GREMLIN Database
HLDD - ADP-L-glycero-D-manno-heptose-6-epimerase
UniProt: P67910 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10838
Length: 310 (284)
Sequences: 58864 (40996)
Seq/√Len: 2432.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_G29_V3.3211.00
18_A219_D2.8311.00
220_V235_L2.7851.00
231_G282_N2.7031.00
249_A296_A2.6901.00
63_G106_E2.6501.00
294_T297_E2.6251.00
91_D95_Q2.4111.00
71_A225_L2.4021.00
252_A296_A2.3811.00
284_R290_K2.3031.00
114_A221_N2.2761.00
281_T285_A2.2561.00
30_V54_E2.2171.00
5_T74_H2.1981.00
73_F225_L2.1501.00
58_I61_M2.1421.00
74_H113_Y2.1301.00
18_A22_K2.1291.00
85_D88_Y2.1151.00
54_E61_M2.0891.00
171_Y298_G2.0791.00
219_D292_F2.0741.00
22_K226_E2.0711.00
4_V16_V2.0421.00
3_I69_V2.0051.00
18_A222_L1.9871.00
28_L50_Y1.8951.00
244_Q248_D1.8941.00
219_D223_W1.8811.00
167_Y221_N1.8401.00
129_E132_E1.8371.00
28_L69_V1.8331.00
253_Y300_T1.8211.00
249_A252_A1.8121.00
215_G301_E1.8011.00
151_V162_I1.7801.00
26_D50_Y1.7691.00
242_S245_A1.7571.00
165_F224_F1.7321.00
190_T194_N1.7271.00
15_I218_A1.7241.00
66_F69_V1.7191.00
15_I73_F1.6931.00
57_L91_D1.6761.00
115_S119_T1.6551.00
33_L51_M1.6511.00
238_G284_R1.6421.00
28_L52_D1.6291.00
59_Q102_H1.5911.00
283_L287_G1.5801.00
213_Y301_E1.5731.00
11_I170_V1.5731.00
245_A248_D1.5531.00
98_K102_H1.5401.00
18_A21_D1.5321.00
98_K150_Y1.5301.00
63_G103_Y1.5241.00
249_A253_Y1.5221.00
15_I75_E1.5171.00
120_Y234_N1.5081.00
130_S282_N1.5071.00
140_Y144_K1.5041.00
74_H97_S1.4931.00
73_F221_N1.4711.00
165_F221_N1.4701.00
95_Q98_K1.4571.00
28_L67_G1.4561.00
22_K222_L1.4311.00
222_L226_E1.4231.00
167_Y217_V1.4221.00
90_M146_L1.4201.00
100_L111_F1.4181.00
17_K174_R1.4121.00
101_L154_I1.4091.00
16_V29_V1.4091.00
213_Y298_G1.4041.00
134_E145_F1.3961.00
18_A218_A1.3851.00
214_V218_A1.3831.00
87_K91_D1.3831.00
280_L284_R1.3741.00
223_W227_N1.3721.00
145_F149_E1.3631.00
110_P161_Q1.3621.00
168_F278_A1.3511.00
191_Q196_E1.3511.00
104_C109_I1.3451.00
93_N143_S1.3391.00
72_I104_C1.3351.00
293_K301_E1.3331.00
114_A167_Y1.3311.00
75_E114_A1.3301.00
59_Q99_E1.3301.00
297_E300_T1.3231.00
97_S147_F1.3101.00
149_E152_R1.2991.00
212_V217_V1.2881.00
63_G107_R1.2861.00
197_S262_I1.2671.00
199_K262_I1.2541.00
210_D238_G1.2511.00
297_E301_E1.2501.00
166_R232_I1.2411.00
129_E279_D1.2211.00
102_H106_E1.2191.00
102_H105_L1.2151.00
24_I226_E1.2061.00
8_A31_D1.2041.00
7_G16_V1.1941.00
20_N49_D1.1721.00
197_S260_E1.1691.00
19_L222_L1.1601.00
280_L291_P1.1591.00
166_R234_N1.1541.00
61_M64_E1.1531.00
56_F96_Y1.1441.00
59_Q63_G1.1401.00
208_K240_A1.1391.00
104_C111_F1.1371.00
213_Y293_K1.1301.00
14_N215_G1.1281.00
152_R232_I1.1241.00
56_F76_G1.1061.00
241_E295_V1.1061.00
142_Y146_L1.1061.00
113_Y147_F1.1021.00
105_L158_A1.0961.00
148_D166_R1.0951.00
251_L258_Q1.0931.00
17_K21_D1.0931.00
244_Q263_P1.0861.00
152_R164_G1.0851.00
13_S174_R1.0811.00
29_V49_D1.0811.00
10_F172_G1.0811.00
131_R282_N1.0721.00
103_Y107_R1.0701.00
171_Y213_Y1.0611.00
3_I30_V1.0591.00
206_N244_Q1.0581.00
30_V62_A1.0521.00
