GREMLIN Database
XANQ - Xanthine permease XanQ
UniProt: P67444 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13065
Length: 466 (405)
Sequences: 4406 (2290)
Seq/√Len: 113.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_L224_A5.4971.00
197_V220_V5.2101.00
170_F191_G4.1941.00
157_M435_G4.1081.00
198_V217_G4.0171.00
241_L355_M3.9341.00
66_I351_G3.6631.00
223_I227_C3.6471.00
234_S238_N3.4351.00
406_L438_T3.1861.00
201_F216_I3.0461.00
131_L263_G2.9861.00
190_V225_S2.9611.00
233_F236_M2.8921.00
69_G348_V2.8261.00
248_F313_A2.7961.00
403_S439_A2.6981.00
395_R447_P2.6881.00
193_L220_V2.6791.00
193_L197_V2.6761.00
239_L355_M2.6391.00
190_V230_M2.5771.00
126_F312_S2.5341.00
277_I300_G2.4581.00
32_L346_M2.4501.00
71_G307_V2.4451.00
28_A342_T2.4231.00
189_G193_L2.3621.00
122_L312_S2.3091.00
120_S253_S2.2971.00
195_L374_L2.2591.00
219_C223_I2.2381.00
25_L346_M2.2371.00
222_Y231_V2.2221.00
190_V228_L2.2141.00
24_A342_T2.1761.00
282_M389_T2.1731.00
73_W344_A2.1541.00
67_A314_V2.1441.00
73_W341_R2.1111.00
126_F309_V2.0871.00
145_V444_I2.0791.00
236_M359_F2.0681.00
223_I226_L2.0541.00
237_R240_P2.0541.00
185_Y189_G2.0501.00
334_V339_V1.9841.00
76_V341_R1.9721.00
46_V100_M1.9311.00
186_E230_M1.9021.00
66_I348_V1.8881.00
235_S362_T1.8841.00
441_L445_I1.8751.00
197_V201_F1.8731.00
119_S253_S1.8701.00
222_Y362_T1.8691.00
197_V224_A1.8391.00
224_A228_L1.8351.00
198_V371_A1.8321.00
345_V349_I1.8121.00
160_L380_A1.8071.00
16_E286_R1.8031.00
126_F130_F1.7971.00
201_F205_R1.7651.00
147_T443_N1.7541.00
239_L358_G1.7391.00
227_C230_M1.7161.00
32_L343_I1.6881.00
234_S237_R1.6841.00
169_D365_S1.6751.00
236_M239_L1.6331.00
287_P290_G1.6231.00
133_V309_V1.6161.00
200_G204_C1.6091.00
208_L212_G1.5771.00
130_F134_G1.5621.00
195_L402_T1.5441.00
296_R299_G1.5391.00
399_I442_L1.5361.00
189_G192_L1.5251.00
255_S258_Q1.5171.00
68_S89_I1.5101.00
119_S254_F1.4971.00
192_L196_I1.4961.00
126_F129_A1.4921.00
18_R338_Y1.4871.00
149_T400_V1.4811.00
221_G367_V1.4791.00
403_S438_T1.4751.00
205_R209_L1.4661.00
101_I104_G1.4591.00
209_L216_I1.4471.00
14_E286_R1.4361.00
121_L124_V1.4281.00
226_L233_F1.4091.00
437_L441_L1.4061.00
224_A227_C1.4031.00
73_W76_V1.4021.00
247_P315_G1.4011.00
286_R296_R1.4011.00
103_L258_Q1.3991.00
248_F251_G1.3881.00
31_H325_N1.3651.00
119_S251_G1.3631.00
235_S238_N1.3571.00
406_L434_A1.3561.00
129_A302_L1.3531.00
104_G121_L1.3441.00
70_I348_V1.3381.00
425_Y429_E1.3371.00
422_A425_Y1.3311.00
254_F259_F1.3291.00
329_I335_A1.3221.00
196_I200_G1.3191.00
129_A309_V1.3151.00
97_V101_I1.3011.00
73_W348_V1.3011.00
