MALK - ECOLI - GREMLIN Contacts

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MALK - Maltose/maltodextrin import ATP-binding protein MalK

UniProt:	P68187	Sequences: MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10558
Length:	371 (315)
Sequences:	15858 (11750)
Seq/√Len:	662.0

ECOLI - MALK YCJV UGPC POTG CYSA FBPC POTA PROV YDCT MODC METN RBSA DPPD DPPF SAPD YEHX OPPD ARAG YADG YHES DDPD OPPF MACB GSIA UUP DDPF YECC TAUB MLAF FEPC HISP CYDC MDLB YTFR NIKE LPTB SAPF MDLA ETTA MSBA SSUB YOJI FHUC FECE LSRA GLNQ PHNC YHDZ CYDD YPHE GLTL MODF PHNK THIQ LIVG ZNUC SUFC ARTP PSTB FTSE XYLG LIVF ALSA LOLD NIKD MGLA BTUD FETA CCMA YBBA YEJF YDDA PHNL YNJD YBHF YBIT
BACSU - MSMX YURJ YVRA OPUAA OPUCA OPUBA METN TAGH OPPD YKFD YFIL DPPD YXLF YHAQ APPF YHCH APPD YDBJ YKPA RBSA YCBN YFMM YVFR YDIF OPPF YTRB FHUC YFMR YFMF ECFA1 YUSV TCYN YTLC SUNT YHEH YFIC ECSA SKFE BCEA YVCR YFIB YGAD YLMA YCLP YKNU YKNV BMRA CYDD YWJA YHEI ECFA2 YXDL ALBC TCYC YXEO SUFC GLNQ MNTB NATA YKOD SSUB FTSE ARTM CYDC PSTB1 YJKB ZNUC EXPZ YVRO PSTB2 YCLH YTHP YKNY YHCG YYBJ YUFO YYDI YTRE
HALSA - Q9HHQ5 Q9HR06 Q9HNZ9 Q9HMX3 Q9HMW0 BTUDA Q9HMT3 Q9HMX2 Q9HMU8 Q9HRJ6 PHNC Q9HMG1 PSTB2 Q9HRH8 Q9HSQ7 Q9HHM2 Q9HMG6 Q9HNY3 Q9HRV7 Q9HRZ9 Y2317 Y1631 PSTB1 Q9HHR7 Q9HR96 Q9HT03 Q9HR21 Q9HS04 Q9HQA8 Q9HMC1 Q9HMW1
SULSO - Q97YY4 Q97UF2 Q97UY8 Q97ZC0 Q97VC1 Q7LX64 Q97VF5 Q97UH3 Q97VH6 Q97YP3 Q97UD4 Q97VK8 Q97VK9 Q97YK2 Q97X18 Q97YP7 Q97VF4 Q97UJ9 Q97YQ7 Q97YP8 Q97Z03 Q980W0 Q97U54 Q97V01 Y1893 Q97UH4 Y2030 PSTB Q97W42 Q97V00 Q7LY07 Q7LXM4 Q97VY4 Q97Z56 Q97VM2 Q7LX80 Q97UG5 Q97Z96 Q97YP4 Q97UC2 Q980K5 Q97ZU0 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
216_G	220_E	4.314	1.00
59_D	66_R	4.014	1.00
8_N	21_D	3.832	1.00
30_E	203_K	3.720	1.00
5_Q	25_D	3.710	1.00
302_G	318_I	3.696	1.00
33_V	201_A	3.686	1.00
7_Q	59_D	3.551	1.00
119_E	124_A	3.515	1.00
17_V	20_K	3.331	1.00
111_N	115_N	3.243	1.00
217_K	220_E	2.710	1.00
10_T	57_S	2.600	1.00
106_K	109_V	2.595	1.00
32_V	205_V	2.579	1.00
7_Q	61_F	2.564	1.00
6_L	9_V	2.540	1.00
20_K	211_R	2.524	1.00
93_A	97_S	2.495	1.00
305_Q	319_Q	2.493	1.00
10_T	17_V	2.459	1.00
5_Q	61_F	2.438	1.00
27_H	30_E	2.428	1.00
213_A	227_D	2.426	1.00
93_A	128_D	2.341	1.00
93_A	111_N	2.332	1.00
8_N	23_N	2.313	1.00
12_A	17_V	2.308	1.00
10_T	21_D	2.255	1.00
11_K	48_M	2.208	1.00
113_R	151_E	2.177	1.00
228_R	282_S	2.171	1.00
76_G	153_S	2.149	1.00
93_A	115_N	2.117	1.00
4_V	154_V	2.115	1.00
126_L	129_R	2.091	1.00
61_F	66_R	2.081	1.00
63_G	153_S	2.065	1.00
48_M	55_I	2.043	1.00
9_V	55_I	2.010	1.00
198_M	219_L	1.998	1.00