75_E221_N1.0521.00
216_D237_T1.0431.00
113_Y151_V1.0401.00
20_N48_A1.0351.00
213_Y216_D1.0331.00
128_I132_E1.0321.00
155_L162_I1.0311.00
269_K272_Y1.0251.00
105_L160_S1.0211.00
112_L165_F1.0181.00
101_L111_F1.0121.00
18_A215_G1.0071.00
92_N96_Y1.0061.00
62_A103_Y0.9991.00
50_Y67_G0.9971.00
170_V217_V0.9881.00
219_D289_D0.9841.00
152_R162_I0.9821.00
253_Y303_M0.9781.00
113_Y164_G0.9781.00
101_L150_Y0.9731.00
240_A275_F0.9691.00
220_V283_L0.9661.00
296_A300_T0.9651.00
60_I63_G0.9601.00
10_F214_V0.9591.00
150_Y153_Q0.9581.00
14_N214_V0.9551.00
60_I64_E0.9511.00
125_S129_E0.9501.00
161_Q229_V0.9491.00
261_Y265_P0.9481.00
111_F151_V0.9401.00
236_G278_A0.9351.00
5_T76_G0.9311.00
115_S148_D0.9301.00
253_Y299_V0.9291.00
248_D251_L0.9291.00
99_E102_H0.9241.00
78_C92_N0.9211.00
152_R156_P0.9191.00
233_F282_N0.9171.00
153_Q157_E0.9101.00
261_Y264_F0.9071.00
219_D293_K0.9061.00
170_V212_V0.9051.00
15_I19_L0.8991.00
102_H154_I0.8991.00
32_N55_D0.8931.00
208_K242_S0.8891.00
254_H303_M0.8851.00
224_F287_G0.8841.00
235_L283_L0.8821.00
206_N242_S0.8791.00
90_M94_Y0.8791.00
220_V289_D0.8781.00
70_E110_P0.8781.00
163_V224_F0.8731.00
95_Q99_E0.8711.00
58_I62_A0.8711.00
240_A277_Q0.8701.00
224_F283_L0.8671.00
101_L151_V0.8641.00
33_L36_G0.8631.00
164_G232_I0.8521.00
20_N27_I0.8521.00
24_I70_E0.8501.00
282_N285_A0.8491.00
268_L272_Y0.8451.00
16_V27_I0.8441.00
238_G280_L0.8421.00
236_G280_L0.8421.00
223_W287_G0.8341.00
184_V188_L0.8321.00
30_V61_M0.8321.00
28_L68_D0.8301.00
89_M143_S0.8291.00
293_K297_E0.8281.00
205_E244_Q0.8251.00
241_E245_A0.8211.00
117_A168_F0.8211.00
5_T100_L0.8211.00
262_I265_P0.8211.00
264_F267_K0.8181.00
223_W226_E0.8101.00
183_S186_F0.8101.00
248_D252_A0.8091.00
59_Q106_E0.8071.00
241_E246_V0.8061.00
270_G273_Q0.8031.00
31_D51_M0.8031.00
103_Y106_E0.7911.00
105_L159_N0.7871.00
293_K298_G0.7861.00
3_I54_E0.7851.00
253_Y296_A0.7851.00
258_Q261_Y0.7821.00
14_N18_A0.7821.00
165_F235_L0.7811.00
14_N17_K0.7781.00
268_L271_R0.7781.00
90_M95_Q0.7761.00
146_L149_E0.7761.00
11_I217_V0.7751.00
96_Y99_E0.7731.00
90_M143_S0.7671.00
57_L92_N0.7671.00
125_S132_E0.7671.00
14_N218_A0.7621.00
239_R294_T0.7611.00
33_L53_K0.7591.00
215_G293_K0.7581.00
15_I221_N0.7551.00
210_D237_T0.7521.00
34_K53_K0.7501.00
105_L154_I0.7501.00
55_D58_I0.7471.00
65_E68_D0.7461.00
136_P141_G0.7451.00
119_T148_D0.7431.00
130_S283_L0.7431.00
2_I24_I0.7401.00
281_T284_R0.7371.00
99_E103_Y0.7351.00
94_Y146_L0.7331.00
173_P301_E0.7251.00
223_W288_Y0.7231.00
147_F151_V0.7231.00
97_S151_V0.7221.00
19_L225_L0.7211.00
219_D222_L0.7191.00
97_S101_L0.7151.00
119_T134_E0.7031.00
154_I160_S0.7021.00
3_I72_I0.7011.00
78_C89_M0.7011.00
72_I100_L0.7011.00
190_T193_N0.7001.00
130_S234_N0.6971.00
24_I27_I0.6971.00
74_H100_L0.6961.00
187_H190_T0.6921.00
88_Y91_D0.6921.00
223_W289_D0.6911.00
78_C93_N0.6871.00
208_K275_F0.6851.00
65_E69_V0.6851.00
173_P213_Y0.6841.00
62_A99_E0.6811.00
149_E153_Q0.6761.00
246_V295_V0.6731.00
154_I158_A0.6721.00
86_G142_Y0.6701.00
189_N193_N0.6681.00
