MALG - ECOLI - GREMLIN Contacts

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MALG - Maltose transport system permease protein MalG

UniProt:	P68183	Sequences: MAMVQPKSQKARLFITHLLLLLFIAAIMFPLLMVVAISLRQGNFATGSLIPEQISWDHWKLALGFSVEQADGRITPPPFPVLLWLWNSVKVAGISAIGIVALSTTCAYAFARMRFPGKATLLKGMLIFQMFPAVLSLVALYALFDRLGEYIPFIGLNTHGGVIFAYLGGIALHVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVGMQQYLNPQNYLWGDFAAAAVMSALPITIVFLLAQRWLVNGLTAGGVKG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10556
Length:	296 (254)
Sequences:	68176 (44321)
Seq/√Len:	2781.0

ECOLI - MALG YCJP POTH UGPE UGPA YCJO YDCU POTI THIP PSTC POTB YDCV PSTA CYST POTC YNJC MALF CYSW MODB TAUC PHNE SSUC YEHY YEHW METI PROW
BACSU - GANQ MDXG ARAQ YESQ LPLC YURM AMYC YTCP GANP AMYD ARAP MDXF YTEP YESP LPLB YURN YQGH YQGI YVGM YTLD SSUC OPUAB TCYB METP OPUCB YXEN TCYL OPUCD OPUBB OPUBD
HALSA - Q9HMT4 Q9HML6 Q9HHQ6 Q9HP01 Q9HHQ7 Q9HP02 Q9HR05 Q9HS11 Q9HPK3 Q9HNI9
SULSO - Q97UF3 Q97UY9 Q97YY3 Q97ZC1 Q97YY2 Q97UZ0 Q97VC0 Q97UF4 Q97ZC2 Q97ZT6 Q97ZT7 Q97Z98

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
201_Q	205_L	3.889	1.00
86_W	90_K	3.174	1.00
193_A	202_A	3.103	1.00
178_K	182_E	2.963	1.00
84_W	248_G	2.653	1.00
83_L	86_W	2.618	1.00
60_K	64_G	2.531	1.00
243_Y	251_Q	2.498	1.00
198_T	201_Q	2.485	1.00
98_G	167_L	2.485	1.00
94_I	163_I	2.471	1.00
180_Y	214_I	2.458	1.00
38_S	59_W	2.425	1.00
112_R	189_E	2.423	1.00
192_A	202_A	2.411	1.00
82_L	86_W	2.358	1.00
189_E	207_L	2.335	1.00
57_D	60_K	2.306	1.00
199_P	202_A	2.288	1.00
96_A	219_F	2.267	1.00
177_I	215_L	2.178	1.00
200_W	204_R	2.144	1.00
259_L	262_D	2.144	1.00
57_D	61_L	2.101	1.00
115_F	118_K	2.077	1.00
201_Q	204_R	2.019	1.00
197_A	201_Q	2.016	1.00
36_A	40_R	1.969	1.00
90_K	159_H	1.952	1.00
173_H	218_V	1.943	1.00
104_T	203_F	1.933	1.00
188_L	210_L	1.920	1.00
111_A	182_E	1.894	1.00
181_F	211_S	1.875	1.00
192_A	197_A	1.874	1.00
122_L	178_K	1.838	1.00
104_T	211_S	1.827	1.00
32_L	36_A	1.784	1.00
100_V	219_F	1.767	1.00
240_V	243_Y	1.758	1.00
83_L	87_N	1.733	1.00
193_A	199_P	1.698	1.00
95_S	226_A	1.681	1.00
90_K	94_I	1.651	1.00
189_E	202_A	1.642	1.00
61_L	262_D	1.637	1.00
104_T	177_I	1.632	1.00
92_A	223_F	1.619	1.00
103_S	173_H	1.612	1.00
189_E	193_A	1.592	1.00
159_H	242_S	1.591	1.00
106_C	174_V	1.585	1.00
186_S	189_E	1.521	1.00
61_L	64_G	1.515	1.00
17_H	21_L	1.515	1.00
248_G	252_Y	1.496	1.00
110_F	174_V	1.486	1.00
35_V	268_V	1.484	1.00
80_P	83_L	1.446	1.00
117_G	120_T	1.413	1.00
230_V	234_S	1.410	1.00
56_W	60_K	1.401	1.00
114_R	118_K	1.400	1.00
173_H	222_S	1.393	1.00