72_T89_I1.2980.99
276_D323_A1.2970.99
22_H26_V1.2900.99
249_K315_G1.2870.99
136_S298_K1.2820.99
35_I39_M1.2810.99
77_N341_R1.2780.99
220_V224_A1.2770.99
280_T329_I1.2740.99
14_E17_D1.2690.99
13_F17_D1.2570.99
107_M255_S1.2510.99
120_S124_V1.2510.99
247_P313_A1.2500.99
133_V305_G1.2440.99
186_E228_L1.2350.99
66_I314_V1.2280.99
100_M121_L1.2270.99
76_V340_G1.2260.99
186_E189_G1.2190.99
402_T438_T1.2120.99
355_M358_G1.2020.99
212_G216_I1.1980.99
123_G254_F1.1970.99
205_R210_R1.1920.99
173_G183_G1.1820.99
175_A181_T1.1820.99
133_V306_L1.1770.99
93_N269_S1.1640.99
119_S123_G1.1620.99
128_G266_Y1.1590.99
181_T184_N1.1550.99
83_G299_G1.1520.99
129_A136_S1.1500.99
289_Q296_R1.1490.99
123_G259_F1.1480.99
149_T153_I1.1410.99
167_I409_G1.1400.99
133_V137_F1.1400.99
88_S280_T1.1390.99
171_G182_F1.1370.99
349_I353_F1.1330.99
284_S287_P1.1280.99
189_G228_L1.1270.99
243_T354_P1.1160.98
256_F259_F1.1130.98
60_L246_H1.1080.98
125_S129_A1.1040.98
281_A288_I1.1020.98
120_S125_S1.0990.98
108_K120_S1.0930.98
273_A277_I1.0760.98
82_V306_L1.0750.98
390_N396_E1.0720.98
311_A319_L1.0650.98
187_H366_A1.0620.98
216_I220_V1.0610.98
21_F25_L1.0560.98
95_S269_S1.0550.98
91_S322_F1.0540.98
277_I304_D1.0480.98
272_E320_T1.0460.98
157_M407_G1.0450.98
404_L408_L1.0440.98
385_R389_T1.0370.98
48_A59_Y1.0330.97
90_Q321_T1.0320.97
276_D326_N1.0280.97
353_F357_G1.0270.97
89_I343_I1.0260.97
99_V265_I1.0230.97
127_V259_F1.0190.97
103_L262_V1.0170.97
222_Y233_F1.0170.97
424_I427_L1.0150.97
34_A328_V1.0140.97
13_F19_P1.0110.97
241_L353_F1.0090.97
19_P336_S1.0060.97
73_W345_V0.9930.97
200_G445_I0.9910.97
393_K396_E0.9900.97
424_I428_V0.9890.97
184_N187_H0.9820.97
156_L404_L0.9820.97
125_S312_S0.9800.96
123_G127_V0.9800.96
225_S229_G0.9790.96
70_I310_I0.9730.96
186_E190_V0.9730.96
19_P24_A0.9710.96
182_F413_D0.9700.96
44_L61_V0.9680.96
338_Y341_R0.9660.96
42_P94_F0.9650.96
226_L231_V0.9630.96
193_L228_L0.9610.96
310_I314_V0.9570.96
19_P339_V0.9550.96
246_H249_K0.9540.96
18_R24_A0.9500.96
20_P23_Q0.9480.96
102_A106_S0.9440.96
88_S321_T0.9410.96
163_I405_G0.9320.95
134_G138_I0.9320.95
398_L402_T0.9290.95
168_I182_F0.9260.95
125_S132_V0.9210.95
102_A105_S0.9130.95
196_I199_I0.9120.95
171_G183_G0.9100.95
232_D235_S0.9070.95
13_F20_P0.9060.95
131_L270_V0.9050.95
273_A300_G0.9040.95
172_G182_F0.9000.94
286_R289_Q0.8950.94
244_I352_L0.8930.94
25_L29_I0.8920.94
29_I346_M0.8920.94
15_L18_R0.8910.94
124_V132_V0.8910.94
124_V128_G0.8880.94
31_H35_I0.8840.94
257_H261_V0.8790.94
197_V216_I0.8740.93
172_G183_G0.8700.93
140_P298_K0.8690.93
