GREMLIN Database
CUTC - Copper homeostasis protein CutC
UniProt: P67826 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12956
Length: 248 (203)
Sequences: 1735 (1253)
Seq/√Len: 88.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_F105_R4.1401.00
175_A192_V3.1161.00
76_L108_K2.9611.00
184_L195_V2.9221.00
124_F164_L2.9071.00
135_N167_H2.8491.00
96_D100_N2.8431.00
14_A46_V2.4401.00
102_D105_R2.3721.00
43_L82_V2.3631.00
101_V120_F2.3411.00
117_A143_A2.3341.00
120_F137_L2.1951.00
130_P160_K2.1461.00
30_A36_L2.0731.00
131_L163_E2.0131.00
44_K77_E1.9991.00
130_P150_Q1.9811.00
153_D156_Q1.9781.00
55_H117_A1.9681.00
165_I192_V1.9391.00
29_A36_L1.9291.00
77_E80_R1.8951.00
16_T20_N1.8941.00
57_I92_T1.8701.00
185_H189_D1.8651.00
80_R112_A1.8111.00
101_V137_L1.7891.00
103_M136_N1.7751.00
144_R194_E1.7691.00
118_V142_I1.7571.00
94_V105_R1.7561.00
47_R54_V1.7491.00
76_L112_A1.7181.00
55_H143_A1.7051.00
138_A172_I1.7011.00
135_N171_P1.6711.00
138_A171_P1.6371.00
83_R116_L1.6231.00
106_M142_I1.6151.00
188_L195_V1.5871.00
14_A50_V1.5411.00
58_I82_V1.5391.00
153_D177_A1.5081.00
56_P87_F1.5031.00
47_R88_P1.5021.00
150_Q160_K1.4881.00
18_Q51_T1.4800.99
90_L117_A1.4550.99
137_L142_I1.4450.99
75_I109_I1.4390.99
110_M118_V1.4310.99
131_L167_H1.4280.99
41_G78_D1.4200.99
145_V173_I1.4150.99
40_L85_L1.4020.99
46_V54_V1.4000.99
9_Y31_P1.3990.99
83_R115_P1.3740.99
58_I79_V1.3560.99
55_H144_R1.3380.99
100_N128_A1.3330.99
64_D205_S1.3180.99
110_M140_L1.3100.99
162_M166_A1.3100.99
41_G74_A1.3010.99
68_S71_E1.3010.99
4_L197_S1.3000.99
96_D102_D1.2690.98
134_L145_V1.2680.98
40_L81_T1.2570.98
61_R71_E1.2360.98
43_L87_F1.2260.98
58_I75_I1.2250.98
155_L158_L1.1710.97
132_Y136_N1.1640.97
127_C133_T1.1560.97
8_C25_V1.1540.97
40_L44_K1.1460.97
72_F108_K1.1340.97
15_L50_V1.1320.97
158_L187_F1.1290.97
55_H91_V1.1250.97
45_S48_Q1.1060.96
95_L123_A1.1050.96
72_F94_V1.0910.96
155_L186_H1.0900.96
55_H88_P1.0870.96
45_S73_A1.0860.96
106_M140_L1.0860.96
8_C13_C1.0840.96
101_V133_T1.0700.95
154_A179_V1.0560.95
129_N132_Y1.0490.95
90_L109_I1.0460.95
103_M107_E1.0420.95
81_T85_L1.0390.95
82_V90_L1.0310.94
6_I199_A1.0270.94
18_Q50_V1.0250.94
168_R171_P1.0230.94
92_T106_M1.0150.94
79_V109_I1.0050.94
137_L145_V1.0050.94
101_V136_N1.0030.94
17_A21_G1.0020.94
179_V187_F1.0000.94
147_T161_I0.9990.93
130_P164_L0.9880.93
92_T118_V0.9870.93
9_Y13_C0.9820.93
39_S78_D0.9780.93
18_Q52_I0.9730.93
72_F76_L0.9690.92
28_C119_T0.9600.92
27_L54_V0.9540.92
135_N138_A0.9540.92
176_G198_S0.9540.92
66_C97_V0.9490.92
90_L116_L0.9430.91
55_H89_G0.9410.91
95_L120_F0.9380.91
82_V87_F0.9370.91
106_M110_M0.9240.91
90_L118_V0.9190.90
165_I190_A0.9150.90
174_M194_E0.9070.90
23_D53_P0.9060.90
103_M139_E0.9050.90
8_C14_A0.9040.90
192_V195_V0.9010.89
27_L46_V0.8950.89
100_N132_Y0.8790.88
120_F123_A0.8730.88
136_N140_L0.8730.88
74_A78_D0.8720.88
7_C198_S0.8720.88
11_M15_L0.8660.87
106_M120_F0.8650.87
158_L190_A0.8640.87
3_L23_D0.8630.87
83_R114_G0.8600.87
177_A200_G0.8550.87
128_A132_Y0.8490.86
175_A190_A0.8470.86
155_L187_F0.8410.86
44_K84_E0.8270.85
12_E16_T0.8270.85
184_L188_L0.8260.85
165_I173_I0.8250.85
124_F130_P0.8220.85
53_P88_P0.8080.84
33_E62_G0.8040.83
175_A194_E0.8020.83
107_E111_A0.8010.83
161_I190_A0.7970.83
15_L19_Q0.7950.83
101_V106_M0.7820.82
151_K156_Q0.7800.81
