GREMLIN Database
MALK - Maltose/maltodextrin import ATP-binding protein MalK
UniProt: P68187 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10558
Length: 371 (315)
Sequences: 15858 (11750)
Seq/√Len: 662.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_G220_E4.3141.00
59_D66_R4.0141.00
8_N21_D3.8321.00
30_E203_K3.7201.00
5_Q25_D3.7101.00
302_G318_I3.6961.00
33_V201_A3.6861.00
7_Q59_D3.5511.00
119_E124_A3.5151.00
17_V20_K3.3311.00
111_N115_N3.2431.00
217_K220_E2.7101.00
10_T57_S2.6001.00
106_K109_V2.5951.00
32_V205_V2.5791.00
7_Q61_F2.5641.00
6_L9_V2.5401.00
20_K211_R2.5241.00
93_A97_S2.4951.00
305_Q319_Q2.4931.00
10_T17_V2.4591.00
5_Q61_F2.4381.00
27_H30_E2.4281.00
213_A227_D2.4261.00
93_A128_D2.3411.00
93_A111_N2.3321.00
8_N23_N2.3131.00
12_A17_V2.3081.00
10_T21_D2.2551.00
11_K48_M2.2081.00
113_R151_E2.1771.00
228_R282_S2.1711.00
76_G153_S2.1491.00
93_A115_N2.1171.00
4_V154_V2.1151.00
126_L129_R2.0911.00
61_F66_R2.0811.00
63_G153_S2.0651.00
48_M55_I2.0431.00
9_V55_I2.0101.00
198_M219_L1.9981.00
122_Q171_Q1.9631.00
19_S48_M1.9251.00
46_L190_V1.8681.00
205_V215_V1.8661.00
49_I188_I1.8461.00
112_Q116_Q1.8411.00
11_K56_T1.8221.00
109_V112_Q1.8031.00
113_R116_Q1.7791.00
108_E112_Q1.7771.00
118_A127_L1.7481.00
67_M70_T1.7081.00
208_D213_A1.6851.00
320_I323_I1.6781.00
319_Q322_S1.6771.00
47_R53_E1.6541.00
90_L98_F1.6491.00
205_V212_V1.6161.00
65_K70_T1.6131.00
117_V149_V1.6101.00
11_K53_E1.6041.00
65_K153_S1.5921.00
157_L187_M1.5911.00
228_R241_F1.5741.00
219_L223_H1.5491.00
62_I67_M1.5451.00
6_L24_L1.5371.00
6_L49_I1.5171.00
12_A56_T1.5031.00
48_M60_L1.4951.00
105_A109_V1.4891.00
116_Q119_E1.4631.00
253_Q256_V1.4601.00
97_S114_V1.4581.00
232_G241_F1.4431.00
66_R69_D1.4381.00
109_V113_R1.4371.00
55_I60_L1.4201.00
32_V215_V1.4171.00
276_Q279_A1.3901.00
115_N119_E1.3891.00
121_L145_G1.3741.00
105_A110_I1.3731.00
258_L261_P1.3711.00
46_L156_L1.3681.00
303_E319_Q1.3631.00
22_I45_L1.3601.00
10_T20_K1.3391.00
251_I254_V1.3341.00
251_I255_Q1.3321.00
19_S22_I1.3321.00
177_S200_L1.3221.00
47_R52_L1.3121.00
93_A114_V1.3081.00
59_D68_N1.3061.00
7_Q23_N1.3031.00
94_E97_S1.2971.00
26_I32_V1.2831.00
24_L205_V1.2641.00
91_S94_E1.2591.00
180_H185_R1.2591.00
91_S130_K1.2491.00
89_H132_K1.2321.00
19_S45_L1.2261.00
32_V203_K1.2191.00
97_S110_I1.2041.00
243_P280_N1.2011.00
228_R232_G1.1971.00
206_V221_L1.1891.00
92_V134_L1.1851.00
12_A15_E1.1811.00
12_A57_S1.1561.00
180_H187_M1.1551.00
60_L67_M1.1541.00
6_L45_L1.1311.00
12_A18_V1.1231.00
87_Y90_L1.1221.00
