GREMLIN Database
NFI - Endonuclease V
UniProt: P68739 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11915
Length: 223 (209)
Sequences: 1027 (708)
Seq/√Len: 49.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_D181_S4.6901.00
112_R157_E3.7781.00
53_K56_S3.6121.00
139_F173_F3.4581.00
206_D210_S2.9481.00
19_R176_T2.9031.00
143_S148_A2.7991.00
113_L117_S2.6291.00
34_A86_L2.6051.00
21_D184_S2.5661.00
161_W186_L2.5501.00
30_L60_V2.3951.00
90_W123_V2.2121.00
181_S184_S2.2071.00
145_E167_A2.1831.00
124_D179_R2.1681.00
107_I117_S2.1611.00
62_Y208_V2.1481.00
105_H108_S2.1191.00
11_I14_A2.0891.00
99_L188_W2.0861.00
165_S193_M2.0571.00
100_V127_T2.0361.00
128_I189_V2.0291.00
165_S172_L2.0241.00
101_F202_T2.0191.00
107_I176_T1.9780.99
51_L95_Q1.9570.99
176_T182_V1.9400.99
13_L113_L1.9160.99
61_E94_S1.9040.99
45_T69_T1.8730.99
38_F69_T1.8190.99
154_D159_L1.8150.99
17_V121_L1.8110.99
210_S213_P1.7960.99
90_W100_V1.7520.99
158_Q161_W1.7200.98
149_L161_W1.7200.98
50_V59_L1.6970.98
7_R77_F1.6950.98
32_A51_L1.6940.98
67_I85_A1.6880.98
101_F189_V1.6840.98
37_G209_A1.6620.98
83_Y119_F1.5850.97
112_R154_D1.5740.97
45_T85_A1.5570.97
139_F142_L1.5550.97
142_L150_A1.5500.97
206_D209_A1.5190.97
134_R162_V1.5130.97
162_V173_F1.5090.96
22_R179_R1.5010.96
55_P192_C1.4690.96
52_L57_L1.4540.96
145_E148_A1.4440.95
32_A49_M1.4390.95
48_A209_A1.4280.95
144_S168_R1.4040.95
71_M206_D1.3860.94
152_L162_V1.3520.94
53_K58_E1.3410.93
101_F192_C1.3220.93
161_W182_V1.3200.93
88_A91_E1.2960.92
36_V86_L1.2900.92
102_V119_F1.2730.91
200_E203_R1.2720.91
67_I88_A1.2710.91
101_F130_V1.2540.91
37_G210_S1.2430.90
51_L94_S1.2250.90
163_W190_Q1.2120.89
34_A119_F1.2080.89
119_F123_V1.2010.89
49_M90_W1.1890.88
21_D179_R1.1670.87
139_F150_A1.1670.87
201_P204_W1.1660.87
12_E16_S1.1520.87
6_L71_M1.1430.86
134_R152_L1.1160.85
171_P197_R1.0960.84
79_S118_H1.0690.82
61_E95_Q1.0620.82
131_A204_W1.0510.81
37_G46_R1.0510.81
34_A78_L1.0350.80
163_W193_M1.0330.80
176_T185_A1.0240.79
102_V201_P1.0220.79
105_H133_K1.0210.79
146_P195_G1.0200.79
9_Q12_E1.0150.79
144_S148_A1.0120.78
18_I22_R1.0110.78
105_H131_A0.9910.77
171_P203_R0.9800.76
105_H135_L0.9780.76
7_R11_I0.9630.75
188_W201_P0.9600.75
131_A159_L0.9510.74
17_V117_S0.9480.74
115_V135_L0.9460.74
100_V125_V0.9340.73
50_V204_W0.9300.72
151_P161_W0.9240.72
54_Y191_R0.9180.71
166_K169_C0.9150.71
46_R210_S0.9120.71
51_L93_L0.9100.71
108_S160_A0.9000.70
14_A17_V0.8910.69
31_I34_A0.8880.69
188_W191_R0.8870.69
189_V197_R0.8870.69
89_A93_L0.8870.69
136_C159_L0.8820.68
128_I188_W0.8820.68
90_W119_F0.8810.68
146_P190_Q0.8790.68
5_S9_Q0.8790.68
163_W186_L0.8730.67
46_R212_R0.8640.67
77_F121_L0.8550.66
28_P188_W0.8550.66
86_L102_V0.8490.65
52_L204_W0.8470.65
22_R181_S0.8420.65
147_G190_Q0.8380.64
36_V45_T0.8350.64
93_L97_P0.8300.63
187_A191_R0.8280.63
13_L16_S0.8180.62
117_S127_T0.8150.62
9_Q77_F0.8140.62
151_P158_Q0.8130.62
32_A98_D0.8130.62
17_V107_I0.8130.62
206_D213_P0.8130.62
33_G202_T0.8090.61
39_E42_G0.8000.61
134_R154_D0.7980.60
23_L26_D0.7960.60
158_Q182_V0.7930.60
134_R137_G0.7910.60
100_V119_F0.7880.59
80_F118_H0.7860.59
36_V85_A0.7860.59
166_K193_M0.7860.59
153_M156_G0.7840.59
121_L178_H0.7810.59
52_L202_T0.7720.58
144_S167_A0.7720.58
196_Y203_R0.7710.58
161_W176_T0.7590.57
101_F123_V0.7590.57
101_F128_I0.7570.56
45_T115_V0.7560.56
5_S74_I0.7510.56
130_V209_A0.7500.56
186_L190_Q0.7490.56
103_D132_K0.7470.55