122_Q	171_Q	1.963	1.00
19_S	48_M	1.925	1.00
46_L	190_V	1.868	1.00
205_V	215_V	1.866	1.00
49_I	188_I	1.846	1.00
112_Q	116_Q	1.841	1.00
11_K	56_T	1.822	1.00
109_V	112_Q	1.803	1.00
113_R	116_Q	1.779	1.00
108_E	112_Q	1.777	1.00
118_A	127_L	1.748	1.00
67_M	70_T	1.708	1.00
208_D	213_A	1.685	1.00
320_I	323_I	1.678	1.00
319_Q	322_S	1.677	1.00
47_R	53_E	1.654	1.00
90_L	98_F	1.649	1.00
205_V	212_V	1.616	1.00
65_K	70_T	1.613	1.00
117_V	149_V	1.610	1.00
11_K	53_E	1.604	1.00
65_K	153_S	1.592	1.00
157_L	187_M	1.591	1.00
228_R	241_F	1.574	1.00
219_L	223_H	1.549	1.00
62_I	67_M	1.545	1.00
6_L	24_L	1.537	1.00
6_L	49_I	1.517	1.00
12_A	56_T	1.503	1.00
48_M	60_L	1.495	1.00
105_A	109_V	1.489	1.00
116_Q	119_E	1.463	1.00
253_Q	256_V	1.460	1.00
97_S	114_V	1.458	1.00
232_G	241_F	1.443	1.00
66_R	69_D	1.438	1.00
109_V	113_R	1.437	1.00
55_I	60_L	1.420	1.00
32_V	215_V	1.417	1.00
276_Q	279_A	1.390	1.00
115_N	119_E	1.389	1.00
121_L	145_G	1.374	1.00
105_A	110_I	1.373	1.00
258_L	261_P	1.371	1.00
46_L	156_L	1.368	1.00
303_E	319_Q	1.363	1.00
22_I	45_L	1.360	1.00
10_T	20_K	1.339	1.00
251_I	254_V	1.334	1.00
251_I	255_Q	1.332	1.00
19_S	22_I	1.332	1.00
177_S	200_L	1.322	1.00
47_R	52_L	1.312	1.00
93_A	114_V	1.308	1.00
59_D	68_N	1.306	1.00
7_Q	23_N	1.303	1.00
94_E	97_S	1.297	1.00
26_I	32_V	1.283	1.00
24_L	205_V	1.264	1.00
91_S	94_E	1.259	1.00
180_H	185_R	1.259	1.00
91_S	130_K	1.249	1.00
89_H	132_K	1.232	1.00
19_S	45_L	1.226	1.00
32_V	203_K	1.219	1.00
97_S	110_I	1.204	1.00
243_P	280_N	1.201	1.00
228_R	232_G	1.197	1.00
206_V	221_L	1.189	1.00
92_V	134_L	1.185	1.00
12_A	15_E	1.181	1.00
12_A	57_S	1.156	1.00
180_H	187_M	1.155	1.00
60_L	67_M	1.154	1.00
6_L	45_L	1.131	1.00
12_A	18_V	1.123	1.00
87_Y	90_L	1.122	1.00
29_G	184_G	1.100	1.00
78_G	147_T	1.099	1.00
252_D	256_V	1.095	1.00
220_E	224_Y	1.091	1.00
212_V	215_V	1.087	1.00
50_A	156_L	1.087	1.00
97_S	101_K	1.086	1.00
275_V	279_A	1.073	1.00
27_H	203_K	1.072	1.00
116_Q	120_V	1.061	1.00
94_E	101_K	1.059	1.00
256_V	259_P	1.057	1.00
110_I	114_V	1.051	1.00
78_G	152_P	1.050	1.00
24_L	215_V	1.044	1.00
107_K	111_N	1.037	1.00
28_E	63_G	1.028	1.00
115_N	127_L	1.022	1.00
266_V	269_P	1.019	1.00
241_F	282_S	1.017	1.00
116_Q	151_E	1.016	1.00
255_Q	258_L	1.012	1.00
271_E	275_V	1.010	1.00
129_R	133_A	1.006	1.00
70_T	74_E	1.006	1.00
9_V	48_M	1.000	1.00
265_Q	268_L	0.999	1.00
61_F	64_E	0.990	1.00
307_V	316_I	0.982	1.00
245_K	280_N	0.981	1.00
275_V	278_G	0.980	1.00
55_I	68_N	0.978	1.00
13_W	18_V	0.973	1.00
252_D	255_Q	0.971	1.00
296_A	299_I	0.967	1.00
8_N	57_S	0.967	1.00
309_Q	314_T	0.960	1.00
45_L	207_L	0.958	1.00
