GREMLIN Database
AMPA - Cytosol aminopeptidase
UniProt: P68767 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10694
Length: 503 (449)
Sequences: 3911 (2787)
Seq/√Len: 131.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
340_T346_V3.5171.00
224_G227_Q3.1451.00
235_S346_V3.0771.00
400_N419_R3.0241.00
321_A362_V2.9961.00
396_M447_A2.9821.00
272_L323_C2.8651.00
191_G295_C2.8021.00
207_A301_Y2.7661.00
307_V312_L2.7031.00
244_Q330_R2.6591.00
428_E431_E2.6401.00
321_A358_V2.6181.00
240_G247_S2.5691.00
384_C394_G2.5671.00
203_L297_A2.5651.00
176_H494_L2.5581.00
221_R253_E2.4901.00
396_M451_G2.4551.00
307_V316_V2.4241.00
319_V366_V2.3981.00
250_S322_G2.3941.00
363_L454_L2.3851.00
199_N245_N2.3141.00
219_I253_E2.2511.00
265_I493_L2.2291.00
393_T484_R2.2211.00
392_I423_G2.1841.00
238_A332_Y2.1601.00
182_A309_E2.1451.00
272_L358_V2.1421.00
238_A338_L2.1181.00
349_L440_I2.1161.00
344_Q456_R2.0631.00
279_I327_P2.0601.00
276_S326_M2.0541.00
427_Q456_R2.0421.00
235_S340_T2.0121.00
206_Q209_Q2.0011.00
397_A403_A1.9611.00
341_M364_T1.9241.00
491_Q495_N1.9221.00
256_G315_N1.9181.00
203_L322_G1.8891.00
403_A419_R1.8851.00
337_V434_F1.8731.00
227_Q230_E1.8601.00
100_L108_A1.8481.00
406_L464_A1.8411.00
386_I443_R1.8121.00
339_T345_T1.8101.00
240_G323_C1.8011.00
433_N479_K1.7811.00
211_A220_T1.7801.00
224_G248_L1.7571.00
305_R309_E1.7541.00
228_M249_M1.7441.00
36_D41_G1.7351.00
377_V489_L1.7291.00
301_Y320_L1.7151.00
420_L447_A1.7141.00
396_M420_L1.7101.00
393_T471_T1.6971.00
97_I133_A1.6951.00
179_A183_G1.6911.00
199_N202_Y1.6851.00
310_L490_A1.6791.00
224_G246_E1.6521.00
183_G302_G1.6511.00
201_A245_N1.6321.00
349_L438_A1.6121.00
225_E229_K1.6081.00
367_E459_R1.6071.00
407_I417_A1.5911.00
266_V366_V1.5881.00
383_A446_G1.5801.00
267_L300_V1.5661.00
198_C202_Y1.5621.00
281_I284_S1.5501.00
332_Y338_L1.5291.00
249_M362_V1.5281.00
173_A177_G1.5211.00
432_S435_A1.5091.00
384_C420_L1.5041.00
405_E496_R1.5041.00
399_H462_N1.5031.00
225_E247_S1.5001.00
409_A491_Q1.4891.00
395_L466_L1.4881.00
376_D463_W1.4831.00
138_Y189_D1.4791.00
253_E369_F1.4731.00
201_A248_L1.4671.00
189_D192_N1.4651.00
183_G306_M1.4601.00
412_Q491_Q1.4591.00
407_I419_R1.4471.00
61_L74_L1.4471.00
385_V444_P1.4401.00
304_M307_V1.4361.00
393_T466_L1.4341.00
225_E246_E1.4211.00
304_M318_G1.4191.00
213_S305_R1.4181.00
267_L303_V1.4181.00
127_R176_H1.4171.00
241_Q332_Y1.4131.00
338_L348_V1.4081.00
244_Q328_G1.4071.00
307_V493_L1.4061.00
406_L492_F1.4041.00
234_H339_T1.4011.00
133_A157_M1.3991.00
257_N261_D1.3991.00
437_M456_R1.3981.00
54_G77_G1.3941.00
384_C447_A1.3941.00
300_V318_G1.3931.00
264_P317_I1.3881.00
400_N404_H1.3881.00
306_M490_A1.3881.00
177_G181_A1.3871.00
288_D349_L1.3771.00
205_S209_Q1.3741.00
344_Q437_M1.3731.00
338_L357_L1.3651.00
229_K241_Q1.3641.00
402_L464_A1.3541.00
200_A273_T1.3501.00
140_F143_L1.3431.00