29_G184_G1.1001.00
78_G147_T1.0991.00
252_D256_V1.0951.00
220_E224_Y1.0911.00
212_V215_V1.0871.00
50_A156_L1.0871.00
97_S101_K1.0861.00
275_V279_A1.0731.00
27_H203_K1.0721.00
116_Q120_V1.0611.00
94_E101_K1.0591.00
256_V259_P1.0571.00
110_I114_V1.0511.00
78_G152_P1.0501.00
24_L215_V1.0441.00
107_K111_N1.0371.00
28_E63_G1.0281.00
115_N127_L1.0221.00
266_V269_P1.0191.00
241_F282_S1.0171.00
116_Q151_E1.0161.00
255_Q258_L1.0121.00
271_E275_V1.0101.00
129_R133_A1.0061.00
70_T74_E1.0061.00
9_V48_M1.0001.00
265_Q268_L0.9991.00
61_F64_E0.9901.00
307_V316_I0.9821.00
245_K280_N0.9811.00
275_V278_G0.9801.00
55_I68_N0.9781.00
13_W18_V0.9731.00
252_D255_Q0.9711.00
296_A299_I0.9671.00
8_N57_S0.9671.00
309_Q314_T0.9601.00
45_L207_L0.9581.00
293_S296_A0.9581.00
222_Y225_P0.9511.00
130_K133_A0.9491.00
115_N124_A0.9471.00
35_V206_V0.9441.00
203_K215_V0.9381.00
283_L286_R0.9361.00
95_N146_R0.9351.00
40_C207_L0.9261.00
37_P40_C0.9241.00
33_V197_A0.9201.00
30_E202_D0.9181.00
107_K110_I0.9161.00
303_E306_V0.9061.00
101_K107_K0.8951.00
248_A251_I0.8941.00
219_L309_Q0.8851.00
93_A127_L0.8841.00
169_R193_D0.8821.00
5_Q64_E0.8821.00
26_I186_T0.8811.00
6_L60_L0.8771.00
256_V260_M0.8761.00
69_D72_P0.8751.00
9_V60_L0.8741.00
96_M145_G0.8731.00
285_I290_L0.8591.00
302_G305_Q0.8561.00
267_W270_V0.8541.00
249_T252_D0.8521.00
286_R290_L0.8521.00
282_S286_R0.8501.00
31_F200_L0.8481.00
103_A150_A0.8421.00
34_F205_V0.8391.00
43_S47_R0.8381.00
292_P295_I0.8381.00
86_L131_P0.8331.00
304_V307_V0.8321.00
177_S199_T0.8311.00
191_T197_A0.8291.00
268_L272_S0.8271.00
189_Y201_A0.8251.00
208_D229_F0.8231.00
98_F102_L0.8211.00
96_M99_G0.8141.00
99_G150_A0.8071.00
250_A254_V0.8041.00
48_M56_T0.8011.00
272_S275_V0.7961.00
117_V120_V0.7961.00
87_Y99_G0.7921.00
208_D211_R0.7911.00
170_V174_I0.7901.00
298_V302_G0.7871.00
151_E185_R0.7841.00
256_V261_P0.7801.00
161_L189_Y0.7781.00
117_V148_L0.7761.00
161_L176_I0.7761.00
253_Q257_E0.7741.00
285_I289_H0.7731.00
96_M149_V0.7731.00
237_P284_G0.7721.00
249_T255_Q0.7711.00
251_I259_P0.7701.00
71_P74_E0.7701.00
144_I157_L0.7691.00
288_E291_L0.7671.00
267_W271_E0.7571.00
31_F187_M0.7561.00
286_R289_H0.7551.00
283_L287_P0.7521.00
281_M286_R0.7511.00
255_Q259_P0.7511.00
166_A170_V0.7501.00
257_E260_M0.7491.00
302_G320_I0.7491.00
273_R276_Q0.7491.00
270_V273_R0.7481.00
14_G17_V0.7481.00
195_V310_L0.7461.00
230_V234_I0.7441.00
99_G146_R0.7421.00
31_F180_H0.7411.00
34_F207_L0.7361.00
131_P142_V0.7351.00
223_H309_Q0.7321.00
248_A253_Q0.7281.00
