GREMLIN Database
FIXC - Protein FixC
UniProt: P68644 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11564
Length: 428 (356)
Sequences: 27071 (20729)
Seq/√Len: 1098.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_L126_I4.2711.00
36_R130_R3.5841.00
9_I153_A3.5731.00
16_A320_A3.4431.00
7_D30_Q3.2641.00
349_R353_E3.1651.00
7_D154_K3.1341.00
6_F32_L2.8481.00
130_R146_A2.7741.00
133_N169_K2.7381.00
117_Q120_E2.7121.00
20_A157_I2.6511.00
34_I151_I2.6421.00
129_I147_D2.5981.00
142_V152_E2.5591.00
142_V150_V2.5481.00
27_E332_L2.5041.00
23_V328_A2.4911.00
66_A116_E2.4441.00
112_A116_E2.3301.00
9_I34_I2.3051.00
9_I143_G2.3031.00
133_N144_V2.2981.00
135_V142_V2.2741.00
140_K152_E2.2291.00
16_A300_A2.2171.00
126_I129_I2.1491.00
132_D146_A2.1421.00
144_V150_V2.1421.00
19_V321_I2.1071.00
330_T351_H2.0421.00
158_L166_L2.0221.00
59_I64_D1.9901.00
66_A117_Q1.9821.00
135_V144_V1.9781.00
38_N128_G1.9511.00
117_Q121_A1.9421.00
129_I145_E1.8791.00
330_T347_E1.8631.00
22_L117_Q1.8621.00
8_A24_L1.8511.00
30_Q124_Q1.8191.00
8_A29_A1.8111.00
353_E357_L1.8101.00
57_H325_E1.7921.00
190_E272_K1.7871.00
54_S318_D1.7551.00
293_V346_A1.7531.00
159_A300_A1.7501.00
131_V143_G1.7491.00
7_D32_L1.7411.00
256_E259_K1.7391.00
252_P256_E1.7281.00
324_G328_A1.7271.00
291_E294_G1.7151.00
34_I145_E1.7021.00
29_A332_L1.7021.00
137_R142_V1.6951.00
25_A123_A1.6931.00
136_Q294_G1.6911.00
145_E151_I1.6841.00
293_V298_L1.6781.00
66_A69_E1.6701.00
158_L299_I1.6681.00
115_M127_T1.6591.00
60_P325_E1.6371.00
118_A123_A1.6131.00
26_R121_A1.6051.00
65_S69_E1.6051.00
326_A351_H1.5901.00
137_R140_K1.5681.00
134_L156_V1.5631.00
66_A120_E1.5601.00
253_Q256_E1.5591.00
165_I169_K1.5551.00
326_A330_T1.5261.00
32_L151_I1.5201.00
21_A33_V1.5171.00
20_A324_G1.5151.00
250_S253_Q1.5101.00
292_L356_P1.5061.00
22_L26_R1.5041.00
9_I151_I1.5011.00
115_M119_E1.4911.00
170_L297_V1.4791.00
155_T345_L1.4721.00
157_I300_A1.4721.00
298_L327_A1.4611.00
291_E349_R1.4521.00
54_S321_I1.4381.00
160_D164_S1.4221.00
23_V61_G1.4111.00
143_G146_A1.4051.00
137_R152_E1.3951.00
11_V131_V1.3921.00
329_K351_H1.3751.00
255_L259_K1.3701.00
278_A282_P1.3571.00
70_R109_K1.3541.00
143_G153_A1.3531.00
25_A121_A1.3521.00
211_L214_G1.3171.00
322_A355_G1.3141.00
256_E260_Q1.3141.00
157_I298_L1.3111.00
15_L317_M1.3081.00
330_T333_S1.3071.00
323_A352_L1.3001.00
32_L124_Q1.2981.00
165_I168_E1.2891.00
6_F9_I1.2761.00
109_K112_A1.2731.00
131_V166_L1.2731.00
330_T344_K1.2711.00
131_V134_L1.2661.00
126_I151_I1.2591.00
10_I20_A1.2581.00
22_L118_A1.2571.00
252_P255_L1.2561.00
40_A127_T1.2551.00
64_D68_V1.2491.00
11_V160_D1.2441.00
292_L349_R1.2431.00
293_V349_R1.2381.00
19_V61_G1.2201.00
187_E190_E1.2061.00
278_A281_V1.2051.00
266_P269_A1.2001.00
175_R290_P1.2001.00
116_E119_E1.1911.00
253_Q257_D1.1881.00
135_V150_V1.1871.00
