GREMLIN Database
RSMJ - Ribosomal RNA small subunit methyltransferase J
UniProt: P68567 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12233
Length: 250 (219)
Sequences: 990 (725)
Seq/√Len: 49.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_V165_P4.7941.00
97_A115_M3.4811.00
116_L152_A3.4591.00
118_R195_G3.3181.00
57_V129_G2.9471.00
152_A157_A2.8631.00
41_H56_F2.7691.00
68_R73_G2.7371.00
115_M147_L2.6721.00
100_G126_L2.6011.00
128_D132_R2.5321.00
66_H70_F2.5091.00
116_L157_A2.4021.00
174_F240_H2.3741.00
166_Q212_T2.3211.00
82_V106_L2.2891.00
92_V106_L2.0881.00
77_A240_H2.0811.00
152_A156_T2.0301.00
225_P234_A2.0271.00
66_H105_V2.0151.00
93_V158_L2.0091.00
62_G65_A1.9670.99
174_F224_P1.9500.99
123_A149_L1.8990.99
206_P210_L1.8870.99
136_D141_G1.8460.99
182_L188_R1.8320.99
91_D112_R1.8240.99
78_V106_L1.8110.99
114_R165_P1.7940.99
22_R127_D1.7930.99
208_R229_V1.7430.99
81_A216_V1.7290.99
208_R215_V1.7220.98
175_P220_P1.6460.98
82_V111_C1.6360.98
84_I109_V1.6300.98
97_A149_L1.6300.98
38_T43_E1.6290.98
118_R153_S1.6290.98
204_L217_V1.6130.98
17_S21_A1.5960.97
159_T202_G1.5820.97
175_P219_R1.5730.97
141_G145_E1.5690.97
155_L202_G1.5450.97
176_H191_Q1.5380.97
91_D114_R1.5170.97
174_F239_G1.5090.96
16_L20_A1.4940.96
157_A161_I1.4830.96
79_A109_V1.4510.96
112_R148_Q1.4360.95
97_A126_L1.4210.95
90_P213_K1.3920.94
63_A242_F1.3840.94
158_L210_L1.3830.94
103_A115_M1.3810.94
153_S156_T1.3810.94
168_V215_V1.3760.94
154_S203_L1.3690.94
74_R78_V1.3620.94
225_P228_N1.3570.94
66_H108_S1.3240.93
219_R225_P1.3160.93
217_V226_L1.3010.92
168_V210_L1.2960.92
170_L203_L1.2780.91
118_R199_D1.2700.91
104_F143_L1.2400.90
120_P151_H1.2340.90
161_I165_P1.2330.90
16_L23_W1.2280.90
35_L44_L1.2220.90
101_R242_F1.2190.89
82_V167_V1.2110.89
114_R148_Q1.2060.89
38_T56_F1.1950.88
95_A170_L1.1920.88
177_K191_Q1.1910.88
187_M190_F1.1860.88
42_L124_A1.1850.88
101_R186_E1.1810.88
166_Q213_K1.1740.88
34_A37_L1.1640.87
14_G18_V1.1600.87
202_G205_E1.1420.86
21_A25_L1.1390.86
91_D165_P1.1300.85
107_A146_R1.1290.85
64_M76_E1.1280.85
235_V239_G1.1200.85
38_T41_H1.1020.84
76_E105_V1.0860.83
221_D237_T1.0780.83
79_A82_V1.0770.83
76_E143_L1.0710.82
83_G214_R1.0490.81
84_I111_C1.0480.81
191_Q196_P1.0410.80
76_E240_H1.0400.80
140_G144_Q1.0360.80
201_D205_E1.0150.79
225_P229_V1.0130.79
99_L129_G1.0120.78
73_G105_V1.0110.78
46_K49_E1.0070.78
237_T241_R1.0050.78
174_F237_T1.0000.78
18_V22_R0.9880.77
60_V186_E0.9870.77
114_R168_V0.9860.77
170_L219_R0.9810.76
20_A23_W0.9780.76
106_L219_R0.9690.75
73_G76_E0.9590.75
78_V82_V0.9570.74
85_K111_C0.9530.74
133_G147_L0.9520.74
82_V214_R0.9440.73
116_L150_I0.9370.73
118_R197_D0.9370.73
127_D131_A0.9350.73
93_V116_L0.9310.72
81_A214_R0.9210.72
93_V161_I0.9150.71
93_V157_A0.9030.70
35_L42_L0.8910.69
36_V45_R0.8840.68
206_P209_L0.8810.68
33_M46_K0.8800.68
186_E189_V0.8760.68
57_V104_F0.8750.68
133_G143_L0.8740.68
42_L128_D0.8720.67
74_R85_K0.8650.67
61_G65_A0.8640.67
89_L111_C0.8630.67
233_N239_G0.8630.67
187_M197_D0.8470.65
58_D129_G0.8420.65
203_L207_A0.8400.64
175_P225_P0.8370.64
48_D55_I0.8360.64
158_L211_A0.8330.64
55_I126_L0.8330.64
207_A215_V0.8250.63
84_I115_M0.8230.63
174_F219_R0.8230.63
131_A134_Y0.8210.63
65_A69_K0.8200.63
143_L147_L0.8170.62
211_A215_V0.8160.62
140_G143_L0.8130.62
66_H76_E0.8040.61
156_T162_T0.7990.61
19_L22_R0.7930.60
66_H69_K0.7930.60
77_A237_T0.7900.60
66_H75_G0.7890.60
143_L146_R0.7880.59
69_K73_G0.7810.59
176_H188_R0.7800.59
146_R228_N0.7780.58
78_V233_N0.7770.58
24_G131_A0.7760.58
104_F133_G0.7670.57
39_P56_F0.7670.57
59_F143_L0.7610.57
22_R31_N0.7600.57
