GREMLIN Database
TADA - tRNA-specific adenosine deaminase
UniProt: P68398 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11372
Length: 167 (144)
Sequences: 8022 (5251)
Seq/√Len: 437.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_H43_E3.2491.00
101_R131_E2.4101.00
13_R137_L2.3941.00
14_H17_T2.2431.00
80_L94_M2.1901.00
105_G141_C2.1651.00
53_D64_R2.1201.00
77_D100_G2.0711.00
79_T103_V2.0571.00
79_T101_R1.9491.00
11_W35_V1.9421.00
47_R61_M1.9411.00
92_G120_V1.9221.00
104_F107_R1.9171.00
11_W40_V1.9011.00
18_L43_E1.8991.00
101_R133_T1.8791.00
106_A149_F1.8721.00
138_A142_A1.8511.00
107_R134_E1.8471.00
47_R51_R1.8311.00
137_L140_E1.8041.00
8_H101_R1.7751.00
36_H39_R1.6671.00
18_L21_R1.6631.00
34_L62_A1.6481.00
21_R45_W1.6321.00
92_G96_H1.5521.00
32_A80_L1.5461.00
8_H133_T1.5391.00
13_R140_E1.5311.00
119_D122_H1.5181.00
142_A153_R1.5051.00
119_D127_N1.4821.00
36_H78_A1.4801.00
104_F118_M1.4571.00
104_F134_E1.4481.00
143_A147_D1.4371.00
14_H40_V1.4271.00
8_H81_Y1.4101.00
94_M102_V1.3841.00
79_T100_G1.3681.00
20_K144_L1.3651.00
18_L45_W1.3191.00
35_V81_Y1.3091.00
42_G65_Q1.2861.00
48_P55_T1.2671.00
8_H103_V1.2631.00
143_A146_S1.2541.00
15_A83_T1.2461.00
147_D151_M1.2441.00
142_A146_S1.2321.00
84_L145_L1.2321.00
23_W151_M1.1921.00
36_H77_D1.1911.00
56_A64_R1.1801.00
80_L99_I1.1741.00
135_G138_A1.1571.00
44_G61_M1.1571.00
25_E45_W1.1531.00
60_I93_A1.1521.00
36_H41_I1.1381.00
9_E137_L1.1361.00
22_A45_W1.1331.00
106_A142_A1.1271.00
14_H18_L1.1071.00
147_D150_R1.0911.00
34_L66_G1.0871.00
20_K140_E1.0841.00
93_A97_S1.0811.00
117_L125_G1.0781.00
49_I73_Y1.0671.00
115_G119_D1.0591.00
76_I98_R1.0501.00
20_K23_W1.0411.00
42_G62_A1.0401.00
17_T20_K1.0351.00
30_V84_L1.0261.00
54_P67_G1.0221.00
61_M65_Q1.0171.00
56_A61_M1.0111.00
23_W29_P1.0041.00
60_I64_R0.9961.00
133_T136_I0.9861.00
41_I78_A0.9801.00
149_F153_R0.9621.00
91_A120_V0.9611.00
47_R50_G0.9581.00
48_P73_Y0.9581.00
42_G69_V0.9561.00
16_L141_C0.9501.00
37_N77_D0.9371.00
34_L80_L0.9311.00
10_Y14_H0.9271.00
19_A144_L0.9251.00
16_L20_K0.9141.00
13_R17_T0.8931.00
15_A31_G0.8811.00
34_L78_A0.8801.00
63_L75_L0.8731.00
139_D143_A0.8591.00
20_K24_D0.8591.00
95_I130_V0.8581.00
9_E13_R0.8561.00
63_L97_S0.8551.00
8_H79_T0.8511.00
95_I120_V0.8451.00
44_G62_A0.8441.00
63_L93_A0.8371.00
112_G116_S0.8371.00
26_R152_R0.8351.00
107_R138_A0.8321.00
25_E50_G0.8321.00
66_G75_L0.8291.00
91_A95_I0.8241.00
63_L67_G0.8221.00