65_A92_M0.7460.55
47_A197_R0.7440.55
90_W96_K0.7420.55
136_C154_D0.7400.55
87_L123_V0.7380.54
63_K92_M0.7370.54
18_I179_R0.7340.54
197_R203_R0.7310.54
158_Q174_I0.7300.54
64_V212_R0.7290.54
39_E46_R0.7280.53
49_M89_A0.7280.53
141_P144_S0.7270.53
44_V66_R0.7260.53
6_L77_F0.7240.53
37_G213_P0.7240.53
69_T85_A0.7230.53
165_S190_Q0.7220.53
14_A113_L0.7080.51
65_A89_A0.7070.51
146_P167_A0.7070.51
48_A64_V0.6990.50
34_A102_V0.6960.50
149_L186_L0.6930.50
52_L59_L0.6920.50
71_M77_F0.6890.49
64_V208_V0.6840.49
101_F168_R0.6800.49
143_S150_A0.6800.49
153_M158_Q0.6740.48
108_S134_R0.6720.48
18_I23_L0.6690.47
140_E150_A0.6680.47
120_G178_H0.6680.47
34_A100_V0.6670.47
96_K125_V0.6650.47
30_L95_Q0.6640.47
79_S105_H0.6640.47
146_P193_M0.6620.47
176_T179_R0.6560.46
40_Q173_F0.6520.46
28_P133_K0.6520.46
22_R26_D0.6500.46
8_A11_I0.6490.45
8_A12_E0.6460.45
166_K201_P0.6430.45
31_I128_I0.6430.45
198_L201_P0.6420.45
154_D157_E0.6410.45
78_L105_H0.6410.45
35_D132_K0.6350.44
77_F186_L0.6330.44
45_T78_L0.6320.44
108_S175_A0.6310.44
207_A211_E0.6290.43
190_Q193_M0.6280.43
73_Y78_L0.6270.43
28_P98_D0.6260.43
39_E66_R0.6240.43
108_S159_L0.6240.43
105_H134_R0.6220.43
17_V113_L0.6210.43
20_E56_S0.6210.43
180_V184_S0.6200.43
46_R209_A0.6170.42
148_A168_R0.6160.42
172_L189_V0.6160.42
130_V189_V0.6090.41
37_G206_D0.6050.41
131_A168_R0.6050.41
79_S155_K0.6020.41
30_L51_L0.6010.41
59_L204_W0.6000.41
38_F78_L0.6000.41
54_Y192_C0.5990.40
204_W207_A0.5980.40
4_A8_A0.5970.40
29_D53_K0.5970.40
83_Y102_V0.5950.40
55_P191_R0.5950.40
71_M210_S0.5950.40
73_Y81_R0.5900.40
107_I113_L0.5900.40
65_A88_A0.5900.40
34_A90_W0.5890.39
164_R197_R0.5880.39
4_A156_G0.5880.39
148_A164_R0.5860.39
46_R213_P0.5840.39
86_L137_G0.5830.39
28_P100_V0.5790.39
116_A129_G0.5790.39
87_L91_E0.5780.38
12_E15_S0.5760.38
105_H137_G0.5760.38
120_G179_R0.5730.38
126_P185_A0.5730.38
99_L128_I0.5720.38
142_L148_A0.5690.38
22_R124_D0.5660.37
4_A91_E0.5650.37
77_F108_S0.5630.37
47_A89_A0.5540.36
34_A127_T0.5530.36
165_S171_P0.5530.36
31_I58_E0.5520.36
42_G50_V0.5520.36
63_K94_S0.5470.35
117_S176_T0.5470.35
108_S152_L0.5470.35
8_A16_S0.5440.35
30_L98_D0.5440.35
196_Y202_T0.5410.35
194_K201_P0.5410.35
196_Y200_E0.5410.35
149_L190_Q0.5390.35
209_A213_P0.5390.35
134_R173_F0.5370.35
18_I21_D0.5360.34
42_G212_R0.5360.34
63_K93_L0.5350.34
134_R142_L0.5350.34
36_V115_V0.5330.34
16_S20_E0.5320.34
178_H184_S0.5300.34
46_R66_R0.5270.34
130_V197_R0.5260.34
5_S172_L0.5240.33
9_Q16_S0.5210.33
95_Q153_M0.5210.33
182_V186_L0.5190.33
132_K175_A0.5180.33
33_G50_V0.5170.33
45_T50_V0.5150.33
131_A202_T0.5150.33
31_I127_T0.5150.33
90_W125_V0.5140.32
45_T48_A0.5130.32
119_F125_V0.5130.32
183_D187_A0.5120.32
13_L17_V0.5100.32
7_R36_V0.5090.32
134_R161_W0.5090.32
148_A167_A0.5070.32
56_S59_L0.5060.32
54_Y184_S0.5050.32
204_W208_V0.5030.32
197_R200_E0.5030.32
60_V127_T0.5010.31
53_K57_L0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ga2A 1 0.9865 100 0.167 Contact Map
4nspA 1 0.9596 100 0.201 Contact Map
2w36A 1 0.9507 100 0.268 Contact Map
3gocA 2 0.9776 100 0.299 Contact Map
2qh9A 2 0.7758 100 0.481 Contact Map
2nrrA 1 0.6188 97.6 0.9 Contact Map
2ygkA 2 0.9507 97.4 0.905 Contact Map
2nrtA 1 0.7354 97.2 0.907 Contact Map
3c65A 1 0.6009 96.6 0.915 Contact Map
4kreA 1 0.9058 88.1 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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