373_A492_F1.3391.00
395_L464_A1.3381.00
404_H407_I1.3371.00
223_I231_L1.3351.00
395_L403_A1.3351.00
253_E315_N1.3311.00
195_P335_G1.3301.00
233_M365_Y1.3301.00
228_M236_Y1.3261.00
85_D88_Q1.3231.00
143_L193_M1.3171.00
265_I373_A1.3071.00
280_S284_S1.3011.00
225_E240_G1.3001.00
342_S364_T1.2941.00
250_S320_L1.2921.00
318_G377_V1.2891.00
214_Y305_R1.2881.00
422_L451_G1.2801.00
211_A252_I1.2761.00
263_R372_E1.2741.00
257_N315_N1.2681.00
377_V485_P1.2621.00
491_Q494_L1.2601.00
319_V362_V1.2561.00
233_M341_M1.2431.00
341_M368_R1.2341.00
300_V377_V1.2211.00
264_P315_N1.2201.00
266_V371_P1.2181.00
391_H425_E1.2171.00
280_S287_M1.2171.00
204_A250_S1.2141.00
175_Q178_L1.2101.00
171_E175_Q1.2060.99
258_A261_D1.2050.99
393_T485_P1.2040.99
272_L321_A1.2020.99
225_E248_L1.1940.99
203_L250_S1.1870.99
220_T252_I1.1820.99
252_I304_M1.1820.99
255_K315_N1.1820.99
266_V319_V1.1780.99
303_V307_V1.1760.99
241_Q330_R1.1750.99
292_Y473_W1.1740.99
205_S208_R1.1740.99
235_S338_L1.1720.99
134_K181_A1.1710.99
202_Y205_S1.1700.99
143_L197_I1.1700.99
218_V304_M1.1620.99
390_H444_P1.1610.99
417_A488_L1.1570.99
200_A324_E1.1550.99
80_K83_E1.1550.99
251_V365_Y1.1540.99
438_A441_G1.1510.99
245_N333_R1.1480.99
236_Y323_C1.1460.99
404_H408_A1.1400.99
294_M298_A1.1350.99
426_Y445_G1.1300.99
235_S360_C1.1240.99
199_N333_R1.1240.99
127_R131_E1.1230.99
264_P372_E1.1170.99
392_I416_R1.1170.99
297_A320_L1.1150.99
101_N139_S1.1130.99
217_N311_Q1.1090.99
332_Y357_L1.1030.99
271_G297_A1.0990.99
228_M233_M1.0990.99
363_L458_T1.0990.99
55_K58_Q1.0960.99
364_T459_R1.0870.99
407_I411_E1.0860.99
385_V447_A1.0840.99
204_A222_V1.0830.99
374_V461_Y1.0800.99
303_V489_L1.0780.99
138_Y192_N1.0770.99
340_T364_T1.0750.99
375_I492_F1.0730.99
200_A240_G1.0730.99
126_V130_V1.0720.99
332_Y348_V1.0710.99
323_C358_V1.0550.99
187_A302_G1.0540.99
373_A462_N1.0540.99
236_Y249_M1.0530.99
219_I255_K1.0520.99
416_R423_G1.0500.99
221_R251_V1.0490.99
370_E461_Y1.0480.99
232_G341_M1.0430.99
218_V308_A1.0430.99
386_I444_P1.0420.99
132_T136_T1.0420.99
187_A299_A1.0420.99
126_V173_A1.0420.99
283_P386_I1.0410.99
405_E492_F1.0400.98
93_I132_T1.0380.98
299_A303_V1.0360.98
179_A310_L1.0350.98
142_Q193_M1.0330.98
140_F189_D1.0320.98
211_A218_V1.0280.98
90_K131_E1.0260.98
202_Y206_Q1.0220.98
427_Q431_E1.0200.98
240_G324_E1.0190.98
226_Q229_K1.0170.98
385_V470_G1.0150.98
93_I129_A1.0140.98
427_Q452_C1.0140.98
223_I251_V1.0130.98
373_A402_L1.0120.98
402_L492_F1.0110.98
225_E237_L1.0090.98
367_E461_Y1.0060.98
483_G486_V1.0060.98
237_L241_Q1.0020.98
227_Q231_L1.0020.98
203_L301_Y1.0020.98
385_V390_H0.9970.98
231_L341_M0.9970.98
190_L294_M0.9950.98
366_V374_V0.9910.98
52_L60_L0.9900.98
448_I452_C0.9890.98
251_V317_I0.9880.98
266_V369_F0.9880.98
398_N455_S0.9860.98
204_A248_L0.9840.98
36_D44_S0.9830.98
242_G327_P0.9830.98
285_E443_R0.9820.98
223_I227_Q0.9810.98