293_S	296_A	0.958	1.00
222_Y	225_P	0.951	1.00
130_K	133_A	0.949	1.00
115_N	124_A	0.947	1.00
35_V	206_V	0.944	1.00
203_K	215_V	0.938	1.00
283_L	286_R	0.936	1.00
95_N	146_R	0.935	1.00
40_C	207_L	0.926	1.00
37_P	40_C	0.924	1.00
33_V	197_A	0.920	1.00
30_E	202_D	0.918	1.00
107_K	110_I	0.916	1.00
303_E	306_V	0.906	1.00
101_K	107_K	0.895	1.00
248_A	251_I	0.894	1.00
219_L	309_Q	0.885	1.00
93_A	127_L	0.884	1.00
169_R	193_D	0.882	1.00
5_Q	64_E	0.882	1.00
26_I	186_T	0.881	1.00
6_L	60_L	0.877	1.00
256_V	260_M	0.876	1.00
69_D	72_P	0.875	1.00
9_V	60_L	0.874	1.00
96_M	145_G	0.873	1.00
285_I	290_L	0.859	1.00
302_G	305_Q	0.856	1.00
267_W	270_V	0.854	1.00
249_T	252_D	0.852	1.00
286_R	290_L	0.852	1.00
282_S	286_R	0.850	1.00
31_F	200_L	0.848	1.00
103_A	150_A	0.842	1.00
34_F	205_V	0.839	1.00
43_S	47_R	0.838	1.00
292_P	295_I	0.838	1.00
86_L	131_P	0.833	1.00
304_V	307_V	0.832	1.00
177_S	199_T	0.831	1.00
191_T	197_A	0.829	1.00
268_L	272_S	0.827	1.00
189_Y	201_A	0.825	1.00
208_D	229_F	0.823	1.00
98_F	102_L	0.821	1.00
96_M	99_G	0.814	1.00
99_G	150_A	0.807	1.00
250_A	254_V	0.804	1.00
48_M	56_T	0.801	1.00
272_S	275_V	0.796	1.00
117_V	120_V	0.796	1.00
87_Y	99_G	0.792	1.00
208_D	211_R	0.791	1.00
170_V	174_I	0.790	1.00
298_V	302_G	0.787	1.00
151_E	185_R	0.784	1.00
256_V	261_P	0.780	1.00
161_L	189_Y	0.778	1.00
117_V	148_L	0.776	1.00
161_L	176_I	0.776	1.00
253_Q	257_E	0.774	1.00
285_I	289_H	0.773	1.00
96_M	149_V	0.773	1.00
237_P	284_G	0.772	1.00
249_T	255_Q	0.771	1.00
251_I	259_P	0.770	1.00
71_P	74_E	0.770	1.00
144_I	157_L	0.769	1.00
288_E	291_L	0.767	1.00
267_W	271_E	0.757	1.00
31_F	187_M	0.756	1.00
286_R	289_H	0.755	1.00
283_L	287_P	0.752	1.00
281_M	286_R	0.751	1.00
255_Q	259_P	0.751	1.00
166_A	170_V	0.750	1.00
257_E	260_M	0.749	1.00
302_G	320_I	0.749	1.00
273_R	276_Q	0.749	1.00
270_V	273_R	0.748	1.00
14_G	17_V	0.748	1.00
195_V	310_L	0.746	1.00
230_V	234_I	0.744	1.00
99_G	146_R	0.742	1.00
31_F	180_H	0.741	1.00
34_F	207_L	0.736	1.00
131_P	142_V	0.735	1.00
223_H	309_Q	0.732	1.00
248_A	253_Q	0.728	1.00
40_C	45_L	0.726	1.00
95_N	131_P	0.725	1.00
155_F	185_R	0.725	1.00
32_V	188_I	0.725	1.00
11_K	44_T	0.725	1.00
90_L	95_N	0.724	1.00
297_D	303_E	0.722	1.00
78_G	150_A	0.719	1.00
153_S	185_R	0.719	1.00
77_V	154_V	0.713	1.00
254_V	259_P	0.713	1.00
281_M	285_I	0.712	1.00
254_V	257_E	0.712	1.00
274_D	278_G	0.712	1.00
175_E	178_R	0.711	1.00
28_E	153_S	0.710	1.00
118_A	123_L	0.710	1.00
115_N	123_L	0.709	1.00
159_E	192_H	0.708	1.00
76_G	150_A	0.703	1.00
252_D	257_E	0.700	1.00
62_I	77_V	0.699	1.00
254_V	258_L	0.699	1.00
247_T	250_A	0.698	1.00
118_A	124_A	0.696	1.00