91_V	244_T	1.390	1.00
29_F	33_M	1.386	1.00
111_A	178_K	1.383	1.00
33_M	37_I	1.353	1.00
208_L	215_L	1.346	1.00
55_S	58_H	1.345	1.00
217_V	221_L	1.314	1.00
181_F	207_L	1.311	1.00
99_I	222_S	1.295	1.00
101_A	105_T	1.293	1.00
107_A	177_I	1.276	1.00
232_V	236_L	1.276	1.00
177_I	218_V	1.274	1.00
186_S	190_E	1.273	1.00
104_T	215_L	1.270	1.00
230_V	250_Q	1.262	1.00
243_Y	248_G	1.260	1.00
112_R	186_S	1.255	1.00
144_F	161_G	1.252	1.00
187_S	190_E	1.249	1.00
279_L	283_R	1.233	1.00
252_Y	256_Q	1.225	1.00
237_L	242_S	1.212	1.00
252_Y	259_L	1.209	1.00
120_T	123_K	1.203	1.00
100_V	215_L	1.196	1.00
192_A	206_V	1.194	1.00
10_K	14_F	1.194	1.00
97_I	101_A	1.186	1.00
165_A	236_L	1.179	1.00
108_Y	181_F	1.175	1.00
11_A	15_I	1.165	1.00
88_S	245_L	1.159	1.00
12_R	16_T	1.152	1.00
157_N	160_G	1.148	1.00
251_Q	255_P	1.142	1.00
21_L	25_A	1.141	1.00
184_I	210_L	1.137	1.00
94_I	97_I	1.135	1.00
212_V	216_A	1.132	1.00
87_N	90_K	1.128	1.00
229_E	232_V	1.114	1.00
142_A	146_R	1.113	1.00
33_M	36_A	1.096	1.00
198_T	202_A	1.082	1.00
44_F	53_Q	1.080	1.00
163_I	167_L	1.078	1.00
239_D	242_S	1.078	1.00
158_T	242_S	1.077	1.00
34_V	268_V	1.073	1.00
120_T	124_G	1.065	1.00
283_R	286_V	1.055	1.00
14_F	18_L	1.054	1.00
11_A	14_F	1.052	1.00
170_I	174_V	1.045	1.00
177_I	214_I	1.038	1.00
98_G	163_I	1.037	1.00
189_E	199_P	1.029	1.00
95_S	99_I	1.021	1.00
111_A	181_F	1.016	1.00
63_L	82_L	1.015	1.00
94_I	98_G	1.008	1.00
159_H	163_I	1.007	1.00
156_L	160_G	1.005	1.00
14_F	17_H	1.000	1.00
41_Q	44_F	0.993	1.00
162_V	233_A	0.989	1.00
105_T	109_A	0.989	1.00
210_L	213_P	0.985	1.00
108_Y	203_F	0.982	1.00
108_Y	199_P	0.977	1.00
176_T	218_V	0.976	1.00
244_T	247_V	0.976	1.00
89_V	93_G	0.975	1.00
243_Y	247_V	0.972	1.00
13_L	17_H	0.972	1.00
197_A	202_A	0.970	1.00
160_G	164_F	0.961	1.00
248_G	266_A	0.953	1.00
97_I	219_F	0.945	1.00
248_G	251_Q	0.940	1.00
149_E	160_G	0.939	1.00
234_S	247_V	0.939	1.00
16_T	20_L	0.939	1.00
202_A	205_L	0.938	1.00
95_S	166_Y	0.921	1.00
233_A	244_T	0.921	1.00
59_W	268_V	0.914	1.00
140_L	236_L	0.909	1.00
156_L	159_H	0.908	1.00
274_I	278_F	0.903	1.00
37_I	40_R	0.901	1.00
85_L	245_L	0.900	1.00
280_L	284_W	0.896	1.00
90_K	93_G	0.892	1.00
78_P	82_L	0.889	1.00
24_I	28_M	0.889	1.00
90_K	160_G	0.888	1.00
118_K	182_E	0.884	1.00
99_I	103_S	0.874	1.00
87_N	159_H	0.873	1.00
62_A	269_M	0.864	1.00
95_S	163_I	0.863	1.00
81_V	266_A	0.861	1.00
91_V	159_H	0.861	1.00
64_G	78_P	0.860	1.00
80_P	240_V	0.859	1.00
107_A	111_A	0.856	1.00
39_L	54_I	0.856	1.00
180_Y	211_S	0.856	1.00
253_L	263_F	0.854	1.00
38_S	42_G	0.852	1.00
93_G	97_I	0.852	1.00
