FIXC - ECOLI - GREMLIN Contacts

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FIXC - Protein FixC

UniProt:	P68644	Sequences: MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIPGFADSAPVERLITHEKLAFMTEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILADGVNSILAEKLGMAKRVKPTDVAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCGLHHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIAGDAAGMCMNLGFTIRGMDLAIAAGEAAAKTVLSAMKSDDFSKQKLAEYRQHLESGPLRDMRMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAPELMRKKILRHGKKVGFINLIKDGMKGVTVL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11564
Length:	428 (356)
Sequences:	27071 (20729)
Seq/√Len:	1098.7

ECOLI - FIXC YDIS YGCN UBIF UBIH UBII MHPA CBRA
BACSU - YHJG YETM
HALSA - Q9HS24 Q9HS01 Q9HQE5 Q9HMA0
SULSO - Q97V59 Q97V18 Q97W83 Q97ZK8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
32_L	126_I	4.271	1.00
36_R	130_R	3.584	1.00
9_I	153_A	3.573	1.00
16_A	320_A	3.443	1.00
7_D	30_Q	3.264	1.00
349_R	353_E	3.165	1.00
7_D	154_K	3.134	1.00
6_F	32_L	2.848	1.00
130_R	146_A	2.774	1.00
133_N	169_K	2.738	1.00
117_Q	120_E	2.712	1.00
20_A	157_I	2.651	1.00
34_I	151_I	2.642	1.00
129_I	147_D	2.598	1.00
142_V	152_E	2.559	1.00
142_V	150_V	2.548	1.00
27_E	332_L	2.504	1.00
23_V	328_A	2.491	1.00
66_A	116_E	2.444	1.00
112_A	116_E	2.330	1.00
9_I	34_I	2.305	1.00
9_I	143_G	2.303	1.00
133_N	144_V	2.298	1.00
135_V	142_V	2.274	1.00
140_K	152_E	2.229	1.00
16_A	300_A	2.217	1.00
126_I	129_I	2.149	1.00
132_D	146_A	2.142	1.00
144_V	150_V	2.142	1.00
19_V	321_I	2.107	1.00
330_T	351_H	2.042	1.00
158_L	166_L	2.022	1.00
59_I	64_D	1.990	1.00
66_A	117_Q	1.982	1.00
135_V	144_V	1.978	1.00
38_N	128_G	1.951	1.00
117_Q	121_A	1.942	1.00
129_I	145_E	1.879	1.00
330_T	347_E	1.863	1.00
22_L	117_Q	1.862	1.00
8_A	24_L	1.851	1.00
30_Q	124_Q	1.819	1.00
8_A	29_A	1.811	1.00
353_E	357_L	1.810	1.00
57_H	325_E	1.792	1.00
190_E	272_K	1.787	1.00
54_S	318_D	1.755	1.00
293_V	346_A	1.753	1.00
159_A	300_A	1.750	1.00
131_V	143_G	1.749	1.00
7_D	32_L	1.741	1.00
256_E	259_K	1.739	1.00
252_P	256_E	1.728	1.00
324_G	328_A	1.727	1.00
291_E	294_G	1.715	1.00
34_I	145_E	1.702	1.00
29_A	332_L	1.702	1.00
137_R	142_V	1.695	1.00
25_A	123_A	1.693	1.00
136_Q	294_G	1.691	1.00
145_E	151_I	1.684	1.00
293_V	298_L	1.678	1.00
66_A	69_E	1.670	1.00
158_L	299_I	1.668	1.00
115_M	127_T	1.659	1.00
60_P	325_E	1.637	1.00
118_A	123_A	1.613	1.00
26_R	121_A	1.605	1.00
65_S	69_E	1.605	1.00
326_A	351_H	1.590	1.00
137_R	140_K	1.568	1.00
134_L	156_V	1.563	1.00
66_A	120_E	1.560	1.00
253_Q	256_E	1.559	1.00
165_I	169_K	1.555	1.00
326_A	330_T	1.526	1.00
32_L	151_I	1.520	1.00
21_A	33_V	1.517	1.00
20_A	324_G	1.515	1.00
250_S	253_Q	1.510	1.00
292_L	356_P	1.506	1.00