266_V374_V0.9780.98
184_I487_A0.9650.98
254_Y311_Q0.9640.98
374_V458_T0.9590.97
107_E156_K0.9590.97
193_M197_I0.9580.97
452_C455_S0.9540.97
422_L452_C0.9510.97
384_C471_T0.9500.97
365_Y369_F0.9490.97
210_L305_R0.9480.97
178_L182_A0.9460.97
430_L440_I0.9430.97
244_Q329_G0.9410.97
412_Q495_N0.9400.97
222_V250_S0.9400.97
357_L439_N0.9380.97
363_L374_V0.9360.97
207_A250_S0.9340.97
283_P286_G0.9320.97
267_L493_L0.9270.97
426_Y448_I0.9190.97
393_T417_A0.9120.97
204_A220_T0.9110.97
253_E317_I0.9100.97
340_T453_F0.9090.96
228_M341_M0.9070.96
406_L417_A0.9050.96
90_K94_Q0.9020.96
375_I489_L0.9010.96
236_Y240_G0.9000.96
89_Y129_A0.9000.96
375_I493_L0.8980.96
108_A154_L0.8970.96
446_G449_T0.8940.96
208_R220_T0.8930.96
228_M237_L0.8930.96
303_V493_L0.8900.96
251_V319_V0.8860.96
427_Q455_S0.8850.96
131_E487_A0.8790.96
191_G481_A0.8750.96
44_S48_R0.8740.96
51_E72_R0.8730.96
299_A486_V0.8700.95
186_A210_L0.8690.95
268_V374_V0.8680.95
377_V466_L0.8680.95
143_L337_V0.8670.95
93_I96_T0.8660.95
135_E487_A0.8650.95
52_L77_G0.8640.95
429_Q442_G0.8620.95
327_P331_A0.8600.95
445_G448_I0.8590.95
203_L320_L0.8590.95
410_S488_L0.8550.95
317_I369_F0.8540.95
312_L494_L0.8530.95
229_K237_L0.8530.95
395_L407_I0.8520.95
416_R425_E0.8460.95
201_A205_S0.8450.95
96_T129_A0.8440.95
367_E458_T0.8430.95
53_E58_Q0.8420.95
408_A412_Q0.8420.95
350_N446_G0.8380.94
161_V170_G0.8380.94
252_I301_Y0.8370.94
54_G58_Q0.8350.94
221_R227_Q0.8320.94
140_F193_M0.8320.94
346_V437_M0.8310.94
242_G328_G0.8250.94
214_Y218_V0.8230.94
89_Y125_K0.8220.94
267_L316_V0.8210.94
485_P488_L0.8200.94
251_V369_F0.8190.94
204_A208_R0.8180.94
223_I365_Y0.8160.94
59_T74_L0.8130.94
202_Y245_N0.8100.93
87_R91_Q0.8080.93
405_E495_N0.8080.93
98_N136_T0.8060.93
292_Y472_A0.8050.93
249_M319_V0.8040.93
280_S283_P0.8030.93
490_A494_L0.7990.93
383_A386_I0.7980.93
429_Q441_G0.7970.93
437_M457_F0.7950.93
128_Q131_E0.7940.93
431_E456_R0.7930.93
263_R370_E0.7920.93
130_V177_G0.7910.93
228_M248_L0.7910.93
132_T135_E0.7900.93
228_M323_C0.7890.93
427_Q437_M0.7890.93
193_M198_C0.7870.92
408_A495_N0.7860.92
398_N458_T0.7860.92
304_M308_A0.7850.92
135_E181_A0.7840.92
423_G426_Y0.7840.92
76_I96_T0.7840.92
258_A315_N0.7830.92
350_N440_I0.7820.92
285_E288_D0.7820.92
314_I493_L0.7820.92
225_E323_C0.7780.92
280_S349_L0.7770.92
295_C299_A0.7750.92
197_I202_Y0.7740.92
266_V317_I0.7730.92
429_Q449_T0.7710.92
367_E460_K0.7710.92
322_G358_V0.7660.91
236_Y358_V0.7650.91
87_R90_K0.7630.91
198_C203_L0.7620.91
319_V365_Y0.7610.91
409_A413_S0.7600.91
406_L488_L0.7590.91
279_I288_D0.7590.91
292_Y481_A0.7580.91
226_Q230_E0.7570.91
134_K178_L0.7560.91
186_A305_R0.7540.91
319_V369_F0.7500.90
279_I286_G0.7490.90
430_L437_M0.7480.90
415_D484_R0.7480.90
36_D39_S0.7460.90
214_Y309_E0.7450.90
397_A419_R0.7420.90
249_M321_A0.7420.90
292_Y295_C0.7410.90
291_K434_F0.7400.90