218_A222_L0.6681.00
249_A295_V0.6661.00
13_S17_K0.6661.00
123_R128_I0.6631.00
189_N303_M0.6571.00
165_F220_V0.6561.00
23_G48_A0.6561.00
192_L251_L0.6551.00
168_F236_G0.6531.00
78_C88_Y0.6521.00
187_H191_Q0.6521.00
239_R296_A0.6501.00
169_N209_R0.6491.00
88_Y92_N0.6471.00
116_S119_T0.6441.00
72_I111_F0.6411.00
260_E263_P0.6401.00
284_R291_P0.6391.00
124_T132_E0.6391.00
146_L150_Y0.6371.00
192_L198_P0.6361.00
162_I230_S0.6361.00
245_A249_A0.6341.00
77_A93_N0.6331.00
150_Y154_I0.6291.00
8_A33_L0.6281.00
26_D48_A0.6281.00
151_V164_G0.6271.00
97_S113_Y0.6261.00
52_D67_G0.6251.00
142_Y149_E0.6231.00
22_K219_D0.6191.00
93_N140_Y0.6191.00
33_L38_K0.6151.00
117_A278_A0.6121.00
84_W89_M0.6111.00
126_D132_E0.6111.00
118_A141_G0.6101.00
251_L259_I0.6071.00
116_S144_K0.6071.00
257_G260_E0.6061.00
189_N250_T0.6061.00
207_F243_F0.6041.00
195_G198_P0.6031.00
112_L225_L0.5981.00
86_G139_V0.5971.00
258_Q264_F0.5961.00
251_L257_G0.5951.00
65_E107_R0.5951.00
46_N49_D0.5901.00
24_I71_A0.5891.00
2_I71_A0.5891.00
167_Y170_V0.5891.00
19_L73_F0.5881.00
138_N141_G0.5871.00
28_L65_E0.5851.00
258_Q265_P0.5841.00
229_V233_F0.5841.00
71_A112_L0.5841.00
142_Y153_Q0.5821.00
254_H257_G0.5801.00
199_K264_F0.5801.00
258_Q262_I0.5791.00
38_K53_K0.5761.00
249_A299_V0.5751.00
233_F283_L0.5741.00
143_S147_F0.5741.00
216_D219_D0.5731.00
222_L225_L0.5721.00
217_V235_L0.5721.00
289_D292_F0.5721.00
22_K223_W0.5721.00
19_L24_I0.5681.00
136_P145_F0.5661.00
14_N174_R0.5641.00
4_V29_V0.5641.00
90_M142_Y0.5621.00
66_F72_I0.5611.00
112_L224_F0.5601.00
259_I264_F0.5601.00
168_F210_D0.5561.00
52_D66_F0.5541.00
3_I66_F0.5541.00
173_P215_G0.5521.00
74_H111_F0.5511.00
139_V142_Y0.5491.00
175_E183_S0.5451.00
247_A251_L0.5431.00
101_L105_L0.5411.00
84_W139_V0.5391.00
71_A110_P0.5391.00
75_E167_Y0.5381.00
15_I222_L0.5341.00
171_Y237_T0.5341.00
134_E149_E0.5341.00
127_F279_D0.5321.00
139_V143_S0.5321.00
4_V19_L0.5311.00
154_I159_N0.5301.00
114_A165_F0.5301.00
119_T166_R0.5291.00
17_K215_G0.5291.00
134_E232_I0.5271.00
73_F222_L0.5261.00
250_T303_M0.5241.00
10_F14_N0.5241.00
230_S233_F0.5231.00
208_K277_Q0.5231.00
121_G135_K0.5211.00
153_Q156_P0.5211.00
210_D240_A0.5191.00
259_I263_P0.5161.00
112_L221_N0.5161.00
209_R243_F0.5141.00
4_V7_G0.5131.00
251_L254_H0.5131.00
268_L273_Q0.5121.00
192_L250_T0.5121.00
29_V51_M0.5111.00
227_N233_F0.5101.00
140_Y143_S0.5091.00
28_L66_F0.5081.00
163_V233_F0.5061.00
260_E265_P0.5051.00
129_E281_T0.5041.00
52_D61_M0.5021.00
204_S273_Q0.5021.00
16_V20_N0.5011.00
110_P228_G0.5001.00
115_S164_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9839 100 0.184 Contact Map
3rufA 2 0.971 100 0.189 Contact Map
3sxpA 3 0.9516 100 0.2 Contact Map
1rpnA 4 0.9839 100 0.202 Contact Map
1rkxA 3 0.9516 100 0.204 Contact Map
3m2pA 2 0.929 100 0.206 Contact Map
1oc2A 2 0.9742 100 0.207 Contact Map
2hunA 2 0.9742 100 0.211 Contact Map
1n7hA 4 0.9839 100 0.211 Contact Map
3slgA 4 0.9645 100 0.211 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.011 seconds.