40_C45_L0.7261.00
95_N131_P0.7251.00
155_F185_R0.7251.00
32_V188_I0.7251.00
11_K44_T0.7251.00
90_L95_N0.7241.00
297_D303_E0.7221.00
78_G150_A0.7191.00
153_S185_R0.7191.00
77_V154_V0.7131.00
254_V259_P0.7131.00
281_M285_I0.7121.00
254_V257_E0.7121.00
274_D278_G0.7121.00
175_E178_R0.7111.00
28_E153_S0.7101.00
118_A123_L0.7101.00
115_N123_L0.7091.00
159_E192_H0.7081.00
76_G150_A0.7031.00
252_D257_E0.7001.00
62_I77_V0.6991.00
254_V258_L0.6991.00
247_T250_A0.6981.00
118_A124_A0.6961.00
176_I187_M0.6941.00
289_H292_P0.6911.00
272_S276_Q0.6911.00
206_V230_V0.6891.00
48_M53_E0.6881.00
310_L315_Q0.6861.00
284_G287_P0.6861.00
265_Q269_P0.6841.00
299_I302_G0.6841.00
266_V270_V0.6831.00
269_P272_S0.6821.00
105_A113_R0.6821.00
312_N315_Q0.6821.00
257_E261_P0.6811.00
179_L183_L0.6801.00
270_V274_D0.6791.00
300_L303_E0.6781.00
29_G186_T0.6771.00
280_N284_G0.6771.00
7_Q25_D0.6771.00
278_G286_R0.6771.00
274_D277_V0.6771.00
203_K214_Q0.6771.00
174_I306_V0.6771.00
251_I256_V0.6751.00
271_E274_D0.6751.00
285_I288_E0.6741.00
197_A201_A0.6741.00
290_L293_S0.6731.00
229_F233_F0.6731.00
34_F45_L0.6681.00
274_D281_M0.6681.00
92_V142_V0.6671.00
307_V310_L0.6631.00
293_S297_D0.6631.00
86_L95_N0.6621.00
271_E278_G0.6601.00
273_R277_V0.6581.00
96_M118_A0.6541.00
278_G281_M0.6541.00
152_P155_F0.6531.00
250_A255_Q0.6531.00
306_V310_L0.6531.00
155_F187_M0.6521.00
308_E311_G0.6511.00
82_Q163_N0.6511.00
156_L188_I0.6511.00
268_L275_V0.6491.00
274_D286_R0.6441.00
101_K110_I0.6441.00
166_A173_R0.6431.00
216_G221_L0.6431.00
218_P222_Y0.6411.00
304_V318_I0.6411.00
114_V117_V0.6411.00
91_S128_D0.6401.00
271_E279_A0.6341.00
144_I200_L0.6331.00
293_S298_V0.6331.00
117_V121_L0.6301.00
243_P282_S0.6291.00
266_V271_E0.6281.00
50_A79_M0.6281.00
304_V316_I0.6271.00
249_T254_V0.6271.00
303_E307_V0.6251.00
106_K110_I0.6231.00
111_N114_V0.6231.00
22_I212_V0.6211.00
206_V225_P0.6181.00
234_I237_P0.6181.00
229_F232_G0.6161.00
267_W275_V0.6161.00
231_A234_I0.6151.00
178_R305_Q0.6141.00
291_L295_I0.6141.00
174_I317_H0.6141.00
122_Q125_H0.6121.00
250_A253_Q0.6121.00
306_V309_Q0.6121.00
275_V281_M0.6111.00
12_A20_K0.6071.00
271_E276_Q0.6031.00
99_G103_A0.6021.00
275_V289_H0.6021.00
171_Q175_E0.6021.00
244_V281_M0.6011.00
222_Y288_E0.6011.00
232_G282_S0.6001.00
251_I257_E0.6001.00
296_A301_E0.5991.00
120_V148_L0.5991.00
310_L313_E0.5981.00
11_K19_S0.5971.00
195_V199_T0.5961.00
113_R117_V0.5961.00
247_T254_V0.5941.00
230_V233_F0.5941.00
31_F176_I0.5931.00
268_L273_R0.5901.00
172_M175_E0.5901.00