22_L	26_R	1.504	1.00
9_I	151_I	1.501	1.00
115_M	119_E	1.491	1.00
170_L	297_V	1.479	1.00
155_T	345_L	1.472	1.00
157_I	300_A	1.472	1.00
298_L	327_A	1.461	1.00
291_E	349_R	1.452	1.00
54_S	321_I	1.438	1.00
160_D	164_S	1.422	1.00
23_V	61_G	1.411	1.00
143_G	146_A	1.405	1.00
137_R	152_E	1.395	1.00
11_V	131_V	1.392	1.00
329_K	351_H	1.375	1.00
255_L	259_K	1.370	1.00
278_A	282_P	1.357	1.00
70_R	109_K	1.354	1.00
143_G	153_A	1.353	1.00
25_A	121_A	1.352	1.00
211_L	214_G	1.317	1.00
322_A	355_G	1.314	1.00
256_E	260_Q	1.314	1.00
157_I	298_L	1.311	1.00
15_L	317_M	1.308	1.00
330_T	333_S	1.307	1.00
323_A	352_L	1.300	1.00
32_L	124_Q	1.298	1.00
165_I	168_E	1.289	1.00
6_F	9_I	1.276	1.00
109_K	112_A	1.273	1.00
131_V	166_L	1.273	1.00
330_T	344_K	1.271	1.00
131_V	134_L	1.266	1.00
126_I	151_I	1.259	1.00
10_I	20_A	1.258	1.00
22_L	118_A	1.257	1.00
252_P	255_L	1.256	1.00
40_A	127_T	1.255	1.00
64_D	68_V	1.249	1.00
11_V	160_D	1.244	1.00
292_L	349_R	1.243	1.00
293_V	349_R	1.238	1.00
19_V	61_G	1.220	1.00
187_E	190_E	1.206	1.00
278_A	281_V	1.205	1.00
266_P	269_A	1.200	1.00
175_R	290_P	1.200	1.00
116_E	119_E	1.191	1.00
253_Q	257_D	1.188	1.00
135_V	150_V	1.187	1.00
20_A	24_L	1.184	1.00
106_L	109_K	1.180	1.00
305_G	323_A	1.173	1.00
279_H	283_E	1.169	1.00
173_A	290_P	1.167	1.00
262_P	265_A	1.165	1.00
22_L	121_A	1.163	1.00
65_S	68_V	1.159	1.00
190_E	232_T	1.158	1.00
9_I	32_L	1.156	1.00
191_L	194_S	1.149	1.00
279_H	282_P	1.149	1.00
129_I	149_D	1.136	1.00
33_V	125_L	1.133	1.00
11_V	166_L	1.133	1.00
134_L	169_K	1.132	1.00
162_V	306_M	1.131	1.00
13_A	18_S	1.127	1.00
153_A	156_V	1.126	1.00
82_E	85_A	1.116	1.00
21_A	31_V	1.115	1.00
81_T	85_A	1.111	1.00
136_Q	296_G	1.103	1.00
20_A	300_A	1.103	1.00
66_A	113_W	1.096	1.00
346_A	350_Q	1.087	1.00
136_Q	141_V	1.083	1.00
140_K	143_G	1.068	1.00
10_I	21_A	1.060	1.00
308_M	319_L	1.055	1.00
34_I	126_I	1.053	1.00
71_L	103_Y	1.053	1.00
6_F	30_Q	1.050	1.00
190_E	231_N	1.049	1.00
115_M	125_L	1.045	1.00
39_S	127_T	1.044	1.00
134_L	170_L	1.042	1.00
294_G	297_V	1.041	1.00
19_V	23_V	1.040	1.00
18_S	118_A	1.038	1.00
299_I	303_A	1.032	1.00
141_V	296_G	1.030	1.00
60_P	329_K	1.028	1.00
254_M	258_F	1.025	1.00
48_G	317_M	1.020	1.00
143_G	156_V	1.020	1.00
300_A	348_Y	1.008	1.00
26_R	117_Q	1.007	1.00
10_I	31_V	1.000	1.00
265_A	269_A	1.000	1.00
132_D	144_V	0.995	1.00
347_E	350_Q	0.995	1.00
357_L	361_R	0.993	1.00
309_N	312_F	0.991	1.00
11_V	156_V	0.991	1.00
40_A	115_M	0.990	1.00
88_M	92_N	0.990	1.00
113_W	116_E	0.990	1.00
298_L	348_Y	0.987	1.00
268_I	271_G	0.982	1.00
6_F	124_Q	0.981	1.00
209_A	212_F	0.979	1.00
257_D	260_Q	0.974	1.00
7_D	29_A	0.974	1.00
293_V	342_K	0.966	1.00
373_P	376_F	0.966	1.00
31_V	123_A	0.960	1.00
188_L	191_L	0.959	1.00
