GREMLIN Database
NEMR - HTH-type transcriptional repressor NemR
UniProt: P67430 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13947
Length: 199 (180)
Sequences: 47841 (37937)
Seq/√Len: 2827.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_S42_K4.1061.00
24_R33_E3.9911.00
19_Q37_T3.5041.00
50_R54_A2.7141.00
21_C29_M2.4771.00
35_L45_F2.1741.00
51_S54_A2.1561.00
138_S157_L2.1341.00
23_Q37_T2.0161.00
20_L29_M2.0161.00
20_L37_T1.9841.00
9_T12_H1.9771.00
11_E62_R1.9631.00
16_T37_T1.9291.00
85_R143_N1.9111.00
138_S142_E1.9041.00
20_L33_E1.8961.00
20_L24_R1.8781.00
12_H16_T1.8641.00
81_N84_D1.8221.00
10_R58_A1.8031.00
32_S36_K1.7931.00
41_P44_S1.7581.00
16_T19_Q1.6841.00
142_E156_P1.6691.00
18_E62_R1.6591.00
11_E15_A1.5971.00
87_L191_K1.5871.00
31_L46_Y1.5861.00
31_L42_K1.5851.00
17_G21_C1.5831.00
14_L58_A1.5581.00
58_A61_E1.4901.00
142_E146_E1.4841.00
33_E37_T1.4791.00
142_E145_R1.4681.00
18_E63_H1.4331.00
33_E36_K1.4241.00
19_Q23_Q1.4241.00
30_G33_E1.4211.00
91_Q187_L1.4171.00
18_E59_M1.3901.00
17_G55_F1.3781.00
62_R66_A1.3751.00
57_V61_E1.3701.00
61_E125_A1.3631.00
162_V166_L1.3431.00
25_G29_M1.3331.00
72_T136_L1.3191.00
57_V125_A1.3151.00
29_M34_L1.3151.00
10_R48_Y1.3131.00
8_D12_H1.3121.00
31_L45_F1.3111.00
15_A62_R1.3071.00
49_F58_A1.3051.00
44_S47_H1.2891.00
134_I161_Q1.2821.00
143_N147_N1.2411.00
25_G28_G1.2321.00
21_C26_F1.2311.00
45_F55_F1.2111.00
24_R28_G1.2061.00
145_R152_F1.2041.00
144_G149_C1.1931.00
144_G150_L1.1891.00
145_R154_G1.1801.00
70_R92_Q1.1751.00
16_T20_L1.1701.00
42_K46_Y1.1641.00
85_R140_A1.1551.00
81_N149_C1.1491.00
41_P47_H1.1231.00
44_S48_Y1.1181.00
54_A58_A1.1161.00
6_E47_H1.1151.00
87_L91_Q1.1061.00
8_D11_E1.1061.00
43_G47_H1.1061.00
84_D88_A1.0921.00
26_F56_G1.0921.00
14_L59_M1.0891.00
40_V44_S1.0881.00
106_C110_K1.0871.00
9_T48_Y1.0781.00
134_I138_S1.0721.00
53_E57_V1.0691.00
155_E158_Q1.0671.00
91_Q184_E1.0671.00
88_A91_Q1.0591.00
46_Y51_S1.0571.00
83_R87_L1.0421.00
151_T154_G1.0401.00
53_E121_D1.0361.00
158_Q185_N1.0281.00
187_L191_K1.0241.00
14_L49_F1.0221.00
17_G59_M1.0171.00
18_E22_L1.0131.00
165_A169_G1.0111.00
53_E119_S1.0041.00
34_L55_F1.0001.00
16_T38_A0.9971.00
138_S156_P0.9881.00
106_C109_V0.9871.00
15_A19_Q0.9831.00
54_A57_V0.9821.00
35_L42_K0.9711.00
182_P185_N0.9671.00
110_K114_E0.9661.00
140_A144_G0.9611.00
136_L139_Q0.9611.00
68_H132_G0.9611.00
24_R37_T0.9591.00
96_Q100_H0.9501.00
80_G88_A0.9491.00
125_A128_K0.9471.00
61_E65_A0.9451.00
87_L188_A0.9451.00
84_D87_L0.9441.00
139_Q143_N0.9391.00
145_R156_P0.9361.00
58_A62_R0.9261.00
7_H11_E0.9221.00
140_A143_N0.9181.00
157_L161_Q0.9171.00
9_T40_V0.9051.00
74_L92_Q0.9041.00
131_R135_A0.8971.00
110_K113_A0.8871.00
82_Y147_N0.8871.00
62_R65_A0.8721.00
88_A92_Q0.8671.00
27_T114_E0.8621.00
42_K47_H0.8591.00
188_A191_K0.8541.00
70_R73_E0.8531.00
72_T76_Q0.8511.00
79_E85_R0.8451.00
135_A139_Q0.8451.00
128_K132_G0.8441.00
92_Q95_N0.8361.00
138_S160_A0.8351.00