52_L81_F0.5891.00
291_L294_D0.5881.00
207_L212_V0.5881.00
247_T252_D0.5871.00
250_A257_E0.5871.00
279_A283_L0.5861.00
314_T317_H0.5851.00
239_M284_G0.5841.00
178_R306_V0.5831.00
232_G236_S0.5801.00
248_A252_D0.5801.00
265_Q271_E0.5781.00
279_A286_R0.5771.00
80_V147_T0.5771.00
120_V178_R0.5771.00
267_W281_M0.5731.00
13_W44_T0.5731.00
219_L314_T0.5721.00
298_V301_E0.5711.00
123_L126_L0.5711.00
174_I178_R0.5711.00
189_Y200_L0.5691.00
261_P265_Q0.5681.00
90_L94_E0.5671.00
190_V194_Q0.5641.00
34_F188_I0.5631.00
13_W53_E0.5621.00
278_G287_P0.5621.00
154_V186_T0.5611.00
242_L246_V0.5611.00
88_P132_K0.5591.00
177_S309_Q0.5581.00
249_T253_Q0.5571.00
224_Y227_D0.5571.00
98_F101_K0.5561.00
307_V314_T0.5561.00
299_I303_E0.5561.00
268_L274_D0.5561.00
157_L189_Y0.5551.00
286_R292_P0.5541.00
222_Y226_A0.5541.00
248_A255_Q0.5521.00
117_V145_G0.5521.00
305_Q317_H0.5501.00
227_D230_V0.5491.00
87_Y95_N0.5481.00
78_G187_M0.5471.00
278_G285_I0.5471.00
296_A303_E0.5461.00
287_P291_L0.5451.00
287_P290_L0.5451.00
92_V95_N0.5421.00
20_K209_A0.5411.00
294_D297_D0.5411.00
91_S95_N0.5401.00
21_D57_S0.5401.00
6_L22_I0.5391.00
288_E293_S0.5391.00
244_V251_I0.5381.00
307_V311_G0.5361.00
180_H202_D0.5361.00
237_P240_N0.5351.00
112_Q119_E0.5351.00
54_T69_D0.5351.00
112_Q115_N0.5341.00
180_H183_L0.5341.00
265_Q270_V0.5290.99
4_V26_I0.5280.99
243_P323_I0.5270.99
266_V273_R0.5260.99
173_R199_T0.5240.99
167_A232_G0.5240.99
296_A300_L0.5230.99
80_V140_Q0.5220.99
253_Q258_L0.5220.99
125_H209_A0.5220.99
306_V317_H0.5210.99
96_M117_V0.5190.99
125_H138_Q0.5180.99
231_A235_G0.5180.99
285_I291_L0.5170.99
170_V236_S0.5160.99
118_A121_L0.5150.99
319_Q323_I0.5140.99
93_A96_M0.5130.99
31_F189_Y0.5130.99
49_I156_L0.5120.99
108_E111_N0.5120.99
244_V255_Q0.5100.99
12_A16_V0.5100.99
177_S202_D0.5090.99
249_T256_V0.5090.99
302_G306_V0.5090.99
277_V281_M0.5070.99
308_E315_Q0.5050.99
292_P299_I0.5050.99
201_A204_I0.5020.99
267_W274_D0.5010.99
304_V308_E0.5010.99
100_L103_A0.5000.99
254_V260_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfA 2 0.9973 100 0.163 Contact Map
2it1A 1 0.9757 100 0.169 Contact Map
1v43A 2 0.9353 100 0.17 Contact Map
2yyzA 1 0.9596 100 0.179 Contact Map
1g291 4 0.9677 100 0.182 Contact Map
1oxxK 1 0.9137 100 0.185 Contact Map
3fvqA 2 0.9245 100 0.205 Contact Map
1z47A 2 0.9191 100 0.216 Contact Map
3d31A 2 0.9137 100 0.222 Contact Map
4tquS 2 0.9677 100 0.224 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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