GREMLIN Database
GRCA - Autonomous glycyl radical cofactor
UniProt: P68066 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11784
Length: 127 (117)
Sequences: 1194 (466)
Seq/√Len: 43.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_D89_H5.8111.00
80_R84_E4.4271.00
112_P116_R3.9331.00
87_V116_R3.5511.00
89_H92_K3.4421.00
85_D92_K3.4021.00
87_V112_P3.2571.00
24_S68_E2.8001.00
11_A14_D2.5041.00
111_T114_Q2.4101.00
65_V70_G2.3271.00
52_I55_R2.2471.00
22_L40_E2.1481.00
23_D73_L2.1260.99
10_A22_L2.0570.99
39_A72_H2.0540.99
31_C38_Y1.8170.98
106_R109_S1.8080.98
51_D54_Y1.6920.97
23_D40_E1.6350.97
53_E57_V1.6230.97
84_E88_K1.5920.96
78_L123_F1.5020.95
66_R70_G1.4050.93
42_E124_T1.3940.92
28_E95_Q1.3810.92
43_V80_R1.3210.90
86_A90_P1.3110.90
10_A37_G1.2980.89
71_Q105_V1.2480.87
40_E73_L1.2480.87
84_E116_R1.2290.86
62_K75_V1.2260.86
19_F42_E1.2250.86
18_S21_L1.1970.85
54_Y57_V1.1580.83
86_A96_L1.1470.82
81_E84_E1.1360.82
21_L25_E1.1340.82
19_F44_V1.1010.80
15_L122_T1.0890.79
112_P115_Q1.0160.74
22_L124_T1.0130.74
66_R104_A0.9920.72
61_V70_G0.9690.70
34_A117_D0.9670.70
88_K116_R0.9570.69
85_D88_K0.9400.68
100_V118_V0.9400.68
39_A101_S0.9390.68
97_T106_R0.9340.67
82_T123_F0.9270.67
87_V115_Q0.9270.67
108_N115_Q0.9180.66
107_F115_Q0.9090.65
43_V123_F0.8940.64
45_A48_K0.8860.63
42_E61_V0.8850.63
36_A71_Q0.8770.62
82_T119_I0.8700.62
19_F61_V0.8560.61
55_R58_P0.8520.60
42_E75_V0.8510.60
97_T104_A0.8490.60
26_K29_A0.8490.60
73_L124_T0.8470.60
47_S79_R0.8470.60
30_R33_V0.8380.59
18_S25_E0.8320.58
78_L108_N0.8160.57
83_L96_L0.8160.57
88_K92_K0.8140.57
103_Y110_L0.8080.56
19_F40_E0.8070.56
12_N120_A0.8000.55
47_S52_I0.7930.55
42_E73_L0.7890.54
28_E104_A0.7870.54
23_D70_G0.7860.54
84_E119_I0.7810.54
45_A123_F0.7760.53
72_H76_N0.7710.53
98_I104_A0.7680.52
53_E56_E0.7640.52
47_S95_Q0.7630.52
106_R117_D0.7600.52
24_S67_V0.7600.52
35_K69_G0.7590.52
38_Y97_T0.7540.51
34_A105_V0.7540.51
17_N120_A0.7510.51
32_I69_G0.7450.50
47_S51_D0.7400.50
105_V114_Q0.7290.49
52_I56_E0.7290.49
14_D36_A0.7110.47
16_L69_G0.7110.47
53_E67_V0.7110.47
103_Y107_F0.7050.46
90_P93_Y0.6970.46
88_K120_A0.6930.45
40_E71_Q0.6920.45
115_Q119_I0.6900.45
14_D42_E0.6900.45
20_W107_F0.6810.44
98_I113_E0.6780.44
84_E87_V0.6750.44
64_E68_E0.6750.44
47_S50_G0.6730.43
9_K22_L0.6690.43
10_A28_E0.6690.43
86_A107_F0.6660.43
61_V66_R0.6650.43
52_I79_R0.6610.42
19_F23_D0.6570.42
49_L62_K0.6510.41
50_G53_E0.6490.41
65_V117_D0.6350.40
71_Q117_D0.6310.40
10_A27_G0.6290.39
24_S125_E0.6220.39
105_V110_L0.6200.39
70_G75_V0.6160.38
57_V60_E0.6150.38
28_E66_R0.6150.38
49_L67_V0.6080.37
58_P101_S0.6040.37
40_E68_E0.6010.37
72_H101_S0.6010.37
13_D25_E0.6000.37
87_V119_I0.5990.37
56_E120_A0.5980.37
44_V51_D0.5900.36
17_N85_D0.5890.36
14_D109_S0.5850.35
83_L93_Y0.5840.35
57_V64_E0.5800.35
16_L94_P0.5770.35
20_W24_S0.5730.34
23_D117_D0.5730.34
17_N88_K0.5720.34
68_E111_T0.5690.34
17_N24_S0.5680.34
94_P109_S0.5640.34
40_E70_G0.5610.33
42_E117_D0.5590.33
47_S56_E0.5570.33
36_A109_S0.5560.33
56_E113_E0.5560.33
70_G111_T0.5530.33
107_F119_I0.5530.33
36_A105_V0.5500.32
116_R120_A0.5430.32
67_V125_E0.5430.32
47_S53_E0.5420.32
12_N117_D0.5370.31
10_A25_E0.5360.31
88_K112_P0.5340.31
36_A95_Q0.5300.31
13_D44_V0.5300.31
38_Y67_V0.5290.31
31_C73_L0.5290.31
86_A93_Y0.5250.30
50_G63_P0.5230.30
27_G70_G0.5230.30
84_E93_Y0.5220.30
20_W61_V0.5190.30
87_V120_A0.5170.30
68_E91_E0.5160.30
80_R97_T0.5160.30
32_I120_A0.5150.30
16_L57_V0.5150.30
80_R123_F0.5100.29
30_R80_R0.5050.29
37_G110_L0.5030.29
9_K74_N0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5a0uA 2 0.9764 100 0.134 Contact Map
1r9dA 2 0.9685 100 0.139 Contact Map
2y8nA 2 0.9685 100 0.141 Contact Map
2f3oA 3 0.9606 100 0.142 Contact Map
1h16A 2 0.9764 100 0.145 Contact Map
4pkfA 2 0.9764 100 0.161 Contact Map
3ajfA 2 0.7244 13.1 0.951 Contact Map
2kwvA 1 0.2756 8.7 0.955 Contact Map
2yvyA 2 0.3858 8.3 0.955 Contact Map
2wx4A 3 0.3543 7.4 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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