GREMLIN Database
YFEO - Putative ion-transport protein YfeO
UniProt: P67729 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14156
Length: 418 (385)
Sequences: 5346 (3777)
Seq/√Len: 192.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
358_G390_V4.1491.00
302_F338_M3.4981.00
110_G115_V3.3871.00
242_W246_R3.3331.00
117_L315_A3.2721.00
115_V315_A3.1971.00
116_S308_K3.1481.00
116_S312_L3.1111.00
354_C390_V3.0611.00
127_N151_A2.9121.00
72_L76_F2.8801.00
88_E91_I2.7921.00
232_I335_L2.7911.00
26_I130_L2.7591.00
63_L66_T2.6461.00
32_K36_V2.6421.00
271_L311_A2.4941.00
229_V339_L2.4671.00
67_G71_G2.4631.00
246_R250_M2.4511.00
226_G354_C2.4451.00
236_A359_I2.4151.00
230_A234_I2.3271.00
168_L372_F2.3231.00
371_L388_C2.3131.00
305_A338_M2.3071.00
222_D351_T2.2331.00
77_S80_H2.1701.00
246_R249_A2.1571.00
272_G280_L2.1521.00
361_L391_M2.1461.00
139_L143_N2.1401.00
243_C313_V2.1381.00
16_A20_G2.1361.00
63_L67_G2.1221.00
236_A335_L2.1061.00
234_I397_L2.0931.00
36_V40_L2.0251.00
140_P143_N2.0041.00
287_M333_V1.9831.00
237_G362_V1.9681.00
251_M318_S1.9641.00
110_G117_L1.9621.00
19_I23_S1.9611.00
66_T113_G1.9511.00
110_G320_F1.9441.00
328_A363_V1.9191.00
267_I314_V1.8681.00
247_L317_A1.8661.00
224_L228_I1.8641.00
305_A335_L1.8611.00
100_L129_A1.8571.00
298_T338_M1.8351.00
78_Q81_A1.8071.00
135_G144_R1.8031.00
73_V80_H1.7611.00
309_L331_V1.7541.00
24_S28_I1.7481.00
235_A239_V1.7411.00
25_L203_F1.7361.00
27_L123_I1.7331.00
290_M334_A1.7261.00
305_A331_V1.7241.00
33_I108_I1.6801.00
227_A393_P1.6671.00
264_G318_S1.6521.00
240_A312_L1.6511.00
23_S127_N1.6291.00
357_L391_M1.6061.00
270_I274_I1.6001.00
87_C128_I1.5921.00
169_I173_T1.5811.00
28_I203_F1.5761.00
286_E330_F1.5711.00
37_L112_A1.5661.00
110_G315_A1.5391.00
226_G390_V1.5191.00
231_A397_L1.5121.00
301_Y337_L1.5111.00
233_A335_L1.5081.00
249_A253_Q1.5041.00
133_A137_R1.5011.00
365_R399_A1.4941.00
71_G75_R1.4881.00
227_A231_A1.4811.00
230_A393_P1.4791.00
225_S343_V1.4651.00
83_P88_E1.4571.00
149_I189_P1.4571.00
104_I126_V1.4511.00
230_A394_A1.4461.00
220_M224_L1.4441.00
328_A359_I1.4341.00
395_W399_A1.4301.00
62_V65_L1.4191.00
74_I79_G1.4181.00
375_A384_L1.4081.00
21_I199_T1.4081.00
73_V77_S1.4071.00
192_A196_G1.3991.00
30_V34_A1.3981.00
333_V352_V1.3951.00
329_V356_I1.3941.00
233_A358_G1.3841.00
69_A73_V1.3761.00
233_A359_I1.3741.00
339_L343_V1.3681.00
305_A334_A1.3661.00
70_V74_I1.3571.00