124_F127_C0.7790.81
36_L62_G0.7740.81
11_M49_R0.7730.81
148_S154_A0.7690.80
148_S157_G0.7690.80
122_R148_S0.7660.80
133_T136_N0.7650.80
144_R174_M0.7640.80
113_A118_V0.7620.80
158_L186_H0.7600.80
175_A179_V0.7580.79
66_C205_S0.7580.79
30_A33_E0.7580.79
163_E167_H0.7560.79
151_K160_K0.7550.79
163_E166_A0.7530.79
38_P43_L0.7510.79
92_T109_I0.7470.78
127_C130_P0.7450.78
12_E68_S0.7440.78
69_D108_K0.7430.78
27_L42_V0.7310.77
197_S201_A0.7310.77
7_C199_A0.7280.77
7_C28_C0.7280.77
160_K163_E0.7270.77
79_V90_L0.7260.77
39_S74_A0.7170.76
25_V53_P0.7080.75
4_L198_S0.7080.75
10_S42_V0.7080.75
177_A180_R0.7080.75
122_R198_S0.7000.74
37_T82_V0.6980.74
9_Y42_V0.6960.73
94_V109_I0.6920.73
55_H119_T0.6900.73
40_L82_V0.6900.73
160_K164_L0.6890.73
29_A33_E0.6810.72
147_T164_L0.6800.72
28_C91_V0.6770.71
43_L56_P0.6740.71
61_R64_D0.6720.71
122_R176_G0.6690.70
13_C198_S0.6680.70
152_S157_G0.6650.70
69_D105_R0.6640.70
42_V74_A0.6640.70
126_M150_Q0.6630.70
25_V46_V0.6610.70
94_V106_M0.6580.69
91_V121_H0.6550.69
134_L168_R0.6530.69
43_L47_R0.6490.68
105_R112_A0.6440.68
47_R87_F0.6410.67
6_I22_A0.6400.67
69_D72_F0.6350.66
77_E81_T0.6330.66
56_P82_V0.6330.66
26_E146_L0.6270.66
118_V143_A0.6220.65
114_G143_A0.6200.65
13_C199_A0.6170.64
108_K111_A0.6170.64
65_F91_V0.6170.64
131_L160_K0.6120.64
165_I175_A0.6120.64
124_F134_L0.6110.64
78_D81_T0.6080.63
28_C31_P0.6060.63
178_G198_S0.6050.63
134_L171_P0.6040.63
37_T78_D0.6030.63
17_A22_A0.6020.62
197_S200_G0.6020.62
76_L109_I0.5970.62
186_H189_D0.5960.62
134_L167_H0.5900.61
173_I193_L0.5870.60
26_E121_H0.5850.60
37_T58_I0.5850.60
187_F192_V0.5830.60
134_L164_L0.5770.59
67_Y92_T0.5760.59
154_A157_G0.5740.59
38_P56_P0.5720.58
90_L142_I0.5720.58
29_A57_I0.5710.58
65_F121_H0.5710.58
154_A177_A0.5650.58
134_L138_A0.5640.57
158_L162_M0.5640.57
103_M140_L0.5630.57
90_L113_A0.5610.57
80_R83_R0.5600.57
108_K112_A0.5600.57
11_M74_A0.5600.57
99_G126_M0.5590.57
46_V50_V0.5590.57
11_M45_S0.5570.56
105_R108_K0.5570.56
17_A157_G0.5570.56
162_M190_A0.5560.56
146_L196_H0.5550.56
30_A62_G0.5540.56
31_P34_G0.5500.56
109_I177_A0.5490.55
131_L135_N0.5470.55
11_M42_V0.5440.55
13_C16_T0.5400.54
159_S186_H0.5390.54
183_N187_F0.5390.54
81_T84_E0.5360.54
153_D179_V0.5360.54
110_M142_I0.5320.53
10_S14_A0.5320.53
55_H194_E0.5300.53
151_K157_G0.5290.53
168_R172_I0.5290.53
170_A193_L0.5280.53
64_D67_Y0.5280.53
136_N139_E0.5260.52
10_S57_I0.5250.52
8_C197_S0.5190.51
26_E65_F0.5150.51
31_P57_I0.5140.51
10_S13_C0.5140.51
57_I62_G0.5120.50
120_F142_I0.5100.50
76_L80_R0.5090.50
92_T113_A0.5090.50
79_V118_V0.5080.50
89_G119_T0.5070.50
44_K48_Q0.5060.50
64_D99_G0.5040.49
73_A77_E0.5030.49
58_I90_L0.5030.49
92_T142_I0.5020.49
9_Y57_I0.5010.49
6_I13_C0.5010.49
100_N127_C0.5010.49
145_V167_H0.5000.49
104_P108_K0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1twdA 2 0.9476 100 0.261 Contact Map
3iwpA 3 0.996 100 0.315 Contact Map
2bdqA 2 0.8105 100 0.476 Contact Map
4r9xA 2 0.8952 100 0.516 Contact Map
3f4wA 2 0.8105 99.4 0.828 Contact Map
1h1yA 2 0.7742 99.4 0.828 Contact Map
1geqA 1 0.8347 99.4 0.83 Contact Map
4nu7A 5 0.8024 99.4 0.832 Contact Map
3tsmA 2 0.7823 99.3 0.834 Contact Map
4ml9A 2 0.8387 99.3 0.834 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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