241_L245_P0.8680.93
161_S432_I0.8670.93
93_N320_T0.8650.93
380_A404_L0.8620.93
70_I74_L0.8600.93
356_I359_F0.8580.93
290_G295_S0.8550.93
123_G136_S0.8520.93
106_S109_S0.8520.93
284_S335_A0.8490.92
25_L342_T0.8480.92
197_V200_G0.8430.92
341_R344_A0.8400.92
169_D376_F0.8390.92
156_L384_I0.8380.92
69_G344_A0.8380.92
306_L310_I0.8380.92
244_I247_P0.8360.92
89_I340_G0.8290.92
146_I436_G0.8270.91
273_A304_D0.8260.91
381_I397_T0.8250.91
236_M355_M0.8230.91
233_F362_T0.8210.91
122_L125_S0.8210.91
31_H34_A0.8210.91
118_M122_L0.8190.91
127_V254_F0.8170.91
132_V136_S0.8130.91
225_S230_M0.8130.91
206_S210_R0.8110.91
25_L237_R0.8090.91
222_Y363_I0.7990.90
236_M358_G0.7990.90
141_Y290_G0.7960.90
32_L350_L0.7960.90
121_L125_S0.7950.90
35_I325_N0.7940.90
192_L228_L0.7930.90
67_A316_S0.7920.90
81_I306_L0.7900.89
231_V362_T0.7890.89
64_A317_L0.7870.89
123_G128_G0.7850.89
129_A305_G0.7830.89
274_V297_L0.7820.89
240_P243_T0.7820.89
350_L356_I0.7810.89
374_L398_L0.7810.89
132_V302_L0.7800.89
223_I349_I0.7790.89
38_P376_F0.7780.89
75_Q86_L0.7760.89
110_D253_S0.7720.88
341_R345_V0.7700.88
88_S328_V0.7700.88
120_S255_S0.7680.88
195_L199_I0.7680.88
76_V337_R0.7670.88
67_A311_A0.7620.88
123_G129_A0.7600.88
38_P324_Q0.7600.88
173_G182_F0.7590.88
155_V276_D0.7580.87
41_T169_D0.7570.87
269_S320_T0.7570.87
88_S277_I0.7530.87
381_I400_V0.7530.87
281_A289_Q0.7520.87
399_I403_S0.7520.87
87_L340_G0.7510.87
109_S117_I0.7490.87
42_P92_V0.7490.87
401_A405_G0.7490.87
39_M68_S0.7480.87
153_I403_S0.7470.87
215_A219_C0.7430.86
149_T396_E0.7430.86
219_C359_F0.7390.86
27_G31_H0.7390.86
410_V434_A0.7380.86
107_M110_D0.7360.86
98_T101_I0.7340.86
309_V313_A0.7340.86
326_N329_I0.7330.86
145_V440_I0.7320.86
67_A310_I0.7310.86
190_V224_A0.7300.85
169_D368_L0.7280.85
128_G132_V0.7270.85
201_F209_L0.7260.85
346_M350_L0.7260.85
273_A320_T0.7260.85
308_S319_L0.7240.85
247_P252_F0.7230.85
166_G191_G0.7220.85
95_S375_M0.7210.85
217_G220_V0.7210.85
133_V302_L0.7200.85
196_I219_C0.7190.85
66_I247_P0.7180.84
402_T442_L0.7170.84
267_L271_L0.7170.84
214_I328_V0.7110.84
267_L279_A0.7100.84
44_L47_G0.7090.84
28_A343_I0.7090.84
92_V96_F0.7070.84
140_P144_R0.7070.84
395_R399_I0.7050.83
295_S299_G0.7020.83
332_T346_M0.7020.83
74_L81_I0.7010.83
156_L387_I0.7000.83
64_A68_S0.6990.83
137_F302_L0.6970.83
47_G60_L0.6970.83
97_V267_L0.6960.83
218_L271_L0.6950.83
263_G266_Y0.6910.82
168_I171_G0.6900.82
225_S228_L0.6900.82
197_V217_G0.6900.82
39_M64_A0.6900.82
388_I392_L0.6890.82
256_F260_L0.6880.82
236_M362_T0.6870.82
123_G126_F0.6860.82
117_I121_L0.6860.82