358_V362_V0.7380.90
326_M333_R0.7360.90
47_L75_L0.7340.90
312_L493_L0.7310.89
219_I230_E0.7300.89
235_S348_V0.7290.89
413_S416_R0.7280.89
424_D455_S0.7260.89
308_A312_L0.7230.89
303_V318_G0.7220.89
474_R477_K0.7200.89
256_G261_D0.7200.89
484_R488_L0.7190.89
272_L362_V0.7110.88
187_A486_V0.7090.88
35_L39_S0.7040.88
261_D315_N0.7040.88
400_N403_A0.7020.87
187_A298_A0.7020.87
401_P405_E0.6980.87
420_L448_I0.6970.87
442_G449_T0.6950.87
209_Q212_D0.6940.87
279_I289_E0.6930.87
299_A377_V0.6920.87
210_L301_Y0.6920.87
365_Y368_R0.6910.87
340_T344_Q0.6890.86
212_D226_Q0.6880.86
284_S287_M0.6880.86
324_E333_R0.6870.86
288_D335_G0.6860.86
264_P371_P0.6860.86
200_A323_C0.6850.86
179_A309_E0.6850.86
422_L463_W0.6850.86
386_I447_A0.6840.86
303_V490_A0.6820.86
249_M358_V0.6790.86
458_T461_Y0.6780.86
348_V440_I0.6770.85
344_Q459_R0.6740.85
188_K478_A0.6740.85
297_A322_G0.6730.85
236_Y247_S0.6720.85
180_I490_A0.6720.85
135_E188_K0.6700.85
283_P287_M0.6700.85
384_C387_A0.6700.85
410_S413_S0.6700.85
415_D488_L0.6690.85
185_K189_D0.6690.85
134_K185_K0.6680.85
96_T133_A0.6670.85
89_Y93_I0.6660.84
130_V174_I0.6660.84
210_L218_V0.6660.84
208_R222_V0.6640.84
450_A454_L0.6620.84
34_Q38_I0.6600.84
284_S288_D0.6580.84
396_M422_L0.6570.84
466_L489_L0.6570.84
396_M448_I0.6540.83
350_N383_A0.6530.83
192_N481_A0.6520.83
128_Q132_T0.6520.83
452_C456_R0.6510.83
256_G313_P0.6500.83
338_L346_V0.6470.83
280_S288_D0.6440.82
183_G186_A0.6430.82
107_E158_V0.6420.82
265_I492_F0.6420.82
289_E475_S0.6410.82
395_L417_A0.6390.82
340_T360_C0.6390.82
203_L207_A0.6380.82
59_T76_I0.6380.82
426_Y452_C0.6370.82
208_R212_D0.6350.82
281_I327_P0.6340.81
176_H180_I0.6320.81
295_C472_A0.6310.81
99_T102_D0.6310.81
183_G187_A0.6310.81
209_Q213_S0.6290.81
383_A450_A0.6280.81
284_S440_I0.6240.80
407_I410_S0.6240.80
295_C481_A0.6240.80
183_G305_R0.6220.80
60_L75_L0.6210.80
51_E63_H0.6200.80
93_I97_I0.6200.80
78_C81_E0.6180.80
186_A206_Q0.6170.80
57_G95_K0.6170.80
283_P443_R0.6150.80
256_G262_A0.6140.79
61_L72_R0.6140.79
403_A407_I0.6130.79
179_A306_M0.6130.79
289_E292_Y0.6130.79
348_V351_T0.6120.79
34_Q41_G0.6110.79
38_I41_G0.6100.79
384_C396_M0.6100.79
238_A241_Q0.6090.79
130_V181_A0.6090.79
92_V96_T0.6060.79
213_S217_N0.6050.78
252_I320_L0.6050.78
406_L489_L0.6040.78
182_A305_R0.6040.78
276_S279_I0.6010.78
262_A372_E0.6010.78
142_Q189_D0.6010.78
242_G331_A0.6010.78
220_T250_S0.6000.78
441_G449_T0.6000.78
68_V73_I0.5990.78
43_I47_L0.5990.78
193_M202_Y0.5980.78
272_L276_S0.5980.78
398_N419_R0.5980.78
131_E177_G0.5970.77
268_V458_T0.5960.77
186_A301_Y0.5940.77
180_I306_M0.5930.77
78_C92_V0.5910.77
262_A313_P0.5900.77
176_H490_A0.5870.76
210_L214_Y0.5860.76
383_A447_A0.5840.76
468_I472_A0.5840.76
214_Y308_A0.5830.76
398_N463_W0.5820.76
364_T367_E0.5820.76
54_G79_G0.5810.76
33_E37_K0.5810.76
430_L452_C0.5800.75
257_N264_P0.5800.75