119_A	122_L	0.850	1.00
58_H	261_G	0.848	1.00
229_E	233_A	0.846	1.00
157_N	239_D	0.846	1.00
211_S	214_I	0.840	1.00
61_L	78_P	0.838	1.00
260_W	263_F	0.832	1.00
110_F	122_L	0.832	1.00
103_S	174_V	0.832	1.00
140_L	165_A	0.829	1.00
165_A	232_V	0.827	1.00
79_F	83_L	0.826	1.00
202_A	207_L	0.825	1.00
212_V	215_L	0.818	1.00
107_A	174_V	0.817	1.00
173_H	177_I	0.817	1.00
91_V	166_Y	0.817	1.00
252_Y	262_D	0.815	1.00
37_I	264_A	0.812	1.00
276_I	280_L	0.809	1.00
141_Y	145_D	0.805	1.00
98_G	101_A	0.803	1.00
204_R	208_L	0.803	1.00
177_I	211_S	0.801	1.00
43_N	46_T	0.801	1.00
203_F	208_L	0.801	1.00
109_A	115_F	0.800	1.00
252_Y	266_A	0.800	1.00
85_L	89_V	0.800	1.00
58_H	61_L	0.798	1.00
160_G	163_I	0.795	1.00
86_W	89_V	0.790	1.00
126_L	175_W	0.787	1.00
116_P	119_A	0.785	1.00
166_Y	226_A	0.785	1.00
54_I	57_D	0.781	1.00
222_S	226_A	0.780	1.00
281_A	284_W	0.780	1.00
250_Q	254_N	0.777	1.00
199_P	203_F	0.769	1.00
60_K	63_L	0.743	1.00
245_L	270_S	0.734	1.00
137_L	235_L	0.733	1.00
99_I	173_H	0.732	1.00
212_V	284_W	0.731	1.00
40_R	44_F	0.731	1.00
99_I	226_A	0.730	1.00
197_A	205_L	0.728	1.00
158_T	161_G	0.725	1.00
37_I	41_Q	0.725	1.00
145_D	156_L	0.724	1.00
157_N	161_G	0.724	1.00
94_I	167_L	0.722	1.00
50_I	53_Q	0.720	1.00
41_Q	53_Q	0.719	1.00
260_W	264_A	0.718	1.00
107_A	181_F	0.717	1.00
188_L	206_V	0.715	1.00
191_A	195_D	0.714	1.00
264_A	268_V	0.713	1.00
137_L	231_P	0.708	1.00
100_V	177_I	0.700	1.00
96_A	223_F	0.699	1.00
136_S	168_G	0.699	1.00
34_V	264_A	0.695	1.00
110_F	178_K	0.695	1.00
84_W	87_N	0.695	1.00
99_I	169_G	0.690	1.00
103_S	177_I	0.690	1.00
270_S	274_I	0.689	1.00
61_L	259_L	0.681	1.00
275_T	279_L	0.680	1.00
42_G	46_T	0.678	1.00
169_G	225_A	0.677	1.00
203_F	207_L	0.677	1.00
110_F	121_L	0.676	1.00
191_A	194_L	0.676	1.00
126_L	129_Q	0.673	1.00
40_R	51_P	0.673	1.00
247_V	251_Q	0.673	1.00
215_L	218_V	0.672	1.00
184_I	211_S	0.671	1.00
109_A	113_M	0.670	1.00
133_A	231_P	0.669	1.00
23_F	27_I	0.668	1.00
34_V	267_A	0.667	1.00
262_D	266_A	0.666	1.00
261_G	264_A	0.663	1.00
18_L	21_L	0.663	1.00
29_F	32_L	0.662	1.00
229_E	244_T	0.661	1.00
169_G	222_S	0.660	1.00
249_M	266_A	0.657	1.00
15_I	18_L	0.656	1.00
92_A	96_A	0.655	1.00
161_G	165_A	0.653	1.00
177_I	181_F	0.650	1.00
96_A	100_V	0.650	1.00
142_A	145_D	0.650	1.00
82_L	85_L	0.648	1.00
84_W	245_L	0.648	1.00
186_S	193_A	0.645	1.00
53_Q	57_D	0.635	1.00
106_C	125_M	0.635	1.00
237_L	243_Y	0.635	1.00
91_V	163_I	0.631	1.00
214_I	218_V	0.630	1.00
246_A	270_S	0.626	1.00
106_C	170_I	0.626	1.00
79_F	82_L	0.626	1.00
80_P	248_G	0.624	1.00
162_V	237_L	0.624	1.00
88_S	246_A	0.624	1.00