63_H66_A0.8321.00
74_L88_A0.8321.00
69_Q73_E0.8321.00
139_Q142_E0.8301.00
134_I157_L0.8281.00
124_S128_K0.8171.00
181_E185_N0.8111.00
65_A69_Q0.8051.00
6_E9_T0.8021.00
68_H72_T0.7961.00
12_H38_A0.7951.00
154_G159_Q0.7911.00
20_L23_Q0.7851.00
91_Q95_N0.7821.00
82_Y144_G0.7811.00
174_A177_S0.7741.00
120_E124_S0.7731.00
179_S182_P0.7711.00
12_H15_A0.7711.00
21_C56_G0.7681.00
91_Q191_K0.7651.00
36_K42_K0.7611.00
123_R127_D0.7581.00
38_A41_P0.7571.00
158_Q189_H0.7551.00
14_L62_R0.7451.00
107_L110_K0.7451.00
80_G84_D0.7361.00
26_F52_K0.7321.00
24_R29_M0.7271.00
135_A138_S0.7231.00
68_H136_L0.7231.00
141_L156_P0.7201.00
145_R148_H0.7181.00
173_Q176_I0.7081.00
156_P160_A0.7031.00
109_V112_S0.7031.00
13_L38_A0.7011.00
111_L114_E0.7011.00
165_A168_L0.7001.00
145_R150_L0.6961.00
13_L45_F0.6961.00
141_L145_R0.6951.00
14_L18_E0.6931.00
32_S46_Y0.6911.00
118_L121_D0.6881.00
141_L163_L0.6871.00
184_E188_A0.6851.00
75_L136_L0.6811.00
158_Q162_V0.6781.00
15_A18_E0.6761.00
23_Q33_E0.6751.00
125_A129_G0.6671.00
31_L35_L0.6671.00
79_E84_D0.6661.00
132_G136_L0.6651.00
90_Y163_L0.6581.00
66_A69_Q0.6491.00
9_T44_S0.6451.00
31_L52_K0.6441.00
183_L186_A0.6361.00
61_E129_G0.6361.00
87_L90_Y0.6341.00
185_N189_H0.6261.00
26_F29_M0.6261.00
143_N146_E0.6241.00
127_D131_R0.6231.00
6_E48_Y0.6231.00
69_Q72_T0.6231.00
132_G135_A0.6191.00
185_N188_A0.6191.00
108_T111_L0.6171.00
81_N85_R0.6151.00
61_E128_K0.6101.00
158_Q161_Q0.6071.00
162_V165_A0.6011.00
95_N183_L0.6001.00
22_L106_C0.5971.00
95_N99_Q0.5961.00
173_Q177_S0.5911.00
82_Y149_C0.5891.00
186_A190_V0.5861.00
118_L122_M0.5851.00
38_A42_K0.5851.00
182_P186_A0.5831.00
26_F53_E0.5821.00
93_T97_F0.5791.00
79_E88_A0.5701.00
158_Q188_A0.5701.00
183_L187_L0.5691.00
120_E123_R0.5671.00
168_L173_Q0.5651.00
168_L172_L0.5591.00
85_R144_G0.5561.00
35_L40_V0.5551.00
64_Y129_G0.5511.00
13_L48_Y0.5491.00
182_P187_L0.5471.00
186_A189_H0.5451.00
83_R149_C0.5421.00
187_L190_V0.5421.00
9_T41_P0.5421.00
91_Q188_A0.5411.00
165_A173_Q0.5411.00
78_G88_A0.5391.00
94_L184_E0.5361.00
18_E66_A0.5331.00
32_S41_P0.5321.00
72_T132_G0.5321.00
35_L41_P0.5271.00
65_A129_G0.5241.00
83_R191_K0.5221.00
155_E159_Q0.5191.00
106_C112_S0.5191.00
146_E150_L0.5181.00
7_H10_R0.5161.00
64_Y132_G0.5161.00
73_E92_Q0.5161.00
47_H50_R0.5151.00
152_F155_E0.5141.00
20_L30_G0.5111.00
96_Q99_Q0.5091.00
27_T117_D0.5071.00
109_V113_A0.5031.00
114_E118_L0.5031.00
42_K45_F0.5011.00
129_G132_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hyjA 2 0.9698 100 0.193 Contact Map
3bruA 2 0.9598 100 0.195 Contact Map
4udsA 2 0.9246 100 0.202 Contact Map
3knwA 2 0.9095 100 0.205 Contact Map
2g7sA 2 0.9548 100 0.21 Contact Map
3eupA 2 0.995 100 0.213 Contact Map
2i10A 2 0.9296 100 0.214 Contact Map
3rd3A 2 0.9397 100 0.216 Contact Map
2xdnA 2 0.9899 100 0.22 Contact Map
4cgrA 2 0.9447 100 0.222 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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