GREMLIN Database
RL25 - 50S ribosomal protein L25
UniProt: P68919 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10885
Length: 94 (89)
Sequences: 1639 (950)
Seq/√Len: 100.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_N64_V3.7041.00
25_K41_E2.9701.00
62_T69_E2.8691.00
20_L41_E2.8681.00
7_E25_K2.8201.00
30_I40_I2.6791.00
43_D46_K2.6451.00
30_I63_I2.4941.00
30_I72_V2.3021.00
11_E19_R2.0521.00
38_L70_I1.8631.00
3_T62_T1.8131.00
64_V69_E1.7711.00
15_G18_R1.7611.00
3_T64_V1.7441.00
25_K43_D1.7131.00
8_V66_D1.5321.00
17_S20_L1.5311.00
44_H48_M1.4901.00
47_V89_I1.4771.00
19_R23_A1.4341.00
48_M52_A1.4081.00
7_E66_D1.3921.00
62_T71_K1.3160.99
63_I72_V1.2960.99
29_I39_A1.2710.99
74_A89_I1.2690.99
55_E59_E1.2330.99
77_V89_I1.2280.99
55_E58_S1.2150.99
5_N46_K1.1940.99
16_A22_A1.1870.98
80_H83_K1.1390.98
77_V91_F1.1360.98
28_A40_I1.1220.98
80_H84_P1.1210.98
73_K92_V1.1100.98
54_A57_Y1.0930.97
54_A74_A1.0750.97
28_A42_L1.0630.97
60_V71_K1.0580.97
28_A47_V1.0260.96
3_T69_E1.0200.96
13_G17_S0.9940.95
49_N52_A0.9700.95
5_N47_V0.9660.95
28_A89_I0.9190.93
66_D69_E0.9130.93
7_E41_E0.9050.92
51_Q86_L0.8970.92
30_I91_F0.8950.92
8_V64_V0.8830.92
65_V70_I0.8750.91
26_F47_V0.8690.91
44_H85_K0.8570.90
60_V73_K0.8540.90
6_A65_V0.8500.90
63_I91_F0.8430.90
12_Q39_A0.8240.88
64_V67_G0.8120.88
75_Q92_V0.8120.88
40_I72_V0.8090.88
58_S75_Q0.7980.87
6_A40_I0.7920.86
10_K24_N0.7910.86
8_V68_K0.7880.86
59_E73_K0.7660.85
80_H87_Q0.7570.84
51_Q77_V0.7560.84
50_M58_S0.7540.84
6_A63_I0.7540.84
49_N53_K0.7500.83
35_E70_I0.7440.83
57_Y79_R0.7440.83
53_K74_A0.7230.81
61_L71_K0.7230.81
30_I70_I0.7170.80
74_A92_V0.7160.80
4_I12_Q0.6990.79
44_H80_H0.6960.78
8_V38_L0.6950.78
51_Q74_A0.6920.78
14_K81_P0.6900.78
52_A79_R0.6770.77
61_L72_V0.6770.77
38_L68_K0.6730.76
14_K37_P0.6620.75
54_A59_E0.6600.75
45_D49_N0.6580.74
81_P87_Q0.6550.74
45_D48_M0.6440.73
60_V75_Q0.6440.73
82_Y85_K0.6430.73
3_T8_V0.6400.72
40_I63_I0.6400.72
5_N8_V0.6380.72
33_G80_H0.6320.72
11_E81_P0.6250.71
51_Q57_Y0.6250.71
14_K50_M0.6240.71
24_N85_K0.6230.70
15_G74_A0.6180.70
17_S22_A0.6180.70
12_Q17_S0.6150.69
48_M82_Y0.6110.69
11_E87_Q0.6090.69
13_G37_P0.6070.68
78_Q83_K0.6010.68
29_I79_R0.5990.67
13_G16_A0.5970.67
4_I43_D0.5890.66
38_L44_H0.5830.65
8_V36_A0.5810.65
20_L29_I0.5740.64
79_R83_K0.5670.63
46_K49_N0.5630.63
55_E73_K0.5610.62
24_N48_M0.5600.62
44_H84_P0.5600.62
3_T50_M0.5560.62
50_M61_L0.5540.61
11_E39_A0.5440.60
48_M85_K0.5430.60
14_K30_I0.5430.60
29_I37_P0.5420.60
76_D84_P0.5420.60
51_Q76_D0.5320.58
53_K61_L0.5260.58
29_I51_Q0.5240.57
20_L25_K0.5190.57
43_D83_K0.5150.56
4_I63_I0.5070.55
79_R84_P0.5070.55
24_N44_H0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b75A 1 1 100 0.124 Contact Map
1feuA 1 0.9468 100 0.219 Contact Map
2zjrS 1 0.9043 100 0.25 Contact Map
2z7bA 3 0.8511 13.5 0.923 Contact Map
3sqgA 4 0.4043 13.5 0.923 Contact Map
2x6uA 1 0.6064 11.3 0.925 Contact Map
1dmlA 1 0.7872 11.3 0.925 Contact Map
3gbwA 1 0.3085 8.6 0.929 Contact Map
4g1kA 2 0.7553 7.9 0.931 Contact Map
2pvpA 2 0.6915 7.9 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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