125_S128_G0.6850.82
174_F181_T0.6840.82
63_M67_A0.6830.81
141_Y145_V0.6810.81
44_L368_L0.6800.81
358_G361_T0.6790.81
62_S357_G0.6790.81
406_L410_V0.6770.81
21_F346_M0.6760.81
74_L303_A0.6760.81
15_L19_P0.6740.81
66_I249_K0.6730.80
211_M447_P0.6670.80
120_S123_G0.6670.80
122_L128_G0.6660.80
64_A92_V0.6640.80
431_P435_G0.6640.80
124_V129_A0.6640.80
132_V269_S0.6630.79
228_L356_I0.6630.79
66_I352_L0.6600.79
161_S430_N0.6560.79
218_L371_A0.6540.79
63_M66_I0.6530.78
399_I447_P0.6520.78
182_F185_Y0.6520.78
280_T326_N0.6500.78
407_G431_P0.6470.78
37_V43_A0.6460.78
289_Q295_S0.6450.78
377_S381_I0.6440.77
239_L354_P0.6430.77
269_S272_E0.6420.77
41_T44_L0.6390.77
190_V366_A0.6390.77
280_T321_T0.6390.77
132_V266_Y0.6380.77
90_Q273_A0.6370.77
201_F220_V0.6350.77
189_G224_A0.6330.76
46_V218_L0.6310.76
48_A217_G0.6300.76
209_L213_G0.6280.76
272_E304_D0.6280.76
107_M258_Q0.6270.76
119_S122_L0.6190.75
35_I89_I0.6150.74
304_D401_A0.6150.74
226_L445_I0.6130.74
101_I105_S0.6130.74
136_S302_L0.6110.74
31_H328_V0.6100.74
84_S296_R0.6100.74
37_V324_Q0.6090.73
149_T399_I0.6080.73
211_M392_L0.6070.73
261_V427_L0.6060.73
103_L107_M0.6060.73
35_I385_R0.6050.73
283_V330_Q0.6050.73
93_N96_F0.6050.73
235_S314_V0.6040.73
170_F373_T0.6040.73
201_F217_G0.6040.73
95_S158_I0.6030.73
45_I101_I0.6020.73
407_G435_G0.6010.73
128_G135_S0.6000.72
17_D336_S0.6000.72
400_V404_L0.6000.72
334_V368_L0.6000.72
188_L192_L0.5980.72
183_G187_H0.5970.72
182_F187_H0.5970.72
163_I401_A0.5970.72
245_P374_L0.5960.72
220_V223_I0.5950.72
39_M42_P0.5950.72
358_G362_T0.5930.72
216_I219_C0.5910.71
69_G73_W0.5900.71
28_A155_V0.5880.71
95_S320_T0.5880.71
155_V158_I0.5870.71
127_V131_L0.5860.71
290_G296_R0.5860.71
147_T327_G0.5860.71
244_I351_G0.5860.71
184_N189_G0.5850.71
330_Q385_R0.5840.70
148_P397_T0.5840.70
100_M262_V0.5800.70
163_I408_L0.5800.70
71_G303_A0.5770.69
275_G407_G0.5770.69
18_R21_F0.5760.69
120_S258_Q0.5750.69
242_I353_F0.5750.69
66_I333_G0.5730.69
440_I448_G0.5730.69
61_V361_T0.5730.69
308_S311_A0.5720.69
187_H331_M0.5710.69
279_A382_A0.5710.69
300_G304_D0.5700.69
86_L300_G0.5680.68
198_V202_N0.5680.68
395_R448_G0.5670.68
152_G383_G0.5670.68
130_F133_V0.5660.68
214_I285_R0.5660.68
423_S426_V0.5660.68
205_R208_L0.5660.68
324_Q376_F0.5650.68
222_Y226_L0.5650.68
173_G351_G0.5650.68
323_A382_A0.5640.68
200_G205_R0.5630.68
60_L75_Q0.5620.67
68_S88_S0.5610.67
132_V270_V0.5610.67
67_A307_V0.5610.67
98_T102_A0.5600.67
168_I174_F0.5570.67
165_V169_D0.5570.67
202_N398_L0.5570.67
134_G240_P0.5570.67
276_D321_T0.5560.67
90_Q308_S0.5560.67
435_G439_A0.5550.67
