GREMLIN Database
FIXX - Ferredoxin-like protein FixX
UniProt: P68646 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11565
Length: 95 (89)
Sequences: 361 (211)
Seq/√Len: 22.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_D39_L4.3801.00
34_Q39_L4.3241.00
85_R88_F3.6941.00
26_V80_Q2.6710.99
16_F86_G2.1930.96
39_L73_G2.0450.94
19_D85_R2.0240.94
47_L59_D1.8300.89
32_D73_G1.8180.89
25_I47_L1.6930.85
42_A58_F1.6720.85
38_L77_A1.6460.84
33_K55_S1.6220.83
8_D49_K1.6170.83
38_L74_L1.5590.80
11_L48_Y1.5400.79
23_P83_Y1.5240.79
34_Q73_G1.5140.78
16_F47_L1.5080.78
46_G49_K1.4650.76
23_P58_F1.4650.76
28_K31_A1.3860.71
42_A72_L1.3850.71
47_L62_G1.3490.69
16_F93_R1.3410.69
37_E50_K1.3370.69
47_L58_F1.3120.67
25_I62_G1.3090.67
7_V35_A1.2470.63
39_L72_L1.2400.63
10_K62_G1.1920.60
26_V78_L1.1890.59
20_E61_A1.1740.58
51_Q57_R1.1680.58
12_G15_K1.1470.57
50_K56_V1.1400.56
69_C81_W1.1400.56
45_A64_L1.1100.54
7_V37_E1.1080.54
25_I58_F1.0790.52
52_D92_F1.0470.50
13_V62_G1.0430.49
14_N62_G1.0370.49
25_I68_T1.0220.48
50_K55_S1.0100.47
27_V58_F0.9690.44
40_V48_Y0.9630.44
13_V61_A0.9620.44
12_G58_F0.9540.43
19_D48_Y0.9430.43
40_V50_K0.9230.41
12_G87_T0.9140.41
15_K87_T0.9130.41
38_L82_E0.9130.41
86_G92_F0.9040.40
14_N90_V0.8930.39
16_F29_A0.8660.38
70_R76_S0.8510.37
32_D72_L0.8510.37
12_G93_R0.8470.36
33_K53_D0.8450.36
24_H66_C0.8420.36
40_V72_L0.8380.36
27_V91_E0.8350.36
47_L60_Y0.8320.35
14_N64_L0.8300.35
9_V42_A0.8220.35
30_D51_Q0.8180.35
18_V71_I0.8120.34
22_H85_R0.8110.34
46_G68_T0.7850.33
11_L64_L0.7820.32
22_H60_Y0.7790.32
7_V19_D0.7770.32
42_A47_L0.7620.31
17_N49_K0.7530.31
49_K82_E0.7520.31
47_L68_T0.7460.30
6_N9_V0.7440.30
56_V91_E0.7370.30
84_P89_G0.7320.29
30_D33_K0.7300.29
10_K16_F0.7140.28
68_T81_W0.7090.28
5_V50_K0.7060.28
12_G90_V0.6980.28
36_L39_L0.6870.27
49_K68_T0.6840.27
12_G25_I0.6790.26
27_V78_L0.6760.26
36_L74_L0.6680.26
50_K54_G0.6510.25
23_P47_L0.6460.25
28_K52_D0.6420.25
7_V42_A0.6390.24
47_L61_A0.6350.24
74_L77_A0.6340.24
56_V94_Y0.6300.24
42_A60_Y0.6190.23
48_Y62_G0.6070.23
10_K13_V0.6060.23
62_G70_R0.6050.23
33_K56_V0.5960.22
11_L14_N0.5950.22
7_V51_Q0.5920.22
35_A77_A0.5900.22
50_K53_D0.5840.22
40_V93_R0.5840.22
10_K86_G0.5830.22
5_V28_K0.5740.21
36_L76_S0.5720.21
16_F46_G0.5720.21
45_A54_G0.5660.21
31_A52_D0.5640.21
40_V88_F0.5630.21
10_K95_G0.5550.20
35_A92_F0.5540.20
51_Q55_S0.5540.20
9_V13_V0.5400.20
16_F62_G0.5390.20
61_A68_T0.5380.20
14_N83_Y0.5330.19
34_Q76_S0.5260.19
7_V46_G0.5250.19
14_N46_G0.5210.19
45_A68_T0.5190.19
77_A92_F0.5190.19
52_D64_L0.5190.19
26_V49_K0.5170.19
35_A38_L0.5130.19
47_L93_R0.5080.18
56_V85_R0.5070.18
18_V53_D0.5030.18
5_V54_G0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gmhA 1 0.9789 99.5 0.626 Contact Map
1hfeL 2 0.9789 98.4 0.77 Contact Map
1q16B 2 0.9684 98.3 0.772 Contact Map
3mm5B 2 0.9579 98 0.789 Contact Map
2ivfB 1 0.9579 98 0.792 Contact Map
3gyxB 1 0.7474 98 0.793 Contact Map
1jnrB 1 0.7474 97.8 0.799 Contact Map
1xerA 2 0.8526 97.8 0.8 Contact Map
1jb0C 1 0.7158 97.7 0.804 Contact Map
7fd1A 1 0.7263 97.7 0.805 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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