56_W	59_W	0.624	1.00
38_S	265_A	0.620	1.00
59_W	63_L	0.618	1.00
62_A	266_A	0.617	1.00
39_L	55_S	0.615	1.00
207_L	210_L	0.614	1.00
24_I	27_I	0.614	1.00
19_L	23_F	0.612	1.00
41_Q	52_E	0.612	1.00
91_V	162_V	0.611	1.00
215_L	219_F	0.609	1.00
15_I	19_L	0.609	1.00
280_L	283_R	0.608	1.00
117_G	121_L	0.608	1.00
20_L	24_I	0.606	1.00
62_A	262_D	0.606	1.00
115_F	121_L	0.602	1.00
125_M	171_A	0.600	1.00
116_P	120_T	0.596	1.00
140_L	143_L	0.593	1.00
134_V	235_L	0.592	1.00
44_F	52_E	0.591	1.00
123_K	127_I	0.591	1.00
276_I	279_L	0.589	1.00
17_H	20_L	0.589	1.00
102_L	167_L	0.589	1.00
119_A	123_K	0.588	1.00
204_R	207_L	0.585	1.00
91_V	95_S	0.584	1.00
225_A	228_T	0.580	1.00
55_S	59_W	0.580	1.00
129_Q	172_L	0.576	1.00
42_G	51_P	0.576	1.00
122_L	175_W	0.574	1.00
141_Y	156_L	0.572	1.00
13_L	16_T	0.565	1.00
102_L	170_I	0.563	1.00
25_A	29_F	0.561	1.00
176_T	214_I	0.559	1.00
219_F	222_S	0.558	1.00
51_P	54_I	0.554	1.00
92_A	226_A	0.554	1.00
37_I	42_G	0.552	1.00
216_A	219_F	0.552	1.00
202_A	206_V	0.551	1.00
100_V	104_T	0.549	1.00
59_W	265_A	0.548	1.00
114_R	119_A	0.548	1.00
107_A	178_K	0.548	1.00
256_Q	259_L	0.547	1.00
108_Y	207_L	0.546	1.00
10_K	13_L	0.546	1.00
87_N	242_S	0.545	1.00
28_M	32_L	0.544	1.00
99_I	167_L	0.543	1.00
40_R	53_Q	0.542	1.00
92_A	227_I	0.542	1.00
226_A	229_E	0.539	1.00
162_V	166_Y	0.537	1.00
53_Q	56_W	0.536	1.00
278_F	282_Q	0.535	1.00
231_P	234_S	0.534	1.00
128_F	171_A	0.533	1.00
224_I	228_T	0.533	1.00
184_I	189_E	0.532	1.00
88_S	227_I	0.531	1.00
113_M	199_P	0.528	1.00
259_L	263_F	0.528	1.00
121_L	125_M	0.522	1.00
83_L	90_K	0.522	1.00
231_P	235_L	0.521	1.00
122_L	182_E	0.520	1.00
264_A	267_A	0.520	1.00
253_L	256_Q	0.518	1.00
279_L	282_Q	0.518	1.00
124_G	128_F	0.518	1.00
137_L	141_Y	0.518	1.00
161_G	236_L	0.518	1.00
80_P	243_Y	0.515	1.00
106_C	109_A	0.515	1.00
103_S	170_I	0.513	1.00
38_S	268_V	0.511	1.00
40_R	52_E	0.510	1.00
166_Y	229_E	0.507	1.00
252_Y	255_P	0.507	1.00
96_A	226_A	0.506	1.00
190_E	193_A	0.503	1.00
86_W	159_H	0.503	1.00
166_Y	169_G	0.501	1.00
18_L	22_L	0.500	1.00
96_A	101_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rlfG	1	0.9595	100	0.266	Contact Map
4tquN	1	0.8919	100	0.313	Contact Map
2onkC	2	0.8311	100	0.349	Contact Map
3d31C	2	0.8176	100	0.368	Contact Map
4tquM	1	0.8851	100	0.369	Contact Map
3rlfF	1	0.8851	100	0.413	Contact Map
4ymuD	2	0.7196	99.9	0.54	Contact Map
3tuiA	2	0.6993	99.9	0.558	Contact Map
2m8rA	1	0.125	9.2	0.952	Contact Map
3hd7A	1	0.125	8.4	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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