GREMLIN Database
AAER - HTH-type transcriptional activator AaeR
UniProt: P67662 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12825
Length: 309 (288)
Sequences: 79680 (57889)
Seq/√Len: 3411.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_R75_E3.5131.00
16_F25_Q3.3661.00
156_R289_T2.6941.00
97_G139_L2.6301.00
68_G82_Q2.3951.00
230_L237_A2.3241.00
162_P241_L2.2171.00
171_Y187_H2.2051.00
113_K291_Y2.2021.00
160_A266_P2.1681.00
12_K25_Q2.1501.00
157_R160_A2.1451.00
21_A24_R2.1371.00
15_E70_R2.1361.00
93_T124_N2.1001.00
93_T122_S2.0661.00
157_R266_P2.0311.00
180_K183_D2.0201.00
227_V247_E1.9961.00
11_A66_Y1.9921.00
9_V36_T1.9831.00
46_V61_A1.9751.00
231_T252_E1.9461.00
95_R124_N1.9391.00
68_G75_E1.9351.00
160_A264_P1.9261.00
167_A256_L1.9041.00
113_K287_S1.9021.00
9_V33_I1.8991.00
19_F37_V1.8951.00
72_M76_V1.8921.00
12_K15_E1.8851.00
11_A70_R1.8781.00
190_L235_G1.8771.00
14_V58_L1.8701.00
12_K16_F1.8401.00
11_A15_E1.8281.00
66_Y70_R1.7991.00
164_V241_L1.7871.00
231_T247_E1.7641.00
65_Y79_V1.7271.00
50_N57_G1.7241.00
114_M284_V1.6761.00
188_S217_R1.6721.00
176_G183_D1.6571.00
64_I82_Q1.6411.00
155_S268_Y1.6351.00
164_V255_I1.6181.00
15_E25_Q1.6151.00
10_F66_Y1.5891.00
133_D138_G1.5691.00
9_V28_M1.5611.00
14_V66_Y1.5611.00
11_A69_C1.5581.00
16_F21_A1.5451.00
154_F273_E1.5331.00
89_T120_G1.5231.00
60_E63_R1.5201.00
20_T30_V1.5161.00
114_M121_L1.5111.00
6_R36_T1.4891.00
132_P136_A1.4811.00
6_R43_E1.4661.00
29_S32_S1.4471.00
11_A73_L1.4421.00
200_F204_A1.4321.00
47_K50_N1.4311.00
156_R271_Y1.4271.00
18_S21_A1.4121.00
277_L281_V1.4021.00
285_I289_T1.3921.00
6_R39_K1.3921.00
12_K26_L1.3921.00
68_G71_R1.3781.00
72_M79_V1.3761.00
144_R270_L1.3711.00
154_F271_Y1.3651.00
146_G268_Y1.3631.00
68_G78_D1.3571.00
169_K252_E1.3471.00
4_L76_V1.3331.00
135_I152_S1.3261.00
113_K117_E1.3241.00
269_A285_I1.3231.00
91_I120_G1.3191.00
104_Q224_M1.3171.00
141_V281_V1.3161.00
3_R6_R1.3141.00
271_Y285_I1.3111.00
283_V286_N1.2971.00
134_L142_V1.2921.00
43_E80_H1.2821.00
133_D139_L1.2761.00
141_V269_A1.2751.00
187_H236_I1.2681.00
95_R126_V1.2661.00
167_A236_I1.2641.00
161_M242_M1.2641.00
65_Y80_H1.2601.00
115_L217_R1.2521.00
241_L245_I1.2431.00
52_S57_G1.2401.00
226_L237_A1.2401.00
247_E252_E1.2381.00
63_R67_Q1.2301.00
38_S42_D1.2301.00
245_I249_N1.2151.00
207_G212_L1.2061.00
190_L226_L1.2041.00
75_E78_D1.2011.00
117_E287_S1.1961.00
94_L284_V1.1791.00
67_Q71_R1.1791.00
228_R231_T1.1781.00
115_L188_S1.1731.00
172_L187_H1.1731.00
10_F49_L1.1731.00
241_L255_I1.1721.00
113_K116_K1.1711.00
177_I254_E1.1691.00
64_I67_Q1.1661.00
68_G79_V1.1631.00
157_R268_Y1.1581.00
112_A116_K1.1581.00
169_K254_E1.1481.00
155_S270_L1.1451.00
10_F48_L1.1321.00
28_M32_S1.1231.00
10_F14_V1.1151.00
8_S77_Q1.1141.00
35_Q38_S1.1131.00
13_V22_A1.1121.00
34_S38_S1.1111.00
114_M287_S1.1041.00
19_F56_I1.0921.00
188_S215_Q1.0891.00
35_Q39_K1.0871.00
272_T275_D1.0831.00
5_K8_S1.0821.00
220_T226_L1.0801.00
124_N219_V1.0771.00
71_R78_D1.0701.00
118_Y283_V1.0691.00
286_N289_T1.0681.00
112_A232_A1.0681.00