17_V195_A1.3531.00
106_A321_R1.3451.00
154_G192_A1.3451.00
265_G269_G1.3441.00
161_G201_G1.3381.00
153_A157_G1.3291.00
103_L321_R1.3271.00
132_V144_R1.3171.00
353_S378_V1.3151.00
40_L44_R1.3101.00
303_L307_I1.3071.00
59_I66_T1.3071.00
360_V364_T1.3011.00
61_G64_T1.2981.00
337_L352_V1.2791.00
31_M34_A1.2741.00
25_L29_V1.2611.00
390_V394_A1.2611.00
231_A235_A1.2591.00
19_I147_W1.2561.00
23_S154_G1.2491.00
153_A170_F1.2481.00
301_Y338_M1.2471.00
101_P105_V1.2421.00
229_V233_A1.2401.00
360_V370_S1.2321.00
55_S58_W1.2281.00
16_A19_I1.2271.00
301_Y334_A1.2251.00
27_L158_A1.2211.00
62_V66_T1.2081.00
41_L113_G1.2081.00
66_T69_A1.2071.00
149_I175_N1.2051.00
251_M264_G1.1971.00
186_L190_L1.1911.00
268_L311_A1.1841.00
73_V78_Q1.1821.00
71_G76_F1.1821.00
362_V394_A1.1791.00
374_A387_L1.1771.00
247_L313_V1.1771.00
150_L192_A1.1731.00
85_P88_E1.1721.00
238_M398_L1.1581.00
86_A90_L1.1581.00
256_N259_L1.1531.00
152_S174_L1.1461.00
225_S339_L1.1461.00
350_I383_L1.1451.00
28_I199_T1.1451.00
12_L16_A1.1361.00
276_G307_I1.1331.00
74_I81_A1.1321.00
36_V39_N1.1251.00
85_P91_I1.1191.00
136_A144_R1.1151.00
35_S39_N1.1151.00
234_I398_L1.1051.00
93_A132_V1.1051.00
164_V372_F1.0951.00
268_L315_A1.0911.00
335_L359_I1.0871.00
122_P160_F1.0851.00
340_H346_V1.0791.00
74_I78_Q1.0771.00
371_L391_M1.0751.00
340_H348_A1.0701.00
71_G74_I1.0651.00
97_P133_A1.0651.00
302_F306_V1.0581.00
82_G103_L1.0571.00
58_W64_T1.0521.00
288_Q292_A1.0501.00
279_S311_A1.0471.00
29_V104_I1.0421.00
297_S300_D1.0421.00
33_I36_V1.0371.00
153_A189_P1.0361.00
66_T109_L1.0361.00
83_P91_I1.0321.00
37_L41_L1.0281.00
237_G363_V1.0171.00
26_I30_V1.0171.00
28_I32_K1.0151.00
257_P260_V1.0131.00
82_G321_R1.0111.00
117_L322_G1.0111.00
64_T67_G1.0061.00
72_L77_S1.0041.00
357_L374_A0.9991.00
191_M195_A0.9900.99
67_G70_V0.9900.99
270_I273_V0.9890.99
383_L387_L0.9800.99
21_I25_L0.9780.99
197_A201_G0.9760.99
82_G85_P0.9740.99
159_L173_T0.9740.99
365_R398_L0.9730.99
59_I63_L0.9680.99
222_D226_G0.9670.99
345_A351_T0.9660.99
30_V107_L0.9620.99
64_T266_F0.9610.99
99_A125_T0.9570.99
29_V33_I0.9570.99
157_G193_A0.9560.99
221_T225_S0.9530.99
153_A193_A0.9510.99
87_C90_L0.9480.99
29_V32_K0.9480.99
16_A31_M0.9450.99
83_P86_A0.9430.99
283_G330_F0.9430.99
201_G206_P0.9340.99
22_A130_L0.9320.99
299_S303_L0.9290.99
348_A352_V0.9270.99
69_A109_L0.9160.99
228_I339_L0.9140.99
286_E289_Q0.9130.99
199_T203_F0.9110.99
346_V351_T0.9100.99
