GREMLIN Database
GLRX1 - Glutaredoxin-1
UniProt: P68688 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10417
Length: 85 (73)
Sequences: 792 (472)
Seq/√Len: 55.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_K61_Q3.1561.00
52_A63_F2.8571.00
72_Y76_A2.7841.00
62_I75_F2.6961.00
61_Q68_H2.5841.00
54_K68_H2.2811.00
47_D51_K2.0671.00
16_R73_T2.0621.00
17_A62_I2.0611.00
17_A72_Y1.9171.00
16_R72_Y1.8790.99
19_D23_K1.7850.99
52_A61_Q1.6700.99
7_G35_Y1.6640.99
5_I21_A1.5940.98
16_R76_A1.5610.98
9_S38_I1.5590.98
22_E31_F1.5130.98
49_Q57_E1.4970.97
18_K35_Y1.4860.97
4_V34_Q1.4280.97
6_F66_Q1.4150.96
75_F78_W1.3600.95
8_R45_K1.3180.95
24_L79_V1.3060.94
64_V67_Q1.3010.94
20_L72_Y1.2960.94
36_V42_G1.2930.94
36_V45_K1.2150.92
46_E57_E1.2100.92
21_A29_D1.1930.91
34_Q39_R1.1040.88
20_L79_V1.0700.86
46_E49_Q1.0700.86
13_Y53_G1.0370.84
69_I78_W0.9900.81
7_G18_K0.9530.79
37_D42_G0.9430.78
23_K79_V0.9380.77
21_A65_D0.9050.75
19_D76_A0.9000.74
74_D77_A0.8930.74
24_L28_R0.8910.74
45_K59_V0.8680.72
46_E58_T0.8550.71
14_C59_V0.8530.70
17_A75_F0.8390.69
13_Y48_L0.8360.69
4_V66_Q0.8350.69
21_A24_L0.8350.69
3_T31_F0.8290.68
5_I24_L0.8050.66
39_R72_Y0.7990.65
20_L76_A0.7960.65
17_A76_A0.7930.65
54_K73_T0.7810.64
47_D66_Q0.7670.62
19_D22_E0.7560.61
9_S37_D0.7400.59
19_D51_K0.7250.58
19_D33_Y0.7230.58
12_P78_W0.7180.57
3_T29_D0.7140.57
20_L24_L0.7130.57
18_K36_V0.6920.54
11_C59_V0.6900.54
6_F39_R0.6880.54
28_R46_E0.6810.53
6_F41_E0.6810.53
15_V40_A0.6810.53
68_H78_W0.6730.52
17_A73_T0.6520.50
62_I72_Y0.6520.50
22_E69_I0.6360.48
21_A35_Y0.6340.48
54_K62_I0.6210.47
45_K57_E0.6080.45
73_T76_A0.6050.45
24_L37_D0.6020.45
31_F34_Q0.5970.44
17_A21_A0.5840.43
19_D44_T0.5780.42
54_K72_Y0.5770.42
29_D41_E0.5760.42
76_A80_K0.5760.42
9_S66_Q0.5730.42
12_P74_D0.5660.41
51_K62_I0.5610.40
41_E63_F0.5600.40
33_Y66_Q0.5570.40
38_I65_D0.5560.40
20_L58_T0.5530.40
29_D63_F0.5520.39
58_T69_I0.5470.39
32_Q74_D0.5450.39
7_G36_V0.5440.39
71_G74_D0.5440.39
64_V78_W0.5430.39
9_S33_Y0.5430.39
49_Q73_T0.5400.38
7_G11_C0.5380.38
53_G63_F0.5290.37
18_K37_D0.5230.37
9_S36_V0.5210.36
22_E32_Q0.5110.35
29_D67_Q0.5100.35
73_T78_W0.5080.35
8_R36_V0.5080.35
16_R68_H0.5020.34
43_I65_D0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jadA 1 0.9765 99.9 0.412 Contact Map
1u6tA 1 0.9059 99.8 0.486 Contact Map
2ct6A 1 0.9176 99.7 0.513 Contact Map
2wciA 3 0.9176 99.7 0.515 Contact Map
3l4nA 1 0.9765 99.7 0.517 Contact Map
3ctgA 1 0.9765 99.7 0.532 Contact Map
2wulA 3 0.9176 99.6 0.537 Contact Map
1t1vA 2 0.9412 99.6 0.541 Contact Map
3gx8A 1 0.9176 99.6 0.542 Contact Map
2x8gA 2 0.9412 99.6 0.545 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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