20_A24_L1.1841.00
106_L109_K1.1801.00
305_G323_A1.1731.00
279_H283_E1.1691.00
173_A290_P1.1671.00
262_P265_A1.1651.00
22_L121_A1.1631.00
65_S68_V1.1591.00
190_E232_T1.1581.00
9_I32_L1.1561.00
191_L194_S1.1491.00
279_H282_P1.1491.00
129_I149_D1.1361.00
33_V125_L1.1331.00
11_V166_L1.1331.00
134_L169_K1.1321.00
162_V306_M1.1311.00
13_A18_S1.1271.00
153_A156_V1.1261.00
82_E85_A1.1161.00
21_A31_V1.1151.00
81_T85_A1.1111.00
136_Q296_G1.1031.00
20_A300_A1.1031.00
66_A113_W1.0961.00
346_A350_Q1.0871.00
136_Q141_V1.0831.00
140_K143_G1.0681.00
10_I21_A1.0601.00
308_M319_L1.0551.00
34_I126_I1.0531.00
71_L103_Y1.0531.00
6_F30_Q1.0501.00
190_E231_N1.0491.00
115_M125_L1.0451.00
39_S127_T1.0441.00
134_L170_L1.0421.00
294_G297_V1.0411.00
19_V23_V1.0401.00
18_S118_A1.0381.00
299_I303_A1.0321.00
141_V296_G1.0301.00
60_P329_K1.0281.00
254_M258_F1.0251.00
48_G317_M1.0201.00
143_G156_V1.0201.00
300_A348_Y1.0081.00
26_R117_Q1.0071.00
10_I31_V1.0001.00
265_A269_A1.0001.00
132_D144_V0.9951.00
347_E350_Q0.9951.00
357_L361_R0.9931.00
309_N312_F0.9911.00
11_V156_V0.9911.00
40_A115_M0.9901.00
88_M92_N0.9901.00
113_W116_E0.9901.00
298_L348_Y0.9871.00
268_I271_G0.9821.00
6_F124_Q0.9811.00
209_A212_F0.9791.00
257_D260_Q0.9741.00
7_D29_A0.9741.00
293_V342_K0.9661.00
373_P376_F0.9661.00
31_V123_A0.9601.00
188_L191_L0.9591.00
326_A329_K0.9511.00
55_L64_D0.9511.00
116_E120_E0.9511.00
45_V48_G0.9461.00
34_I129_I0.9441.00
205_N209_A0.9401.00
29_A335_M0.9361.00
58_I63_A0.9351.00
32_L153_A0.9311.00
63_A117_Q0.9261.00
251_V255_L0.9231.00
257_D261_H0.9211.00
143_G147_D0.9201.00
56_E59_I0.9191.00
63_A113_W0.9191.00
333_S347_E0.9161.00
22_L61_G0.9111.00
25_A31_V0.9091.00
113_W117_Q0.9031.00
23_V26_R0.9021.00
131_V165_I0.8981.00
262_P266_P0.8921.00
15_L321_I0.8901.00
243_H246_D0.8891.00
210_C213_A0.8841.00
308_M360_M0.8811.00
70_R113_W0.8801.00
134_L297_V0.8791.00
35_E127_T0.8771.00
205_N208_A0.8771.00
289_L299_I0.8721.00
66_A70_R0.8711.00
23_V27_E0.8691.00
81_T84_S0.8691.00
18_S115_M0.8681.00
280_V283_E0.8661.00
141_V156_V0.8631.00
172_M289_L0.8621.00
278_A283_E0.8611.00
28_G31_V0.8581.00
131_V169_K0.8581.00
25_A122_G0.8581.00
13_A35_E0.8581.00
48_G107_R0.8541.00
53_H315_R0.8521.00
225_F236_G0.8481.00
347_E351_H0.8481.00
111_D115_M0.8481.00
158_L297_V0.8441.00
25_A118_A0.8421.00
53_H322_A0.8401.00
34_I153_A0.8391.00
55_L103_Y0.8361.00
377_S381_E0.8351.00
260_Q265_A0.8331.00
206_Q209_A0.8281.00
119_E124_Q0.8281.00
24_L331_V0.8231.00
136_Q295_D0.8151.00
234_S238_V0.8141.00
55_L59_I0.8121.00
166_L297_V0.8111.00
283_E364_Q0.8111.00
325_E329_K0.8111.00
70_R112_A0.8081.00
7_D153_A0.8081.00
24_L29_A0.8041.00
248_K251_V0.8011.00
67_P110_F0.8001.00
67_P113_W0.7981.00
299_I304_A0.7941.00
263_A266_P0.7931.00
214_G219_G0.7921.00
364_Q368_A0.7901.00
266_P270_G0.7891.00