326_A	329_K	0.951	1.00
55_L	64_D	0.951	1.00
116_E	120_E	0.951	1.00
45_V	48_G	0.946	1.00
34_I	129_I	0.944	1.00
205_N	209_A	0.940	1.00
29_A	335_M	0.936	1.00
58_I	63_A	0.935	1.00
32_L	153_A	0.931	1.00
63_A	117_Q	0.926	1.00
251_V	255_L	0.923	1.00
257_D	261_H	0.921	1.00
143_G	147_D	0.920	1.00
56_E	59_I	0.919	1.00
63_A	113_W	0.919	1.00
333_S	347_E	0.916	1.00
22_L	61_G	0.911	1.00
25_A	31_V	0.909	1.00
113_W	117_Q	0.903	1.00
23_V	26_R	0.902	1.00
131_V	165_I	0.898	1.00
262_P	266_P	0.892	1.00
15_L	321_I	0.890	1.00
243_H	246_D	0.889	1.00
210_C	213_A	0.884	1.00
308_M	360_M	0.881	1.00
70_R	113_W	0.880	1.00
134_L	297_V	0.879	1.00
35_E	127_T	0.877	1.00
205_N	208_A	0.877	1.00
289_L	299_I	0.872	1.00
66_A	70_R	0.871	1.00
23_V	27_E	0.869	1.00
81_T	84_S	0.869	1.00
18_S	115_M	0.868	1.00
280_V	283_E	0.866	1.00
141_V	156_V	0.863	1.00
172_M	289_L	0.862	1.00
278_A	283_E	0.861	1.00
28_G	31_V	0.858	1.00
131_V	169_K	0.858	1.00
25_A	122_G	0.858	1.00
13_A	35_E	0.858	1.00
48_G	107_R	0.854	1.00
53_H	315_R	0.852	1.00
225_F	236_G	0.848	1.00
347_E	351_H	0.848	1.00
111_D	115_M	0.848	1.00
158_L	297_V	0.844	1.00
25_A	118_A	0.842	1.00
53_H	322_A	0.840	1.00
34_I	153_A	0.839	1.00
55_L	103_Y	0.836	1.00
377_S	381_E	0.835	1.00
260_Q	265_A	0.833	1.00
206_Q	209_A	0.828	1.00
119_E	124_Q	0.828	1.00
24_L	331_V	0.823	1.00
136_Q	295_D	0.815	1.00
234_S	238_V	0.814	1.00
55_L	59_I	0.812	1.00
166_L	297_V	0.811	1.00
283_E	364_Q	0.811	1.00
325_E	329_K	0.811	1.00
70_R	112_A	0.808	1.00
7_D	153_A	0.808	1.00
24_L	29_A	0.804	1.00
248_K	251_V	0.801	1.00
67_P	110_F	0.800	1.00
67_P	113_W	0.798	1.00
299_I	304_A	0.794	1.00
263_A	266_P	0.793	1.00
214_G	219_G	0.792	1.00
364_Q	368_A	0.790	1.00
266_P	270_G	0.789	1.00
374_R	377_S	0.787	1.00
71_L	74_H	0.784	1.00
157_I	327_A	0.783	1.00
332_L	336_K	0.783	1.00
292_L	304_A	0.782	1.00
187_E	191_L	0.781	1.00
134_L	166_L	0.780	1.00
208_A	211_L	0.780	1.00
164_S	167_A	0.778	1.00
58_I	321_I	0.773	1.00
105_V	110_F	0.773	1.00
335_M	338_D	0.772	1.00
292_L	353_E	0.768	1.00
308_M	313_T	0.768	1.00
354_S	358_R	0.768	1.00
49_R	102_S	0.767	1.00
158_L	170_L	0.765	1.00
139_G	296_G	0.761	1.00
59_I	68_V	0.761	1.00
139_G	143_G	0.760	1.00
328_A	332_L	0.760	1.00
264_V	267_L	0.757	1.00
366_L	369_F	0.755	1.00
54_S	57_H	0.752	1.00
317_M	321_I	0.752	1.00
172_M	294_G	0.747	1.00
351_H	354_S	0.746	1.00
25_A	119_E	0.744	1.00
24_L	328_A	0.743	1.00
43_K	46_T	0.742	1.00
334_A	347_E	0.742	1.00
7_D	151_I	0.737	1.00
19_V	114_L	0.735	1.00
375_M	378_G	0.727	1.00
18_S	111_D	0.726	1.00
87_T	90_Y	0.725	1.00
53_H	56_E	0.725	1.00
155_T	298_L	0.723	1.00
313_T	363_Y	0.722	1.00
87_T	91_C	0.721	1.00
207_G	210_C	0.721	1.00
339_D	343_Q	0.720	1.00
334_A	338_D	0.720	1.00
8_A	155_T	0.718	1.00
