_L105_M0.7310.99
25_F44_A0.7230.99
38_G41_S0.7230.99
91_K95_G0.7050.99
94_I98_L0.7050.99
69_G80_G0.6980.99
61_L84_F0.6920.99
100_L104_I0.6890.99
39_L42_L0.6890.99
7_V10_A0.6850.99
82_I85_G0.6840.98
20_I79_A0.6770.98
70_G103_M0.6750.98
43_A47_A0.6740.98
45_V69_G0.6740.98
25_F41_S0.6730.98
66_A96_L0.6700.98
17_V75_A0.6700.98
19_E48_A0.6540.98
77_L106_V0.6370.98
17_V21_V0.6370.98
49_F56_V0.6330.98
25_F29_S0.6310.97
60_D63_V0.6250.97
86_Q89_N0.6210.97
29_S34_R0.6140.97
54_Q58_G0.6110.97
15_A51_A0.6090.97
81_W87_R0.6090.97
66_A108_L0.6070.97
71_F75_A0.5920.96
24_V80_G0.5900.96
27_K30_D0.5860.96
45_V61_L0.5830.96
32_F37_F0.5760.96
81_W86_Q0.5660.95
11_W55_A0.5610.95
94_I97_V0.5580.95
22_A41_S0.5560.95
24_V27_K0.5550.95
26_L68_W0.5470.94
63_V66_A0.5470.94
29_S33_R0.5460.94
47_A51_A0.5450.94
8_H55_A0.5430.94
80_G92_G0.5370.94
33_R87_R0.5360.94
15_A52_L0.5350.94
24_V61_L0.5310.93
68_W99_L0.5250.93
32_F35_K0.5240.93
16_I103_M0.5210.93
38_G53_S0.5210.93
25_F42_L0.5180.93
81_W93_W0.5160.92
29_S41_S0.5120.92
20_I61_L0.5070.92
23_N45_V0.5070.92
26_L49_F0.5060.92
12_L64_A0.5020.91
40_L44_A0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5dA 2 0.9266 99.9 0.326 Contact Map
2i68A 2 0.7156 99.9 0.362 Contact Map
4o9uB 2 0.6147 5.6 0.933 Contact Map
4pypA 1 1 3.9 0.938 Contact Map
4o93B 1 0.6147 3.4 0.94 Contact Map
3rqwA 4 0.5046 3.2 0.941 Contact Map
4gx0A 3 0.7064 2.5 0.944 Contact Map
3effK 4 0.7339 2.4 0.944 Contact Map
4q65A 1 0.7064 2.3 0.945 Contact Map
2r9rB 3 0.7706 2.3 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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