176_I	187_M	0.694	1.00
289_H	292_P	0.691	1.00
272_S	276_Q	0.691	1.00
206_V	230_V	0.689	1.00
48_M	53_E	0.688	1.00
310_L	315_Q	0.686	1.00
284_G	287_P	0.686	1.00
265_Q	269_P	0.684	1.00
299_I	302_G	0.684	1.00
266_V	270_V	0.683	1.00
269_P	272_S	0.682	1.00
105_A	113_R	0.682	1.00
312_N	315_Q	0.682	1.00
257_E	261_P	0.681	1.00
179_L	183_L	0.680	1.00
270_V	274_D	0.679	1.00
300_L	303_E	0.678	1.00
29_G	186_T	0.677	1.00
280_N	284_G	0.677	1.00
7_Q	25_D	0.677	1.00
278_G	286_R	0.677	1.00
274_D	277_V	0.677	1.00
203_K	214_Q	0.677	1.00
174_I	306_V	0.677	1.00
251_I	256_V	0.675	1.00
271_E	274_D	0.675	1.00
285_I	288_E	0.674	1.00
197_A	201_A	0.674	1.00
290_L	293_S	0.673	1.00
229_F	233_F	0.673	1.00
34_F	45_L	0.668	1.00
274_D	281_M	0.668	1.00
92_V	142_V	0.667	1.00
307_V	310_L	0.663	1.00
293_S	297_D	0.663	1.00
86_L	95_N	0.662	1.00
271_E	278_G	0.660	1.00
273_R	277_V	0.658	1.00
96_M	118_A	0.654	1.00
278_G	281_M	0.654	1.00
152_P	155_F	0.653	1.00
250_A	255_Q	0.653	1.00
306_V	310_L	0.653	1.00
155_F	187_M	0.652	1.00
308_E	311_G	0.651	1.00
82_Q	163_N	0.651	1.00
156_L	188_I	0.651	1.00
268_L	275_V	0.649	1.00
274_D	286_R	0.644	1.00
101_K	110_I	0.644	1.00
166_A	173_R	0.643	1.00
216_G	221_L	0.643	1.00
218_P	222_Y	0.641	1.00
304_V	318_I	0.641	1.00
114_V	117_V	0.641	1.00
91_S	128_D	0.640	1.00
271_E	279_A	0.634	1.00
144_I	200_L	0.633	1.00
293_S	298_V	0.633	1.00
117_V	121_L	0.630	1.00
243_P	282_S	0.629	1.00
266_V	271_E	0.628	1.00
50_A	79_M	0.628	1.00
304_V	316_I	0.627	1.00
249_T	254_V	0.627	1.00
303_E	307_V	0.625	1.00
106_K	110_I	0.623	1.00
111_N	114_V	0.623	1.00
22_I	212_V	0.621	1.00
206_V	225_P	0.618	1.00
234_I	237_P	0.618	1.00
229_F	232_G	0.616	1.00
267_W	275_V	0.616	1.00
231_A	234_I	0.615	1.00
178_R	305_Q	0.614	1.00
291_L	295_I	0.614	1.00
174_I	317_H	0.614	1.00
122_Q	125_H	0.612	1.00
250_A	253_Q	0.612	1.00
306_V	309_Q	0.612	1.00
275_V	281_M	0.611	1.00
12_A	20_K	0.607	1.00
271_E	276_Q	0.603	1.00
99_G	103_A	0.602	1.00
275_V	289_H	0.602	1.00
171_Q	175_E	0.602	1.00
244_V	281_M	0.601	1.00
222_Y	288_E	0.601	1.00
232_G	282_S	0.600	1.00
251_I	257_E	0.600	1.00
296_A	301_E	0.599	1.00
120_V	148_L	0.599	1.00
310_L	313_E	0.598	1.00
11_K	19_S	0.597	1.00
195_V	199_T	0.596	1.00
113_R	117_V	0.596	1.00
247_T	254_V	0.594	1.00
230_V	233_F	0.594	1.00
31_F	176_I	0.593	1.00
268_L	273_R	0.590	1.00
172_M	175_E	0.590	1.00
52_L	81_F	0.589	1.00
291_L	294_D	0.588	1.00
207_L	212_V	0.588	1.00
247_T	252_D	0.587	1.00
250_A	257_E	0.587	1.00
279_A	283_L	0.586	1.00
314_T	317_H	0.585	1.00
239_M	284_G	0.584	1.00
178_R	306_V	0.583	1.00
232_G	236_S	0.580	1.00
248_A	252_D	0.580	1.00