7_M69_C1.0651.00
72_M75_E1.0591.00
282_Q286_N1.0571.00
58_L62_G1.0561.00
12_K22_A1.0551.00
166_C255_I1.0541.00
110_L288_L1.0461.00
36_T39_K1.0401.00
287_S291_Y1.0401.00
168_A233_G1.0371.00
103_A127_T1.0301.00
227_V231_T1.0221.00
128_G133_D1.0181.00
178_P259_R1.0141.00
165_V236_I1.0081.00
64_I68_G0.9971.00
228_R232_A0.9971.00
109_G232_A0.9901.00
9_V26_L0.9871.00
179_E183_D0.9871.00
156_R285_I0.9871.00
255_I258_P0.9841.00
77_Q81_E0.9831.00
117_E290_D0.9821.00
14_V49_L0.9821.00
80_H84_Y0.9811.00
28_M33_I0.9741.00
181_P260_Y0.9731.00
166_C244_V0.9731.00
77_Q80_H0.9661.00
162_P264_P0.9631.00
201_E204_A0.9591.00
114_M118_Y0.9571.00
13_V19_F0.9501.00
10_F58_L0.9441.00
171_Y188_S0.9421.00
65_Y69_C0.9411.00
246_N250_R0.9341.00
191_E216_G0.9331.00
167_A171_Y0.9291.00
49_L56_I0.9281.00
110_L287_S0.9271.00
220_T229_W0.9261.00
152_S273_E0.9251.00
135_I150_D0.9251.00
14_V62_G0.9241.00
133_D136_A0.9231.00
74_H78_D0.9231.00
171_Y174_Q0.9221.00
278_P281_V0.9211.00
10_F40_L0.9141.00
46_V83_L0.9131.00
287_S290_D0.9121.00
97_G142_V0.9081.00
122_S215_Q0.8961.00
139_L142_V0.8941.00
244_V247_E0.8881.00
22_A33_I0.8871.00
153_L270_L0.8831.00
39_K42_D0.8751.00
97_G144_R0.8701.00
67_Q70_R0.8691.00
167_A172_L0.8681.00
21_A25_Q0.8561.00
171_Y175_Y0.8551.00
100_S222_D0.8541.00
96_I141_V0.8541.00
20_T24_R0.8521.00
126_V133_D0.8511.00
183_D186_S0.8501.00
286_N290_D0.8471.00
203_I207_G0.8471.00
121_L280_K0.8471.00
188_S216_G0.8471.00
5_K36_T0.8471.00
13_V37_V0.8441.00
189_W214_P0.8431.00
175_Y188_S0.8391.00
166_C237_A0.8391.00
17_G57_G0.8351.00
146_G266_P0.8351.00
52_S55_S0.8271.00
26_L33_I0.8271.00
172_L177_I0.8201.00
131_A135_I0.8141.00
71_R74_H0.8111.00
248_I251_G0.8091.00
173_T187_H0.8041.00
14_V17_G0.8021.00
170_S174_Q0.7991.00
10_F65_Y0.7991.00
154_F157_R0.7941.00
17_G63_R0.7931.00
201_E205_P0.7921.00
90_P118_Y0.7911.00
61_A83_L0.7911.00
13_V49_L0.7901.00
38_S47_K0.7841.00
4_L73_L0.7841.00
141_V284_V0.7791.00
126_V139_L0.7791.00
92_G280_K0.7761.00
112_A234_A0.7761.00
247_E250_R0.7741.00
206_E210_T0.7731.00
182_A185_S0.7721.00
30_V34_S0.7711.00
168_A234_A0.7691.00
277_L282_Q0.7681.00
15_E66_Y0.7681.00
244_V248_I0.7631.00
75_E79_V0.7631.00
76_V79_V0.7571.00
58_L63_R0.7511.00
143_I288_L0.7501.00
229_W234_A0.7471.00
117_E283_V0.7471.00
16_F22_A0.7461.00
84_Y87_N0.7421.00
162_P257_L0.7411.00
162_P262_S0.7401.00
135_I153_L0.7381.00
17_G55_S0.7361.00
279_L283_V0.7351.00
6_R9_V0.7341.00
57_G63_R0.7341.00
61_A86_F0.7341.00
64_I86_F0.7331.00
166_C239_V0.7321.00
200_F219_V0.7321.00
78_D82_Q0.7281.00
113_K290_D0.7271.00
95_R139_L0.7211.00
248_I255_I0.7191.00
185_S212_L0.7171.00
166_C248_I0.7151.00
174_Q254_E0.7121.00
61_A64_I0.7111.00
32_S36_T0.7101.00
115_L234_A0.7101.00
167_A254_E0.7091.00
240_P243_W0.7081.00
79_V83_L0.7071.00
92_G121_L0.7071.00
110_L291_Y0.7071.00
13_V33_I0.7061.00
69_C72_M0.7061.00
180_K259_R0.7051.00
76_V80_H0.7041.00
202_L206_E0.7041.00
8_S12_K0.7021.00
19_F55_S0.7021.00
205_P208_I0.6941.00
19_F33_I0.6941.00
114_M283_V0.6941.00
95_R140_D0.6921.00
222_D225_T0.6871.00