29_P145_L0.8171.00
65_Q69_V0.8111.00
40_V43_E0.8101.00
65_Q68_L0.8091.00
23_W147_D0.7931.00
114_A121_L0.7901.00
16_L144_L0.7841.00
110_K152_R0.7781.00
12_M135_G0.7731.00
118_M125_G0.7721.00
39_R69_V0.7681.00
94_M130_V0.7621.00
10_Y13_R0.7621.00
121_L130_V0.7591.00
88_V120_V0.7401.00
103_V133_T0.7381.00
102_V130_V0.7371.00
34_L42_G0.7341.00
20_K147_D0.7331.00
103_V136_I0.7321.00
102_V121_L0.7301.00
11_W81_Y0.7301.00
55_T93_A0.7271.00
51_R61_M0.7261.00
116_S120_V0.7221.00
104_F115_G0.7171.00
21_R24_D0.7091.00
84_L106_A0.7021.00
51_R68_L0.7021.00
120_V128_H0.6911.00
126_M130_V0.6891.00
67_G75_L0.6861.00
12_M15_A0.6861.00
43_E65_Q0.6841.00
44_G65_Q0.6801.00
39_R74_R0.6671.00
52_H72_N0.6651.00
145_L149_F0.6621.00
36_H70_M0.6601.00
46_N55_T0.6541.00
36_H74_R0.6530.99
53_D56_A0.6450.99
35_V40_V0.6450.99
107_R118_M0.6430.99
51_R56_A0.6410.99
11_W14_H0.6410.99
52_H71_Q0.6410.99
121_L125_G0.6380.99
33_V40_V0.6370.99
29_P46_N0.6350.99
21_R25_E0.6350.99
95_I121_L0.6320.99
56_A60_I0.6240.99
118_M121_L0.6240.99
47_R65_Q0.6190.99
91_A121_L0.6170.99
16_L140_E0.6150.99
48_P96_H0.6140.99
116_S119_D0.6120.99
141_C144_L0.6110.99
108_D111_T0.6100.99
95_I127_N0.6070.99
88_V108_D0.6060.99
102_V114_A0.6060.99
72_N76_I0.6040.99
63_L94_M0.5980.99
125_G129_R0.5950.99
55_T61_M0.5910.99
63_L99_I0.5880.99
47_R56_A0.5850.99
78_A99_I0.5830.99
23_W144_L0.5830.99
60_I96_H0.5810.99
76_I100_G0.5700.99
34_L63_L0.5670.99
29_P147_D0.5640.99
117_L121_L0.5500.98
142_A149_F0.5480.98
49_I55_T0.5480.98
24_D49_I0.5470.98
113_A120_V0.5460.98
118_M122_H0.5380.98
41_I69_V0.5380.98
81_Y103_V0.5370.98
134_E138_A0.5270.98
32_A58_A0.5250.98
140_E143_A0.5250.98
61_M64_R0.5230.98
113_A118_M0.5210.98
84_L108_D0.5180.97
118_M126_M0.5150.97
138_A141_C0.5140.97
25_E29_P0.5130.97
22_A29_P0.5120.97
17_T21_R0.5100.97
113_A116_S0.5060.97
14_H33_V0.5060.97
146_S150_R0.5030.97
33_V43_E0.5010.97
113_A126_M0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z3aA 2 0.9281 100 0.211 Contact Map
2nx8A 2 0.988 100 0.211 Contact Map
3dh1A 2 0.9042 100 0.222 Contact Map
2b3jA 2 0.9102 100 0.248 Contact Map
1wwrA 3 0.9341 100 0.267 Contact Map
2a8nA 2 0.8383 100 0.279 Contact Map
2g84A 2 0.9521 100 0.303 Contact Map
1wkqA 2 0.9162 100 0.321 Contact Map
1p6oA 2 0.9162 100 0.353 Contact Map
2b3zA 3 0.8802 100 0.353 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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