155_L159_T0.7580.56
43_E56_F0.7580.56
76_E109_V0.7550.56
72_G76_E0.7530.56
75_G80_K0.7510.56
191_Q194_V0.7500.56
208_R216_V0.7460.55
17_S20_A0.7460.55
82_V92_V0.7450.55
204_L208_R0.7420.55
195_G199_D0.7370.54
67_R220_P0.7360.54
168_V193_L0.7350.54
19_L37_L0.7330.54
237_T240_H0.7270.53
137_A140_G0.7260.53
205_E229_V0.7250.53
225_P230_A0.7240.53
64_M68_R0.7230.53
113_V202_G0.7230.53
197_D200_A0.7160.52
179_K187_M0.7150.52
156_T159_T0.7130.52
164_R212_T0.7120.52
78_V190_F0.7090.52
122_V194_V0.7060.51
19_L124_A0.7050.51
23_W151_H0.7040.51
91_D148_Q0.7020.51
16_L37_L0.7010.51
24_G160_D0.7000.51
124_A128_D0.6970.50
16_L26_E0.6950.50
14_G24_G0.6940.50
40_E91_D0.6930.50
175_P179_K0.6870.49
76_E242_F0.6790.48
96_T171_D0.6780.48
21_A29_E0.6740.48
68_R74_R0.6730.48
58_D61_G0.6730.48
153_S157_A0.6720.48
187_M217_V0.6720.48
159_T206_P0.6700.48
201_D206_P0.6700.48
224_P228_N0.6690.47
44_L193_L0.6690.47
130_L144_Q0.6680.47
75_G187_M0.6670.47
105_V217_V0.6660.47
28_D47_R0.6650.47
119_N194_V0.6600.47
92_V187_M0.6590.46
107_A231_T0.6590.46
78_V174_F0.6580.46
84_I106_L0.6570.46
37_L40_E0.6570.46
135_A141_G0.6570.46
147_L213_K0.6550.46
21_A159_T0.6540.46
31_N34_A0.6520.46
175_P187_M0.6520.46
203_L216_V0.6510.46
189_V242_F0.6510.46
170_L207_A0.6480.45
74_R187_M0.6470.45
206_P228_N0.6470.45
164_R209_L0.6460.45
166_Q169_Y0.6450.45
123_A151_H0.6420.45
141_G162_T0.6420.45
24_G159_T0.6390.44
64_M78_V0.6330.44
42_L132_R0.6290.43
27_H31_N0.6290.43
131_A156_T0.6190.42
91_D160_D0.6180.42
108_S215_V0.6160.42
17_S103_A0.6130.42
100_G106_L0.6120.42
121_V193_L0.6100.42
29_E32_L0.6090.41
76_E119_N0.6030.41
186_E194_V0.6010.41
34_A38_T0.6010.41
79_A83_G0.6000.41
131_A135_A0.5940.40
61_G64_M0.5930.40
116_L133_G0.5930.40
176_H190_F0.5900.40
159_T209_L0.5880.39
19_L127_D0.5840.39
211_A240_H0.5820.39
59_F130_L0.5810.39
203_L217_V0.5790.39
72_G197_D0.5790.39
40_E43_E0.5790.39
92_V109_V0.5730.38
90_P111_C0.5710.38
161_I210_L0.5700.38
204_L215_V0.5700.38
181_A216_V0.5700.38
59_F144_Q0.5700.38
18_V112_R0.5690.38
198_L230_A0.5670.37
80_K162_T0.5660.37
21_A202_G0.5660.37
67_R231_T0.5650.37
96_T170_L0.5650.37
44_L128_D0.5620.37
187_M194_V0.5610.37
186_E219_R0.5590.37
33_M189_V0.5560.36
100_G128_D0.5530.36
97_A106_L0.5530.36
28_D154_S0.5520.36
165_P212_T0.5520.36
122_V240_H0.5510.36
63_A219_R0.5510.36
69_K154_S0.5500.36
37_L124_A0.5500.36
223_A226_L0.5480.36
77_A222_Y0.5470.36
179_K204_L0.5470.36
164_R202_G0.5460.35
61_G220_P0.5430.35
151_H157_A0.5410.35
49_E154_S0.5410.35
60_V101_R0.5400.35
147_L242_F0.5370.35
177_K188_R0.5360.34
74_R89_L0.5350.34
23_W26_E0.5350.34
47_R190_F0.5330.34
89_L209_L0.5320.34
157_A163_P0.5300.34
20_A26_E0.5290.34
226_L229_V0.5280.34
60_V189_V0.5260.34
177_K180_S0.5250.33
59_F104_F0.5250.33
222_Y237_T0.5220.33
216_V238_K0.5160.33
222_Y239_G0.5140.33
237_T242_F0.5130.32
196_P206_P0.5110.32
22_R25_L0.5110.32
180_S238_K0.5100.32
209_L236_V0.5080.32
175_P224_P0.5070.32
100_G133_G0.5060.32
182_L189_V0.5060.32
45_R54_G0.5030.32
15_A25_L0.5020.31
175_P180_S0.5010.31
152_A215_V0.5000.31
109_V167_V0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oyrA 1 0.976 100 0.462 Contact Map
2r6zA 2 0.916 100 0.503 Contact Map
3axsA 2 0.788 98.7 0.864 Contact Map
2dulA 2 0.784 98.7 0.865 Contact Map
3ll7A 1 0.872 98.6 0.869 Contact Map
1uwvA 1 0.828 98.5 0.875 Contact Map
3c0kA 2 0.92 98.5 0.876 Contact Map
1dusA 1 0.74 98.4 0.878 Contact Map
2as0A 2 0.912 98.4 0.878 Contact Map
1wg8A 1 0.636 98.3 0.882 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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