230_A358_G0.9060.99
67_G265_G0.9050.99
62_V67_G0.9040.99
116_S268_L0.9000.99
64_T269_G0.8980.99
250_M254_M0.8950.99
309_L313_V0.8920.99
167_A190_L0.8910.99
54_D58_W0.8900.99
367_G370_S0.8900.99
86_A91_I0.8890.99
339_L351_T0.8890.99
64_T262_G0.8870.99
71_G261_L0.8850.99
330_F334_A0.8820.99
264_G311_A0.8810.99
22_A26_I0.8810.99
26_I100_L0.8790.99
120_E159_L0.8770.99
234_I394_A0.8740.99
351_T355_A0.8730.99
21_I195_A0.8730.99
60_I63_L0.8670.99
84_D124_M0.8670.99
304_L334_A0.8620.99
278_V304_L0.8610.99
313_V317_A0.8610.99
240_A315_A0.8590.99
279_S307_I0.8570.99
364_T377_V0.8540.98
243_C309_L0.8520.98
87_C91_I0.8500.98
250_M253_Q0.8490.98
278_V289_Q0.8460.98
108_I112_A0.8440.98
238_M401_K0.8440.98
340_H351_T0.8400.98
74_I77_S0.8400.98
251_M260_V0.8380.98
76_F80_H0.8370.98
325_I377_V0.8370.98
207_H211_P0.8330.98
283_G287_M0.8280.98
83_P121_H0.8260.98
16_A23_S0.8260.98
59_I62_V0.8260.98
71_G258_V0.8240.98
37_L108_I0.8180.98
124_M169_I0.8130.98
68_I71_G0.8130.98
255_K263_I0.8110.98
393_P397_L0.8110.98
117_L316_A0.8040.98
56_P59_I0.8030.98
127_N131_A0.7990.98
259_L262_G0.7960.98
238_M242_W0.7960.98
30_V126_V0.7950.98
290_M337_L0.7930.98
115_V320_F0.7920.98
15_P140_P0.7880.97
92_G96_P0.7860.97
65_L69_A0.7850.97
102_G106_A0.7820.97
236_A239_V0.7810.97
219_E222_D0.7810.97
166_A169_I0.7810.97
165_A369_L0.7800.97
233_A362_V0.7780.97
16_A191_M0.7780.97
349_A352_V0.7760.97
235_A397_L0.7710.97
31_M35_S0.7700.97
62_V69_A0.7700.97
64_T265_G0.7650.97
41_L44_R0.7600.97
38_Q42_W0.7590.97
85_P90_L0.7570.97
276_G303_L0.7550.97
364_T367_G0.7540.97
248_H252_H0.7540.97
392_L396_L0.7520.97
239_V243_C0.7500.97
63_L265_G0.7500.97
166_A170_F0.7480.96
68_I75_R0.7450.96
123_I326_F0.7450.96
53_Q57_L0.7420.96
73_V76_F0.7420.96
54_D57_L0.7400.96
266_F271_L0.7390.96
103_L155_T0.7380.96
259_L263_I0.7350.96
239_V309_L0.7310.96
66_T70_V0.7270.96
65_L113_G0.7250.96
284_L326_F0.7230.96
173_T316_A0.7180.96
66_T73_V0.7180.96
231_A393_P0.7180.96
83_P90_L0.7180.96
352_V355_A0.7160.96
289_Q294_Q0.7160.96
276_G279_S0.7150.95
96_P133_A0.7140.95
369_L373_M0.7140.95
262_G266_F0.7140.95
157_G197_A0.7140.95
94_P136_A0.7130.95
261_L265_G0.7120.95
268_L271_L0.7120.95
350_I354_C0.7070.95
76_F79_G0.7070.95
82_G86_A0.7070.95
144_R148_T0.7040.95
303_L306_V0.7030.95
387_L391_M0.7000.95
139_L142_V0.7000.95
80_H102_G0.6980.95
58_W61_G0.6970.95
31_M159_L0.6960.95
226_G350_I0.6960.95
306_V310_A0.6950.95
