GREMLIN Database
HICB - Antitoxin HicB
UniProt: P67697 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13760
Length: 138 (133)
Sequences: 286 (227)
Seq/√Len: 19.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_V67_D3.5941.00
85_A88_Q3.2761.00
29_G35_A2.9850.99
17_V35_A2.7610.99
94_Q98_R2.6740.98
110_L117_T2.6030.98
95_E99_R2.4980.97
4_P61_S2.4720.97
85_A89_S2.4610.97
19_F25_A2.3830.96
19_F43_L2.2170.94
5_V36_M2.1930.94
24_E50_Y1.9860.90
18_S26_L1.9380.89
5_V19_F1.9140.88
93_Q108_T1.8810.88
6_T20_V1.8770.87
49_F53_D1.8110.85
91_I95_E1.7440.83
20_V64_N1.7310.83
17_V29_G1.7120.82
74_L78_S1.6120.78
92_T95_E1.5900.77
31_T34_E1.5830.76
72_V126_A1.5760.76
100_I123_Q1.5360.74
51_F83_L1.5200.73
27_T42_A1.5070.73
106_E110_L1.4610.70
64_N67_D1.4020.67
102_K122_V1.3910.66
21_D61_S1.3840.66
16_M28_Q1.3750.66
54_N90_E1.3730.65
78_S132_E1.3550.64
91_I99_R1.3470.64
103_P106_E1.3380.63
78_S122_V1.3230.62
72_V110_L1.3120.62
47_F50_Y1.2890.60
62_P65_S1.2770.60
22_I50_Y1.2660.59
25_A46_A1.2570.58
22_I46_A1.2560.58
47_F57_I1.2550.58
79_K118_K1.2540.58
25_A43_L1.2490.58
17_V39_A1.2290.57
32_V68_H1.2250.56
22_I25_A1.1860.54
86_F111_F1.1760.53
6_T67_D1.1580.52
86_F91_I1.1510.52
48_D52_E1.1420.51
29_G34_E1.1390.51
13_G16_M1.1340.51
27_T43_L1.1260.50
56_L87_L1.1130.49
104_K111_F1.0910.48
20_V69_F1.0820.47
50_Y55_E1.0820.47
14_G28_Q1.0800.47
108_T112_N1.0780.47
8_T18_S1.0770.47
41_D45_T1.0660.46
93_Q105_Q1.0660.46
108_T111_F1.0570.46
74_L123_Q1.0510.45
63_L66_H1.0510.45
7_L36_M1.0340.44
83_L111_F1.0310.44
72_V85_A1.0280.44
17_V27_T1.0220.43
48_D51_F1.0200.43
104_K108_T1.0140.43
20_V61_S1.0130.43
84_N87_L1.0080.43
112_N118_K0.9990.42
36_M70_I0.9870.41
7_L28_Q0.9720.40
45_T50_Y0.9650.40
8_T16_M0.9550.39
63_L69_F0.9470.39
96_L129_L0.9410.38
72_V77_A0.9390.38
9_P13_G0.9330.38
79_K117_T0.9280.38
92_T108_T0.9250.37
59_L62_P0.8890.35
103_P121_A0.8870.35
110_L121_A0.8870.35
22_I51_F0.8740.34
21_D43_L0.8640.34
80_V84_N0.8610.34
19_F42_A0.8490.33
86_F89_S0.8370.32
84_N120_D0.8330.32
54_N92_T0.8320.32
15_Y114_H0.8280.32
82_L126_A0.8030.30
20_V63_L0.7970.30
50_Y78_S0.7940.30
31_T92_T0.7940.30
8_T12_E0.7860.29
78_S133_L0.7800.29
22_I119_I0.7760.29
111_F126_A0.7630.28
81_L126_A0.7620.28
69_F72_V0.7560.28
23_P122_V0.7510.28
19_F22_I0.7430.27
50_Y84_N0.7320.27
78_S119_I0.7300.27
60_P134_S0.7260.26
40_K71_E0.7240.26
53_D83_L0.7210.26
24_E46_A0.7190.26
25_A50_Y0.7150.26
57_I114_H0.7120.26
29_G36_M0.7060.25
65_S88_Q0.7020.25
57_I82_L0.6950.25
94_Q124_L0.6940.25
13_G28_Q0.6930.25
75_S120_D0.6900.25
100_I103_P0.6880.25
36_M77_A0.6800.24
79_K111_F0.6780.24
92_T106_E0.6710.24
45_T49_F0.6690.24
57_I60_P0.6660.23
9_P40_K0.6620.23
20_V47_F0.6590.23
12_E16_M0.6590.23
63_L67_D0.6540.23
5_V70_I0.6530.23
105_Q108_T0.6430.22
54_N108_T0.6420.22
93_Q111_F0.6320.22
9_P128_A0.6290.22
66_H101_G0.6280.22
99_R121_A0.6260.22
49_F83_L0.6220.22
24_E74_L0.6220.22
34_E92_T0.6210.21
80_V83_L0.6170.21
125_A130_G0.6170.21
73_P87_L0.6100.21
5_V57_I0.6090.21
10_A28_Q0.6080.21
93_Q123_Q0.6040.21
8_T74_L0.6000.21
43_L126_A0.5960.20
51_F73_P0.5910.20
5_V47_F0.5860.20
55_E61_S0.5850.20
94_Q102_K0.5810.20
16_M26_L0.5770.20
54_N86_F0.5700.19
31_T42_A0.5690.19
78_S81_L0.5630.19
35_A127_K0.5620.19
79_K120_D0.5620.19
45_T52_E0.5570.19
121_A124_L0.5550.19
24_E133_L0.5530.19
64_N69_F0.5520.19
38_A41_D0.5510.19
59_L65_S0.5500.19
14_G26_L0.5480.18
113_L120_D0.5460.18
18_S115_H0.5460.18
4_P12_E0.5420.18
17_V94_Q0.5410.18
75_S117_T0.5410.18
86_F129_L0.5400.18
49_F120_D0.5370.18
55_E128_A0.5370.18
56_L135_L0.5370.18
15_Y65_S0.5370.18
9_P31_T0.5350.18
30_E55_E0.5340.18
19_F26_L0.5310.18
17_V22_I0.5310.18
64_N124_L0.5300.18
13_G62_P0.5270.18
94_Q104_K0.5250.18
17_V32_V0.5230.18
79_K86_F0.5230.18
78_S127_K0.5230.18
13_G122_V0.5230.18
75_S83_L0.5200.17
3_Y80_V0.5180.17
20_V25_A0.5140.17
70_I133_L0.5130.17
7_L17_V0.5100.17
58_P79_K0.5090.17
73_P119_I0.5030.17
36_M131_K0.5020.17
12_E28_Q0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p78A 2 0.5435 99.7 0.653 Contact Map
2dsyA 3 0.4783 99.5 0.702 Contact Map
3kwrA 2 0.558 99.4 0.717 Contact Map
2yztA 2 0.471 99.3 0.721 Contact Map
1wv8A 2 0.5 99.2 0.74 Contact Map
2a6cA 2 0.5362 97.3 0.848 Contact Map
2ef8A 2 0.5145 96.4 0.865 Contact Map
2k9qA 2 0.4565 96.4 0.866 Contact Map
2kpjA 1 0.5072 96.1 0.869 Contact Map
1nr3A 1 0.3841 96.1 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.