GREMLIN Database
MALG - Maltose transport system permease protein MalG
UniProt: P68183 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10556
Length: 296 (254)
Sequences: 68176 (44321)
Seq/√Len: 2781.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_Q205_L3.8891.00
86_W90_K3.1741.00
193_A202_A3.1031.00
178_K182_E2.9631.00
84_W248_G2.6531.00
83_L86_W2.6181.00
60_K64_G2.5311.00
243_Y251_Q2.4981.00
198_T201_Q2.4851.00
98_G167_L2.4851.00
94_I163_I2.4711.00
180_Y214_I2.4581.00
38_S59_W2.4251.00
112_R189_E2.4231.00
192_A202_A2.4111.00
82_L86_W2.3581.00
189_E207_L2.3351.00
57_D60_K2.3061.00
199_P202_A2.2881.00
96_A219_F2.2671.00
177_I215_L2.1781.00
200_W204_R2.1441.00
259_L262_D2.1441.00
57_D61_L2.1011.00
115_F118_K2.0771.00
201_Q204_R2.0191.00
197_A201_Q2.0161.00
36_A40_R1.9691.00
90_K159_H1.9521.00
173_H218_V1.9431.00
104_T203_F1.9331.00
188_L210_L1.9201.00
111_A182_E1.8941.00
181_F211_S1.8751.00
192_A197_A1.8741.00
122_L178_K1.8381.00
104_T211_S1.8271.00
32_L36_A1.7841.00
100_V219_F1.7671.00
240_V243_Y1.7581.00
83_L87_N1.7331.00
193_A199_P1.6981.00
95_S226_A1.6811.00
90_K94_I1.6511.00
189_E202_A1.6421.00
61_L262_D1.6371.00
104_T177_I1.6321.00
92_A223_F1.6191.00
103_S173_H1.6121.00
189_E193_A1.5921.00
159_H242_S1.5911.00
106_C174_V1.5851.00
186_S189_E1.5211.00
61_L64_G1.5151.00
17_H21_L1.5151.00
248_G252_Y1.4961.00
110_F174_V1.4861.00
35_V268_V1.4841.00
80_P83_L1.4461.00
117_G120_T1.4131.00
230_V234_S1.4101.00
56_W60_K1.4011.00
114_R118_K1.4001.00
173_H222_S1.3931.00
91_V244_T1.3901.00
29_F33_M1.3861.00
111_A178_K1.3831.00
33_M37_I1.3531.00
208_L215_L1.3461.00
55_S58_H1.3451.00
217_V221_L1.3141.00
181_F207_L1.3111.00
99_I222_S1.2951.00
101_A105_T1.2931.00
107_A177_I1.2761.00
232_V236_L1.2761.00
177_I218_V1.2741.00
186_S190_E1.2731.00
104_T215_L1.2701.00
230_V250_Q1.2621.00
243_Y248_G1.2601.00
112_R186_S1.2551.00
144_F161_G1.2521.00
187_S190_E1.2491.00
279_L283_R1.2331.00
252_Y256_Q1.2251.00
237_L242_S1.2121.00
252_Y259_L1.2091.00
120_T123_K1.2031.00
100_V215_L1.1961.00
192_A206_V1.1941.00
10_K14_F1.1941.00
97_I101_A1.1861.00
165_A236_L1.1791.00
108_Y181_F1.1751.00
11_A15_I1.1651.00
88_S245_L1.1591.00
12_R16_T1.1521.00
157_N160_G1.1481.00
251_Q255_P1.1421.00
21_L25_A1.1411.00
184_I210_L1.1371.00
94_I97_I1.1351.00
212_V216_A1.1321.00
87_N90_K1.1281.00
229_E232_V1.1141.00
142_A146_R1.1131.00
33_M36_A1.0961.00
198_T202_A1.0821.00
44_F53_Q1.0801.00
163_I167_L1.0781.00
239_D242_S1.0781.00
158_T242_S1.0771.00
34_V268_V1.0731.00
120_T124_G1.0651.00
283_R286_V1.0551.00
14_F18_L1.0541.00
11_A14_F1.0521.00
170_I174_V1.0451.00
177_I214_I1.0381.00
98_G163_I1.0371.00
189_E199_P1.0291.00
95_S99_I1.0211.00
111_A181_F1.0161.00
63_L82_L1.0151.00
94_I98_G1.0081.00
159_H163_I1.0071.00
