GREMLIN Database
DHSC - Succinate dehydrogenase cytochrome b556 subunit
UniProt: P69054 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10933
Length: 129 (121)
Sequences: 1497 (1054)
Seq/√Len: 95.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_V116_I4.6941.00
20_F24_A3.0481.00
21_P24_A2.9991.00
14_D17_T2.9651.00
86_V120_L2.9091.00
20_F25_I2.7331.00
82_A124_A2.4521.00
55_P59_E2.4001.00
101_E105_A2.2831.00
79_T117_T2.1311.00
12_N17_T1.9851.00
89_I93_M1.9821.00
22_I107_K1.9071.00
13_L18_I1.8581.00
90_R109_S1.8111.00
118_V122_L1.7941.00
103_F107_K1.7631.00
78_L125_G1.7531.00
26_A83_Y1.6591.00
87_V113_S1.6141.00
79_T121_S1.6051.00
104_E108_R1.5901.00
67_S70_V1.5441.00
26_A114_F1.5081.00
23_T107_K1.4821.00
107_K111_K1.4821.00
84_H88_G1.4791.00
93_M96_F1.4491.00
30_H87_V1.3740.99
22_I111_K1.3440.99
86_V113_S1.3340.99
57_G61_A1.3100.99
97_G100_E1.3090.99
68_F72_F1.3070.99
110_A113_S1.2990.99
108_R111_K1.2790.99
101_E104_E1.2690.99
25_I29_L1.2670.99
116_I120_L1.2590.99
68_F71_K1.2430.99
48_L51_S1.2420.99
46_W61_A1.2090.98
108_R112_I1.2000.98
34_G88_G1.1980.98
91_H94_M1.1870.98
34_G84_H1.1810.98
59_E62_S1.1680.98
13_L17_T1.1450.98
47_L51_S1.1410.98
82_A120_L1.1310.97
111_K115_V1.0970.97
79_T83_Y1.0940.97
72_F76_G1.0890.97
46_W50_T1.0800.97
64_I73_I1.0800.97
67_S71_K1.0760.97
32_V35_V1.0630.96
69_F76_G1.0490.96
53_S57_G1.0470.96
119_V123_L1.0300.96
33_S36_I1.0250.96
75_W125_G0.9990.95
105_A109_S0.9900.95
18_I21_P0.9890.95
93_M109_S0.9880.95
92_M96_F0.9750.94
91_H95_D0.9580.94
57_G60_Q0.9500.93
46_W49_G0.9470.93
83_Y87_V0.9440.93
73_I76_G0.9420.93
32_V36_I0.9350.93
12_N18_I0.9340.93
56_E59_E0.9250.92
83_Y91_H0.9230.92
76_G80_A0.9100.92
99_L105_A0.9040.91
99_L109_S0.9020.91
115_V119_V0.9000.91
74_M78_L0.8950.91
21_P110_A0.8920.91
47_L70_V0.8840.91
54_S58_F0.8760.90
59_E63_A0.8750.90
75_W79_T0.8600.89
58_F62_S0.8600.89
60_Q64_I0.8530.89
26_A106_G0.8430.88
105_A108_R0.8310.88
36_I39_V0.8280.87
23_T106_G0.8150.87
46_W53_S0.8130.86
103_F106_G0.8120.86
114_F118_V0.8020.86
78_L124_A0.7920.85
33_S70_V0.7900.85
22_I110_A0.7850.84
56_E60_Q0.7760.84
47_L50_T0.7740.84
37_T80_A0.7610.83
45_L49_G0.7600.83
11_V14_D0.7460.81
21_P106_G0.7430.81
71_K125_G0.7420.81
82_A86_V0.7370.81
94_M106_G0.7350.80
11_V15_L0.7330.80
69_F72_F0.7320.80
36_I76_G0.7170.79
40_A43_I0.7130.78
26_A29_L0.7120.78
21_P25_I0.6980.77
7_K101_E0.6940.76
46_W65_M0.6840.75
21_P103_F0.6830.75
26_A30_H0.6810.75
41_V77_I0.6780.75
30_H95_D0.6760.75
74_M80_A0.6750.74
26_A94_M0.6750.74
44_L77_I0.6620.73
100_E106_G0.6610.73
64_I67_S0.6580.73
113_S117_T0.6520.72
26_A110_A0.6470.71
98_Y101_E0.6400.71
50_T57_G0.6320.70
120_L124_A0.6310.69
75_W121_S0.6290.69
61_A123_L0.6270.69
14_D18_I0.6240.69
106_G109_S0.6180.68
20_F23_T0.6170.68
93_M99_L0.6160.68
37_T77_I0.5990.65
22_I106_G0.5980.65
63_A126_V0.5940.65
46_W57_G0.5910.64
83_Y110_A0.5910.64
93_M98_Y0.5900.64
108_R119_V0.5900.64
82_A121_S0.5890.64
23_T111_K0.5860.64
69_F73_I0.5860.64
17_T33_S0.5780.63
116_I123_L0.5780.63
13_L16_Q0.5780.63
100_E103_F0.5770.63
123_L126_V0.5700.62
87_V92_M0.5680.61
75_W127_L0.5600.60
107_K110_A0.5600.60
79_T118_V0.5570.60
97_G101_E0.5570.60
62_S66_G0.5560.60
83_Y113_S0.5550.60
98_Y119_V0.5540.59
119_V127_L0.5500.59
60_Q63_A0.5500.59
108_R123_L0.5480.59
61_A81_L0.5420.58
110_A117_T0.5400.58
109_S113_S0.5400.58
41_V61_A0.5400.58
36_I80_A0.5380.57
51_S54_S0.5370.57
77_I124_A0.5360.57
30_H34_G0.5340.57
99_L108_R0.5320.56
100_E105_A0.5250.55
25_I28_I0.5240.55
11_V19_R0.5220.55
83_Y117_T0.5220.55
79_T82_A0.5200.55
41_V45_L0.5200.55
31_R90_R0.5180.54
85_V89_I0.5130.54
49_G109_S0.5130.54
86_V89_I0.5070.53
86_V117_T0.5040.52
94_M100_E0.5010.52
33_S52_L0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ysxC 1 0.9535 100 0.184 Contact Map
1zoyC 1 0.9535 100 0.204 Contact Map
2wdqC 1 0.938 100 0.207 Contact Map
4ytpC 1 0.9535 100 0.208 Contact Map
2h88C 2 0.9535 100 0.213 Contact Map
2wdqD 2 0.7984 99.6 0.621 Contact Map
2bs2C 2 0.9612 96.9 0.829 Contact Map
4ytpD 1 0.6202 74.4 0.898 Contact Map
1kf6D 2 0.8605 70 0.901 Contact Map
1kf6C 1 0.938 67.7 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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