GREMLIN Database
YHEU - UPF0270 protein YheU
UniProt: P67624 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12905
Length: 72 (69)
Sequences: 259 (152)
Seq/√Len: 18.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_S12_T3.8291.00
27_D32_E3.5341.00
51_A64_I2.7050.98
12_T15_N2.3430.95
20_F64_I2.2120.93
22_L56_S2.1550.92
41_D55_W2.0960.91
22_L58_L2.0660.90
8_L53_L1.9800.88
18_E39_V1.9140.86
22_L59_H1.8570.85
33_R41_D1.6710.77
19_S55_W1.6430.76
17_I42_V1.6140.75
14_E43_K1.6060.75
56_S59_H1.5830.73
21_V42_V1.5680.73
23_R27_D1.5030.69
40_A47_Q1.4380.66
46_L53_L1.3930.63
9_S15_N1.2100.52
34_T37_Q1.1950.51
17_I43_K1.1900.51
36_E43_K1.1560.49
5_W53_L1.1420.48
14_E37_Q1.1410.48
35_L52_V1.1360.48
11_E30_E1.1300.47
40_A43_K1.0940.45
24_E58_L1.0850.45
5_W63_N1.0580.43
3_I18_E1.0290.41
21_V46_L1.0210.41
1_M56_S1.0190.41
16_L62_V0.9810.38
24_E59_H0.9440.36
37_Q55_W0.9430.36
5_W55_W0.9390.36
36_E40_A0.9300.35
54_V60_E0.8860.33
19_S41_D0.8810.33
54_V65_M0.8810.33
23_R32_E0.8790.33
3_I53_L0.8550.31
22_L57_E0.8490.31
33_R55_W0.8380.30
20_F42_V0.8270.30
51_A68_S0.8050.29
61_T69_Q0.7710.27
2_L52_V0.7630.27
16_L43_K0.7610.27
1_M52_V0.7600.26
1_M57_E0.7600.26
35_L64_I0.7550.26
30_E44_R0.7450.26
19_S42_V0.7440.26
2_L5_W0.7420.26
37_Q40_A0.7280.25
21_V30_E0.7250.25
10_P48_C0.7210.25
50_E68_S0.7150.24
12_T61_T0.6960.24
63_N66_P0.6930.23
31_H36_E0.6930.23
65_M69_Q0.6690.22
30_E35_L0.6660.22
48_C61_T0.6650.22
16_L44_R0.6630.22
39_V43_K0.6610.22
59_H63_N0.6520.22
11_E17_I0.6520.22
21_V39_V0.6510.22
54_V58_L0.6500.22
16_L42_V0.6400.21
28_Y38_K0.6390.21
16_L50_E0.6360.21
8_L51_A0.6340.21
9_S68_S0.6290.21
55_W65_M0.6170.20
46_L64_I0.6160.20
27_D55_W0.6040.20
14_E41_D0.6040.20
50_E67_R0.5960.19
12_T21_V0.5940.19
43_K47_Q0.5880.19
39_V42_V0.5880.19
2_L15_N0.5620.18
31_H43_K0.5590.18
34_T38_K0.5500.18
24_E45_Q0.5480.18
27_D33_R0.5430.17
14_E47_Q0.5390.17
10_P14_E0.5380.17
23_R69_Q0.5370.17
21_V24_E0.5360.17
7_D20_F0.5310.17
39_V50_E0.5300.17
42_V55_W0.5230.17
17_I62_V0.5230.17
51_A63_N0.5200.17
39_V46_L0.5110.16
6_Q34_T0.5110.16
2_L51_A0.5030.16
8_L18_E0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y0nA 1 0.8889 100 0.115 Contact Map
3onhA 1 0.9306 48.2 0.893 Contact Map
1snnA 2 0.5 29.1 0.905 Contact Map
1tksA 2 0.5278 19.6 0.913 Contact Map
3mioA 2 0.5556 19.5 0.913 Contact Map
4i14A 2 0.5556 16.3 0.916 Contact Map
4bwpA 2 0.9861 16 0.916 Contact Map
2fqxA 1 0.8611 15.9 0.916 Contact Map
4ffjA 2 0.5417 15.4 0.916 Contact Map
2nysA 2 0.8889 10.8 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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