288_M	357_L	0.716	1.00
49_R	104_S	0.713	1.00
21_A	118_A	0.713	1.00
235_L	239_C	0.710	1.00
76_K	89_D	0.706	1.00
235_L	238_V	0.706	1.00
258_F	261_H	0.706	1.00
293_V	345_L	0.705	1.00
23_V	57_H	0.703	1.00
25_A	124_Q	0.702	1.00
255_L	269_A	0.701	1.00
267_L	270_G	0.699	1.00
187_E	235_L	0.697	1.00
333_S	338_D	0.695	1.00
129_I	146_A	0.694	1.00
191_L	233_L	0.688	1.00
51_Y	318_D	0.687	1.00
289_L	292_L	0.685	1.00
126_I	149_D	0.683	1.00
130_R	165_I	0.683	1.00
190_E	193_K	0.681	1.00
319_L	359_D	0.681	1.00
207_G	211_L	0.679	1.00
288_M	292_L	0.679	1.00
208_A	212_F	0.677	1.00
271_G	274_V	0.677	1.00
118_A	125_L	0.677	1.00
346_A	349_R	0.676	1.00
267_L	271_G	0.675	1.00
40_A	111_D	0.673	1.00
89_D	92_N	0.672	1.00
27_E	328_A	0.671	1.00
21_A	123_A	0.670	1.00
118_A	122_G	0.669	1.00
372_N	377_S	0.669	1.00
177_K	180_D	0.666	1.00
375_M	379_Y	0.665	1.00
358_R	362_M	0.664	1.00
358_R	361_R	0.663	1.00
181_V	184_G	0.663	1.00
195_V	205_N	0.663	1.00
209_A	214_G	0.660	1.00
86_M	89_D	0.660	1.00
342_K	346_A	0.659	1.00
140_K	154_K	0.658	1.00
170_L	294_G	0.657	1.00
295_D	342_K	0.656	1.00
306_M	323_A	0.656	1.00
107_R	111_D	0.655	1.00
298_L	345_L	0.655	1.00
22_L	25_A	0.654	1.00
87_T	92_N	0.654	1.00
59_I	65_S	0.653	1.00
317_M	320_A	0.652	1.00
255_L	261_H	0.652	1.00
8_A	20_A	0.652	1.00
171_G	174_K	0.651	1.00
319_L	356_P	0.650	1.00
207_G	212_F	0.649	1.00
367_P	371_D	0.648	1.00
119_E	122_G	0.646	1.00
31_V	118_A	0.645	1.00
329_K	333_S	0.645	1.00
20_A	328_A	0.643	1.00
270_G	273_L	0.642	1.00
209_A	213_A	0.642	1.00
23_V	325_E	0.641	1.00
315_R	319_L	0.640	1.00
178_P	181_V	0.639	1.00
255_L	258_F	0.638	1.00
34_I	143_G	0.636	1.00
187_E	192_P	0.635	1.00
191_L	195_V	0.634	1.00
185_V	188_L	0.633	1.00
84_S	87_T	0.629	1.00
244_L	247_A	0.628	1.00
187_E	194_S	0.627	1.00
272_K	275_E	0.626	1.00
83_K	86_M	0.625	1.00
356_P	360_M	0.622	1.00
308_M	363_Y	0.621	1.00
76_K	208_A	0.620	1.00
271_G	275_E	0.619	1.00
288_M	353_E	0.618	1.00
78_A	86_M	0.617	1.00
13_A	33_V	0.617	1.00
16_A	157_I	0.617	1.00
334_A	343_Q	0.615	1.00
155_T	335_M	0.614	1.00
190_E	194_S	0.613	1.00
18_S	125_L	0.612	1.00
373_P	377_S	0.611	1.00
37_G	43_K	0.610	1.00
155_T	331_V	0.607	1.00
18_S	33_V	0.607	1.00
263_A	267_L	0.604	1.00
365_K	368_A	0.603	1.00
158_L	164_S	0.602	1.00
322_A	326_A	0.601	1.00
334_A	337_S	0.599	1.00
377_S	380_P	0.599	1.00
339_D	344_K	0.594	1.00
240_G	243_H	0.594	1.00
51_Y	54_S	0.593	1.00
265_A	270_G	0.591	1.00
376_F	379_Y	0.590	1.00
22_L	123_A	0.589	1.00
372_N	375_M	0.589	1.00
37_G	41_G	0.589	1.00
334_A	344_K	0.588	1.00
275_E	278_A	0.587	1.00
58_I	67_P	0.585	1.00
350_Q	354_S	0.583	1.00
158_L	165_I	0.583	1.00
59_I	100_Q	0.582	1.00
57_H	322_A	0.580	1.00
141_V	145_E	0.579	1.00
223_G	227_Y	0.576	1.00
210_C	214_G	0.573	1.00