374_R377_S0.7871.00
71_L74_H0.7841.00
157_I327_A0.7831.00
332_L336_K0.7831.00
292_L304_A0.7821.00
187_E191_L0.7811.00
134_L166_L0.7801.00
208_A211_L0.7801.00
164_S167_A0.7781.00
58_I321_I0.7731.00
105_V110_F0.7731.00
335_M338_D0.7721.00
292_L353_E0.7681.00
308_M313_T0.7681.00
354_S358_R0.7681.00
49_R102_S0.7671.00
158_L170_L0.7651.00
139_G296_G0.7611.00
59_I68_V0.7611.00
139_G143_G0.7601.00
328_A332_L0.7601.00
264_V267_L0.7571.00
366_L369_F0.7551.00
54_S57_H0.7521.00
317_M321_I0.7521.00
172_M294_G0.7471.00
351_H354_S0.7461.00
25_A119_E0.7441.00
24_L328_A0.7431.00
43_K46_T0.7421.00
334_A347_E0.7421.00
7_D151_I0.7371.00
19_V114_L0.7351.00
375_M378_G0.7271.00
18_S111_D0.7261.00
87_T90_Y0.7251.00
53_H56_E0.7251.00
155_T298_L0.7231.00
313_T363_Y0.7221.00
87_T91_C0.7211.00
207_G210_C0.7211.00
339_D343_Q0.7201.00
334_A338_D0.7201.00
8_A155_T0.7181.00
288_M357_L0.7161.00
49_R104_S0.7131.00
21_A118_A0.7131.00
235_L239_C0.7101.00
76_K89_D0.7061.00
235_L238_V0.7061.00
258_F261_H0.7061.00
293_V345_L0.7051.00
23_V57_H0.7031.00
25_A124_Q0.7021.00
255_L269_A0.7011.00
267_L270_G0.6991.00
187_E235_L0.6971.00
333_S338_D0.6951.00
129_I146_A0.6941.00
191_L233_L0.6881.00
51_Y318_D0.6871.00
289_L292_L0.6851.00
126_I149_D0.6831.00
130_R165_I0.6831.00
190_E193_K0.6811.00
319_L359_D0.6811.00
207_G211_L0.6791.00
288_M292_L0.6791.00
208_A212_F0.6771.00
271_G274_V0.6771.00
118_A125_L0.6771.00
346_A349_R0.6761.00
267_L271_G0.6751.00
40_A111_D0.6731.00
89_D92_N0.6721.00
27_E328_A0.6711.00
21_A123_A0.6701.00
118_A122_G0.6691.00
372_N377_S0.6691.00
177_K180_D0.6661.00
375_M379_Y0.6651.00
358_R362_M0.6641.00
358_R361_R0.6631.00
181_V184_G0.6631.00
195_V205_N0.6631.00
209_A214_G0.6601.00
86_M89_D0.6601.00
342_K346_A0.6591.00
140_K154_K0.6581.00
170_L294_G0.6571.00
295_D342_K0.6561.00
306_M323_A0.6561.00
107_R111_D0.6551.00
298_L345_L0.6551.00
22_L25_A0.6541.00
87_T92_N0.6541.00
59_I65_S0.6531.00
317_M320_A0.6521.00
255_L261_H0.6521.00
8_A20_A0.6521.00
171_G174_K0.6511.00
319_L356_P0.6501.00
207_G212_F0.6491.00
367_P371_D0.6481.00
119_E122_G0.6461.00
31_V118_A0.6451.00
329_K333_S0.6451.00
20_A328_A0.6431.00
270_G273_L0.6421.00
209_A213_A0.6421.00
23_V325_E0.6411.00
315_R319_L0.6401.00
178_P181_V0.6391.00
255_L258_F0.6381.00
34_I143_G0.6361.00
187_E192_P0.6351.00
191_L195_V0.6341.00
185_V188_L0.6331.00
84_S87_T0.6291.00
244_L247_A0.6281.00
187_E194_S0.6271.00
272_K275_E0.6261.00
83_K86_M0.6251.00
356_P360_M0.6221.00
308_M363_Y0.6211.00
76_K208_A0.6201.00
271_G275_E0.6191.00
288_M353_E0.6181.00
78_A86_M0.6171.00
13_A33_V0.6171.00
16_A157_I0.6171.00
334_A343_Q0.6151.00
155_T335_M0.6141.00
190_E194_S0.6131.00
18_S125_L0.6121.00
373_P377_S0.6111.00
37_G43_K0.6101.00
155_T331_V0.6071.00
18_S33_V0.6071.00
263_A267_L0.6041.00
365_K368_A0.6031.00
158_L164_S0.6021.00