156_L160_G1.0051.00
14_F17_H1.0001.00
41_Q44_F0.9931.00
162_V233_A0.9891.00
105_T109_A0.9891.00
210_L213_P0.9851.00
108_Y203_F0.9821.00
108_Y199_P0.9771.00
176_T218_V0.9761.00
244_T247_V0.9761.00
89_V93_G0.9751.00
243_Y247_V0.9721.00
13_L17_H0.9721.00
197_A202_A0.9701.00
160_G164_F0.9611.00
248_G266_A0.9531.00
97_I219_F0.9451.00
248_G251_Q0.9401.00
149_E160_G0.9391.00
234_S247_V0.9391.00
16_T20_L0.9391.00
202_A205_L0.9381.00
95_S166_Y0.9211.00
233_A244_T0.9211.00
59_W268_V0.9141.00
140_L236_L0.9091.00
156_L159_H0.9081.00
274_I278_F0.9031.00
37_I40_R0.9011.00
85_L245_L0.9001.00
280_L284_W0.8961.00
90_K93_G0.8921.00
78_P82_L0.8891.00
24_I28_M0.8891.00
90_K160_G0.8881.00
118_K182_E0.8841.00
99_I103_S0.8741.00
87_N159_H0.8731.00
62_A269_M0.8641.00
95_S163_I0.8631.00
81_V266_A0.8611.00
91_V159_H0.8611.00
64_G78_P0.8601.00
80_P240_V0.8591.00
107_A111_A0.8561.00
39_L54_I0.8561.00
180_Y211_S0.8561.00
253_L263_F0.8541.00
38_S42_G0.8521.00
93_G97_I0.8521.00
119_A122_L0.8501.00
58_H261_G0.8481.00
229_E233_A0.8461.00
157_N239_D0.8461.00
211_S214_I0.8401.00
61_L78_P0.8381.00
260_W263_F0.8321.00
110_F122_L0.8321.00
103_S174_V0.8321.00
140_L165_A0.8291.00
165_A232_V0.8271.00
79_F83_L0.8261.00
202_A207_L0.8251.00
212_V215_L0.8181.00
107_A174_V0.8171.00
173_H177_I0.8171.00
91_V166_Y0.8171.00
252_Y262_D0.8151.00
37_I264_A0.8121.00
276_I280_L0.8091.00
141_Y145_D0.8051.00
98_G101_A0.8031.00
204_R208_L0.8031.00
177_I211_S0.8011.00
43_N46_T0.8011.00
203_F208_L0.8011.00
109_A115_F0.8001.00
252_Y266_A0.8001.00
85_L89_V0.8001.00
58_H61_L0.7981.00
160_G163_I0.7951.00
86_W89_V0.7901.00
126_L175_W0.7871.00
116_P119_A0.7851.00
166_Y226_A0.7851.00
54_I57_D0.7811.00
222_S226_A0.7801.00
281_A284_W0.7801.00
250_Q254_N0.7771.00
199_P203_F0.7691.00
60_K63_L0.7431.00
245_L270_S0.7341.00
137_L235_L0.7331.00
99_I173_H0.7321.00
212_V284_W0.7311.00
40_R44_F0.7311.00
99_I226_A0.7301.00
197_A205_L0.7281.00
158_T161_G0.7251.00
37_I41_Q0.7251.00
145_D156_L0.7241.00
157_N161_G0.7241.00
94_I167_L0.7221.00
50_I53_Q0.7201.00
41_Q53_Q0.7191.00
260_W264_A0.7181.00
107_A181_F0.7171.00
188_L206_V0.7151.00
191_A195_D0.7141.00
264_A268_V0.7131.00
137_L231_P0.7081.00
100_V177_I0.7001.00
96_A223_F0.6991.00
136_S168_G0.6991.00
34_V264_A0.6951.00
110_F178_K0.6951.00
84_W87_N0.6951.00
99_I169_G0.6901.00
103_S177_I0.6901.00
270_S274_I0.6891.00
61_L259_L0.6811.00
275_T279_L0.6801.00
42_G46_T0.6781.00
169_G225_A0.6771.00
203_F207_L0.6771.00
110_F121_L0.6761.00
191_A194_L0.6761.00
126_L129_Q0.6731.00
40_R51_P0.6731.00
247_V251_Q0.6731.00
215_L218_V0.6721.00
184_I211_S0.6711.00
109_A113_M0.6701.00
133_A231_P0.6691.00
23_F27_I0.6681.00
34_V267_A0.6671.00
262_D266_A0.6661.00
261_G264_A0.6631.00
18_L21_L0.6631.00