166_A370_S0.6940.95
247_L251_M0.6920.95
193_A197_A0.6870.94
67_G262_G0.6870.94
283_G308_K0.6820.94
75_R78_Q0.6820.94
354_C358_G0.6810.94
59_I70_V0.6800.94
293_N297_S0.6790.94
145_M148_T0.6770.94
337_L348_A0.6760.94
69_A72_L0.6740.94
135_G151_A0.6740.94
69_A74_I0.6710.94
157_G381_T0.6710.94
240_A331_V0.6690.94
59_I75_R0.6690.94
28_I204_F0.6690.94
116_S315_A0.6670.93
30_V121_H0.6670.93
230_A233_A0.6670.93
242_W245_P0.6660.93
34_A119_P0.6650.93
190_L392_L0.6650.93
63_L79_G0.6640.93
103_L122_P0.6630.93
221_T224_L0.6610.93
24_S34_A0.6590.93
237_G361_L0.6560.93
152_S329_V0.6550.93
73_V79_G0.6540.93
60_I64_T0.6520.93
60_I270_I0.6510.93
312_L331_V0.6510.93
27_L31_M0.6510.93
103_L121_H0.6500.93
258_V261_L0.6470.92
338_M341_E0.6460.92
290_M352_V0.6460.92
199_T202_L0.6450.92
366_D369_L0.6440.92
91_I174_L0.6440.92
65_L68_I0.6430.92
71_G262_G0.6430.92
397_L400_G0.6390.92
73_V102_G0.6370.92
237_G359_I0.6360.92
23_S27_L0.6360.92
82_G87_C0.6350.92
143_N315_A0.6340.92
195_A198_L0.6310.91
271_L274_I0.6300.91
359_I363_V0.6290.91
19_I131_A0.6280.91
375_A381_T0.6270.91
62_V70_V0.6270.91
244_L247_L0.6270.91
374_A383_L0.6270.91
298_T341_E0.6260.91
60_I67_G0.6250.91
337_L340_H0.6230.91
234_I362_V0.6220.91
121_H321_R0.6220.91
190_L368_W0.6210.91
308_K319_G0.6210.91
372_F375_A0.6200.91
338_M342_H0.6190.91
35_S38_Q0.6190.91
68_I262_G0.6170.91
330_F333_V0.6130.90
321_R324_R0.6130.90
68_I72_L0.6110.90
226_G230_A0.6110.90
34_A38_Q0.6110.90
96_P99_A0.6110.90
336_G340_H0.6100.90
241_V245_P0.6100.90
294_Q297_S0.6070.90
23_S31_M0.6050.90
34_A111_L0.6050.90
38_Q41_L0.6040.90
111_L123_I0.6030.90
229_V355_A0.6030.90
74_I80_H0.6030.90
63_L70_V0.6020.89
41_L62_V0.6020.89
285_D289_Q0.6000.89
28_I31_M0.5990.89
71_G259_L0.5990.89
300_D303_L0.5990.89
186_L197_A0.5980.89
200_T204_F0.5980.89
277_P280_L0.5970.89
329_V359_I0.5970.89
278_V281_F0.5950.89
16_A28_I0.5950.89
237_G241_V0.5940.89
332_G355_A0.5930.89
286_E334_A0.5910.89
14_L18_A0.5900.89
83_P321_R0.5900.89
17_V191_M0.5860.88
188_A317_A0.5850.88
61_G69_A0.5830.88
16_A192_A0.5820.88
230_A389_I0.5820.88
364_T373_M0.5820.88
133_A136_A0.5820.88
69_A78_Q0.5810.88
149_I170_F0.5810.88
12_L23_S0.5800.88
59_I65_L0.5800.88
121_H376_V0.5790.88
32_K35_S0.5780.88
248_H321_R0.5760.87
70_V81_A0.5750.87
232_I339_L0.5720.87
66_T112_A0.5710.87
159_L316_A0.5710.87
171_S189_P0.5710.87
283_G329_V0.5700.87
111_L122_P0.5690.87
186_L395_W0.5690.87