265_Q	271_E	0.578	1.00
279_A	286_R	0.577	1.00
80_V	147_T	0.577	1.00
120_V	178_R	0.577	1.00
267_W	281_M	0.573	1.00
13_W	44_T	0.573	1.00
219_L	314_T	0.572	1.00
298_V	301_E	0.571	1.00
123_L	126_L	0.571	1.00
174_I	178_R	0.571	1.00
189_Y	200_L	0.569	1.00
261_P	265_Q	0.568	1.00
90_L	94_E	0.567	1.00
190_V	194_Q	0.564	1.00
34_F	188_I	0.563	1.00
13_W	53_E	0.562	1.00
278_G	287_P	0.562	1.00
154_V	186_T	0.561	1.00
242_L	246_V	0.561	1.00
88_P	132_K	0.559	1.00
177_S	309_Q	0.558	1.00
249_T	253_Q	0.557	1.00
224_Y	227_D	0.557	1.00
98_F	101_K	0.556	1.00
307_V	314_T	0.556	1.00
299_I	303_E	0.556	1.00
268_L	274_D	0.556	1.00
157_L	189_Y	0.555	1.00
286_R	292_P	0.554	1.00
222_Y	226_A	0.554	1.00
248_A	255_Q	0.552	1.00
117_V	145_G	0.552	1.00
305_Q	317_H	0.550	1.00
227_D	230_V	0.549	1.00
87_Y	95_N	0.548	1.00
78_G	187_M	0.547	1.00
278_G	285_I	0.547	1.00
296_A	303_E	0.546	1.00
287_P	291_L	0.545	1.00
287_P	290_L	0.545	1.00
92_V	95_N	0.542	1.00
20_K	209_A	0.541	1.00
294_D	297_D	0.541	1.00
91_S	95_N	0.540	1.00
21_D	57_S	0.540	1.00
6_L	22_I	0.539	1.00
288_E	293_S	0.539	1.00
244_V	251_I	0.538	1.00
307_V	311_G	0.536	1.00
180_H	202_D	0.536	1.00
237_P	240_N	0.535	1.00
112_Q	119_E	0.535	1.00
54_T	69_D	0.535	1.00
112_Q	115_N	0.534	1.00
180_H	183_L	0.534	1.00
265_Q	270_V	0.529	0.99
4_V	26_I	0.528	0.99
243_P	323_I	0.527	0.99
266_V	273_R	0.526	0.99
173_R	199_T	0.524	0.99
167_A	232_G	0.524	0.99
296_A	300_L	0.523	0.99
80_V	140_Q	0.522	0.99
253_Q	258_L	0.522	0.99
125_H	209_A	0.522	0.99
306_V	317_H	0.521	0.99
96_M	117_V	0.519	0.99
125_H	138_Q	0.518	0.99
231_A	235_G	0.518	0.99
285_I	291_L	0.517	0.99
170_V	236_S	0.516	0.99
118_A	121_L	0.515	0.99
319_Q	323_I	0.514	0.99
93_A	96_M	0.513	0.99
31_F	189_Y	0.513	0.99
49_I	156_L	0.512	0.99
108_E	111_N	0.512	0.99
244_V	255_Q	0.510	0.99
12_A	16_V	0.510	0.99
177_S	202_D	0.509	0.99
249_T	256_V	0.509	0.99
302_G	306_V	0.509	0.99
277_V	281_M	0.507	0.99
308_E	315_Q	0.505	0.99
292_P	299_I	0.505	0.99
201_A	204_I	0.502	0.99
267_W	274_D	0.501	0.99
304_V	308_E	0.501	0.99
100_L	103_A	0.500	0.99
254_V	260_M	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rlfA	2	0.9973	100	0.163	Contact Map
2it1A	1	0.9757	100	0.169	Contact Map
1v43A	2	0.9353	100	0.17	Contact Map
2yyzA	1	0.9596	100	0.179	Contact Map
1g291	4	0.9677	100	0.182	Contact Map
1oxxK	1	0.9137	100	0.185	Contact Map
3fvqA	2	0.9245	100	0.205	Contact Map
1z47A	2	0.9191	100	0.216	Contact Map
3d31A	2	0.9137	100	0.222	Contact Map
4tquS	2	0.9677	100	0.224	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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