29_F32_L0.6621.00
229_E244_T0.6611.00
169_G222_S0.6601.00
249_M266_A0.6571.00
15_I18_L0.6561.00
92_A96_A0.6551.00
161_G165_A0.6531.00
177_I181_F0.6501.00
96_A100_V0.6501.00
142_A145_D0.6501.00
82_L85_L0.6481.00
84_W245_L0.6481.00
186_S193_A0.6451.00
53_Q57_D0.6351.00
106_C125_M0.6351.00
237_L243_Y0.6351.00
91_V163_I0.6311.00
214_I218_V0.6301.00
246_A270_S0.6261.00
106_C170_I0.6261.00
79_F82_L0.6261.00
80_P248_G0.6241.00
162_V237_L0.6241.00
88_S246_A0.6241.00
56_W59_W0.6241.00
38_S265_A0.6201.00
59_W63_L0.6181.00
62_A266_A0.6171.00
39_L55_S0.6151.00
207_L210_L0.6141.00
24_I27_I0.6141.00
19_L23_F0.6121.00
41_Q52_E0.6121.00
91_V162_V0.6111.00
215_L219_F0.6091.00
15_I19_L0.6091.00
280_L283_R0.6081.00
117_G121_L0.6081.00
20_L24_I0.6061.00
62_A262_D0.6061.00
115_F121_L0.6021.00
125_M171_A0.6001.00
116_P120_T0.5961.00
140_L143_L0.5931.00
134_V235_L0.5921.00
44_F52_E0.5911.00
123_K127_I0.5911.00
276_I279_L0.5891.00
17_H20_L0.5891.00
102_L167_L0.5891.00
119_A123_K0.5881.00
204_R207_L0.5851.00
91_V95_S0.5841.00
225_A228_T0.5801.00
55_S59_W0.5801.00
129_Q172_L0.5761.00
42_G51_P0.5761.00
122_L175_W0.5741.00
141_Y156_L0.5721.00
13_L16_T0.5651.00
102_L170_I0.5631.00
25_A29_F0.5611.00
176_T214_I0.5591.00
219_F222_S0.5581.00
51_P54_I0.5541.00
92_A226_A0.5541.00
37_I42_G0.5521.00
216_A219_F0.5521.00
202_A206_V0.5511.00
100_V104_T0.5491.00
59_W265_A0.5481.00
114_R119_A0.5481.00
107_A178_K0.5481.00
256_Q259_L0.5471.00
108_Y207_L0.5461.00
10_K13_L0.5461.00
87_N242_S0.5451.00
28_M32_L0.5441.00
99_I167_L0.5431.00
40_R53_Q0.5421.00
92_A227_I0.5421.00
226_A229_E0.5391.00
162_V166_Y0.5371.00
53_Q56_W0.5361.00
278_F282_Q0.5351.00
231_P234_S0.5341.00
128_F171_A0.5331.00
224_I228_T0.5331.00
184_I189_E0.5321.00
88_S227_I0.5311.00
113_M199_P0.5281.00
259_L263_F0.5281.00
121_L125_M0.5221.00
83_L90_K0.5221.00
231_P235_L0.5211.00
122_L182_E0.5201.00
264_A267_A0.5201.00
253_L256_Q0.5181.00
279_L282_Q0.5181.00
124_G128_F0.5181.00
137_L141_Y0.5181.00
161_G236_L0.5181.00
80_P243_Y0.5151.00
106_C109_A0.5151.00
103_S170_I0.5131.00
38_S268_V0.5111.00
40_R52_E0.5101.00
166_Y229_E0.5071.00
252_Y255_P0.5071.00
96_A226_A0.5061.00
190_E193_A0.5031.00
86_W159_H0.5031.00
166_Y169_G0.5011.00
18_L22_L0.5001.00
96_A101_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfG 1 0.9595 100 0.266 Contact Map
4tquN 1 0.8919 100 0.313 Contact Map
2onkC 2 0.8311 100 0.349 Contact Map
3d31C 2 0.8176 100 0.368 Contact Map
4tquM 1 0.8851 100 0.369 Contact Map
3rlfF 1 0.8851 100 0.413 Contact Map
4ymuD 2 0.7196 99.9 0.54 Contact Map
3tuiA 2 0.6993 99.9 0.558 Contact Map
2m8rA 1 0.125 9.2 0.952 Contact Map
3hd7A 1 0.125 8.4 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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