GREMLIN Database
HIGA - Antitoxin HigA
UniProt: P67701 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12724
Length: 138 (109)
Sequences: 858 (629)
Seq/√Len: 60.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_L49_L4.9111.00
37_V57_I4.3601.00
86_T90_Q3.7341.00
79_G113_G3.5121.00
100_E128_R3.2781.00
117_L122_A3.0631.00
95_L108_S3.0231.00
40_L50_L2.6171.00
59_A63_S2.5901.00
27_E30_Y2.4511.00
105_S108_S2.0541.00
123_K137_I1.9891.00
106_M109_R1.9651.00
44_D48_P1.8541.00
109_R114_K1.7270.99
55_A59_A1.7210.99
84_I87_L1.6280.99
23_G52_L1.5050.98
120_E124_K1.4950.98
30_Y60_W1.4800.98
87_L91_Y1.4390.98
133_P137_I1.4300.97
102_G107_V1.3410.96
91_Y128_R1.3270.96
25_Q48_P1.3190.96
82_A85_R1.3030.96
101_I106_M1.2870.95
41_L50_L1.2620.95
99_P107_V1.2490.94
41_L54_C1.2330.94
37_V40_L1.2310.94
110_V121_H1.2160.94
100_E129_F1.2080.93
122_A137_I1.1840.93
87_L129_F1.1640.92
37_V50_L1.1320.91
23_G55_A1.1240.91
93_L107_V1.1230.90
108_S114_K1.1120.90
129_F136_F1.1060.90
34_L61_E1.0860.89
83_V135_L1.0650.88
93_L97_D1.0580.88
88_M94_T1.0530.87
49_L129_F1.0280.86
21_L52_L1.0210.86
121_H136_F1.0180.86
36_L53_V1.0170.86
84_I110_V1.0010.85
116_K120_E0.9900.84
80_G121_H0.9750.83
119_L122_A0.9720.83
126_A133_P0.9630.82
107_V129_F0.9530.82
68_A78_P0.9500.81
95_L105_S0.9240.80
117_L136_F0.9230.79
25_Q51_D0.9170.79
87_L90_Q0.9160.79
30_Y34_L0.9020.78
125_L128_R0.8940.77
33_A57_I0.8910.77
34_L41_L0.8900.77
81_I113_G0.8880.77
119_L132_S0.8850.77
27_E45_P0.8780.76
58_T62_E0.8730.76
43_N50_L0.8530.74
95_L99_P0.8410.73
21_L29_Q0.8350.72
99_P103_S0.8340.72
84_I136_F0.8290.72
26_N29_Q0.8250.71
37_V54_C0.8210.71
64_A67_F0.8140.70
119_L123_K0.8040.69
113_G116_K0.8000.69
31_T34_L0.7880.68
51_D55_A0.7870.68
23_G56_K0.7830.67
34_L37_V0.7810.67
59_A130_G0.7800.67
87_L136_F0.7790.67
38_D104_K0.7740.66
24_I33_A0.7710.66
78_P83_V0.7630.65
103_S108_S0.7570.65
80_G136_F0.7360.63
106_M110_V0.7340.62
43_N47_N0.7280.62
84_I131_I0.7240.61
34_L38_D0.7240.61
119_L137_I0.7190.61
69_E83_V0.7140.60
88_M93_L0.7070.59
100_E107_V0.7050.59
104_K108_S0.7010.59
93_L128_R0.6920.58
33_A102_G0.6840.57
36_L40_L0.6840.57
28_E31_T0.6830.57
42_L96_S0.6810.57
106_M115_R0.6790.56
94_T119_L0.6740.56
101_I110_V0.6710.55
28_E32_Q0.6640.55
33_A53_V0.6630.55
95_L101_I0.6540.54
95_L106_M0.6540.54
69_E78_P0.6540.54
83_V109_R0.6490.53
41_L67_F0.6480.53
27_E31_T0.6340.51
98_L101_I0.6330.51
88_M97_D0.6300.51
84_I126_A0.6300.51
36_L39_H0.6210.50
37_V78_P0.6170.49
64_A110_V0.6150.49
40_L54_C0.6120.49
81_I121_H0.6030.48
45_P48_P0.6030.48
52_L56_K0.6010.48
27_E64_A0.5980.47
125_L129_F0.5950.47
55_A130_G0.5920.47
22_A48_P0.5910.46
94_T127_T0.5850.46
29_Q33_A0.5810.45
78_P130_G0.5780.45
108_S115_R0.5720.44
32_Q35_E0.5700.44
38_D108_S0.5660.44
83_V86_T0.5630.43
126_A131_I0.5620.43
41_L57_I0.5550.42
94_T108_S0.5500.42
97_D107_V0.5480.42
42_L54_C0.5470.42
97_D125_L0.5470.42
88_M125_L0.5450.41
24_I56_K0.5440.41
32_Q59_A0.5430.41
89_D94_T0.5410.41
84_I121_H0.5400.41
109_R115_R0.5400.41
103_S109_R0.5390.41
62_E137_I0.5320.40
94_T124_K0.5300.40
35_E115_R0.5280.40
117_L121_H0.5270.39
47_N132_S0.5250.39
95_L109_R0.5240.39
39_H88_M0.5230.39
122_A136_F0.5200.39
85_R89_D0.5170.38
94_T99_P0.5160.38
81_I117_L0.5150.38
117_L134_A0.5080.37
39_H49_L0.5080.37
29_Q52_L0.5070.37
78_P82_A0.5010.37
54_C116_K0.5010.37
96_S124_K0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rykA 2 0.4565 98.3 0.792 Contact Map
4mctA 2 0.4855 98.2 0.798 Contact Map
3qwgA 2 0.442 98.2 0.798 Contact Map
3trbA 3 0.4638 98.2 0.801 Contact Map
2ictA 2 0.4855 98.1 0.802 Contact Map
3cecA 1 0.4638 98.1 0.802 Contact Map
3r1fA 2 0.4493 98.1 0.803 Contact Map
4mcxA 2 0.4855 98.1 0.804 Contact Map
2a6cA 2 0.5217 98.1 0.805 Contact Map
3zhiA 1 0.4493 98 0.807 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0061 seconds.