123_G132_V0.5550.67
158_I322_F0.5550.67
247_P251_G0.5540.66
387_I390_N0.5540.66
385_R393_K0.5540.66
122_L131_L0.5540.66
266_Y308_S0.5540.66
351_G357_G0.5530.66
276_D382_A0.5510.66
218_L368_L0.5510.66
223_I242_I0.5500.66
118_M121_L0.5490.66
169_D372_M0.5490.66
104_G117_I0.5490.66
15_L336_S0.5480.66
163_I373_T0.5470.65
146_I207_P0.5460.65
72_T344_A0.5450.65
226_L229_G0.5440.65
144_R444_I0.5420.65
43_A47_G0.5400.64
100_M104_G0.5400.64
141_Y146_I0.5400.64
154_V195_L0.5390.64
405_G408_L0.5390.64
440_I444_I0.5380.64
309_V312_S0.5380.64
186_E224_A0.5380.64
392_L400_V0.5370.64
92_V320_T0.5370.64
207_P210_R0.5360.64
87_L284_S0.5360.64
73_W77_N0.5360.64
304_D320_T0.5350.64
306_L341_R0.5350.64
63_M122_L0.5340.64
107_M117_I0.5320.63
126_F252_F0.5320.63
269_S277_I0.5310.63
202_N210_R0.5300.63
274_V278_T0.5300.63
377_S397_T0.5290.63
70_I314_V0.5290.63
41_T45_I0.5280.63
27_G146_I0.5280.63
29_I171_G0.5270.63
286_R290_G0.5270.63
151_S354_P0.5270.63
202_N331_M0.5260.62
195_L407_G0.5260.62
40_V61_V0.5250.62
82_V155_V0.5250.62
368_L371_A0.5240.62
47_G284_S0.5240.62
96_F308_S0.5240.62
219_C445_I0.5240.62
139_L274_V0.5230.62
183_G408_L0.5230.62
325_N328_V0.5230.62
92_V276_D0.5220.62
183_G188_L0.5220.62
68_S265_I0.5210.62
446_L449_G0.5210.62
273_A321_T0.5210.62
240_P355_M0.5200.62
171_G174_F0.5190.61
21_F345_V0.5180.61
380_A384_I0.5170.61
267_L440_I0.5170.61
135_S301_V0.5170.61
72_T320_T0.5160.61
161_S431_P0.5150.61
156_L380_A0.5150.61
337_R341_R0.5140.61
21_F24_A0.5130.60
122_L309_V0.5120.60
166_G194_V0.5120.60
170_F174_F0.5120.60
134_G441_L0.5120.60
306_L309_V0.5110.60
288_I296_R0.5110.60
39_M347_L0.5100.60
246_H312_S0.5100.60
402_T408_L0.5100.60
203_C381_I0.5090.60
129_A132_V0.5090.60
168_I219_C0.5090.60
433_C437_L0.5090.60
173_G187_H0.5080.60
287_P295_S0.5080.60
223_I237_R0.5080.60
381_I384_I0.5070.60
19_P338_Y0.5070.60
280_T360_F0.5060.59
229_G367_V0.5050.59
381_I401_A0.5050.59
346_M437_L0.5030.59
270_V319_L0.5020.59
153_I439_A0.5020.59
121_L132_V0.5010.59
193_L227_C0.5000.59
159_G166_G0.5000.59
63_M315_G0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.8541 100 0.439 Contact Map
1pw4A 1 0.8755 95.4 0.948 Contact Map
4ikvA 1 0.8884 92.7 0.954 Contact Map
4j05A 3 0.8326 90.8 0.956 Contact Map
2jlnA 1 0.8412 88.1 0.959 Contact Map
3o7qA 1 0.4163 87.3 0.959 Contact Map
3wdoA 1 0.8391 86.4 0.96 Contact Map
4m64A 1 0.8391 83.9 0.961 Contact Map
4w6vA 1 0.8584 83 0.961 Contact Map
4tphA 2 0.8262 80.6 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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