186_S215_Q0.6871.00
50_N59_T0.6861.00
182_A210_T0.6861.00
167_A173_T0.6851.00
168_A171_Y0.6841.00
199_E203_I0.6821.00
207_G214_P0.6811.00
98_C107_L0.6811.00
50_N55_S0.6801.00
98_C103_A0.6781.00
41_E46_V0.6751.00
61_A65_Y0.6741.00
218_F229_W0.6731.00
206_E209_S0.6711.00
178_P257_L0.6701.00
69_C73_L0.6701.00
134_L270_L0.6701.00
180_K260_Y0.6681.00
94_L280_K0.6671.00
70_R74_H0.6651.00
199_E202_L0.6651.00
275_D278_P0.6651.00
74_H77_Q0.6641.00
140_D281_V0.6621.00
192_Y226_L0.6621.00
78_D81_E0.6561.00
205_P209_S0.6551.00
41_E51_R0.6521.00
122_S219_V0.6491.00
170_S173_T0.6471.00
193_S219_V0.6441.00
65_Y83_L0.6411.00
60_E64_I0.6401.00
5_K39_K0.6381.00
203_I206_E0.6381.00
22_A26_L0.6371.00
63_R66_Y0.6341.00
246_N249_N0.6321.00
37_V41_E0.6321.00
24_R27_Q0.6301.00
13_V18_S0.6291.00
137_D272_T0.6281.00
189_W236_I0.6281.00
200_F203_I0.6261.00
170_S254_E0.6261.00
159_G267_V0.6241.00
283_V287_S0.6241.00
169_K251_G0.6231.00
165_V184_L0.6211.00
170_S233_G0.6191.00
8_S11_A0.6161.00
165_V189_W0.6151.00
64_I83_L0.6081.00
226_L230_L0.6081.00
68_G72_M0.6081.00
284_V288_L0.6071.00
104_Q228_R0.6051.00
141_V285_I0.6041.00
204_A208_I0.6031.00
173_T179_E0.6021.00
193_S221_N0.6021.00
100_S129_I0.6011.00
154_F274_K0.5991.00
229_W235_G0.5991.00
58_L66_Y0.5951.00
94_L141_V0.5941.00
91_I122_S0.5941.00
134_L153_L0.5931.00
31_S35_Q0.5871.00
107_L110_L0.5861.00
279_L282_Q0.5841.00
32_S35_Q0.5831.00
5_K9_V0.5831.00
165_V238_Y0.5821.00
176_G179_E0.5811.00
172_L175_Y0.5781.00
161_M265_R0.5771.00
81_E85_A0.5771.00
44_L83_L0.5741.00
163_M238_Y0.5741.00
173_T176_G0.5731.00
127_T222_D0.5711.00
29_S35_Q0.5691.00
44_L65_Y0.5681.00
46_V50_N0.5631.00
172_L176_G0.5631.00
37_V49_L0.5621.00
145_V265_R0.5601.00
271_Y282_Q0.5601.00
49_L58_L0.5581.00
127_T221_N0.5551.00
201_E206_E0.5541.00
178_P183_D0.5531.00
220_T225_T0.5521.00
109_G113_K0.5511.00
194_V219_V0.5511.00
44_L47_K0.5451.00
73_L76_V0.5441.00
92_G118_Y0.5421.00
69_C76_V0.5421.00
109_G112_A0.5411.00
67_Q82_Q0.5411.00
223_P240_P0.5401.00
9_V37_V0.5381.00
111_T123_V0.5381.00
102_M106_V0.5361.00
167_A174_Q0.5341.00
171_Y236_I0.5331.00
97_G128_G0.5331.00
8_S73_L0.5331.00
143_I269_A0.5311.00
239_V244_V0.5271.00
73_L77_Q0.5251.00
281_V285_I0.5231.00
132_P138_G0.5221.00
68_G83_L0.5211.00
158_L269_A0.5201.00
92_G120_G0.5151.00
9_V22_A0.5141.00
47_K61_A0.5131.00
19_F51_R0.5131.00
7_M65_Y0.5121.00
104_Q222_D0.5091.00
3_R39_K0.5081.00
231_T250_R0.5061.00
19_F30_V0.5061.00
204_A207_G0.5051.00
28_M36_T0.5021.00
17_G56_I0.5011.00
97_G126_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fxqA 3 0.9385 100 0.116 Contact Map
2esnA 3 0.9417 100 0.12 Contact Map
3fzvA 4 0.9223 100 0.123 Contact Map
1uthA 2 0.7249 100 0.125 Contact Map
3hhgA 3 0.9482 100 0.128 Contact Map
3szpA 3 0.9385 100 0.129 Contact Map
1ixcA 4 0.9385 100 0.131 Contact Map
1al3A 1 0.7152 100 0.133 Contact Map
4x6gA 4 0.9709 100 0.146 Contact Map
2h98A 2 0.6796 100 0.147 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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