373_P	380_P	0.573	1.00
181_V	185_V	0.571	1.00
22_L	63_A	0.570	1.00
57_H	60_P	0.570	1.00
81_T	86_M	0.570	1.00
167_A	299_I	0.569	1.00
315_R	318_D	0.567	1.00
46_T	107_R	0.566	1.00
58_I	110_F	0.565	1.00
154_K	335_M	0.562	1.00
276_Y	280_V	0.562	1.00
88_M	91_C	0.562	1.00
106_L	232_T	0.561	1.00
234_S	239_C	0.560	1.00
300_A	324_G	0.560	1.00
264_V	268_I	0.560	1.00
53_H	355_G	0.560	1.00
134_L	141_V	0.559	1.00
57_H	61_G	0.558	1.00
224_G	227_Y	0.558	1.00
154_K	296_G	0.558	1.00
326_A	348_Y	0.558	1.00
82_E	86_M	0.558	1.00
50_L	54_S	0.557	1.00
222_G	257_D	0.557	1.00
249_K	253_Q	0.557	1.00
78_A	87_T	0.556	1.00
56_E	60_P	0.556	1.00
156_V	297_V	0.555	1.00
374_R	378_G	0.555	1.00
312_F	367_P	0.555	1.00
29_A	331_V	0.552	1.00
206_Q	210_C	0.552	1.00
259_K	265_A	0.550	1.00
302_D	320_A	0.549	1.00
19_V	58_I	0.548	1.00
172_M	175_R	0.547	1.00
20_A	159_A	0.547	1.00
229_N	232_T	0.547	1.00
305_G	356_P	0.546	1.00
168_E	173_A	0.540	1.00
145_E	149_D	0.539	1.00
145_E	150_V	0.539	1.00
78_A	89_D	0.539	1.00
254_M	259_K	0.539	1.00
166_L	169_K	0.539	1.00
119_E	123_A	0.539	1.00
40_A	112_A	0.538	1.00
67_P	103_Y	0.537	1.00
259_K	269_A	0.537	1.00
118_A	121_A	0.535	1.00
38_N	127_T	0.534	1.00
33_V	123_A	0.533	1.00
6_F	154_K	0.532	1.00
50_L	317_M	0.531	1.00
219_G	222_G	0.530	1.00
190_E	274_V	0.529	1.00
361_R	365_K	0.529	1.00
109_K	113_W	0.529	1.00
19_V	57_H	0.528	1.00
315_R	359_D	0.526	1.00
313_T	366_L	0.526	1.00
254_M	261_H	0.525	1.00
184_G	187_E	0.522	1.00
258_F	264_V	0.521	1.00
8_A	157_I	0.521	1.00
106_L	229_N	0.519	1.00
70_R	105_V	0.519	1.00
341_S	344_K	0.518	1.00
227_Y	236_G	0.518	1.00
224_G	228_T	0.517	1.00
208_A	213_A	0.517	1.00
277_S	282_P	0.516	1.00
333_S	337_S	0.515	1.00
182_A	186_K	0.515	1.00
366_L	370_L	0.514	1.00
334_A	339_D	0.514	1.00
31_V	124_Q	0.514	1.00
233_L	237_L	0.513	1.00
157_I	331_V	0.512	1.00
145_E	148_G	0.512	1.00
158_L	303_A	0.512	1.00
286_I	306_M	0.511	1.00
70_R	74_H	0.510	1.00
131_V	145_E	0.510	1.00
119_E	127_T	0.508	1.00
242_H	245_H	0.505	1.00
155_T	334_A	0.504	1.00
326_A	352_L	0.504	1.00
361_R	364_Q	0.504	1.00
254_M	257_D	0.503	1.00
68_V	71_L	0.503	1.00
29_A	336_K	0.501	1.00
188_L	192_P	0.501	1.00
20_A	23_V	0.500	1.00
68_V	73_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4n9xA	5	0.8388	100	0.396	Contact Map
2qa1A	2	0.9089	100	0.397	Contact Map
4bjzA	2	0.8808	100	0.397	Contact Map
1pn0A	3	0.9322	100	0.399	Contact Map
2qa2A	2	0.9136	100	0.4	Contact Map
2x3nA	1	0.8178	100	0.402	Contact Map
4k22A	4	0.8061	100	0.403	Contact Map
3c96A	1	0.8271	100	0.41	Contact Map
4k5sA	2	0.9182	100	0.411	Contact Map
3aljA	1	0.8458	100	0.416	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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