19_I26_I0.5680.87
119_P125_T0.5670.87
103_L125_T0.5660.86
290_M301_Y0.5650.86
116_S311_A0.5640.86
237_G313_V0.5630.86
220_M223_I0.5620.86
90_L132_V0.5610.86
224_L227_A0.5600.86
126_V387_L0.5600.86
62_V74_I0.5600.86
226_G229_V0.5590.86
332_G336_G0.5580.86
107_L364_T0.5570.86
125_T321_R0.5560.85
124_M325_I0.5540.85
86_A103_L0.5530.85
165_A366_D0.5510.85
13_S396_L0.5510.85
20_G31_M0.5510.85
152_S156_I0.5500.85
39_N236_A0.5500.85
62_V73_V0.5500.85
72_L75_R0.5490.85
150_L189_P0.5490.85
284_L288_Q0.5480.85
85_P89_P0.5480.85
71_G78_Q0.5460.84
162_T205_H0.5460.84
233_A363_V0.5450.84
123_I369_L0.5450.84
40_L43_Q0.5450.84
62_V78_Q0.5420.84
107_L119_P0.5420.84
75_R258_V0.5410.84
99_A103_L0.5410.84
23_S26_I0.5390.84
156_I325_I0.5380.84
42_W46_P0.5380.84
91_I168_L0.5380.84
95_V129_A0.5380.84
185_R189_P0.5370.83
173_T366_D0.5370.83
13_S20_G0.5370.83
17_V199_T0.5360.83
165_A324_R0.5340.83
15_P134_I0.5340.83
97_P136_A0.5310.83
73_V105_V0.5300.83
22_A134_I0.5290.83
279_S286_E0.5280.82
66_T110_G0.5280.82
146_E150_L0.5270.82
93_A96_P0.5240.82
111_L370_S0.5230.82
148_T181_P0.5230.82
296_F301_Y0.5220.82
229_V351_T0.5220.82
110_G321_R0.5220.82
83_P87_C0.5210.82
16_A150_L0.5210.82
34_A108_I0.5200.81
66_T264_G0.5200.81
43_Q47_G0.5180.81
233_A237_G0.5180.81
203_F207_H0.5180.81
181_P200_T0.5180.81
304_L330_F0.5180.81
255_K259_L0.5180.81
18_A22_A0.5160.81
39_N43_Q0.5150.81
266_F270_I0.5140.81
111_L324_R0.5130.81
279_S282_K0.5130.81
171_S186_L0.5130.81
63_L269_G0.5130.81
197_A385_P0.5120.80
162_T325_I0.5120.80
103_L106_A0.5120.80
28_I34_A0.5090.80
329_V360_V0.5090.80
43_Q342_H0.5090.80
291_V349_A0.5080.80
155_T366_D0.5070.80
83_P122_P0.5070.80
117_L326_F0.5070.80
325_I329_V0.5050.80
28_I158_A0.5050.80
346_V349_A0.5040.79
66_T78_Q0.5040.79
71_G77_S0.5040.79
167_A171_S0.5040.79
340_H362_V0.5020.79
61_G65_L0.5020.79
31_M119_P0.5010.79
53_Q56_P0.5010.79
67_G261_L0.5010.79
245_P249_A0.5000.79
325_I369_L0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nd0A 2 0.9785 100 0.159 Contact Map
4eneA 2 0.9928 100 0.178 Contact Map
3orgA 2 0.9139 100 0.25 Contact Map
1jcnA 6 0.2033 98.7 0.876 Contact Map
3usbA 4 0.1962 46.3 0.96 Contact Map
1ldfA 3 0.1962 24.7 0.965 Contact Map
4nefA 4 0.2153 20.8 0.966 Contact Map
2ksfA 1 0.2464 19.7 0.967 Contact Map
2nq2A 2 0.4474 19.1 0.967 Contact Map
4g1uA 2 0.4498 18.7 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0119 seconds.