322_A326_A0.6011.00
334_A337_S0.5991.00
377_S380_P0.5991.00
339_D344_K0.5941.00
240_G243_H0.5941.00
51_Y54_S0.5931.00
265_A270_G0.5911.00
376_F379_Y0.5901.00
22_L123_A0.5891.00
372_N375_M0.5891.00
37_G41_G0.5891.00
334_A344_K0.5881.00
275_E278_A0.5871.00
58_I67_P0.5851.00
350_Q354_S0.5831.00
158_L165_I0.5831.00
59_I100_Q0.5821.00
57_H322_A0.5801.00
141_V145_E0.5791.00
223_G227_Y0.5761.00
210_C214_G0.5731.00
373_P380_P0.5731.00
181_V185_V0.5711.00
22_L63_A0.5701.00
57_H60_P0.5701.00
81_T86_M0.5701.00
167_A299_I0.5691.00
315_R318_D0.5671.00
46_T107_R0.5661.00
58_I110_F0.5651.00
154_K335_M0.5621.00
276_Y280_V0.5621.00
88_M91_C0.5621.00
106_L232_T0.5611.00
234_S239_C0.5601.00
300_A324_G0.5601.00
264_V268_I0.5601.00
53_H355_G0.5601.00
134_L141_V0.5591.00
57_H61_G0.5581.00
224_G227_Y0.5581.00
154_K296_G0.5581.00
326_A348_Y0.5581.00
82_E86_M0.5581.00
50_L54_S0.5571.00
222_G257_D0.5571.00
249_K253_Q0.5571.00
78_A87_T0.5561.00
56_E60_P0.5561.00
156_V297_V0.5551.00
374_R378_G0.5551.00
312_F367_P0.5551.00
29_A331_V0.5521.00
206_Q210_C0.5521.00
259_K265_A0.5501.00
302_D320_A0.5491.00
19_V58_I0.5481.00
172_M175_R0.5471.00
20_A159_A0.5471.00
229_N232_T0.5471.00
305_G356_P0.5461.00
168_E173_A0.5401.00
145_E149_D0.5391.00
145_E150_V0.5391.00
78_A89_D0.5391.00
254_M259_K0.5391.00
166_L169_K0.5391.00
119_E123_A0.5391.00
40_A112_A0.5381.00
67_P103_Y0.5371.00
259_K269_A0.5371.00
118_A121_A0.5351.00
38_N127_T0.5341.00
33_V123_A0.5331.00
6_F154_K0.5321.00
50_L317_M0.5311.00
219_G222_G0.5301.00
190_E274_V0.5291.00
361_R365_K0.5291.00
109_K113_W0.5291.00
19_V57_H0.5281.00
315_R359_D0.5261.00
313_T366_L0.5261.00
254_M261_H0.5251.00
184_G187_E0.5221.00
258_F264_V0.5211.00
8_A157_I0.5211.00
106_L229_N0.5191.00
70_R105_V0.5191.00
341_S344_K0.5181.00
227_Y236_G0.5181.00
224_G228_T0.5171.00
208_A213_A0.5171.00
277_S282_P0.5161.00
333_S337_S0.5151.00
182_A186_K0.5151.00
366_L370_L0.5141.00
334_A339_D0.5141.00
31_V124_Q0.5141.00
233_L237_L0.5131.00
157_I331_V0.5121.00
145_E148_G0.5121.00
158_L303_A0.5121.00
286_I306_M0.5111.00
70_R74_H0.5101.00
131_V145_E0.5101.00
119_E127_T0.5081.00
242_H245_H0.5051.00
155_T334_A0.5041.00
326_A352_L0.5041.00
361_R364_Q0.5041.00
254_M257_D0.5031.00
68_V71_L0.5031.00
29_A336_K0.5011.00
188_L192_P0.5011.00
20_A23_V0.5001.00
68_V73_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n9xA 5 0.8388 100 0.396 Contact Map
2qa1A 2 0.9089 100 0.397 Contact Map
4bjzA 2 0.8808 100 0.397 Contact Map
1pn0A 3 0.9322 100 0.399 Contact Map
2qa2A 2 0.9136 100 0.4 Contact Map
2x3nA 1 0.8178 100 0.402 Contact Map
4k22A 4 0.8061 100 0.403 Contact Map
3c96A 1 0.8271 100 0.41 Contact Map
4k5sA 2 0.9182 100 0.411 Contact Map
3aljA 1 0.8458 100 0.416 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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