422_L455_S0.5800.75
217_N254_Y0.5800.75
417_A485_P0.5780.75
291_K347_E0.5770.75
141_D144_K0.5770.75
110_C129_A0.5760.75
174_I177_G0.5760.75
432_S437_M0.5760.75
208_R211_A0.5740.75
341_M365_Y0.5730.75
418_W421_P0.5720.74
38_I68_V0.5710.74
279_I326_M0.5670.74
181_A185_K0.5650.74
230_E258_A0.5650.74
228_M247_S0.5630.73
211_A214_Y0.5630.73
426_Y449_T0.5620.73
214_Y217_N0.5610.73
143_L189_D0.5610.73
410_S416_R0.5600.73
346_V453_F0.5600.73
186_A481_A0.5600.73
397_A400_N0.5590.73
366_V369_F0.5580.73
236_Y362_V0.5580.73
141_D147_K0.5580.73
194_P291_K0.5560.72
348_V439_N0.5550.72
94_Q101_N0.5550.72
301_Y322_G0.5550.72
218_V305_R0.5540.72
189_D206_Q0.5530.72
289_E473_W0.5530.72
197_I337_V0.5530.72
413_S491_Q0.5520.72
388_L420_L0.5520.72
212_D230_E0.5520.72
222_V248_L0.5510.72
300_V489_L0.5510.72
35_L40_D0.5510.72
196_N279_I0.5500.72
189_D193_M0.5490.71
304_M316_V0.5490.71
353_A382_G0.5490.71
127_R180_I0.5490.71
392_I426_Y0.5490.71
227_Q248_L0.5470.71
257_N262_A0.5470.71
95_K99_T0.5460.71
288_D440_I0.5450.71
238_A357_L0.5440.71
492_F496_R0.5440.71
36_D40_D0.5430.71
135_E184_I0.5420.70
42_Y66_P0.5400.70
50_G60_L0.5400.70
429_Q444_P0.5400.70
145_T344_Q0.5390.70
106_M155_R0.5390.70
441_G446_G0.5380.70
84_L89_Y0.5370.70
404_H419_R0.5370.70
191_G470_G0.5370.70
218_V252_I0.5360.70
308_A318_G0.5340.69
458_T463_W0.5330.69
91_Q95_K0.5310.69
279_I335_G0.5310.69
262_A315_N0.5310.69
64_H67_N0.5310.69
48_R82_R0.5300.69
228_M240_G0.5300.69
417_A484_R0.5290.69
184_I486_V0.5290.69
244_Q281_I0.5290.69
413_S488_L0.5280.68
171_E226_Q0.5280.68
163_T169_S0.5270.68
423_G452_C0.5260.68
424_D428_E0.5250.68
237_L240_G0.5240.68
372_E496_R0.5230.68
276_S291_K0.5230.68
108_A157_M0.5230.68
264_P369_F0.5220.68
242_G279_I0.5210.67
100_L103_T0.5210.67
201_A246_E0.5200.67
299_A483_G0.5200.67
274_F418_W0.5190.67
378_A463_W0.5180.67
33_E39_S0.5180.67
86_E128_Q0.5170.67
350_N357_L0.5170.67
266_V461_Y0.5140.66
404_H411_E0.5140.66
347_E432_S0.5130.66
303_V306_M0.5120.66
186_A302_G0.5110.66
263_R373_A0.5110.66
221_R368_R0.5100.66
265_I314_I0.5100.66
228_M358_V0.5090.66
346_V360_C0.5090.66
440_I443_R0.5070.65
323_C333_R0.5070.65
249_M323_C0.5070.65
280_S335_G0.5070.65
101_N104_G0.5060.65
193_M206_Q0.5050.65
245_N323_C0.5050.65
367_E374_V0.5050.65
172_R175_Q0.5030.65
289_E335_G0.5020.65
242_G330_R0.5020.65
56_P88_Q0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gytA 6 0.998 100 0.038 Contact Map
3h8gF 5 0.9841 100 0.049 Contact Map
3jruB 5 0.9702 100 0.054 Contact Map
3peiA 5 0.9026 100 0.066 Contact Map
4ksiA 5 0.9662 100 0.089 Contact Map
3kzwA 6 0.9622 100 0.089 Contact Map
1lamA 5 0.9165 100 0.103 Contact Map
3kr4A 5 0.9622 100 0.109 Contact Map
3ij3A 5 0.9006 100 0.151 Contact Map
4efdA 5 0.9324 100 0.206 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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